Strain

Poland_Pol17_03029_C201_2016-2017 (Region: Poland;  Strain: Pol17_03029_C201;  Date: 2016-2017)

Gene

G1211R

Description

Annotated in NCBI,  aphidicolin-resistant

Location

MG939587.1(+):113195-116815

GenBank Accession

AXZ96052.1

Full name

DNA polymerase       + More
DNA polymerase beta      

CDS

ATGATATCTATCATGGACCGTTCTGAGATTGTTGCACGGGAGAACCCGGTGATTACCCAACGAGTTACAAATCTCCTACAAACCAATGCTCCTCTACTATTCATGCCCATTGATATCCATGAAGTACGATATGGAGCCTACACACTTTTCATGTATGGTTCCCTCGAAAACGGTTACAAAGCAGAAGTAAGGATTGAAAACATCCCAGTTTTCTTTGACGTACAGATTGAGTTCAATGATACAAACCAGCTTTTTTTAAAGTCGCTACTGACGGCTGAAAATATTGTGTATGAACGGCTGGAGACGCTCACCCAGCGTCCTGTAATGGGGTACCGCGAGAAGGAAAAAGAGTTTGCACCATACATTCGAATATTTTTTAAAAGCCTGTATGAGCGACGAAAAGCCATTACTTACTTAAATAATATGGGCTACAACACGGCCGCGGACGACACAACCTGTTATTACCGAATGGTTTCCCGAGAATTAAAACTACCTCTTACAAGTTGGATACAGCTTCAGCACTATTCCTACGAGCCTCGCGGCTTGGTACACAGGTTTTCCGTAACCCCCGAGGATCTTGTTTCCTATCAGAATGATGGCCCCACAGACCACAGCATCGTTATGGCCTACGATATAGAGACCTATAGCCCTGTTAAGGGAACCGTTCCGGACCCAAATCAGGCAAACGACGTGGTGTTCATGATATGCATGCGCATTTTTTGGATTCACTCCACAGAGCCTCTAGCGAGCACGTGCATCACCATGGCACCCTGCAAAAAGTCCTCAGAGTGGACCACCATTCTATGCTCCTCTGAAAAAAATTTGTTGTTAAGCTTTGCTGAACAGTTTAGCCGCTGGGCTCCTGATATATGCACAGGGTTCAATGATTCTCGGTACGACTGGCCCTTTATCGTTGAAAAATCTATGCAGCACGGTATTCTAGAAGAAATCTTTAACAAAATGAGCCTTTTCTGGCACCAAAAGCTGGATACCATTCTAAAATGCTATTACGTAAAGGAAAAGAGAGTCAAAATCTCGGCCGAAAAATCGATCATTTCCTCCTTTTTGCATACCCCTGGATGCCTACCCATTGATGTCCGCAACATGTGTATGCAGCTTTACCCTAAAGCCGAAAAAACAAGCTTGAAAGCGTTTTTAGAAAATTGTGGGTTAGATTCGAAGGTAGACCTGCCGTACCATCTCATGTGGAAGTATTATGAAACACGAGACAGCGAAAAAATAGCCGACGTGGCCTATTACTGCATTATAGATGCCCAGCGCTGTCAGGACCTTCTGGTGCGCCACAATGTTATCCCCGATCGCAGAGAGGTAGGAATTCTGTCATACACCTCGCTGTATGACTGTATCTACTACGCGGGAGGACACAAGGTATGCAATATGCTCATTGCCTATGCCATCCATGATGAATACGGCCGTATTGCTTGCAGTACCATTGCCCGAGGTAAGCGGGAACACGGAAAATATCCCGGCGCCTTTGTGATAGACCCCGTTAAAGGGCTTGAACAGGATAAACCCACCACAGGTCTCGACTTTGCGTCGCTGTACCCCTCACTCATCATGGCCTACAACTTTTCGCCAGAAAAATTTGTAGCCTCTCGGGATGAGGCAAATAGCCTCATGGCCAAGGGTGAATCTCTTCACTACGTCTCCTTTCACTTTAACAATCGTCTCGTGGAAGGATGGTTTGTGCGGCATAATAACGTTCCTGATAAAATGGGATTGTACCCAAAAGTACTCATCGATCTACTTAACAAACGGACCGCCCTTAAACAAGAGCTTAAAAAACTAGGTGAGAAAAAAGAATGTATCCATGAATCCCATCCTGGGTTTAAGGAACTACAGTTTCGCCATGCCATGGTAGACGCGAAGCAAAAGGCGTTGAAAATTTTCATGAACACGTTTTACGGCGAGGCAGGTAACAATTTGTCGCCCTTCTTTCTGCTTCCTCTAGCCGGAGGAGTCACCAGTTCGGGTCAATATAATCTTAAACTTGTCTATAACTTTGTTATCAATAAAGGTTACGGCATCAAGTACGGTGACACCGACTCATTATACATTACATGCCCAGATAGTCTTTATACAGAGGTAACAGACGCATATTTAAACAGCCAAAAAACGATAAAACATTATGAGCAACTCTGCCACGAAAAAGTGCTTCTGTCTATGAAAGCCATGTCTACACTATGCGCCGAGGTGAATGAATACCTGCGACAAGATAATGGCACCAGTTACCTACGTATGGCCTACGAGGAAGTACTCTTTCCTGTGTGCTTTACAGGCAAGAAAAAGTATTATGGTATTGCTCATGTAAACACACCCAATTTTAATACAAAAGAATTATTCATCCGCGGAATAGATATCATTAAGCAGGGTCAAACAAAACTCACCAAAACGATAGGAACGCGAATTATGGAAGAATCCATGAAACTACGCCGCCCTGAGGACCATCGCCCCCCTCTTATTGAAATCGTTAAAACGGTTTTGAAGGATGCTGTGGTTAACATGAAGCAGTGGAATTTTGAAGACTTCATCCAAACAGATGCGTGGAGACCGGACAAAGACAACAAAGCAGTCCAAATCTTTATGTCTCGCATGCACGCTCGGCGTGAGCAACTAAAAAAACACGGCGCTGCAGCATCGCAATTTGCTGAGCCCGAGCCGGGAGAACGCTTCTCCTACGTTATCGTGGAAAAACAGGTACAGTTTGATATCCAGGGCCACCGCACAGATTCCTCCAGAAAGGGGGACAAGATGGAATACGTCTCTGAAGCAAAGGCTAAAAATCTTCCTATTGATATATTGTTTTATATCAACAACTATGTTCTAGGCTTGTGCGCGAGATTCATTAATGAAAATGAAGAATTTCAACCCCCTGACAACGTCAGCAATAAGGATGAATACGCTCAGCGCCGAGCTAAATCCTACCTACAAAAATTCGTGCAATCCATTCACCCTAAAGACAAGTCTGTCATTAAGCAAGGCAATGTTCATCGACAGTGCTACAAATACATTCACCAAGAAATTAAAAAAAAAATAGGCATCTTTGCCGACCTTTATAAGGAATTTTTTAACAACACCACAAACCCCATCGAAAGCTTTATTCAAAGCACTCAGTTTATGATACAATACTTTGATGGAGAACAAAAAGTAAACCATTCTATGAAAAAAATGGTTGAACAGCATGCTACGGCTAGTAATCGAGCTGGTAAGCCCGCTGGTAATCCAGCCGGCAATGCGCTGATGCGGGCTATATTTACGCAGCTGATTACGGAAGAAAAAAAAATTGTACAAGCCTTATACAATAAGGGGGATGCAATACACGATCTTCTCACCTATATCATTAACAATATAAATTACAAAATTGCCACGTTTCAGACGAAACAGATGTTGACGTTCGAGTTTTCCAGTACTCATGTAGAACTGCTATTAAAGCTGAATAAAACGTGGCTTATTTTGGCTGGAATTCATGTGGCAAAAAAACATCTGCAAGCTTTTTTGGATTCATATAACAATGAATCGCCGTCTAGAACATTCATTCAGCAGGCTATAGAGGAAGAATGTGGCAGTATTAAACCATCTTGCTACGACTTTATTTCCTAA

