ASFVdb The African Swine Fever Virus Database
Strain
Uganda_R7_2015 (Region: Uganda, Tororo district;  Strain: R7;  Date: 2015)
Gene
p505-2R
Description
Annotated in NCBI,  CBH29126.1
Location
MH025917.1(+):33311-34885
GenBank Accession
AXB49429.1
Full name
Protein MGF 505-2R       + More
Protein MGF 505-10R      
Protein MGF 505-5R      
Protein MGF 505-4R      
Protein MGF 505-7R      
Protein MGF 505-6R      
Protein MGF 505-1R      
Protein MGF 505-9R      
 

Sequence

CDS
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACAATTGGGGCTGTACTGGGAAAAACACGGCTCTCTTCAACGAATAGGGAACGATCACATACTCATACGGCGGGATCTCATCCTTTCTATCAACGAGGCCTTAAAAATAGCGGCAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTATGCCATCATAGGAGCCTTGCAGGGTGACCAATATGACCTCATCCATACGTACGAAAACCAAATCGAAGACTATCATCATATCTTGCCATTGATTCAAGATGCGAAAACGTTTGAAAAATGCCACGCCTTGGAACGTTTTTGTGATGTTCCATGCCTACTAGAACATGCTACAAAACACAACATGCTCCCTATTCTCCAAAAATACCAAGAAGAGCTGTTTATAAGAGTGTATCTCCGCGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATATCCTTAAATGGATAGAGCAAACCATGCATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTAAGCATGTACTCTTTAGGATATATTCTCCTTTTTAATAGAGGGAACACCGATGTTGCGTTAGCAACGTTGCTAACGCAACATCTCGAGAAGACAGCGGCCAAGGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGTAACATAAACATCGTCCTCTCCCAAGCCGTAAAATACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAAAATATTGAAAAACTTTTGTTGCTGGCCGTACAGGAAAGGGCTTCTAAGAAAACATTGAACTTACTGTTGTCTTATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGCATGAGTCCACACTGGTGATAAGGATTTTATTAAAAAAAAGAATAAACCTAATAGACGCCGTGTTGGAAAAGACTGTAAGATATTTTTCTATGACTAAAGTGAGGACGATCATGGATGAGCTTTCGATTAATCCGGAAAAAGTCATTAAAATGGCCGTGCAGAAAATGAGAACGGATATCGTGATCCATACTTCTTATGTTTGGGAGGATGATCTAGAAAGACTTATTCGTCTTAAAAATATGCTATACACTATAAAGTATGAGCATGAAAAAAAAATGCTAATTAAAGTCATTCACGGCATATACAAAAACTTATACGGCGAAAAAGAAAAAGTCATGTTTAATTTGGCCAAGTTCTATGCTGCTCAAAACGCGGCCACCCAATTCAAAGACACTTGTAAAGACTGTTGCAAACTGGATGTGGCGCGGTTTAAACAACTAATTTTAGACTGTTTAGACATTATTACTAAAAAAACGTGCCTCAGTATCATGGAAATCTTAGAAAATCATATTATTTCGCTATTTGCTATGAAAATGATGACGGAGGATGAAAAAAACTTAGGTTTAGAAATATTATATAAAGTAATTAGTTACAAAATGATATCATATTAA
Protein
MFSLQDLCRKHLFILPDVFGEHVLQQLGLYWEKHGSLQRIGNDHILIRRDLILSINEALKIAAEEGNNEVVKLLLLWKGNLHYAIIGALQGDQYDLIHTYENQIEDYHHILPLIQDAKTFEKCHALERFCDVPCLLEHATKHNMLPILQKYQEELFIRVYLRETLFELACLWQRYDILKWIEQTMHVYDLKIMFNIAISKRDLSMYSLGYILLFNRGNTDVALATLLTQHLEKTAAKGLLHFVLETLKYGGNINIVLSQAVKYNHRKLLDYFLRQLPRKNIEKLLLLAVQERASKKTLNLLLSYLNYSVKRIKKLLRYVIEHESTLVIRILLKKRINLIDAVLEKTVRYFSMTKVRTIMDELSINPEKVIKMAVQKMRTDIVIHTSYVWEDDLERLIRLKNMLYTIKYEHEKKMLIKVIHGIYKNLYGEKEKVMFNLAKFYAAQNAATQFKDTCKDCCKLDVARFKQLILDCLDIITKKTCLSIMEILENHIISLFAMKMMTEDEKNLGLEILYKVISYKMISY

