ASFVdb The African Swine Fever Virus Database
Strain
Uganda_R25_2015 (Region: Uganda, Tororo district;  Strain: R25;  Date: 2015)
Gene
pP1192R
Description
Annotated in NCBI,  gene expression: late
GenBank Accession
Full name
DNA topoisomerase 2      
Alternative Name
DNA topoisomerase II
 

Sequence

CDS
ATGGAAACGTTTGAAATCAGTGATTTCAAAGAGCATGCGAAGAAAAAAAGCATGTGGGCTGGTGCCCTCAACAAAGTCACTATTTCGGGTCTTATGGGGGTCTTTACAGAAGATGAGGACCTTATGGCGCTACCCATTCACAGAGACCACTGCCCCGCTTTGTTAAAAATTTTTGACGAGCTCATCGTAAACGCCACGGATCATGAAAGAGCTTGCCATAACAAAACAAAAAAAGTAACCTACATCAAAATTTCGTTTGATAAAGGTGTGTTTTCTTGTGAAAACGATGGCCCGGGAATCCCCATTGTAAAGCATGAGCAGGCCAGCCTTATCGCAAAGCGCGATGTGTATGTCCCCGAGGTAGCTTCATGCTATTTTCTAGCCGGAACAAACATCAATAAGGCTAAGGACTGTATCAAGGGGGGGACCAACGGCGTTGGGCTGAAGCTCGCCATGGTGCATTCACAGTGGGCCATTCTTACCACCGCCGACGGCTCGCAAAAGTATGTTCAACATATAAACCAGCGCCTAGATAACATTGAGCCACCTACCATTACACCCTCCAGAGAAATGTTTACACGTATCGAGCTCATGCCCGTATACCAGGAACTAGGGTATGCACAGCCTCTGTCTGAAACGGAGCAAGCAGACCTTTCCGCCTGGATTTACCTTCGCGCCTGCCAATGCGCGGCCTACGTGGGAAAAGGCACCACCATTTATTACAATGATAAGCCTTGCAGCACGAGCTCCGTAATGGCGCTGGCCAAAATGTACACCCTAGTGACTGCGCCCAATAGCACCATATATACGGCCACCATTAAGGCTGACGCAAAGCCCTATAGCCTGCACCCCCTGCAGGTTGCGGCGGTCGTCTCCCCCAAGTTTAAAAAATTTGAACACGTGTCCATTATCAACGGGGTAAATTGTGTAAAGGGAGAACATGTCACCTTTTTGAAAAAGGCCATTAATGAAATGGTCGTTAAAAAATTTCAACAGACGATTAAAGATAAAAACCGCAAAACAACATTACGCGACAGCTGTTCAAACATCTTTGTCGTTATCGTGGGTTCCATTCCAGGCATAGAATGGACCGGCCAGCGGAAGGATGAACTAAGCATCGCAGAAAACGTTTTTAAAACGCATTACTCCATCCCTTCTAGTTTTTTAACAAGCATGACAAGATCTATCGTGGATATTCTTCTGCAATCCATTTCTAAAAAAGATAACCATAAACAGATCGACGTAGACAAATATACGCGTGCCCGCAATGCGGGTGGAAAAAAGGCGCAAGACTGTATGCTACTCGCGGCGGAAGGGGATAGCGCACTTTCCCTGCTGCGCGCGGGACTGACCCTGGGAAAGTCCAACCCAAGCGGGCCTTCCTTTGACTTCTGCGGCATGATCTCCCTGGGAGGGGTCATCATGAATGCCTGCAAAAAGGTGACAAACATTACAACGGACTCTGGAGAAACCATCATGGTGCGCAACGAACAGCTCACCAATAATAAAGTATTACAGGGAATCGTGCAGGTATTGGGTCTAGACTTCAACTGCCATTACAAAACGCAGGAAGAGCGAGCAAAGCTGCGATATGGCTGCATTGTTGCGTGCGTTGACCAAGATCTGGACGGATGTGGAAAAATTCTTGGACTGCTGCTGGCCTACTTTCACCTGTTTTGGCCTCAGCTTATTGTCCATGGTTTCGTAAAACGACTGCTTACCCCGCTGATACGTGTGTATGAAAAGGGCAATACCGTGCCCGTGGAATTTTACTACGAACAAGAGTTTGATGCATGGGCGAAAAAGCAGACTAGCCTGGCTAATCATACTGTAAAATATTATAAGGGATTGGCGGCGCACGACACCCATGAAGTAAAAAGCATGTTCAAACATTTTGACAAAATGGTGTACACGTTTACCCTAGATGACTCAGCAAAGGAGTTGTTTCATATTTATTTTGGTGGGGAGTCGGAGTTGCGAAAAAGAGAGCTTTGCACCGGCGTAGTGCCGCTCACCGAAACCCAGACGCAGTCCATTCATAGTGTCCGACGAATTCCTTGCAGCCTGCACCTGCAGGTAGACACCAAGGCCTACAAGCTAGATGCCATCGAGCGGCAAATTCCCAACTTCTTAGATGGGATGACGCGGGCACGGCGCAAAATTTTAGCCGGAGGGTTGAAATGCTTCGCCTCCAATAACCGCGAACGAAAGGTTTTTCAATTCGGGGGCTACGTTGCGGACCACATGTTTTATCACCATGGCGATATGTCGTTAAACACAAGTATCATAAAAGCTGCCCAATACTACCCGGGCTCTTCCCATCTCTATCCTGTATTTATAGGCATAGGAAGCTTTGGCTCCAGGCATCTGGGAGGAAAAGATGCAGGATCCCCAAGATACATCAGTGTGCAGCTTGCGTCTGAATTTATTAAAACAATGTTCCCCACGGAGGACTCATGGCTTCTCCCCTACGTTTTTGAGGACGGCCAACGGGCGGAACCAGAATACTACGTGCCTGTATTGCCGCTTGCCATTATGGAGTACGGCGCCAACCCATCGGAGGGCTGGAAGTACACCACTTGGGCCCGCCAACTGGAAGACATTTTGGCCTTGGTGAGGGCCTACGTCGATAAGAACAATCCAAAACACGAGCTCCTGCACTACGCAATAGACCATAAGATTACTGTACTTCCGCTACGGCCCTCTAATTACAATTTTAAGGGTCACTTGAAACGATTCGGCCAATACTACTACAGCTACGGCACTTACGTCGTCTCAGAGCAGCGAAATATGATTACTATTACGGAGCTCCCGCTGCGTGTTCCTACGGTTGCTTACATTGAAAGTATAAAAAAATCGAGTAACCGCATGGCATTTATTGAAGAAATCGTCGACTACAGTAGTTCAGAAACCATTGAAATTTTGGTAAAGCTGAAGCCAAATAGCCTTAGCCGGATCATGGAAGAATTTAAGGAGACTGAGGAGCAGAATTCTATAGAAAATTTTCTACGTTTACGCAATTGTTTACATTCGCACCTAAACTTTGTAAAACCTAAAGGAGGCATCATCGAGTTTAACTCATATTATGAAATTTTATACGCATGGCTGCCTTACAGGCGTGATCTTTACCAAAAACGTCTTATGCGTGAGCGCGCCGTGTTAAAGCTGCGCCTTATCATGGAAACTGCCATTGTGCGCTACATCAATGAGTCCGCGGATCTAAATCTTTCCCACTATGAGGATGAAAAGGAGGCGGGCCGTATTTTGAGCGAGCACGGGTTCCCCCCGCTAAACCAGTCGCTCATCACCTCTCCGGAGTTTGCCACCATAGAGGAACTCAACCAAAAAGCACTGCAGGGCTGTTATACCTATATACTATCTTTGCAGGCTCGAGAATTGCTTATCGCAGCCAAGACTCGTCGGGTGGAAAAAATAAAAAAAATGCAAGCGCGTCTTGATAAGGTTGAGCAGCTTTTGCAGGAGTCTCCCTTTCCCGGCGCCAGCGTATGGTTGGAGGAGATTGATGCGGTGGAAAAAGCTATTATAAAAGGAAGAAATACACAGTGGAAATTTCATTAA
Protein
METFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCPALLKIFDELIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPIVKHEQASLIAKRDVYVPEVASCYFLAGTNINKAKDCIKGGTNGVGLKLAMVHSQWAILTTADGSQKYVQHINQRLDNIEPPTITPSREMFTRIELMPVYQELGYAQPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCSTSSVMALAKMYTLVTAPNSTIYTATIKADAKPYSLHPLQVAAVVSPKFKKFEHVSIINGVNCVKGEHVTFLKKAINEMVVKKFQQTIKDKNRKTTLRDSCSNIFVVIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTRSIVDILLQSISKKDNHKQIDVDKYTRARNAGGKKAQDCMLLAAEGDSALSLLRAGLTLGKSNPSGPSFDFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVLGLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQLIVHGFVKRLLTPLIRVYEKGNTVPVEFYYEQEFDAWAKKQTSLANHTVKYYKGLAAHDTHEVKSMFKHFDKMVYTFTLDDSAKELFHIYFGGESELRKRELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLDGMTRARRKILAGGLKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSIIKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKTMFPTEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWARQLEDILALVRAYVDKNNPKHELLHYAIDHKITVLPLRPSNYNFKGHLKRFGQYYYSYGTYVVSEQRNMITITELPLRVPTVAYIESIKKSSNRMAFIEEIVDYSSSETIEILVKLKPNSLSRIMEEFKETEEQNSIENFLRLRNCLHSHLNFVKPKGGIIEFNSYYEILYAWLPYRRDLYQKRLMRERAVLKLRLIMETAIVRYINESADLNLSHYEDEKEAGRILSEHGFPPLNQSLITSPEFATIEELNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQESPFPGASVWLEEIDAVEKAIIKGRNTQWKFH