Protein

MISIMDRSEIVARENPVITQRVTNLLQTNAPLLFMPIDIHEVRYGAYTLFMYGSLENGYKAEVRIENIPVFFDVQIEFNDTNQLFLKSLLTAENIVYERLETLTQRPVMGYREKEKEFAPYIRIFFKSLYERRKAITYLNNMGYNTAADDTTCYYRMVSRELKLPLTSWIQLQHYSYEPRGLVHRFSVTPEDLVSYQNDGPTDHSIVMAYDIETYSPVKGTVPDPNQANDVVFMICMRIFWIHSTEPLASTCITMAPCKKSSEWTTILCSSEKNLLLSFAEQFSRWAPDICTGFNDSRYDWPFIVEKSMQHGILEEIFNKMSLFWHQKLDTILKCYYVKEKRVKISAEKSIISSFLHTPGCLPIDVRNMCMQLYPKAEKTSLKAFLENCGLDSKVDLPYHLMWKYYETRDSEKIADVAYYCIIDAQRCQDLLVRHNVIPDRREVGILSYTSLYDCIYYAGGHKVCNMLIAYAIHDEYGRIACSTIARGKREHGKYPGAFVIDPVKGLEQDKPTTGLDFASLYPSLIMAYNFSPEKFVASRDEANSLMAKGESLHYVSFHFNNRLVEGWFVRHNNVPDKMGLYPKVLIDLLNKRTALKQELKKLGEKKECIHESHPGFKELQFRHAMVDAKQKALKIFMNTFYGEAGNNLSPFFLLPLAGGVTSSGQYNLKLVYNFVINKGYGIKYGDTDSLYITCPDSLYTEVTDAYLNSQKTIKHYEQLCHEKVLLSMKAMSTLCAEVNEYLRQDNGTSYLRMAYEEVLFPVCFTGKKKYYGIAHVNTPNFNTKELFIRGIDIIKQGQTKLTKTIGTRIMEESMKLRRPEDHRPPLIEIVKTVLKDAVVNMKQWNFEDFIQTDAWRPDKDNKAVQIFMSRMHARREQLKKHGAAASQFAEPEPGERFSYVIVEKQVQFDIQGHRTDSSRKGDKMEYVSEAKAKNLPIDILFYINNYVLGLCARFINENEEFQPPDNVSNKDEYAQRRAKSYLQKFVQSIHPKDKSVIKQGNVHRQCYKYIHQEIKKKIGIFADLYKEFFNNTTNPIESFIQSTQFMIQYFDGEQKVNHSMKKMVEQHATASNRAGKPAGNPAGNALMRAIFTQLITEEKKIVQALYNKGDAIHDLLTYIINNINYKIATFQTKQMLTFEFSSTHVELLLKLNKTWLILAGIHVAKKHLQAFLDSYNNESPSRTFIQQAIEEECGSIKPSCYDFIS

Function

DNA-directed DNA polymerase involved in viral DNA replication.

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Miscellaneous

Consistent with its intracellular location, ASFV encodes its own replicative DNA polymerase and three base excision repair enzymes: a class II AP endonuclease, the repair polymerase Pol X, and an ATP-dependent DNA ligase.

Similarity

Belongs to the DNA polymerase type-B family.

Keywords

Complete proteome   DNA replication   DNA-binding   DNA-directed DNA polymerase   Nucleotidyltransferase   Reference proteome   Repeat   Transferase   Viral DNA replication  

Feature

chain  DNA polymerase beta

Uniprot

E0WM40   A0A2X0SE14   D4I5S7   A9JLY2   A0A0A1E0S9   A9JL52   + More
A0A1C6ZXW4   P42489   P0C971   P0C973   A0A0C5BCR1   P0C972   A0A0C5BC98   P0C974   P43139   A0A397RZU3   A0A397IYT1   A0A397U3N3   A0A372QH90   A0A2I1FF43   A0A2H5SNY6   A0A015L417   A0A2P4PH58   A0A015LIA5   A0A397VBF3   A0A372Q7U9   A0A2N0NSD9   A0A397TTP9   A0A397JBZ1   A0A397JIU8   A0A372RP47   A0A397SAQ1   A0A2H5U9Y1   A0A015KK97   A0A2Z6Q746   A0A2Z6RJP1   A0A2Z6QKX8   A0A2H5RWE2   A0A2I1HQM3   A0A2P4QBB7   A0A2Z6RC87   A0A397V2P0   A0A2Z6S9R4   A0A397UWA3   A0A2P4QNY4   A0A2I1GMI8   A0A397UIG3   A0A397SL57   A0A2N0QRA2   A0A397JFV4   A0A397UYH4   A0A2H5SZE8   A0A015LZ95   A0A397VLP2   A0A2N0REB3   A0A2Z6QNU7   A0A2N1MB26   A0A2H5UD06   A0A2I1FDZ4   A0A397SLE2   A0A2Z6RET5  

EC Number

2.7.7.7

Pubmed

21470447    18198370    25406173    26618713    8293992    11831707    + More
8121806    25645905    8525640    24277808    29355972    30271968   

