ASFVdb The African Swine Fever Virus Database
Strain
Italy_26544_OG10_2010 (Region: Sardinian,Italy;  Strain: 26544/OG10;  Date: 2010)
Gene
ribonucleotide reductase of class Ia alpha subunit
Description
Annotated in NCBI,  pF778R
GenBank Accession
Full name
Ribonucleoside-diphosphate reductase       + More
Ribonucleoside-diphosphate reductase large subunit      
Alternative Name
Ribonucleotide reductase large subunit
 

Sequence

CDS
ATGGAGACGTTTTTTATTGAGACGTTGGCATCTGATGTGTATGGAAAGGCGTTGAATGTTGATTTAGATAGACTATCGCAGGCGCAGGTTAAATATACCCTTCAAGAGCTTATTTCCTACTGCAGCGCTCTAACCATTTTACATTATGACTATTCAACCCTTGCGGCGCGACTTTCGGTGTACCAGCTGCACCAGTCAACGGCCTCCTCCTTCTCAAAGGCGGTGAGGCTGCAGGCCGCACAATCCTGCTCACGCCTGTCCCCCCAGTTTGTGGACGTCGTTTACAAGTACAAAGCCATTTTTGACAGCTACATTGACTATAACAGAGATTACAAGCTGTCCCTCCTGGGGATAGAAACCATGAAAAATTCCTATTTGTTAAAAAATAAAGATGGGGTCATCATGGAACGCCCGCAGGACGCCTATATGCGCGTCGCCATTATGATCTATGGAATGGGAAAAGTAGTTAATATAAAGATGATTCTGCTGACCTATGACCTGCTTTCCCGGCACGTCATCACACACGCGTCGCCCACCATGTTCAATGCAGGCACCAAAAAGCCGCAGCTTTCCAGCTGCTTTCTGCTAAATGTAAATGATAATTTAGAGAATTTATACGATATGGTCAAAACGGCCGGCATCATTTCAGGCGGCGGCGGTGGAATAGGGCTGTGCTTGTCAGGAATACGCGCAAAAAATAGCTTTATTTCTAGCAGTGGTCTTAGAAGCAACGGCATTCAAAACTATATTATGCTACAAAATGCCTCACAATGCTACGCGAACCAGGGAGGCCTACGCCCTGGGGCCTATGCGGTCTACTTAGAACTATGGCACCAAGACATCTTTACATTTCTGCAGATGCCCCGCTTGAAAGGACAAATGGCTGAACAGAGGCTTAATGCCCCCAATCTCAAGTACGGTCTATGGGTCCCCGACCTATTTATGGAAATACTTGAAGACCAAATACATAACAGAGGCGACGGCACCTGGTACCTCTTTTCACCGGATCAGGCCCCCAATCTACATAAGGTTTTTGATTTGGAACGGTCACAGCACGAAAACGCACATCGCGAATTTAAAAAGCTTTACTATCAGTATGTTGCTGAAAAAAGGTACACCGGTGTTACGACGGCCAAGGAAATCATTAAAGAGTGGTTCAAAACAGTTATCCAGGTGGGAAACCCCTATATCGGATTTAAAGATGCCATAAATCGTAAAAGTAATCTTTCACATGTAGGCACTATCACGAACTCCAATCTTTGTATTGAAGTCACAATCCCCTGCTGGGAGGGTGATAAGGCTGAACAAGGCGTTTGTAACCTGGCCGCGGTAAATCTAGCCGCCTTTATACGTGAAAATGGCTATGACTACCGTGGGCTCATGGAAGCATCAGGCAACGTCACAGAAAATTTAGATAATATTATAGATAATGGCTACTACCCCACAGAAGCCACGCGGAGAAGCAATATGCGTCACCGACCTATTGGCATCGGGGTCTTTGGCCTAGCCGACGTGTTTGCGTCTTTAAAAATGAAATTTGGTTCACCCGAGGCCATTGCCATGGATGAGGCCATCCATGCGGCCCTATACTACGGGGCCATGCGACGATCCATAGAACTTGCAAAAGAAAAAGGAAGTCATCCCAGCTTTCCGGGGTCTGCGGCCTCAAAGGGTCTACTGCAACCCGACCTATGGGTTCGCTGCGGTGATTTAAGTTCCTCCTGGGAAGAACGCGTGGCACAGACGACGCAGGGTGTGTTAACGCGGAAAAGCTGGTGGCAACTACGGCTGGCGGCCATGCAGGGAGTTCGAAATGGATATCTCACGGCCCTTATGCCCACCGCAACCTCCTCAAATTCTACAGGAAAAAACGAATGTTTTGAGCCCTTTACCTCCAATCTATATACACGTAGAACGTTAAGCGGGGAGTTTATTGTTTTAAATAAGTATTTAATAGACGATTTAAAAGAAATTGATCTTTGGACAGAAGCCATTCAACAGCAGCTACTAAATGCAGGAGGTAGCATTCAGCACATTTTGGATATACCGGCCGAGATCCGTGATCGGTATAAAACCTCTAGGGAAATGAATCAAAAAATTTTAACAAAACACGCGGCCGCACGAAACCCCTTTGTGTCCCAAAGTATGTCTTTGAACTACTACTTTTATGAACCTGAACTAAGCCAGGTACTTACGGTGCTCGTCCTAGGCTGGAAAAAAGGTCTAACCACCGGTTCCTATTACTGTCATTTTAGCCCTGGAGCGGGTACCCAAAAAAAGATTATAAGAAACTCTGAGAAAGCGTGTAATGCGGACTGCGAGGCGTGTCTTCTGTAG
Protein
METFFIETLASDVYGKALNVDLDRLSQAQVKYTLQELISYCSALTILHYDYSTLAARLSVYQLHQSTASSFSKAVRLQAAQSCSRLSPQFVDVVYKYKAIFDSYIDYNRDYKLSLLGIETMKNSYLLKNKDGVIMERPQDAYMRVAIMIYGMGKVVNIKMILLTYDLLSRHVITHASPTMFNAGTKKPQLSSCFLLNVNDNLENLYDMVKTAGIISGGGGGIGLCLSGIRAKNSFISSSGLRSNGIQNYIMLQNASQCYANQGGLRPGAYAVYLELWHQDIFTFLQMPRLKGQMAEQRLNAPNLKYGLWVPDLFMEILEDQIHNRGDGTWYLFSPDQAPNLHKVFDLERSQHENAHREFKKLYYQYVAEKRYTGVTTAKEIIKEWFKTVIQVGNPYIGFKDAINRKSNLSHVGTITNSNLCIEVTIPCWEGDKAEQGVCNLAAVNLAAFIRENGYDYRGLMEASGNVTENLDNIIDNGYYPTEATRRSNMRHRPIGIGVFGLADVFASLKMKFGSPEAIAMDEAIHAALYYGAMRRSIELAKEKGSHPSFPGSAASKGLLQPDLWVRCGDLSSSWEERVAQTTQGVLTRKSWWQLRLAAMQGVRNGYLTALMPTATSSNSTGKNECFEPFTSNLYTRRTLSGEFIVLNKYLIDDLKEIDLWTEAIQQQLLNAGGSIQHILDIPAEIRDRYKTSREMNQKILTKHAAARNPFVSQSMSLNYYFYEPELSQVLTVLVLGWKKGLTTGSYYCHFSPGAGTQKKIIRNSEKACNADCEACLL