Summary

Function
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
Similarity
Belongs to the asfivirus MGF 505 family.
Keywords
Complete proteome   Reference proteome   ANK repeat   Repeat  
Feature
chain  Protein MGF 505-2R
Uniprot
A0A2Z5DEX1   A0A0C5B2F7   P0C9S7   Q65128   P0C9S9   A9JKV3   + More
A0A0A1E2Z4   E0WMG1   A0A2X0RU65   D4I5L3   Q89702   P0C9S8   A0A0C5B227   D4I5M0   P0C9V0   A0A0C5AYV0   A0A0C5AZ79   A0A2Z5DF55   A9JLM1   A0A0A1DY08   A0A0A1E0I6   A0A1C6ZXX4   Q89869   A9JKW5   Q65114   P0C9V1   P0C9V2   E0WMG9   A0A2X0TKE5   A0A0C5AWL2   E0WMG5   A0A2X0TC45   A0A385KLZ1   A9JKV8   D4I5L6   A0A0A1E043   Q89777   P0C9T8   A9JLL5   A0A0A1E0Y6   P0C9T6   P0C9T9   P0C9T7   A0A385KLZ6   E0WMG4   A0A2X0RVA3   A0A0C5AW92   A9JKV6   D4I5L5   A9JLL3   A0A0A1E0I1   Q89768   P0C9T5   A0A0C5BC47   P0C9T2   P0C9T3   A0A0C5BCK1   A0A2Z5DEF5   P0C9T4   E0WMG7   A0A2X0RTS3   P0C9U5   P0C9U4   Q89925   D4I5L7   A9JLL7   A0A0A1E0L2   A9JKW0   A0A3G1EUV7   A0A0N7CQW3   A9JKW2   A0A0A1E2Z7   D4I5L8   E0WMG6   A0A2X0S742   P0C9U3   A9JLL8   A0A0A1DY94   P0C9U0   P0C9U2   A0A0C5AZC1   P0C9U1   A0A0C5AZV5   A0A2Z5DFS5   P0C9S6   A0A0C5B231   A0A0C5B2G2   P0C9U6   P0C9S5   A0A0C5B2F2   A0A0C5AYU4   A0A2Z5DGS0   A9JKU5   D4I5K9   A0A0A1DXH2   A0A1C6ZXX7   A9JKW3   D4I5L9   A9JLM0   A0A0A1DXI4  
Pubmed
25645905    8030263    18198370    25406173    26618713    21470447    + More
11831707   
EMBL
MH025916    MH025917    MH025918    MH025919    MH025920    AXB49255.1    + More
AXB49429.1    AXB49601.1    AXB49773.1    AXB49945.1    KM111295    AJL34206.1    AY261360    U03762    AY261361    AY261366    AM712239    CAN10124.1    KM262844    KM102979    KP055815    KX354450    AIY22216.1    AJZ77062.1    AKO62707.1    AOO54349.1    FR682468    CBW46689.1    MG939583    MG939587    MG939588    LS478113    AXZ95802.1    AXZ95990.1    AXZ96085.1    SPS73446.1    FN557520    CBH29126.1    U02468    U18466    AY261363    KM111294    AJL34041.1    CBH29133.1    AJL34047.1    AJL34212.1    AXB49261.1    AXB49435.1    AXB49607.1    AXB49778.1    AXB49951.1    AM712240    CAN10380.1    KM262845    AIY22382.1    AIY22223.1    AKO62714.1    AJZ77055.1    AOO54359.1    CAN10131.1    U03761    CBW46697.1    AXZ95809.1    AXZ95997.1    AXZ96092.1    SPS73454.1    AJL34209.1    AXB49258.1    AXB49432.1    AXB49604.1    AXB49775.1    AXB49948.1    CBW46693.1    SPS73450.1    AXZ95806.1    AXZ95994.1    AXZ96089.1    CAN10127.1    CBH29129.1    AIY22219.1    AJZ77066.1    AKO62710.1    AOO54354.1    CAN10376.1    AIY22378.1    AXZ95805.1    CBW46692.1    AXZ95993.1    AXZ96088.1    SPS73449.1    AJL34044.1    CAN10126.1    CBH29128.1    