ASFVdb The African Swine Fever Virus Database
Strain
Uganda_R35_2015 (Region: Uganda, Tororo district;  Strain: R35;  Date: 2015)
Gene
pG1211R
Description
Annotated in NCBI,  aphidicolin-resistant
GenBank Accession
Full name
DNA polymerase beta       + More
DNA polymerase      
 

Sequence

CDS
ATGGACCGTTCTGAGATTGTTGCACGGGAAAATCCGGTGATTACCCAACGGGTTACAAATCTCCTACGAACCAATGCTCCTCTACTATTCATGCCCATTGATATCCATGAAGTACGATATGGAGCCTACATGCTCTTCATGTATGGTTCCCTCGAAAACGGTTACAAAGCAGAAGTAAGGATTGAAAACATCCCAGTTTTCTTTGACGTACAGATTGAGTCTGATAACACAAATCAGCTTTTTTTAAAGTCGCTGCTGGCGGCTGAAAATATTACGTATGAACGGCTAGAGACGCTGACCCAGCGCCCAGTAATGGGGTATCGCGAGAAGGAAAAAGAGTTTGCGCCGTACATTCGAATATTTTTTAAAAGCTTATATGAGCGGCGAAAGGCGATTACTTACCTGAACAATATGGGTTACAACACGGCCGCGGACGACACAACCTGTTACTACCGAATGGTTTCCCGAGAGTTAAAACTGCCTCTTACAAGTTGGATACAGCTTCAGCAATATACCTATGAGCCTCGCGGCTTGGTACACAGGTTTTCAGTAACCCCTGAAGGTCTTGTTTCCTATCAGGATGATGTCCCCACAGACCACAGCATCGTAATGGCCTACGATATAGAAACCTATAGCCCTATTAAGGGAACCGTCCCGGACCCAAATCAGGCAAACGACGTGGTGTTCATGATATGCATGCGCATTTTTTGGATTCACTCCACAGAGCCTCTAGCAAGCACGTGCATCACCATGGCACCCTGTAAAAAATCCTCAGAGTGGACCACCATCGTATGTTCCTCTGAAAAAAATTTGCTGTTAAGCTTTGCTGAACAGTTTAGCCGCTGGGCTCCGGATATATGCACGGGGTTTAATGATTCTCGGTACGACTGGCCCTTTATCGTCGAAAAATCCATGCAGCACGGTATTCTCGAAGAAGTCTTTAACAAAATGAGCCTTTTCTGGCCCCAAAAGCTGGATACCATTCTAAAATGCTATTATGTGAAGGAAAAGAGAGTCAAAATCTCGGCCGAAAAATCTATCATTTCCTCCTTTTTGCATACCCCTGGATGCCTGCCCATTGATGTCCGCAACATGTGCATGCAGCTTTACCCTAAAGCCGAAAAAACAAGTCTAAAAGCGTTTTTAGAAAATTGTGGGCTAGATTCGAAGATAGACCTGCCGTACCATCTCATGTGGAAGTATTATGAAACGCGAGACAGTGAAAAGATGGCCGACGTGGCCTACTACTGCATTATAGATGCCCAGCGCTGTCAGGACCTTCTGGTGCGCCACAATGTTATCGCCGATCGCAGAGAGGTAGGAATCTTGTCATACACCTCGTTGTATGACTGTATCTACTACGCGGGAGGGCACAAGGTATGCAATATGCTTATTGCCTACGCCATCCATGATGAGTACGGCCGCATTGCCTGCAGCACCATTGCTCGGGGTAAGCGGGAACACGGAAAATATCCCGGCGCCTTTGTGATTGACCCCGTTAAAGGGCTTGAACAGGATAAACCCACCACCGGCCTCGACTTTGCGTCGCTATACCCCTCCCTCATCATGGCCTACAACTTTTCGCCAGAAAAATTTGTAGCCTCTCGGGATGAGGCAAATAGCCTCATAGCTAAGGGCGAGTCTCTTCACTACGTCTCCTTTCACTTCAATAACCGTCTAGTAGAAGGATGGTTTGTGCGGCATAATAACGTTCCTGATAAAATGGGATTGTACCCAAAAGTACTCATTGATCTACTTAATAAACGAACCGCTCTTAAACAAGAGCTTAAAAAACTAGGTGAAAAGAAGGAATGTATCCATGAATCCCATCCTGGGTTTAAGGAACTACAGTTCCGCCATGCCATGGTAGACGCGAAACAAAAGGCATTGAAAATTTTCATGAACACTTTTTACGGCGAGGCGGGTAACAATTTGTCACCCTTCTTTCTGCTTCCTCTGGCCGGAGGAGTCACCAGTTCGGGTCAATATAATCTTAAACTCGTCTATAACTTTGTTATCAACAAAGGTTACGGAATCAAGTACGGCGACACCGACTCATTATACATTACATGCCCGGATAGTCTTTATACAGAGGTAACAGACGCATACTTAAATAGTCAAAAAACAATAAAACATTATGAGCAACTCTGTCATGAAAAGGTGCTTCTGTCCATGAAGGCCATGTCTACACTATGCGCTGAGGTGAATGAATACCTGCGACAAGATAATGGTACCAGTTATCTACGTATGGCCTACGAGGAAGTACTCTTCCCCGTTTGCTTTACAGGCAAGAAAAAATATTACGGCATTGCTCATGTAAACACACCCAATTTTAATACAAAAGAATTATTCATCCGCGGAATAGATATCATTAAGCAGGGTCAAACAAAACTCACCAAAACGATAGGTACGCGAATTATGGAAGAATCCATGAAACTGCGCCGCCCTGAGGACCATCGCCCGCCTCTTATTGAAATCGTTAAAACGGTTTTAAAGGATGCTGTGGTTAACATGAAACAGTGGAATTTTGAAGACTTTATCCAAACAGATGCGTGGAGACCGGACAAAGACAACAAAGCAGTCCAAATCTTTATGTCTCGCATGCACGCTCGGCGTGAGCAACTAAAAAAACACGGCGCCGCCGCAACATCGCAATTTGCTGAGCCCGAGCCGGGAGAACGCTTCTCCTACGTTATCGTGGAAAAACAGGTGCAATTTGATATCCAAGGCCACCGCACAGACACCACCAGAAAGGGAGACAAAATGGAATACGTCTCTGAAGCAAAGGCTAAAAATCTTCCAATCGATATATTGTTTTATATCAATAACTATGTTCTAGGCCTGTGCGCGAGATTCATTAATGAAAATGAAGAGTTTCAGCCCCCCGGCAACGTCAGCAATAAGGACGAATACGCCCAGCGCCGAGCCAAATCCTACCTGCAAAAATTCGTGCAATCCATTCATCCTAAAGACAAGTCTGTCATTAAGCAAGGCATTGTTCATCGACAGTGCTACAAATACGTTCATCAAGAAATCAAAAAAAAAATAGGCATCTTTGCCGATCTTTATAAAGAATTTTTTAACAATACCACAAACCCCATCGAAAGCTTTATTCAAAGCACTCAGTTTATGATACATTACTTTGATGAAGAACAAAAAGTAAACCATTCAATGAAAAAAATGGTTGAGCAGCGTACTACTTTGGCTGGTAACCCGGCTGGTAACCCGGCTGGTAACCCAGCCAGCAATGCGCTGATGCGGGCTATATTTACGCAGTTGATTACGGAAGAAAAAAAAATTGTACAAGCCTTATACAATAAGGGGGACGCAATACACGACCTTCTCTCCTATATCATTAACAATATAAACTACAAAATTGCCACATTTCAGACGAAGCAGATGTTGACGTTCGAGCTTTCCAGTACTCATGTAGAACTGCTATTAAAACTAAACAAAACGTGGCTTATTTTGGTGGGAATTCATGTAGCAAAAAAACATCTGCATACTCTTTTGGGTTTATCTAACAATGAACCGCCGTCTAAGACATTCATTCAGCAAGCTATAGAGGAAGAATGTGGCAGTATTAAACCATCTTGCTACGACTTTATTTCCTAA
Protein
MDRSEIVARENPVITQRVTNLLRTNAPLLFMPIDIHEVRYGAYMLFMYGSLENGYKAEVRIENIPVFFDVQIESDNTNQLFLKSLLAAENITYERLETLTQRPVMGYREKEKEFAPYIRIFFKSLYERRKAITYLNNMGYNTAADDTTCYYRMVSRELKLPLTSWIQLQQYTYEPRGLVHRFSVTPEGLVSYQDDVPTDHSIVMAYDIETYSPIKGTVPDPNQANDVVFMICMRIFWIHSTEPLASTCITMAPCKKSSEWTTIVCSSEKNLLLSFAEQFSRWAPDICTGFNDSRYDWPFIVEKSMQHGILEEVFNKMSLFWPQKLDTILKCYYVKEKRVKISAEKSIISSFLHTPGCLPIDVRNMCMQLYPKAEKTSLKAFLENCGLDSKIDLPYHLMWKYYETRDSEKMADVAYYCIIDAQRCQDLLVRHNVIADRREVGILSYTSLYDCIYYAGGHKVCNMLIAYAIHDEYGRIACSTIARGKREHGKYPGAFVIDPVKGLEQDKPTTGLDFASLYPSLIMAYNFSPEKFVASRDEANSLIAKGESLHYVSFHFNNRLVEGWFVRHNNVPDKMGLYPKVLIDLLNKRTALKQELKKLGEKKECIHESHPGFKELQFRHAMVDAKQKALKIFMNTFYGEAGNNLSPFFLLPLAGGVTSSGQYNLKLVYNFVINKGYGIKYGDTDSLYITCPDSLYTEVTDAYLNSQKTIKHYEQLCHEKVLLSMKAMSTLCAEVNEYLRQDNGTSYLRMAYEEVLFPVCFTGKKKYYGIAHVNTPNFNTKELFIRGIDIIKQGQTKLTKTIGTRIMEESMKLRRPEDHRPPLIEIVKTVLKDAVVNMKQWNFEDFIQTDAWRPDKDNKAVQIFMSRMHARREQLKKHGAAATSQFAEPEPGERFSYVIVEKQVQFDIQGHRTDTTRKGDKMEYVSEAKAKNLPIDILFYINNYVLGLCARFINENEEFQPPGNVSNKDEYAQRRAKSYLQKFVQSIHPKDKSVIKQGIVHRQCYKYVHQEIKKKIGIFADLYKEFFNNTTNPIESFIQSTQFMIHYFDEEQKVNHSMKKMVEQRTTLAGNPAGNPAGNPASNALMRAIFTQLITEEKKIVQALYNKGDAIHDLLSYIINNINYKIATFQTKQMLTFELSSTHVELLLKLNKTWLILVGIHVAKKHLHTLLGLSNNEPPSKTFIQQAIEEECGSIKPSCYDFIS

