ASFVdb The African Swine Fever Virus Database
Strain
Poland_Pol17_03029_C201_2016-2017 (Region: Poland;  Strain: Pol17_03029_C201;  Date: 2016-2017)
Gene
G1211R
Description
Annotated in NCBI,  aphidicolin-resistant
GenBank Accession
Full name
DNA polymerase       + More
DNA polymerase beta      
 

Sequence

CDS
ATGATATCTATCATGGACCGTTCTGAGATTGTTGCACGGGAGAACCCGGTGATTACCCAACGAGTTACAAATCTCCTACAAACCAATGCTCCTCTACTATTCATGCCCATTGATATCCATGAAGTACGATATGGAGCCTACACACTTTTCATGTATGGTTCCCTCGAAAACGGTTACAAAGCAGAAGTAAGGATTGAAAACATCCCAGTTTTCTTTGACGTACAGATTGAGTTCAATGATACAAACCAGCTTTTTTTAAAGTCGCTACTGACGGCTGAAAATATTGTGTATGAACGGCTGGAGACGCTCACCCAGCGTCCTGTAATGGGGTACCGCGAGAAGGAAAAAGAGTTTGCACCATACATTCGAATATTTTTTAAAAGCCTGTATGAGCGACGAAAAGCCATTACTTACTTAAATAATATGGGCTACAACACGGCCGCGGACGACACAACCTGTTATTACCGAATGGTTTCCCGAGAATTAAAACTACCTCTTACAAGTTGGATACAGCTTCAGCACTATTCCTACGAGCCTCGCGGCTTGGTACACAGGTTTTCCGTAACCCCCGAGGATCTTGTTTCCTATCAGAATGATGGCCCCACAGACCACAGCATCGTTATGGCCTACGATATAGAGACCTATAGCCCTGTTAAGGGAACCGTTCCGGACCCAAATCAGGCAAACGACGTGGTGTTCATGATATGCATGCGCATTTTTTGGATTCACTCCACAGAGCCTCTAGCGAGCACGTGCATCACCATGGCACCCTGCAAAAAGTCCTCAGAGTGGACCACCATTCTATGCTCCTCTGAAAAAAATTTGTTGTTAAGCTTTGCTGAACAGTTTAGCCGCTGGGCTCCTGATATATGCACAGGGTTCAATGATTCTCGGTACGACTGGCCCTTTATCGTTGAAAAATCTATGCAGCACGGTATTCTAGAAGAAATCTTTAACAAAATGAGCCTTTTCTGGCACCAAAAGCTGGATACCATTCTAAAATGCTATTACGTAAAGGAAAAGAGAGTCAAAATCTCGGCCGAAAAATCGATCATTTCCTCCTTTTTGCATACCCCTGGATGCCTACCCATTGATGTCCGCAACATGTGTATGCAGCTTTACCCTAAAGCCGAAAAAACAAGCTTGAAAGCGTTTTTAGAAAATTGTGGGTTAGATTCGAAGGTAGACCTGCCGTACCATCTCATGTGGAAGTATTATGAAACACGAGACAGCGAAAAAATAGCCGACGTGGCCTATTACTGCATTATAGATGCCCAGCGCTGTCAGGACCTTCTGGTGCGCCACAATGTTATCCCCGATCGCAGAGAGGTAGGAATTCTGTCATACACCTCGCTGTATGACTGTATCTACTACGCGGGAGGACACAAGGTATGCAATATGCTCATTGCCTATGCCATCCATGATGAATACGGCCGTATTGCTTGCAGTACCATTGCCCGAGGTAAGCGGGAACACGGAAAATATCCCGGCGCCTTTGTGATAGACCCCGTTAAAGGGCTTGAACAGGATAAACCCACCACAGGTCTCGACTTTGCGTCGCTGTACCCCTCACTCATCATGGCCTACAACTTTTCGCCAGAAAAATTTGTAGCCTCTCGGGATGAGGCAAATAGCCTCATGGCCAAGGGTGAATCTCTTCACTACGTCTCCTTTCACTTTAACAATCGTCTCGTGGAAGGATGGTTTGTGCGGCATAATAACGTTCCTGATAAAATGGGATTGTACCCAAAAGTACTCATCGATCTACTTAACAAACGGACCGCCCTTAAACAAGAGCTTAAAAAACTAGGTGAGAAAAAAGAATGTATCCATGAATCCCATCCTGGGTTTAAGGAACTACAGTTTCGCCATGCCATGGTAGACGCGAAGCAAAAGGCGTTGAAAATTTTCATGAACACGTTTTACGGCGAGGCAGGTAACAATTTGTCGCCCTTCTTTCTGCTTCCTCTAGCCGGAGGAGTCACCAGTTCGGGTCAATATAATCTTAAACTTGTCTATAACTTTGTTATCAATAAAGGTTACGGCATCAAGTACGGTGACACCGACTCATTATACATTACATGCCCAGATAGTCTTTATACAGAGGTAACAGACGCATATTTAAACAGCCAAAAAACGATAAAACATTATGAGCAACTCTGCCACGAAAAAGTGCTTCTGTCTATGAAAGCCATGTCTACACTATGCGCCGAGGTGAATGAATACCTGCGACAAGATAATGGCACCAGTTACCTACGTATGGCCTACGAGGAAGTACTCTTTCCTGTGTGCTTTACAGGCAAGAAAAAGTATTATGGTATTGCTCATGTAAACACACCCAATTTTAATACAAAAGAATTATTCATCCGCGGAATAGATATCATTAAGCAGGGTCAAACAAAACTCACCAAAACGATAGGAACGCGAATTATGGAAGAATCCATGAAACTACGCCGCCCTGAGGACCATCGCCCCCCTCTTATTGAAATCGTTAAAACGGTTTTGAAGGATGCTGTGGTTAACATGAAGCAGTGGAATTTTGAAGACTTCATCCAAACAGATGCGTGGAGACCGGACAAAGACAACAAAGCAGTCCAAATCTTTATGTCTCGCATGCACGCTCGGCGTGAGCAACTAAAAAAACACGGCGCTGCAGCATCGCAATTTGCTGAGCCCGAGCCGGGAGAACGCTTCTCCTACGTTATCGTGGAAAAACAGGTACAGTTTGATATCCAGGGCCACCGCACAGATTCCTCCAGAAAGGGGGACAAGATGGAATACGTCTCTGAAGCAAAGGCTAAAAATCTTCCTATTGATATATTGTTTTATATCAACAACTATGTTCTAGGCTTGTGCGCGAGATTCATTAATGAAAATGAAGAATTTCAACCCCCTGACAACGTCAGCAATAAGGATGAATACGCTCAGCGCCGAGCTAAATCCTACCTACAAAAATTCGTGCAATCCATTCACCCTAAAGACAAGTCTGTCATTAAGCAAGGCAATGTTCATCGACAGTGCTACAAATACATTCACCAAGAAATTAAAAAAAAAATAGGCATCTTTGCCGACCTTTATAAGGAATTTTTTAACAACACCACAAACCCCATCGAAAGCTTTATTCAAAGCACTCAGTTTATGATACAATACTTTGATGGAGAACAAAAAGTAAACCATTCTATGAAAAAAATGGTTGAACAGCATGCTACGGCTAGTAATCGAGCTGGTAAGCCCGCTGGTAATCCAGCCGGCAATGCGCTGATGCGGGCTATATTTACGCAGCTGATTACGGAAGAAAAAAAAATTGTACAAGCCTTATACAATAAGGGGGATGCAATACACGATCTTCTCACCTATATCATTAACAATATAAATTACAAAATTGCCACGTTTCAGACGAAACAGATGTTGACGTTCGAGTTTTCCAGTACTCATGTAGAACTGCTATTAAAGCTGAATAAAACGTGGCTTATTTTGGCTGGAATTCATGTGGCAAAAAAACATCTGCAAGCTTTTTTGGATTCATATAACAATGAATCGCCGTCTAGAACATTCATTCAGCAGGCTATAGAGGAAGAATGTGGCAGTATTAAACCATCTTGCTACGACTTTATTTCCTAA
Protein
MISIMDRSEIVARENPVITQRVTNLLQTNAPLLFMPIDIHEVRYGAYTLFMYGSLENGYKAEVRIENIPVFFDVQIEFNDTNQLFLKSLLTAENIVYERLETLTQRPVMGYREKEKEFAPYIRIFFKSLYERRKAITYLNNMGYNTAADDTTCYYRMVSRELKLPLTSWIQLQHYSYEPRGLVHRFSVTPEDLVSYQNDGPTDHSIVMAYDIETYSPVKGTVPDPNQANDVVFMICMRIFWIHSTEPLASTCITMAPCKKSSEWTTILCSSEKNLLLSFAEQFSRWAPDICTGFNDSRYDWPFIVEKSMQHGILEEIFNKMSLFWHQKLDTILKCYYVKEKRVKISAEKSIISSFLHTPGCLPIDVRNMCMQLYPKAEKTSLKAFLENCGLDSKVDLPYHLMWKYYETRDSEKIADVAYYCIIDAQRCQDLLVRHNVIPDRREVGILSYTSLYDCIYYAGGHKVCNMLIAYAIHDEYGRIACSTIARGKREHGKYPGAFVIDPVKGLEQDKPTTGLDFASLYPSLIMAYNFSPEKFVASRDEANSLMAKGESLHYVSFHFNNRLVEGWFVRHNNVPDKMGLYPKVLIDLLNKRTALKQELKKLGEKKECIHESHPGFKELQFRHAMVDAKQKALKIFMNTFYGEAGNNLSPFFLLPLAGGVTSSGQYNLKLVYNFVINKGYGIKYGDTDSLYITCPDSLYTEVTDAYLNSQKTIKHYEQLCHEKVLLSMKAMSTLCAEVNEYLRQDNGTSYLRMAYEEVLFPVCFTGKKKYYGIAHVNTPNFNTKELFIRGIDIIKQGQTKLTKTIGTRIMEESMKLRRPEDHRPPLIEIVKTVLKDAVVNMKQWNFEDFIQTDAWRPDKDNKAVQIFMSRMHARREQLKKHGAAASQFAEPEPGERFSYVIVEKQVQFDIQGHRTDSSRKGDKMEYVSEAKAKNLPIDILFYINNYVLGLCARFINENEEFQPPDNVSNKDEYAQRRAKSYLQKFVQSIHPKDKSVIKQGNVHRQCYKYIHQEIKKKIGIFADLYKEFFNNTTNPIESFIQSTQFMIQYFDGEQKVNHSMKKMVEQHATASNRAGKPAGNPAGNALMRAIFTQLITEEKKIVQALYNKGDAIHDLLTYIINNINYKIATFQTKQMLTFEFSSTHVELLLKLNKTWLILAGIHVAKKHLQAFLDSYNNESPSRTFIQQAIEEECGSIKPSCYDFIS

