Strain

Kenya_Bus_2006 (Region: Kenya;  Strain: Ken06.Bus;  Date: 2006)

Gene

BA71V-F334L

Description

Annotated in NCBI,  similar to African swine fever virus E75 strain E75 of INSD accession FN557520

Location

KM111295.1(-):52539-53522

GenBank Accession

AJL34223.1

Full name

Ribonucleoside-diphosphate reductase small chain       + More
Ribonucleoside-diphosphate reductase subunit beta      

Alternative Name

Ribonucleotide reductase small subunit

CDS

ATGGAGGAATTACTAATTGAAAATTCCCAACGTTTCACTATTTTTCCTATTCAGCACCCAGAATGTTGGAACTGGTACAAAAAATTAGAAAGTTTGACGTGGACGGCGCAGGAGGTGGACATGTGTAAGGACATGGATGACTGGGAGGCCATGCCAAAGCCGCAGCGCGAATTTTATAAACAAATTTTAGCCTTCTTTGTCGTTGCCGACGAAATTGTTATCGAAAACCTTTTAACCAACTTTATGCGCGAAATTAAAGTAAAGGAAGTGCTATACTTTTATACAATGCAGGCTGCCCAAGAGTGCGTTCATAGCGAGGCCTACTCAATACAGATAAAAACGCTGATCCCAGATGAAAAGGAACAACAGCGCATCTTCAGCGGTATTGAAAAACATCCTATCATAAAAAAAATAGCTCAGTGGGTGCGACAGTGGATGGACCCCGCTAAAAACAGTCTGGGCGAGCGACTTGTGGGCTTCGCCGCCGTGGAGGGCATTTTATTTCAAAACCACTTTGTGGCGATCCAGTTTCTTAAGGAACAAAATATTATGCCGGGGCTTGTAAGCTATAATGAGTTTATCTCACGCGATGAGGGAGTACACTGTAGCTTTGCGTGTTTTCTTGTCTCAAATTATGTGTATAACATTCCCGAAGAAAAGGTCATTCACAAAATTCTGAAGGAGGCCGTGGAACTGGTGGATGAGTTCATTAGCTATGCCTTTGACAAGGCAAGGGGAAGAGTTCCCGGTTTTTCAAAAGAAATGCTATTTCAATATATACGCTACTTTACAGATAATCTGTGCTTCATGTTGCAGTGCAAAAGTATTTATAAGGTGGAAAACCCTTTTCCTCAGATGACTAAATTCTTTCTTAATGAAGTAGAAAAAACCAACTTTTTCGAGTTAAGACCTACGCAGTATCAGAACTGTGTTAAGGATGATGCGTTTGCCTTCAAACTCTTTTTAAACGACGATGATTTTTAA

Protein

MEELLIENSQRFTIFPIQHPECWNWYKKLESLTWTAQEVDMCKDMDDWEAMPKPQREFYKQILAFFVVADEIVIENLLTNFMREIKVKEVLYFYTMQAAQECVHSEAYSIQIKTLIPDEKEQQRIFSGIEKHPIIKKIAQWVRQWMDPAKNSLGERLVGFAAVEGILFQNHFVAIQFLKEQNIMPGLVSYNEFISRDEGVHCSFACFLVSNYVYNIPEEKVIHKILKEAVELVDEFISYAFDKARGRVPGFSKEMLFQYIRYFTDNLCFMLQCKSIYKVENPFPQMTKFFLNEVEKTNFFELRPTQYQNCVKDDAFAFKLFLNDDDF

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic Activity

[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate

Cofactor

Fe cation

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).

Similarity

Belongs to the ribonucleoside diphosphate reductase small chain family.

Keywords

Complete proteome   DNA replication   Iron   Metal-binding   Oxidoreductase   Reference proteome  

