Strain

Poland_Pol17_04461_C210_2016-2017 (Region: Poland;  Strain: Pol17_04461_C210;  Date: 2016-2017)

Gene

F778R

Description

Annotated in NCBI,  pF778R

Location

MG939588.1(+):57018-59354

GenBank Accession

AXZ96104.1

Full name

Ribonucleoside-diphosphate reductase       + More
Ribonucleoside-diphosphate reductase large subunit      

Alternative Name

Ribonucleotide reductase large subunit

CDS

ATGGAGACGTTTTTTATTGAGACGTTGGCATCTGATGTGTATGGAAAGGCGTTAAATGTTGATTTAGATAGACTATCGCAGGCGCAGGTTAAATATACCCTTCAAGAGCTTATTTCCTACTGCAGCGCTCTAACCATTTTACATTATGACTATTCAACCCTTGCGGCGCGTCTTTCGGTGTACCAGCTGCACCAGTCAACGGCCTCCTCCTTCTCAAAGGCGGTGAGGCTGCAGGCCGCACAATCCTGCTCACGCCTGTCCCCCCAGTTTGTGGACGTCGTTTACAAGTACAAAGCCATTTTTGACAGCTACATTGACTATAGCAGAGATTACAAGCTGTCCCTCCTGGGGATAGAAACCATGAAAAATTCTTATTTGTTAAAAAATAAAGATGGGGTCATCATGGAACGCCCGCAGGATGCTTATATGCGGGTTGCCATCATGATCTATGGGATGGGAAGAGTGGTCAATATGAAAATGATTCTGCTAACCTATGACCTGCTTTCCCAGCACGTCATCACACACGCGTCGCCCACCATGTTCAATGCAGGCACCAAAAAGCCACAACTCTCCAGCTGTTTCCTGCTAAATGTAAATGATAATTTAGAAAATTTATATGATATGGTCAAAACGGCCGGCATCATTTCAGGCGGCGGCGGTGGAATAGGGCTGTGCTTGTCAGGAATACGGGCAAAGAATAGTTTTATTTCTGGTAGTGGTCTTAAAAGTAACGGCATACAGAATTATATTGTGCTGCAAAATGCTTCACAATGCTACGCGAACCAGGGAGGCCTACGTCCCGGAGCCTACGCCGTCTACTTAGAGCTGTGGCACCAAGACATCTTTACATTTTTACAAATGCCTCGCCTAAAAGGACAAATGGCTGAACAACGGCTTAATGCCCCTAATCTCAAGTACGGCCTATGGGTCCCCGACCTATTCATGGAAATACTTGAAGACCAAATACACAACAGAGGCGACGGCAAATGGTACCTCTTTTCGCCGGATCAGGCCCCCAATCTACATAAGGTCTTTGATTTGGAACGGTCGCAGCACGAAAACGCACACCGCGAATTTAAAAAGCTTTACTATCAGTATGTTGCTGAAAAAAGGTACACCGGCGTCACAACGGCCAAAGAGATTATCAAAGAGTGGTTCAAAACAGTTGTTCAAGTAGGGAATCCCTATATCGGGTTTAAAGATGCCATAAATCGTAAAAGTAATCTTTCACATGTAGGCACTATCACGAACTCCAATCTTTGTATTGAAGTCACAATCCCCTGCTGGGAGGGTGATAAGGCTGAACAAGGTGTTTGTAATCTGGCCGCAGTAAATCTAGCCGCCTTTATACGTGAAAATGGCTACGACTACCGTGGGCTCATAGAAGCATCAGGCAATGTCACAGAAAATTTAGATAATATTATAGATAATGGCTACTACCCCACAGAAGCCACGCGGAGAAGCAATATGCGTCACCGACCTATTGGCATCGGGGTCTTTGGCCTAGCCGACGTGTTTGCGTCTTTAAAAATGAAATTTGGTTCACCCGAGGCCATTGCCATGGATGAGGCCATCCATGCGGCCCTATACTACGGGGCCATGCGACGATCCATAGAACTTGCAAAAGAAAAAGGAAGTCATCCCAGCTTTCCGGGGTCTGCGGCCTCAAAGGGTCTACTGCAGCCCGACCTATGGGTTCGCTGTGGTGATTTAGTTTCCTCCTGGGAAGAACGCGTGGCACAGACGACGCAGGGTGTGTTGACGCCGAAAAGGTGGTCGCAGCTACGCCTGGCGGCTATGCAGGGACTTCGAAATGGATATGTCACAGCTCTTATGCCCACCGCAACCTCCTCAAATTCTACAGGAAAAAACGAATGTTTTGAGCCCTTTACATCCAATCTATATACACGTAGAACGTTAAGCGGGGAGTTTATTGTTTTAAATAAGTATTTAATAGACGATTTAAAAGAAATTAATCTTTGGACAGAAGCCATTCAACAGCAGCTACTAAATGCGGGAGGTAGCATTCAGCACATTTTGGATATACCGGCCGAGATCCGCGATCGGTATAAAACCTCCAGGGAAATGAATCAAAAAATTTTAACAAAACACGCGGCCGCACGAAACCCCTTTGTATCCCAAAGTATGTCCTTGAACTATTACTTTTATGAACCTGAACTAAGCCAGGTACTTACAGTGCTCGTCCTAGGCTGGAAAAAAGGTTTAACTACCGGTTCCTATTACTGTCATTTTAGCCCTGGAGCGGGTACCCAAAAAAAGATTATAAGAAACTCTGAGAAAGCGTGTAATGCGGACTGCGAGGCGTGTCTTCTGTAG