Summary

Function
DNA-directed DNA polymerase involved in viral DNA replication.
Catalytic Activity
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
Miscellaneous
Consistent with its intracellular location, ASFV encodes its own replicative DNA polymerase and three base excision repair enzymes: a class II AP endonuclease, the repair polymerase Pol X, and an ATP-dependent DNA ligase.
Similarity
Belongs to the DNA polymerase type-B family.
Keywords
Complete proteome   DNA replication   DNA-binding   DNA-directed DNA polymerase   Nucleotidyltransferase   Reference proteome   Repeat   Transferase   Viral DNA replication  
Feature
chain  DNA polymerase beta
EC Number
2.7.7.7
EMBL
FR682468    CBW46756.1    MG939583    MG939587    MG939588    LS478113    + More
AXZ95864.1    AXZ96052.1    AXZ96147.1    SPS73513.1    FN557520    CBH29190.1    AM712240    CAN10439.1    KM262844    KM262845    KP055815    KX354450    AIY22281.1    AIY22439.1    AKO62771.1    AOO54438.1    AM712239    CAN10189.1    KM102979    AJZ77043.1    L19042    U18466    AY261363    AY261366    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34268.1    AXB49318.1    AXB49492.1    AXB49664.1    AXB49835.1    AXB50008.1    AY261361    KM111294    AJL34103.1    AY261360    X73330    U27573    U27574    U27575    QKYT01001161    RIA79750.1    PQFF01000115    RHZ81111.1    QKWP01002329    RIB03758.1    QKKE01000594    RGB26687.1    LLXK01002766    PKY32984.1    BDIQ01000097    GBC32028.1    JEMT01012872    EXX74474.1    AUPC02000234    POG64677.1    JEMT01015443    EXX72396.1    QKWP01000454    RIB19785.1    QKKE01000878    RGB24093.1    LLXJ01003171    PKB97499.1    QKWP01003150    RIB01390.1    PQFF01000074    RHZ84622.1    PQFF01000055    RHZ85906.1    QKKE01000041    RGB41248.1    QKYT01000725    RIA81939.1    BDIQ01000191    GBC51647.1    JEMT01026038    EXX60121.1    BEXD01000217    GBB85385.1    BEXD01002443    GBB98304.1    BEXD01000219    GBB85411.1    BDIQ01000062    GBC22393.1    LLXI01005036    PKY61189.1    AUPC02000066    POG74918.1    BEXD01001539    GBB94571.1    QKWP01000757    RIB15279.1    BEXD01003502    GBC01347.1    QKWP01001092    RIB11813.1    AUPC02000025    POG79363.1    LLXI01000582    PKY47853.1    QKWP01001294    RIB10075.1    QKYT01000562    RIA83541.1    LLXH01004079    PKC53585.1    PQFF01000036    RHZ87219.1    RIB15280.1    BDIQ01000111    AUPC02000007    GBC35690.1    POG82023.1    JEMT01009706    JEMT01009705    EXX78060.1    EXX78061.1    QKWP01000288    RIB22902.1    LLXH01000955    PKC61639.1    BEXD01000935    GBB91215.1    LLXL01003351    PKK58840.1    BDIQ01000194    GBC52743.1    LLXK01002565    LLXK01002567    PKY32612.1    PKY32615.1    QKYT01000362    RIA86472.1    BEXD01001864    GBB96059.1   
Pfam
PF03104   DNA_pol_B_exo1
PF00136   DNA_pol_B
Interpro
IPR006172   DNA-dir_DNA_pol_B
IPR017964   DNA-dir_DNA_pol_B_CS
IPR036397   RNaseH_sf
IPR023211   DNA_pol_palm_dom_sf
IPR006134   DNA-dir_DNA_pol_B_multi_dom
IPR012337   RNaseH-like_sf
IPR006133   DNA-dir_DNA_pol_B_exonuc
SUPFAM
SSF53098   SSF53098
Gene 3D
PDB
6TNZ     E-value=4.66016e-23,     Score=272

