ASFVdb The African Swine Fever Virus Database
Strain
Portugal_NHV_1968 (Region: Portugal;  Strain: NHV;  Date: 1968)
Gene
pC962R
Description
Annotated in NCBI,  CBH29172.1
Location
KM262845.1(+):74541-77429
GenBank Accession
AIY22421.1
Full name
Putative helicase C962R      
 

Sequence

CDS
ATGCGCGAGGAATCATGGGAAGACCACGATACCATTCAGCTCACCGCTCAGCGCAAATATCTCGCCGAGGTGCAAGCTCTAGAGACCCTTTTGACTCGAGAGCTTTCAGCCTTTCTCACAGAGCCAGGCAGCAAAAAAACAAATATTATTAATAGAATCACAGGAAAAACCTACGCACTTCCCAGCACAGAGCTACTAAGACTCTACGAGCATCTCGAGCAATGTCGCAAGCAAGGCGCCCTCATGTATTTTTTGGAAAGACAGGGGACCTACTCGGGTCTCATGTTGGACTATGACCTTAAACTCAATACAAATGCTGTTCCCCCGCTGGAACCCCCCGCGCTATCACGGCTTTGCCATCGAATATTTGTACATATAAAAAACAGCAGTGTGCTGCCTGAGGGCAGCCATAAAATCCACTTCTTTTTTACATTAAAACCTGAAGTGGTCCAGGGCAAATATGGGTTCCATGTGCTCATTCCTGGTCTCAAGCTGGCGGCTTCTACCAAAAAAAGCATCATAGGATCCCTACAGCACGATGCCACCGTACAAAAAATTCTACACGAACAGGGCGTTGCAAATCCTGAGTCCTGTCTGGACCCCCACTCCGCCTCTGTTCCCTCGCTCCTCTACGGCTCCTCCAAACTAAACCACAAGCCCTACCAACTGAAAACCGGCTTTGAGTTAGTCTTTGATAGCTCTGATCCCGACTACATTCCCATTCATCAAATAAAAAATATAGAATCTTATAATTTAGTTTCTGAGTTGAGCCTTACGAATGAACAAGGAAGCCTTGTAAGGCCTGTCTATTGCGCGGCAGACATTGCCGCTGAGAAGGAGGAGGAGATCCCGACCGACGACCACTCACTCTCCATATTAATGCTACATGATCCCGAAGCTCGGTATTTACATAAAATTTTAAACCTGCTTCCTCCAGAGTATTATGTGGAGTACCCCCTATGGAGCAACGTCGTATTCGCCTTGGCCAATACATCCGCCAACTATCGGCCCCTCGCCGAATGGTTTTCACAAAAATGTCCTGAAAAATGGAATACGGGAGGAAAAGAGAAACTAGAAAAACTTTGGAATGATGCCTCGCGCCACACTGAAAAGAAAATCACCAAGCGGTCCATTATGTATTGGGCCCACAAGCATGCTCCCCAGCAATACAAAGAAATTGTAGAACAAGGTTACTTTTCCATTCTCGCTGAATATGTGTATAGCTATAACGGCATGCTTGAGCACTACATGATCGCCAAAGTCATCTATGCCATGATGGGCAACAAGTTTGTGGTGGACGTGGACTCAAACGGGAAGTACGTTTGGTTCGAATTTGTGCTACCGGGCCAGCCAATGAATCAGGGAGAAATATGGAAGTGGCGCAAAGAGGTAAACCCGGATGAGCTGCACATCTATATTTCCGAAAACTTTTCAAGGGTGATGGACCGAATCACGGAGCACATCAAATACCACCTCAGTCAGCCCCATGAAACCAATATTTTAAATTATTATAAAAAACTACTAAAAGCCTTTGAACGCTCTAAAAGTAAAATCTTTAATGACAGTTTTAAAAAGGGAGTTATTAGGCAAGCCGAGTTTTTATTTCGCCAAAGAAGCTTTATTCAAACTCTGGATACCAATCCCCACCTACTGGGGGTTGGCAACGGGGTTCTCTCCATTGAGACCATCCCGGCCAAGCTCATTAATCATTTTCACGAGCATCCCATTCATCAGTACACACACATATGTTATGTGCCCTTTAATCCCGAAAACCCCTGGACAAAACTATTATTGAATGCACTCCAAGACATCATCCCAGAACTTGATGCTAGGCTGTGGATCATGTTCTACCTGAGCACGGCCATATTTCGCGGCCTGAAGGAGGCTCTGATGCTTTTGTGGCTTGGAGGTGGCTGCAATGGAAAAACTTTTCTAATGCGACTTGTGGCCATGGTATTGGGCGATCACTATGCCTCCAAGCTCAACATCAGCCTTCTTACAAGCTGCAGAGAAACCGCGGAAAAACCCAACAGTGCCTTCATGCGGCTTAAGGGGCGGGGATATGGGTACTTTGAGGAAACCAACAAAAGCGAGGTTCTAAATACGTCGCGGCTGAAGGAAATGGTAAATCCGGGCGATGTCACCGCTCGAGAGCTTAATCAAAAACAGGAAAGCTTTCAGATGACGGCCACCATGGTCGCCGCGTCCAACTATAACTTCATCATTGACACGACGGACCACGGCACATGGAGAAGACTGCGGCATTATCGTTCAAAGGTGAAATTCTGCCATAACCCCGACCCCGGTAACCCCTACGAGAAAAAGGAAGATCCTCGCTTTATTCACGAGTACATCATGGATCCAGACTGCCAAAACGCATTCTTCAGCATACTCGTCTATTTTTGGGAGAAGCTACAGAAGGAATACAACGGGCAGATTAAAAAAGTGTTTTGTCCCACCATTGAGAGCGAAACGGAGGCGTACAGAAAGTCACAAGATACGCTACATAGGTTTATCACAGAAAGAGTCGTGGAGTCGCCCTCGGCAGAAACTGTGTACAACCTATCCGAGGTCGTGACGGCCTACGCGGAATGGTACAACGCCAACATTAACGTAAAGCGCCATATTGCCCTTGAGCTATCCCAGGAGTTAGAAAACTCTGTGCTAGAAAAATACCTTCAGTGGTCTCCCAACAAAACGCGAATTCTAAAGGGTTGCCGTATTTTGCATAAATTTGAAACGCTGCAGCCCGGCGAATCCTACATTGGGGTGTCCACGGCCGGCACACTCCTAAACACACCCATATGCGAGCCAAAAAATAAATGGTGGGAATGGTCTCCTAATCTCTCTGCCCCTCCTGAGAAAGAAGCGTCTGCACCAACTCCTTAG
Protein
MREESWEDHDTIQLTAQRKYLAEVQALETLLTRELSAFLTEPGSKKTNIINRITGKTYALPSTELLRLYEHLEQCRKQGALMYFLERQGTYSGLMLDYDLKLNTNAVPPLEPPALSRLCHRIFVHIKNSSVLPEGSHKIHFFFTLKPEVVQGKYGFHVLIPGLKLAASTKKSIIGSLQHDATVQKILHEQGVANPESCLDPHSASVPSLLYGSSKLNHKPYQLKTGFELVFDSSDPDYIPIHQIKNIESYNLVSELSLTNEQGSLVRPVYCAADIAAEKEEEIPTDDHSLSILMLHDPEARYLHKILNLLPPEYYVEYPLWSNVVFALANTSANYRPLAEWFSQKCPEKWNTGGKEKLEKLWNDASRHTEKKITKRSIMYWAHKHAPQQYKEIVEQGYFSILAEYVYSYNGMLEHYMIAKVIYAMMGNKFVVDVDSNGKYVWFEFVLPGQPMNQGEIWKWRKEVNPDELHIYISENFSRVMDRITEHIKYHLSQPHETNILNYYKKLLKAFERSKSKIFNDSFKKGVIRQAEFLFRQRSFIQTLDTNPHLLGVGNGVLSIETIPAKLINHFHEHPIHQYTHICYVPFNPENPWTKLLLNALQDIIPELDARLWIMFYLSTAIFRGLKEALMLLWLGGGCNGKTFLMRLVAMVLGDHYASKLNISLLTSCRETAEKPNSAFMRLKGRGYGYFEETNKSEVLNTSRLKEMVNPGDVTARELNQKQESFQMTATMVAASNYNFIIDTTDHGTWRRLRHYRSKVKFCHNPDPGNPYEKKEDPRFIHEYIMDPDCQNAFFSILVYFWEKLQKEYNGQIKKVFCPTIESETEAYRKSQDTLHRFITERVVESPSAETVYNLSEVVTAYAEWYNANINVKRHIALELSQELENSVLEKYLQWSPNKTRILKGCRILHKFETLQPGESYIGVSTAGTLLNTPICEPKNKWWEWSPNLSAPPEKEASAPTP