CAN10375.1    AIY22218.1    AIY22377.1    AJZ77065.1    AKO62709.1    AOO54353.1    AJL34043.1    AJL34208.1    AXB49257.1    AXB49431.1    AXB49603.1    AXB49947.1    CBW46695.1    SPS73452.1    CBH29130.1    CAN10377.1    AIY22220.1    AIY22379.1    AJZ77060.1    AKO62711.1    AOO54355.1    CAN10128.1    AOO54356.1    AKO62712.1    CAN10129.1    AIY22221.1    AJZ77061.1    CBH29131.1    CBW46694.1    AXZ95807.1    AXZ95995.1    AXZ96090.1    SPS73451.1    CAN10378.1    AIY22380.1    AJL34045.1    AJL34210.1    AXB49259.1    AXB49433.1    AXB49605.1    AXB49776.1    AXB49949.1    AJL34046.1    AJL34211.1    AXB49260.1    AXB49434.1    AXB49606.1    AXB49777.1    AXB49950.1    AJL34201.1    AJL34037.1    AXB49251.1    AXB49425.1    AXB49597.1    AXB49770.1    AXB49941.1    CAN10120.1    CBH29122.1    AIY22212.1    AKO62703.1    AJZ77058.1    AOO54340.1    CAN10130.1    CBH29132.1    CAN10379.1    AIY22222.1    AIY22381.1    AJZ77064.1    AKO62713.1    AOO54358.1   
Proteomes
UP000101566    UP000000861    UP000000860    UP000000858    UP000130745    UP000117635    + More
UP000142390    UP000241813    UP000266411    UP000141072    UP000101090    UP000000624    UP000000859    UP000105860    UP000108903    UP000110401   
PRIDE
P0C9S7    Q65128    Q89702    P0C9V0    Q65114    P0C9V1    + More
P0C9V2    P0C9U5    P0C9U4    Q89925    P0C9U0    P0C9U2    P0C9S6    P0C9U6    P0C9S5   
Pfam
PF03158   DUF249
Interpro
IPR004858   MGF_505
IPR036770   Ankyrin_rpt-contain_sf
SUPFAM
SSF48403   SSF48403
Gene 3D
1.25.40.20    
ProteinModelPortal
A0A2Z5DEX1   A0A0C5B2F7   P0C9S7   Q65128   P0C9S9   A9JKV3   + More
A0A0A1E2Z4   E0WMG1   A0A2X0RU65   D4I5L3   Q89702   P0C9S8   A0A0C5B227   D4I5M0   P0C9V0   A0A0C5AYV0   A0A0C5AZ79   A0A2Z5DF55   A9JLM1   A0A0A1DY08   A0A0A1E0I6   A0A1C6ZXX4   Q89869   A9JKW5   Q65114   P0C9V1   P0C9V2   E0WMG9   A0A2X0TKE5   A0A0C5AWL2   E0WMG5   A0A2X0TC45   A0A385KLZ1   A9JKV8   D4I5L6   A0A0A1E043   Q89777   P0C9T8   A9JLL5   A0A0A1E0Y6   P0C9T6   P0C9T9   P0C9T7   A0A385KLZ6   E0WMG4   A0A2X0RVA3   A0A0C5AW92   A9JKV6   D4I5L5   A9JLL3   A0A0A1E0I1   Q89768   P0C9T5   A0A0C5BC47   P0C9T2   P0C9T3   A0A0C5BCK1   A0A2Z5DEF5   P0C9T4   E0WMG7   A0A2X0RTS3   P0C9U5   P0C9U4   Q89925   D4I5L7   A9JLL7   A0A0A1E0L2   A9JKW0   A0A3G1EUV7   A0A0N7CQW3   A9JKW2   A0A0A1E2Z7   D4I5L8   E0WMG6   A0A2X0S742   P0C9U3   A9JLL8   A0A0A1DY94   P0C9U0   P0C9U2   A0A0C5AZC1   P0C9U1   A0A0C5AZV5   A0A2Z5DFS5   P0C9S6   A0A0C5B231   A0A0C5B2G2   P0C9U6   P0C9S5   A0A0C5B2F2   A0A0C5AYU4   A0A2Z5DGS0   A9JKU5   D4I5K9   A0A0A1DXH2   A0A1C6ZXX7   A9JKW3   D4I5L9   A9JLM0   A0A0A1DXI4  
PDB
4ECO     E-value=7.35521,     Score=68