Ontologies

KEGG

Subcellular Location

From MSLVP
Capsid

Topology

Length:
1206
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0295299999999999
Exp number, first 60 AAs:
0.01615
Total prob of N-in:
0.00091
outside
1  -  1206
 
 

Population Genetic Test Statistics

Pi
0.0332379
Theta
0.0386839
Tajima's D
-0.7152389
CLR
0.042515
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62771.1
China_AnhuiXCGQ_2018 Protein
AYW34061.1
China_ASFV-SY18_2018 Protein
AKO62771.1
Poland_Pol16_20186_o7_2016-2017 Protein
AXZ95864.1
Poland_Pol16_20538_o9_2016-2017 Protein
CAN10439.1
Poland_Pol16_20540_o10_2016-2017 Protein
CAN10439.1
Poland_Pol16_29413_o23_2016-2017 Protein
CAN10439.1
Poland_Pol17_03029_C201_2016-2017 Protein
AXZ96052.1
Poland_Pol17_04461_C210_2016-2017 Protein
AXZ96147.1
Poland_Pol17_05838_C220_2016-2017 Protein
CAN10439.1
Poland_ASFV_POL_Podlaskie_2015 Protein
CAN10439.1
Uganda_R8_2015 Protein
AXB49318.1
Uganda_R7_2015 Protein
AXB49492.1
Uganda_R25_2015 Protein
AXB49664.1
Uganda_N10_2015 Protein
AXB49835.1
Uganda_R35_2015 Protein
AXB50008.1
Estonia_2014 Protein
SPS73513.1
Italy_26544_OG10_2010 Protein
AJZ77043.1
Italy_47_Ss_2008_2008 Protein
AOO54438.1
Portugal_OURT_88.3_1988 Protein
Protein
CAN10439.1
CAN10439.1
Spain_E75_1975 Protein
CBH29190.1
Russia_Georgia_2007 Protein
CBW46756.1
Kenya_Tk1_2005 Protein
AJL34103.1
Kenya_Bus_2006 Protein
AJL34268.1
Russia_Odintsovo_2014 Protein
CAN10439.1
Portugal_L60_1960 Protein
AIY22281.1
Portugal_NHV_1968 Protein
AIY22439.1
Russia_Kashino_2013 Protein
CAN10439.1
Benin_1997 Protein
CAN10189.1
South_Africa_KNP_Pretorisuskop_1996 Protein
CAN10439.1
South_Africa_MGR_Mkuzi_1979 Protein
CAN10439.1
Malawi_Lil_1983 Protein
CAN10439.1
Kenya_1950 Protein
CAN10439.1
Namibia_Warthog_1980 Protein
CAN10439.1
South_Africa_Warmbaths_1987 Protein
CAN10439.1
Malawi_Tengani_1962 Protein
CAN10439.1
China_HLJ_2018 Protein
QBH90578.1
China_LN_2018 Protein
QBH90763.1
China_wbBS01_2018 Protein
QDL88121.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
Protein
QED21679.1
QED21680.1
QED21681.1
QED21682.1
Belgium_Etalle_wb_2018 Protein
QED90533.1
Lithuania_LT14_2014 Protein
QEY87896.1
South_Africa_1985 Protein
QGM12923.1
South_Africa_2_2008 Protein
QGM12849.1
Zambia_LIV_1983 Protein
QGM12734.1
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