EMBL

FR682468    CBW46756.1    MG939583    MG939587    MG939588    LS478113    + More
AXZ95864.1    AXZ96052.1    AXZ96147.1    SPS73513.1    FN557520    CBH29190.1    AM712240    CAN10439.1    KM262844    KM262845    KP055815    KX354450    AIY22281.1    AIY22439.1    AKO62771.1    AOO54438.1    AM712239    CAN10189.1    KM102979    AJZ77043.1    L19042    U18466    AY261363    AY261366    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34268.1    AXB49318.1    AXB49492.1    AXB49664.1    AXB49835.1    AXB50008.1    AY261361    KM111294    AJL34103.1    AY261360    X73330    U27573    U27574    U27575    QKYT01001161    RIA79750.1    PQFF01000115    RHZ81111.1    QKWP01002329    RIB03758.1    QKKE01000594    RGB26687.1    LLXK01002766    PKY32984.1    BDIQ01000097    GBC32028.1    JEMT01012872    EXX74474.1    AUPC02000234    POG64677.1    JEMT01015443    EXX72396.1    QKWP01000454    RIB19785.1    QKKE01000878    RGB24093.1    LLXJ01003171    PKB97499.1    QKWP01003150    RIB01390.1    PQFF01000074    RHZ84622.1    PQFF01000055    RHZ85906.1    QKKE01000041    RGB41248.1    QKYT01000725    RIA81939.1    BDIQ01000191    GBC51647.1    JEMT01026038    EXX60121.1    BEXD01000217    GBB85385.1    BEXD01002443    GBB98304.1    BEXD01000219    GBB85411.1    BDIQ01000062    GBC22393.1    LLXI01005036    PKY61189.1    AUPC02000066    POG74918.1    BEXD01001539    GBB94571.1    QKWP01000757    RIB15279.1    BEXD01003502    GBC01347.1    QKWP01001092    RIB11813.1    AUPC02000025    POG79363.1    LLXI01000582    PKY47853.1    QKWP01001294    RIB10075.1    QKYT01000562    RIA83541.1    LLXH01004079    PKC53585.1    PQFF01000036    RHZ87219.1    RIB15280.1    BDIQ01000111    AUPC02000007    GBC35690.1    POG82023.1    JEMT01009706    JEMT01009705    EXX78060.1    EXX78061.1    QKWP01000288    RIB22902.1    LLXH01000955    PKC61639.1    BEXD01000935    GBB91215.1    LLXL01003351    PKK58840.1    BDIQ01000194    GBC52743.1    LLXK01002565    LLXK01002567    PKY32612.1    PKY32615.1    QKYT01000362    RIA86472.1    BEXD01001864    GBB96059.1   

Proteomes

UP000141072    UP000101090    UP000108903    UP000110401    UP000142390    UP000241813    + More
UP000266411    UP000130745    UP000117635    UP000000624    UP000000859    UP000000858    UP000101566    UP000000860    UP000105860    UP000000861    UP000265703    UP000266673    UP000263633    UP000236242    UP000022910    UP000018888    UP000232722    UP000247702    UP000234323    UP000232688    UP000233469   

PRIDE

P42489    P0C971    P0C974    P43139   

Pfam

PF03104   DNA_pol_B_exo1
PF00136   DNA_pol_B

Interpro

IPR006172   DNA-dir_DNA_pol_B
IPR017964   DNA-dir_DNA_pol_B_CS
IPR036397   RNaseH_sf
IPR023211   DNA_pol_palm_dom_sf
IPR006134   DNA-dir_DNA_pol_B_multi_dom
IPR012337   RNaseH-like_sf
IPR006133   DNA-dir_DNA_pol_B_exonuc

SUPFAM

SSF53098   SSF53098

Gene 3D

3.30.420.10     3.90.1600.10    

ProteinModelPortal

E0WM40   A0A2X0SE14   D4I5S7   A9JLY2   A0A0A1E0S9   A9JL52   + More
A0A1C6ZXW4   P42489   P0C971   P0C973   A0A0C5BCR1   P0C972   A0A0C5BC98   P0C974   P43139   A0A397RZU3   A0A397IYT1   A0A397U3N3   A0A372QH90   A0A2I1FF43   A0A2H5SNY6   A0A015L417   A0A2P4PH58   A0A015LIA5   A0A397VBF3   A0A372Q7U9   A0A2N0NSD9   A0A397TTP9   A0A397JBZ1   A0A397JIU8   A0A372RP47   A0A397SAQ1   A0A2H5U9Y1   A0A015KK97   A0A2Z6Q746   A0A2Z6RJP1   A0A2Z6QKX8   A0A2H5RWE2   A0A2I1HQM3   A0A2P4QBB7   A0A2Z6RC87   A0A397V2P0   A0A2Z6S9R4   A0A397UWA3   A0A2P4QNY4   A0A2I1GMI8   A0A397UIG3   A0A397SL57   A0A2N0QRA2   A0A397JFV4   A0A397UYH4   A0A2H5SZE8   A0A015LZ95   A0A397VLP2   A0A2N0REB3   A0A2Z6QNU7   A0A2N1MB26   A0A2H5UD06   A0A2I1FDZ4   A0A397SLE2   A0A2Z6RET5  

PDB

6TNZ     E-value=4.66016e-23,     Score=272