Summary

Function
Type II topoisomerase. Processively relaxes supercoiled DNA. Displays DNA-supercoiling activity only when associated with the viral histone-like protein.
Type II topoisomerase (PubMed:27060564, PubMed:25463606). Processively relaxes supercoiled DNA (PubMed:27060564). Displays DNA-supercoiling activity only when associated with the viral histone-like protein (PubMed:28381576).
Catalytic Activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
Similarity
Belongs to the type II topoisomerase family.
Keywords
ATP-binding   Complete proteome   DNA-binding   Host cytoplasm   Isomerase   Late protein   Magnesium   Metal-binding   Nucleotide-binding   Topoisomerase   Reference proteome  
Feature
chain  DNA topoisomerase 2
EC Number
5.99.1.3
Pfam
PF00521   DNA_topoisoIV
PF16898   TOPRIM_C
PF02518   HATPase_c
Interpro
IPR020568   Ribosomal_S5_D2-typ_fold
IPR013759   Topo_IIA_B_C
IPR002205   Topo_IIA_A/C
IPR001241   Topo_IIA
IPR013758   Topo_IIA_A/C_ab
IPR036890   HATPase_C_sf
IPR013760   Topo_IIA-like_dom_sf
IPR014721   Ribosomal_S5_D2-typ_fold_subgr
IPR013757   Topo_IIA_A_a_sf
IPR031660   TOPRIM_C
IPR018522   TopoIIA_CS
IPR003594   HATPase_C
SUPFAM
SSF56719   SSF56719
SSF55874   SSF55874
SSF54211   SSF54211
PDB
4GFH     E-value=1.48562e-78,     Score=750

Ontologies

KEGG

Subcellular Location

From MSLVP
Capsid
From Uniprot
Host cytoplasm   Localizes to the cytoplasmic viral factories.   With evidence from 3 publications.

Topology

Length:
1192
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.324460000000001
Exp number, first 60 AAs:
0.18433
Total prob of N-in:
0.01167
outside
1  -  1192
 
 

Population Genetic Test Statistics

Pi
0.0339213
Theta
0.0364103
Tajima's D
-0.5251604
CLR
0
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62793.1
China_AnhuiXCGQ_2018 Protein
AYW34083.1
China_ASFV-SY18_2018 Protein
AKO62793.1
Poland_Pol16_20186_o7_2016-2017 Protein
AXZ95885.1
Poland_Pol16_20538_o9_2016-2017 Protein
CAN10212.1
Poland_Pol16_20540_o10_2016-2017 Protein
CAN10212.1
Poland_Pol16_29413_o23_2016-2017 Protein
CAN10212.1
Poland_Pol17_03029_C201_2016-2017 Protein
CAN10212.1
Poland_Pol17_04461_C210_2016-2017 Protein
AXZ96168.1
Poland_Pol17_05838_C220_2016-2017 Protein
CAN10212.1
Poland_ASFV_POL_Podlaskie_2015 Protein
CAN10212.1
Uganda_R8_2015 Protein
AXB49341.1
Uganda_R7_2015 Protein
AXB49515.1
Uganda_R25_2015 Protein
AXB49687.1
Uganda_N10_2015 Protein
AXB49858.1
Uganda_R35_2015 Protein
AXB50031.1
Estonia_2014 Protein
SPS73535.1
Italy_26544_OG10_2010 Protein
AJZ77044.1
Italy_47_Ss_2008_2008 Protein
AOO54473.1
Portugal_OURT_88.3_1988 Protein
CAN10461.1
Spain_E75_1975 Protein
CBH29212.1
Russia_Georgia_2007 Protein
CBW46778.1
Kenya_Tk1_2005 Protein
AJL34125.1
Kenya_Bus_2006 Protein
AJL34290.1
Russia_Odintsovo_2014 Protein
CAN10212.1
Portugal_L60_1960 Protein
AIY22303.1
Portugal_NHV_1968 Protein
AIY22461.1
Russia_Kashino_2013 Protein
CAN10212.1
Benin_1997 Protein
Protein
CAN10212.1
CAN10212.1
South_Africa_KNP_Pretorisuskop_1996 Protein
CAN10212.1
South_Africa_MGR_Mkuzi_1979 Protein
CAN10212.1
Malawi_Lil_1983 Protein
CAN10212.1
Kenya_1950 Protein
CAN10212.1
Namibia_Warthog_1980 Protein
CAN10212.1
South_Africa_Warmbaths_1987 Protein
CAN10212.1
Malawi_Tengani_1962 Protein
CAN10212.1
China_HLJ_2018 Protein
QBH90600.1
China_LN_2018 Protein
QBH90785.1
China_wbBS01_2018 Protein
QDL88143.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
Protein
QED21716.1
QED21717.1
QED21718.1
QED21719.1
Belgium_Etalle_wb_2018 Protein
QED90555.1
Lithuania_LT14_2014 Protein
QEY87918.1
South_Africa_1985 Protein
QGM12932.1
South_Africa_2_2008 Protein
QGM12858.1
Zambia_LIV_1983    
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