ASFVdb The African Swine Fever Virus Database
Strain
Ukraine_Kyiv_2014 (Region: Ukraine;  Strain: ASFV/Kyiv/2016/131;  Date: 2014)
Gene
NP1450L
Description
Annotated in NCBI,  ASFV_Kyiv_2016_131_00160
Location
MN194591.1(-):134159-135094
GenBank Accession
QED21696.1
Full name
DNA-directed RNA polymerase subunit       + More
Probable DNA-directed RNA polymerase subunit 1 homolog      
 

Sequence

CDS
ATGGAGGCTGGATATGCCGAAATAGCCGCCGTTCAGTTCAATATTGCCGGTGACAATGATCATAAGAGGCAAGGCGTTATGGAGGTTACCATTTCTAATTTATTTGAGGGCACCCTTCCCGCCGAAGGGGGTATCTATGATGCGCGAATGGGAACCACCGATCACCATTATAAATGCATCACTTGCTCACACCAGCGCAAGCAATGTATGGGACACCCTGGGATACTGCAGATGCATGCTCCGGTGCTTCAGCCGCTCTTCATCGCCGAAATACGACGATGGTTAAGGGTTATATGTCTCAACTGCGGGGCTCCCATCGTTGACCTAAAGAGGTACGAGCACCTTATTAGGCCTAAGCGTCTTATTGAAGCGGCTTCAAGCCAAACCGAAGGAAAGCAGTGCTACGTCTGTAAGGCAGTACACCCCAAAATTGTTAAGGACTCGGAAGATTATTTTACCTTTTGGGCGGATCAGCAGGGCAAGATTGACAAACTGTACCCGCAGATCATCAGAGAGATTTTTTCGCGCGTAACCTACGACACCGTTGTAAAACTGGGGCGAAGTAAAAACTCCCATCCCGAAAAACTTGTGCTTAAGGCCATTCAGATCCCCCCCATCAGCATACGACCTGGCATCAGATTGGGAATCGGGTCAGGCCCCCAAAGCTTTCACGACATTAACAACGTGATTCAGTATCTGGTTCGAAAGAATCTGCTGATCCCGAAGGACCTACAAATCGTGCGCGGCCAAAAAATACCTTTAAATATTGACCGCAATTTGCAAACCATACAGCAACTTTACTATAACTTTTTGTTGGATTCCGTTTCCACCACCGCAACCCAGGGAGGCACGGGAAAGCGTGGGATCGTCATGGGGGGCACGCCCTGCTCCCTCCATCATGCGAAGACTTCCTCGCAAGGAGGGAAGAATTCGTAA
Protein
MEAGYAEIAAVQFNIAGDNDHKRQGVMEVTISNLFEGTLPAEGGIYDARMGTTDHHYKCITCSHQRKQCMGHPGILQMHAPVLQPLFIAEIRRWLRVICLNCGAPIVDLKRYEHLIRPKRLIEAASSQTEGKQCYVCKAVHPKIVKDSEDYFTFWADQQGKIDKLYPQIIREIFSRVTYDTVVKLGRSKNSHPEKLVLKAIQIPPISIRPGIRLGIGSGPQSFHDINNVIQYLVRKNLLIPKDLQIVRGQKIPLNIDRNLQTIQQLYYNFLLDSVSTTATQGGTGKRGIVMGGTPCSLHHAKTSSQGGKNS