Summary

Similarity
Belongs to the asfivirus helicase C962R family.
Keywords
ATP-binding   Complete proteome   DNA replication   Helicase   Hydrolase   Nucleotide-binding   Reference proteome  
Feature
chain  Putative helicase C962R
Uniprot
D4I5Q9   A9JLV6   A9JL24   A0A0A1E0M4   Q65162   E0WMK9   + More
A0A2X0TKI6   P0C9X3   P0C9X1   Q8V9U4   P0C9X2   A0A0C5AZG0   A0A0C5B022  
Pubmed
18198370    25406173    26618713    11831707    21470447    25645905    + More
EMBL
FN557520    CBH29172.1    AM712240    CAN10420.1    AM712239    CAN10171.1    + More
KM262844    KM262845    KM102979    KP055815    KX354450    AIY22263.1    AIY22421.1    AJZ77047.1    AKO62753.1    AOO54407.1    U18466    FR682468    CBW46737.1    MG939583    MG939587    MG939588    LS478113    AXZ95845.1    AXZ96033.1    AXZ96128.1    SPS73494.1    AY261363    AY261366    L00966    AY261361    AY261360    KM111294    AJL34085.1    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34250.1    AXB49300.1    AXB49474.1    AXB49646.1    AXB49817.1    AXB49990.1   
Proteomes
UP000101090    UP000108903    UP000130745    UP000110401    UP000117635    UP000142390    + More
UP000241813    UP000266411    UP000000624    UP000141072    UP000000859    UP000000858    UP000000860    UP000000861    UP000105860    UP000101566   
Pfam
PF08707   PriCT_2
PF08706   D5_N
Interpro
IPR014015   Helicase_SF3_DNA-vir
IPR014819   PriCT_2
IPR027417   P-loop_NTPase
IPR014818   Phage/plasmid_primase_P4_C
SUPFAM
SSF52540   SSF52540
ProteinModelPortal
D4I5Q9   A9JLV6   A9JL24   A0A0A1E0M4   Q65162   E0WMK9   + More
A0A2X0TKI6   P0C9X3   P0C9X1   Q8V9U4   P0C9X2   A0A0C5AZG0   A0A0C5B022  
PDB
5X42     E-value=2.94147,     Score=74

Ontologies

KEGG
vg:22220301    
GO
GO:0016817  F:hydrolase activity, acting on acid anhydrides
 GO:0005524  F:ATP binding
 GO:0004386  F:helicase activity
 GO:0006260  P:DNA replication

Subcellular Location

From MSLVP
Single-Pass Membrane

Topology

Length:
962
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.10997
Exp number, first 60 AAs:
0.00076
Total prob of N-in:
0.00049
outside
1  -  962
 
 