Summary

Function
DNA-directed DNA polymerase involved in viral DNA replication.
Catalytic Activity
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
Miscellaneous
Consistent with its intracellular location, ASFV encodes its own replicative DNA polymerase and three base excision repair enzymes: a class II AP endonuclease, the repair polymerase Pol X, and an ATP-dependent DNA ligase.
Similarity
Belongs to the DNA polymerase type-B family.
Keywords
Complete proteome   DNA replication   DNA-binding   DNA-directed DNA polymerase   Nucleotidyltransferase   Repeat   Transferase   Viral DNA replication   Reference proteome  
Feature
chain  DNA polymerase beta
EC Number
2.7.7.7
EMBL
AY261363    AM712239    CAN10189.1    KM102979    AJZ77043.1    L19042    + More
U18466    AY261360    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34268.1    AXB49318.1    AXB49492.1    AXB49664.1    AXB49835.1    AXB50008.1    KM111294    AJL34103.1    AY261361    X73330    U27573    U27574    U27575    AY261366    FN557520    CBH29190.1    AM712240    CAN10439.1    KM262844    KM262845    KP055815    KX354450    AIY22281.1    AIY22439.1    AKO62771.1    AOO54438.1    FR682468    CBW46756.1    MG939583    MG939587    MG939588    LS478113    AXZ95864.1    AXZ96052.1    AXZ96147.1    SPS73513.1    PQFF01000115    RHZ81111.1    QKYT01001161    RIA79750.1    QKKE01000594    RGB26687.1    LLXK01002766    PKY32984.1    JEMT01015443    EXX72396.1    QKWP01002329    RIB03758.1    PQFF01000074    RHZ84622.1    PQFF01000055    RHZ85906.1    BDIQ01000191    GBC51647.1    JEMT01026038    EXX60121.1    QKWP01000454    RIB19785.1    QKKE01000041    RGB41248.1    QKWP01003150    RIB01390.1    QKYT01000725    RIA81939.1    LLXJ01003171    PKB97499.1    BEXD01003502    GBC01347.1    QKKE01000878    RGB24093.1    LLXI01005036    PKY61189.1    BEXD01000217    GBB85385.1    BDIQ01000062    GBC22393.1    AUPC02000066    POG74918.1    QKWP01000028    RIB29843.1    BEXD01002443    GBB98304.1    BDIQ01000111    AUPC02000007    GBC35690.1    POG82023.1    JEMT01009706    JEMT01009705    EXX78060.1    EXX78061.1    AUPC02000025    POG79363.1    QKWP01000757    RIB15279.1    LLXI01000582    PKY47853.1    QKWP01000288    RIB22902.1    RIB15280.1    QKWP01001294    RIB10075.1    BEXD01001158    GBB92641.1    LLXL01003351    PKK58840.1    LLXK01002565    LLXK01002567    PKY32612.1    PKY32615.1    LLXH01000952    LLXK01001701    PKC61656.1    PKY30249.1    QKWP01001092    RIB11813.1    LLXH01004079    PKC53585.1    BEXD01000219    GBB85411.1    LLXJ01001653    PKC01275.1    BEXD01000935    GBB91215.1    LLXH01000955    PKC61639.1    BEXD01001864    GBB96059.1    LLXL01000689    PKK69789.1    QKYT01000562    RIA83541.1   
Pfam
PF03104   DNA_pol_B_exo1
PF00136   DNA_pol_B
Interpro
IPR036397   RNaseH_sf
IPR006133   DNA-dir_DNA_pol_B_exonuc
IPR012337   RNaseH-like_sf
IPR017964   DNA-dir_DNA_pol_B_CS
IPR006172   DNA-dir_DNA_pol_B
IPR006134   DNA-dir_DNA_pol_B_multi_dom
IPR023211   DNA_pol_palm_dom_sf
SUPFAM
SSF53098   SSF53098
Gene 3D
PDB
6TNZ     E-value=4.66016e-23,     Score=272