Summary

Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Component of the DNA-dependent RNA polymerase that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
Catalytic Activity
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
Subunit
Component of the RNA polymerase that consists of at least 6 subunits.
Similarity
Belongs to the RNA polymerase beta' chain family.
Keywords
Complete proteome   DNA-directed RNA polymerase   Nucleotidyltransferase   Transcription   Transferase   Reference proteome  
Feature
chain  Probable DNA-directed RNA polymerase subunit 1 homolog
Uniprot
A0A0C5AYY7   A9JL66   D4I5T6   A9JLZ8   A0A0A1E152   A0A0C5AZF3   + More
A0A3S7XUW7   P0C988   P0C987   P0C989   P42486   E0WM49   A0A2X0RTZ9   Q65215   A0A5B8XDB9   U6M4A1   A0A329RRR1   A0A250XN27   U6GRR7   U6MW15   U6KKW3   A0A2R6WP03   U6LPX1   Q30BD9   Q1L5X2   W2MTL0   W2PT81   W2KPH2   A0A3M0Y973   A0A2E9LI20   V9DV95   A0A3Q7IKN7   A0A2H5QXG7   A0A2D6XA72   R1BS78   A0A3M1FI56   A0A0C9LWV8   A0A2G9T733   A0A2K1JHT7   A9U396   A0A067D0I1   A0A0D8XSQ9   A0A0R3Q1A0   S2JMD7   R1C2R8   R1DFU6   A0A0B7NJ98   A0A0C9S823   A0A397TXX1   A0A4S2N437   A0A0D9XW28   A0A158P6W8   A0A1V9XR03   A0A2C6KUP3  
EC Number
2.7.7.6
Pubmed
25645905    18198370    25406173    26618713    30866784    30637968    + More
8506138    11831707    21470447    8021596    16336687    17160640    29337314    22660326    29259619    23760476    18079367    29237241    28327890    28161402   
EMBL
KM111294    AJL34112.1    AM712239    CAN10198.1    FN557520    CBH29199.1    + More
AM712240    CAN10448.1    KM262844    KM262845    KM102979    KP055815    KX354450    AIY22290.1    AIY22448.1    AJZ77039.1    AKO62780.1    AOO54449.1    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34277.1    AXB49327.1    AXB49501.1    AXB49673.1    AXB49844.1    AXB50017.1    MK128995    MK333180    MK333181    AYW34070.1    QBH90587.1    QBH90772.1    AY261366    AY261363    AY261360    Z21489    U18466    FR682468    CBW46765.1    MG939583    MG939588    LS478113    AXZ95873.1    AXZ96156.1    SPS73522.1    AY261361    X71982    MN194591    QED21696.1    HG719890    CDJ58856.1    MJFZ01000606    RAW26909.1    BEGY01000127    GAX84485.1    HG672961    CDI82946.1    HG723336    CDJ65915.1    HG674029    CDJ38757.1    KZ772742    PTQ35585.1    HG713088    CDJ52196.1    DQ223185    ABA64469.1    DQ020658    AAY89364.1    KI694488    ETM39671.1    KI669605    ETN04168.1    KI681241    ETL86504.1    RFLC01000091    RMD67105.1    PCAH01000013    MBT97111.1    ANIZ01004714    ETI29912.1    BDQV01001177    GAY69314.1    NZER01000235    MAH47815.1    KB867630    EOD12973.1    RFJO01000017    RME55349.1    DF836539    GAN09200.1    KZ406433    PIO53789.1    ABEU02000014    PNR41118.1    DS545340    EDQ49860.1    KK795258    KDO36243.1    KN716409    KJH45411.1    UYYA01005215    VDM64360.1    KE124061    EPB83723.1    KB866687    EOD16843.1    KB867443    EOD13395.1    LN733683    CEP17467.1    GCHU01012411    JAG87453.1    QKWP01002953    RIB01748.1    ML220113    TGZ83978.1    MNPL01005667    OQR75863.1    MIGC01003198    PHJ19813.1   