Ontologies

KEGG
vg:22220408     vg:22220414     vg:22220411     vg:22220410     vg:22220412    

Subcellular Location

From MSLVP
Multi-Pass Membrane

Topology

Length:
524
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.03541
Exp number, first 60 AAs:
0.00464
Total prob of N-in:
0.00327
outside
1  -  524
 
 

Population Genetic Test Statistics

Pi
0.071056
Theta
0.1183583
Tajima's D
-1.4489045
CLR
0.066748
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
 AKO62707.1
China_AnhuiXCGQ_2018 Protein
 AYW33995.1
China_ASFV-SY18_2018 Protein
Protein
 CBH29126.1
AKO62707.1
Poland_Pol16_20186_o7_2016-2017 Protein
 AXZ95802.1
Poland_Pol16_20538_o9_2016-2017 Protein
 CAN10124.1
Poland_Pol16_20540_o10_2016-2017 Protein
 CAN10124.1
Poland_Pol16_29413_o23_2016-2017 Protein
 CAN10124.1
Poland_Pol17_03029_C201_2016-2017 Protein
 AXZ95990.1
Poland_Pol17_04461_C210_2016-2017 Protein
 AXZ96085.1
Poland_Pol17_05838_C220_2016-2017 Protein
 CAN10124.1
Poland_ASFV_POL_Podlaskie_2015 Protein
 CAN10124.1
Uganda_R8_2015 Protein
 AXB49255.1
Uganda_R7_2015 Protein
 AXB49429.1
Uganda_R25_2015 Protein
 AXB49601.1
Uganda_N10_2015 Protein
 AXB49773.1
Uganda_R35_2015 Protein
 AXB49945.1
Estonia_2014 Protein
 SPS73446.1
Italy_26544_OG10_2010 Protein
 AJZ77062.1
Italy_47_Ss_2008_2008 Protein
 AOO54349.1
Portugal_OURT_88.3_1988    
Spain_E75_1975 Protein
 CBH29126.1
Russia_Georgia_2007 Protein
 CBW46689.1
Kenya_Tk1_2005 Protein
 AJL34041.1
Kenya_Bus_2006 Protein
 AJL34206.1
Russia_Odintsovo_2014 Protein
 CAN10124.1
Portugal_L60_1960 Protein
 AIY22216.1
Portugal_NHV_1968    
Russia_Kashino_2013 Protein
 CAN10124.1
Benin_1997 Protein
Protein
 CAN10124.1
CAN10124.1
South_Africa_KNP_Pretorisuskop_1996 Protein
 CAN10124.1
South_Africa_MGR_Mkuzi_1979 Protein
 CAN10124.1
Malawi_Lil_1983 Protein
 CAN10124.1
Kenya_1950 Protein
 CAN10124.1
Namibia_Warthog_1980 Protein
 CAN10124.1
South_Africa_Warmbaths_1987 Protein
 CAN10124.1
Malawi_Tengani_1962 Protein
 CAN10124.1
China_HLJ_2018 Protein
 QBH90511.1
China_LN_2018 Protein
 QBH90696.1
China_wbBS01_2018 Protein
 QDL88054.1
Ukraine_Kyiv_2014 Protein
 QED21580.1
Belgium_Etalle_wb_2018 Protein
 QED90466.1
Lithuania_LT14_2014 Protein
 QEY87829.1
South_Africa_1985 Protein
 QGM12889.1
South_Africa_2_2008 Protein
 QGM12814.1
Zambia_LIV_1983 Protein
 QGM12692.1
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