Population Genetic Test Statistics

Pi
0.0281924
Theta
0.0341329
Tajima's D
-0.6926865
CLR
0.178983
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
Protein
 QED21643.1
AKO62753.1
China_AnhuiXCGQ_2018 Protein
Protein
 QED21643.1
AYW34042.1
China_ASFV-SY18_2018 Protein
Protein
Protein
 CBH29172.1
CBH29173.1
AKO62753.1
Poland_Pol16_20186_o7_2016-2017 Protein
Protein
 QED21643.1
AXZ95845.1
Poland_Pol16_20538_o9_2016-2017 Protein
Protein
 CAN10171.1
QED21643.1
Poland_Pol16_20540_o10_2016-2017 Protein
Protein
 CAN10171.1
QED21643.1
Poland_Pol16_29413_o23_2016-2017 Protein
Protein
 CAN10171.1
QED21643.1
Poland_Pol17_03029_C201_2016-2017 Protein
Protein
 QED21643.1
AXZ96033.1
Poland_Pol17_04461_C210_2016-2017 Protein
Protein
 QED21643.1
AXZ96128.1
Poland_Pol17_05838_C220_2016-2017 Protein
Protein
 CAN10171.1
QED21643.1
Poland_ASFV_POL_Podlaskie_2015 Protein
Protein
 CAN10171.1
QED21643.1
Uganda_R8_2015 Protein
Protein
 QED21643.1
AXB49300.1
Uganda_R7_2015 Protein
Protein
 QED21643.1
AXB49474.1
Uganda_R25_2015 Protein
Protein
 QED21643.1
AXB49646.1
Uganda_N10_2015 Protein
Protein
 QED21643.1
AXB49817.1
Uganda_R35_2015 Protein
Protein
 QED21643.1
AXB49990.1
Estonia_2014 Protein
Protein
 QED21643.1
SPS73494.1
Italy_26544_OG10_2010 Protein
Protein
 QED21643.1
AJZ77047.1
Italy_47_Ss_2008_2008 Protein
Protein
Protein
 QED21643.1
AOO54407.1
AOO54408.1
Portugal_OURT_88.3_1988 Protein
Protein
 QED21643.1
CAN10420.1
Spain_E75_1975 Protein
Protein
 CBH29172.1
CBH29173.1
Russia_Georgia_2007 Protein
Protein
 QED21643.1
CBW46737.1
Kenya_Tk1_2005 Protein
Protein
 QED21643.1
AJL34085.1
Kenya_Bus_2006 Protein
Protein
 QED21643.1
AJL34250.1
Russia_Odintsovo_2014 Protein
Protein
 CAN10171.1
QED21643.1
Portugal_L60_1960 Protein
Protein
 QED21643.1
AIY22263.1
Portugal_NHV_1968 Protein
Protein
 QED21643.1
AIY22421.1
Russia_Kashino_2013 Protein
Protein
 CAN10171.1
QED21643.1
Benin_1997 Protein
Protein
Protein
 CAN10171.1
QED21643.1
CAN10171.1
South_Africa_KNP_Pretorisuskop_1996 Protein
Protein
 CAN10171.1
QED21643.1
South_Africa_MGR_Mkuzi_1979 Protein
Protein
 CAN10171.1
QED21643.1
Malawi_Lil_1983 Protein
Protein
 CAN10171.1
QED21643.1
Kenya_1950 Protein
Protein
 CAN10171.1
QED21643.1
Namibia_Warthog_1980 Protein
Protein
 CAN10171.1
QED21643.1
South_Africa_Warmbaths_1987 Protein
Protein
 CAN10171.1
QED21643.1
Malawi_Tengani_1962 Protein
Protein
 CAN10171.1
QED21643.1
China_HLJ_2018 Protein
Protein
 QED21643.1
QBH90559.1
China_LN_2018 Protein
Protein
 QED21643.1
QBH90744.1
China_wbBS01_2018 Protein
Protein
 QED21643.1
QDL88102.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
 QED21643.1
QED21644.1
QED21645.1
Belgium_Etalle_wb_2018 Protein
Protein
 QED21643.1
QED90514.1
Lithuania_LT14_2014 Protein
Protein
 QED21643.1
QEY87877.1
South_Africa_1985 Protein
Protein
 QED21643.1
QGM12919.1
South_Africa_2_2008 Protein
Protein
 QED21643.1
QGM12844.1
Zambia_LIV_1983 Protein
 QED21643.1
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