Protein

METFFIETLASDVYGKALNVDLDRLSQAQVKYTLQELISYCSALTILHYDYSTLAARLSVYQLHQSTASSFSKAVRLQAAQSCSRLSPQFVDVVYKYKAIFDSYIDYSRDYKLSLLGIETMKNSYLLKNKDGVIMERPQDAYMRVAIMIYGMGRVVNMKMILLTYDLLSQHVITHASPTMFNAGTKKPQLSSCFLLNVNDNLENLYDMVKTAGIISGGGGGIGLCLSGIRAKNSFISGSGLKSNGIQNYIVLQNASQCYANQGGLRPGAYAVYLELWHQDIFTFLQMPRLKGQMAEQRLNAPNLKYGLWVPDLFMEILEDQIHNRGDGKWYLFSPDQAPNLHKVFDLERSQHENAHREFKKLYYQYVAEKRYTGVTTAKEIIKEWFKTVVQVGNPYIGFKDAINRKSNLSHVGTITNSNLCIEVTIPCWEGDKAEQGVCNLAAVNLAAFIRENGYDYRGLIEASGNVTENLDNIIDNGYYPTEATRRSNMRHRPIGIGVFGLADVFASLKMKFGSPEAIAMDEAIHAALYYGAMRRSIELAKEKGSHPSFPGSAASKGLLQPDLWVRCGDLVSSWEERVAQTTQGVLTPKRWSQLRLAAMQGLRNGYVTALMPTATSSNSTGKNECFEPFTSNLYTRRTLSGEFIVLNKYLIDDLKEINLWTEAIQQQLLNAGGSIQHILDIPAEIRDRYKTSREMNQKILTKHAAARNPFVSQSMSLNYYFYEPELSQVLTVLVLGWKKGLTTGSYYCHFSPGAGTQKKIIRNSEKACNADCEACLL

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).

Catalytic Activity

[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).

Similarity

Belongs to the ribonucleoside diphosphate reductase large chain family.

Keywords

Allosteric enzyme   ATP-binding   Complete proteome   Disulfide bond   DNA replication   Early protein   Nucleotide-binding   Oxidoreductase   Reference proteome  

Feature

chain  Ribonucleoside-diphosphate reductase large subunit

Uniprot

E0WMI3   A0A2X0RUV2   A0A1C6ZXX1   D4I5N3   A9JLP8   A0A0A1E309   + More
P42491   A9JKY7   P0C8H8   P0C8H9   P0C8H7   A0A0C5AWA1   A0A0C5AWM9   A0A2Z5DF77   P26685   A0A2W7QP19   A0A327NVI3  

EC Number

1.17.4.1

Pubmed

21470447    18198370    25406173    26618713    11831707    25645905    + More
1871976   

EMBL

FR682468    CBW46711.1    MG939583    MG939587    MG939588    LS478113    + More
AXZ95821.1    AXZ96009.1    AXZ96104.1    SPS73468.1    KM102979    KX354450    AJZ77051.1    AOO54375.1    FN557520    CBH29146.1    AM712240    CAN10393.1    KM262844    KM262845    KP055815    AIY22236.1    AIY22395.1    AKO62727.1    U18466    AM712239    CAN10144.1    AY261363    AY261366    AY261360    KM111294    AJL34059.1    KM111295    AJL34224.1    MH025916    MH025917    MH025918    MH025919    MH025920    AXB49274.1    AXB49448.1    AXB49620.1    AXB49791.1    AXB49964.1    M64728    QKZU01000025    PZX50114.1    QLLK01000018    RAI84158.1   

Proteomes

UP000141072    UP000117635    UP000266411    UP000101090    UP000108903    UP000110401    + More
UP000142390    UP000241813    UP000000624    UP000130745    UP000000859    UP000000858    UP000000861    UP000105860    UP000101566    UP000249115    UP000249610   

PRIDE

P42491    P0C8H7    P26685   

Pfam

PF02867   Ribonuc_red_lgC
PF00317   Ribonuc_red_lgN
PF03477   ATP-cone

Interpro

IPR008926   RNR_R1-su_N
IPR000788   RNR_lg_C
IPR013509   RNR_lsu_N
IPR039718   Rrm1
IPR013346   NrdE_NrdA
IPR005144   ATP-cone_dom

SUPFAM

SSF48168   SSF48168

ProteinModelPortal

E0WMI3   A0A2X0RUV2   A0A1C6ZXX1   D4I5N3   A9JLP8   A0A0A1E309   + More
P42491   A9JKY7   P0C8H8   P0C8H9   P0C8H7   A0A0C5AWA1   A0A0C5AWM9   A0A2Z5DF77   P26685   A0A2W7QP19   A0A327NVI3  

PANTHER

PTHR11573  

PDB

3S8B     E-value=4.81754e-140,     Score=1279