Proteomes
UP000105860    UP000130745    UP000101090    UP000108903    UP000110401    UP000117635    + More
UP000142390    UP000241813    UP000266411    UP000101566    UP000290386    UP000291821    UP000292678    UP000000858    UP000000859    UP000000861    UP000000624    UP000141072    UP000000860    UP000321214    UP000251314    UP000232323    UP000054532    UP000018817    UP000054423    UP000018721    UP000004994    UP000236630    UP000013827    UP000053815    UP000006727    UP000027120    UP000050601    UP000014254    UP000054107    UP000266673    UP000298138    UP000032180    UP000035642    UP000192247   
PRIDE
P0C988    P0C987    P0C989    P42486    Q65215    A9U396    + More
Pfam
PF04998   RNA_pol_Rpb1_5
PF05000   RNA_pol_Rpb1_4
PF00623   RNA_pol_Rpb1_2
PF04997   RNA_pol_Rpb1_1
PF04990   RNA_pol_Rpb1_7
PF04983   RNA_pol_Rpb1_3
PF04992   RNA_pol_Rpb1_6
PF05001   RNA_pol_Rpb1_R
PF00488   MutS_V
PF05190   MutS_IV
PF00264   Tyrosinase
Interpro
IPR007066   RNA_pol_Rpb1_3
IPR038593   RNA_pol_Rpb1_7_sf
IPR038120   Rpb1_funnel_sf
IPR007083   RNA_pol_Rpb1_4
IPR006592   RNA_pol_N
IPR000722   RNA_pol_asu
IPR007081   RNA_pol_Rpb1_5
IPR007073   RNA_pol_Rpb1_7
IPR007080   RNA_pol_Rpb1_1
IPR042102   RNA_pol_Rpb1_3_sf
IPR007075   RNA_pol_Rpb1_6
IPR000684   RNA_pol_II_repeat_euk
IPR015699   DNA-dir_RNA_pol1_lsu
IPR008922   Unchr_di-copper_centre
IPR036187   DNA_mismatch_repair_MutS_sf
IPR002227   Tyrosinase_Cu-bd
IPR007861   DNA_mismatch_repair_MutS_clamp
IPR027417   P-loop_NTPase
IPR000432   DNA_mismatch_repair_MutS_C
IPR035697   RNAP_III_RPC1_N
IPR035698   RNAP_III_Rpc1_C
SUPFAM
SSF48334   SSF48334
SSF52540   SSF52540
SSF48056   SSF48056
Gene 3D
1.10.132.30     3.30.1360.140     1.10.274.100     1.10.1280.10    
CDD
cd02583  RNAP_III_RPC1_N
 cd02736  RNAP_III_Rpc1_C
ProteinModelPortal
A0A0C5AYY7   A9JL66   D4I5T6   A9JLZ8   A0A0A1E152   A0A0C5AZF3   + More
A0A3S7XUW7   P0C988   P0C987   P0C989   P42486   E0WM49   A0A2X0RTZ9   Q65215   A0A5B8XDB9   U6M4A1   A0A329RRR1   A0A250XN27   U6GRR7   U6MW15   U6KKW3   A0A2R6WP03   U6LPX1   Q30BD9   Q1L5X2   W2MTL0   W2PT81   W2KPH2   A0A3M0Y973   A0A2E9LI20   V9DV95   A0A3Q7IKN7   A0A2H5QXG7   A0A2D6XA72   R1BS78   A0A3M1FI56   A0A0C9LWV8   A0A2G9T733   A0A2K1JHT7   A9U396   A0A067D0I1   A0A0D8XSQ9   A0A0R3Q1A0   S2JMD7   R1C2R8   R1DFU6   A0A0B7NJ98   A0A0C9S823   A0A397TXX1   A0A4S2N437   A0A0D9XW28   A0A158P6W8   A0A1V9XR03   A0A2C6KUP3  
PANTHER
PTHR19376:SF11  
PDB
6J51     E-value=4.64905e-133,     Score=1221