Ontologies

KEGG

Subcellular Location

From MSLVP
Capsid

Topology

Length:
1204
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.568539999999995
Exp number, first 60 AAs:
0.55148
Total prob of N-in:
0.02715
outside
1  -  1204
 
 

Population Genetic Test Statistics

Pi
0.0332379
Theta
0.0386849
Tajima's D
-0.7152389
CLR
0
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62771.1
China_AnhuiXCGQ_2018 Protein
AYW34061.1
China_ASFV-SY18_2018 Protein
AKO62771.1
Poland_Pol16_20186_o7_2016-2017 Protein
AXZ95864.1
Poland_Pol16_20538_o9_2016-2017 Protein
CAN10439.1
Poland_Pol16_20540_o10_2016-2017 Protein
CAN10439.1
Poland_Pol16_29413_o23_2016-2017 Protein
CAN10439.1
Poland_Pol17_03029_C201_2016-2017 Protein
AXZ96052.1
Poland_Pol17_04461_C210_2016-2017 Protein
AXZ96147.1
Poland_Pol17_05838_C220_2016-2017 Protein
CAN10439.1
Poland_ASFV_POL_Podlaskie_2015 Protein
CAN10439.1
Uganda_R8_2015 Protein
AXB49318.1
Uganda_R7_2015 Protein
AXB49492.1
Uganda_R25_2015 Protein
AXB49664.1
Uganda_N10_2015 Protein
AXB49835.1
Uganda_R35_2015 Protein
AXB50008.1
Estonia_2014 Protein
SPS73513.1
Italy_26544_OG10_2010 Protein
AJZ77043.1
Italy_47_Ss_2008_2008 Protein
AOO54438.1
Portugal_OURT_88.3_1988 Protein
Protein
CAN10439.1
CAN10439.1
Spain_E75_1975 Protein
CBH29190.1
Russia_Georgia_2007 Protein
CBW46756.1
Kenya_Tk1_2005 Protein
AJL34103.1
Kenya_Bus_2006 Protein
AJL34268.1
Russia_Odintsovo_2014 Protein
CAN10439.1
Portugal_L60_1960 Protein
AIY22281.1
Portugal_NHV_1968 Protein
AIY22439.1
Russia_Kashino_2013 Protein
CAN10439.1
Benin_1997 Protein
CAN10189.1
South_Africa_KNP_Pretorisuskop_1996 Protein
CAN10439.1
South_Africa_MGR_Mkuzi_1979 Protein
CAN10439.1
Malawi_Lil_1983 Protein
CAN10439.1
Kenya_1950 Protein
CAN10439.1
Namibia_Warthog_1980 Protein
CAN10439.1
South_Africa_Warmbaths_1987 Protein
CAN10439.1
Malawi_Tengani_1962 Protein
CAN10439.1
China_HLJ_2018 Protein
QBH90578.1
China_LN_2018 Protein
QBH90763.1
China_wbBS01_2018 Protein
QDL88121.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
Protein
QED21679.1
QED21680.1
QED21681.1
QED21682.1
Belgium_Etalle_wb_2018 Protein
QED90533.1
Lithuania_LT14_2014 Protein
QEY87896.1
South_Africa_1985 Protein
QGM12923.1
South_Africa_2_2008 Protein
QGM12849.1
Zambia_LIV_1983 Protein
QGM12734.1
Copyright@ 2018-2023    Any Comments and suggestions mail to:  zhuzl@cqu.edu.cn, mg@cau.edu.cn   渝ICP备19006517号

渝公网安备 50010602502065号

In processing...
Login to ASFVdb
Email
Password
Please go to Regist if without an account.
If you have forgotten your password, you can once again Regist an account with a registed or new email.
Change my password
Enter new password
Reenter new password
Regist an account of ASFVdb
It is required that you provide your institutional e-mail address (with edu or org in the domain) as confirmation of your affiliation.
Enter email
Reenter email
First Name
Last Name
Institution
You can directly go to if with an account.
Registraion Success
Your password has been sent to your email.
Please check it and login later.
Welcome to use ASFVdb.