Summary

Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Catalytic Activity
[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate
Subunit
Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).
Similarity
Belongs to the ribonucleoside diphosphate reductase large chain family.
Keywords
Allosteric enzyme   ATP-binding   Complete proteome   Disulfide bond   DNA replication   Early protein   Nucleotide-binding   Oxidoreductase   Reference proteome  
Feature
chain  Ribonucleoside-diphosphate reductase large subunit
EC Number
1.17.4.1
Pfam
PF02867   Ribonuc_red_lgC
PF00317   Ribonuc_red_lgN
PF03477   ATP-cone
Interpro
IPR008926   RNR_R1-su_N
IPR000788   RNR_lg_C
IPR013509   RNR_lsu_N
IPR039718   Rrm1
IPR013346   NrdE_NrdA
IPR005144   ATP-cone_dom
SUPFAM
SSF48168   SSF48168
PDB
3S8B     E-value=4.81754e-140,     Score=1279

Ontologies

KEGG

Subcellular Location

From MSLVP
Nucleus

Topology

Length:
778
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.718179999999998
Exp number, first 60 AAs:
0.01938
Total prob of N-in:
0.02289
outside
1  -  778
 
 

Population Genetic Test Statistics

Pi
0.0540479
Theta
0.0523371
Tajima's D
0.0964339
CLR
0.212612
Interpretation
Possibly Balancing Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
Protein
AJL34224.1
AKO62727.1
China_AnhuiXCGQ_2018 Protein
Protein
AJL34224.1
AYW34017.1
China_ASFV-SY18_2018 Protein
AKO62727.1
Poland_Pol16_20186_o7_2016-2017 Protein
Protein
AJL34224.1
AXZ95821.1
Poland_Pol16_20538_o9_2016-2017 Protein
AJL34224.1
Poland_Pol16_20540_o10_2016-2017 Protein
AJL34224.1
Poland_Pol16_29413_o23_2016-2017 Protein
AJL34224.1
Poland_Pol17_03029_C201_2016-2017 Protein
Protein
AJL34224.1
AXZ96009.1
Poland_Pol17_04461_C210_2016-2017 Protein
Protein
AJL34224.1
AXZ96104.1
Poland_Pol17_05838_C220_2016-2017 Protein
AJL34224.1
Poland_ASFV_POL_Podlaskie_2015 Protein
AJL34224.1
Uganda_R8_2015 Protein
AXB49274.1
Uganda_R7_2015 Protein
AXB49448.1
Uganda_R25_2015 Protein
AXB49620.1
Uganda_N10_2015 Protein
AXB49791.1
Uganda_R35_2015 Protein
AXB49964.1
Estonia_2014 Protein
Protein
AJL34224.1
SPS73468.1
Italy_26544_OG10_2010 Protein
Protein
AJL34224.1
AJZ77051.1
Italy_47_Ss_2008_2008 Protein
Protein
AJL34224.1
AOO54375.1
Portugal_OURT_88.3_1988 Protein
Protein
AJL34224.1
CAN10393.1
Spain_E75_1975 Protein
Protein
AJL34224.1
CBH29146.1
Russia_Georgia_2007 Protein
Protein
AJL34224.1
CBW46711.1
Kenya_Tk1_2005 Protein
AJL34059.1
Kenya_Bus_2006 Protein
Protein
AJL34224.1
AJL34224.1
Russia_Odintsovo_2014 Protein
AJL34224.1
Portugal_L60_1960 Protein
Protein
AJL34224.1
AIY22236.1
Portugal_NHV_1968 Protein
Protein
AJL34224.1
AIY22395.1
Russia_Kashino_2013 Protein
AJL34224.1
Benin_1997 Protein
Protein
AJL34224.1
CAN10144.1
South_Africa_KNP_Pretorisuskop_1996 Protein
AJL34224.1
South_Africa_MGR_Mkuzi_1979 Protein
AJL34224.1
Malawi_Lil_1983 Protein
AJL34224.1
Kenya_1950 Protein
AJL34224.1
Namibia_Warthog_1980    
South_Africa_Warmbaths_1987 Protein
AJL34224.1
Malawi_Tengani_1962 Protein
AJL34224.1
China_HLJ_2018 Protein
Protein
AJL34224.1
QBH90533.1
China_LN_2018 Protein
Protein
AJL34224.1
QBH90718.1
China_wbBS01_2018 Protein
Protein
AJL34224.1
QDL88076.1
Ukraine_Kyiv_2014 Protein
Protein
QED21601.1
QED21602.1
Belgium_Etalle_wb_2018 Protein
Protein
AJL34224.1
QED90488.1
Lithuania_LT14_2014 Protein
Protein
AJL34224.1
QEY87851.1
South_Africa_1985 Protein
QGM12901.1
South_Africa_2_2008 Protein
QGM12827.1
Zambia_LIV_1983 Protein
QGM12707.1
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