Ontologies

KEGG
vg:22220328    
GO
GO:0006351  P:transcription, DNA-templated
 GO:0003677  F:DNA binding
 GO:0003899  F:DNA-directed 5'-3' RNA polymerase activity
 GO:0039695  P:DNA-templated viral transcription
 GO:0006366  P:transcription by RNA polymerase II
 GO:0005665  C:RNA polymerase II, core complex
 GO:0010494  C:cytoplasmic stress granule
 GO:0001055  F:RNA polymerase II activity
 GO:0019985  P:translesion synthesis
 GO:0000790  C:nuclear chromatin
 GO:0003968  F:RNA-directed 5'-3' RNA polymerase activity
 GO:0005524  F:ATP binding
 GO:0006298  P:mismatch repair
 GO:0046872  F:metal ion binding
 GO:0030983  F:mismatched DNA binding
 GO:0016491  F:oxidoreductase activity

Subcellular Location

From MSLVP
Cytoplasm

Topology

Length:
311
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01078
Exp number, first 60 AAs:
0.00094
Total prob of N-in:
0.02018
outside
1  -  311
 
 

Population Genetic Test Statistics

Pi
0.0325544
Theta
0.0398217
Tajima's D
-0.8576294
CLR
0.180351
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
 AKO62780.1
China_AnhuiXCGQ_2018 Protein
 AYW34070.1
China_ASFV-SY18_2018 Protein
 AKO62780.1
Poland_Pol16_20186_o7_2016-2017 Protein
 AXZ95873.1
Poland_Pol16_20538_o9_2016-2017 Protein
 CBW46765.1
Poland_Pol16_20540_o10_2016-2017 Protein
 CBW46765.1
Poland_Pol16_29413_o23_2016-2017 Protein
 CBW46765.1
Poland_Pol17_03029_C201_2016-2017 Protein
 CBW46765.1
Poland_Pol17_04461_C210_2016-2017 Protein
 AXZ96156.1
Poland_Pol17_05838_C220_2016-2017 Protein
 CBW46765.1
Poland_ASFV_POL_Podlaskie_2015 Protein
 CBW46765.1
Uganda_R8_2015 Protein
 AXB49327.1
Uganda_R7_2015 Protein
 AXB49501.1
Uganda_R25_2015 Protein
 AXB49673.1
Uganda_N10_2015 Protein
 AXB49844.1
Uganda_R35_2015 Protein
 AXB50017.1
Estonia_2014 Protein
 SPS73522.1
Italy_26544_OG10_2010 Protein
 AJZ77039.1
Italy_47_Ss_2008_2008 Protein
 AOO54449.1
Portugal_OURT_88.3_1988 Protein
 CAN10448.1
Spain_E75_1975 Protein
 CBH29199.1
Russia_Georgia_2007 Protein
Protein
 CBW46765.1
CBW46765.1
Kenya_Tk1_2005 Protein
 AJL34112.1
Kenya_Bus_2006 Protein
 AJL34277.1
Russia_Odintsovo_2014 Protein
 CBW46765.1
Portugal_L60_1960 Protein
 AIY22290.1
Portugal_NHV_1968 Protein
 AIY22448.1
Russia_Kashino_2013 Protein
 CBW46765.1
Benin_1997 Protein
 CAN10198.1
South_Africa_KNP_Pretorisuskop_1996 Protein
 CBW46765.1
South_Africa_MGR_Mkuzi_1979 Protein
 CBW46765.1
Malawi_Lil_1983 Protein
 CBW46765.1
Kenya_1950 Protein
 CBW46765.1
Namibia_Warthog_1980 Protein
 CBW46765.1
South_Africa_Warmbaths_1987 Protein
 CBW46765.1
Malawi_Tengani_1962 Protein
 CBW46765.1
China_HLJ_2018 Protein
 QBH90587.1
China_LN_2018 Protein
 QBH90772.1
China_wbBS01_2018 Protein
 QDL88130.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
Protein
 QED21693.1
QED21694.1
QED21695.1
QED21696.1
Belgium_Etalle_wb_2018 Protein
 QED90542.1
Lithuania_LT14_2014 Protein
 QEY87905.1
South_Africa_1985    
South_Africa_2_2008    
Zambia_LIV_1983    
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