Feature

chain  Ribonucleoside-diphosphate reductase small chain

Uniprot

A0A0C5BCL6   P0C8I2   P42492   A9JKY6   A0A1C6ZY12   D4I5N2   + More
A9JLN9   E0WMI2   A0A0A1E0M7   P26713   A0A0C5BC64   P0C8I0   P0C8I1   M1JSJ7   D3TQH9   A0A1B0A7I9   A0A1B0FQN1   A0A1A9UY57   A0A1A9Y0F4   A0A1B0BB24   I4DQD3   A0A223FML1   A0A223FN71   A0A0K8TMM2   A0A328B6Y1   A0A194QA43   A0A2G1VVU8   A0A2G2J464   I4AKY5   H9JVE7   A0A182PIU1   A0A212FIQ5   A0A182FFL1   Q91BG2   A0A2V1ANI0   A4S0Z8   W8EVA9   A0A076HQM0   A0A2E3F0Z3   A0A2W1BFZ9   T1DRH5   A0A182WMC5   A0A3D9LHD1   A0A2A4JLF6   S4PCX5   A0A2M4ASK8   W5J0Z2   A0A182X294   A0A2T5YT83   A0A1I2TZW7   A0A182K769   A0A182I6F5   A0A358Y5L0   A0A2H1W8N5   A0A140HQZ1   A0A2P7YGT9   A0A2M4CHV7   A0A388LV04   A0A1M7CGH5   A0A182L3Y8   R1BJX5   A0A0L7LTX7   A0A182TWD5   A0A182UUW7   Q7QIF4   A0A238WXR9   A0A372E4R8   A0A2W7QNQ1   A0A1D8QNI3   A0A2S1XBD3   A0A140HRH7   A0A182Y867   A0A0D3QW76   A0A140HQG9   A0A1A9WBA5   A0A0A0YZ80   Q9YMK7   A0A364RJB2   V9TIJ5   A0A142HF45   A0A1Z9P0K8   A0A1S5YDT4   A0A142EIC8   A0A2V1ADM0   A0A388LUZ5   A0A1V9X8M1   A0A2T2VQT0   A0A182RUY6   M7N2T7   A0A243WHX6   A0A212UEL1   G3EI98   A0A349NQK5   A0A0N1PGL6   A0A087SHF3   A0A1B9E4J1   A0A1B2YMN9   A0A1H1LZM2   A0A1D2A7I1   A0A090M877  

EC Number

1.17.4.1

Pubmed

25645905    11831707    18198370    21470447    25406173    26618713    + More
1871976    23219924    20353571    22651552    28762208    26369729    26354079    29099490    19121390    24081323    24773378    22118469    11531416    17460045    28756777    23622113    20920257    23761445    30148503    30007417    20966253    23760476    26227816    12364791    14747013    17210077    26728722    25244985    25908142    25593255    9887315    24370838    28392286    27174266    28327890    23682146    21813608    25012212    27348854    16868079    25494611   

EMBL

KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    + More
AJL34223.1    AXB49273.1    AXB49447.1    AXB49619.1    AXB49790.1    AXB49963.1    AY261366    U18466    AM712239    CAN10143.1    KM102979    AJZ77097.1    FN557520    CBH29145.1    AM712240    CAN10392.1    FR682468    CBW46710.1    KM262844    KM262845    KP055815    KX354450    MG939583    MG939587    MG939588    LS478113    AIY22235.1    AIY22394.1    AKO62726.1    AOO54374.1    AXZ95820.1    AXZ96008.1    AXZ96103.1    SPS73467.1    M64728    AY261361    KM111294    AJL34058.1    AY261360    AY261363    JX454574    AGE89912.1    EZ423681    ADD19957.1    CCAG010009454    JXJN01011284    AK404052    BAM20123.1    MF001304    AST09231.1    MF001305    AST09433.1    GDAI01002180    JAI15423.1    QHKM01000012    RAK62657.1    KQ459465    KPJ00301.1    NQXA01000001    PHQ30906.1    NVVZ01000139    PHR93058.1    CP003345    AFM04620.1    BABH01036043    BABH01036044    BABH01036045    BABH01036046    AB703263    BAL72672.1    AGBW02008342    OWR53617.1    AF325155    AAL01745.1    PKFO01000001    PVH19272.1    CP000588    ABO97569.1    CP007145    AHJ95667.1    CP006587    AII52115.1    PAPI01000004    MBA80142.1    KZ150213    PZC72157.1    GAMD01000630    JAB00961.1    QREG01000001    REE05914.1    NWSH01001095    PCG72649.1    GAIX01003906    JAA88654.1    GGFK01010436    MBW43757.1    ADMH02002207    ETN57812.1    QBKI01000001    PTX22513.1    FOOT01000003    SFG70422.1    APCN01003635    DORI01000167    HBW86445.1    ODYU01007043    SOQ49459.1    KT626571    AMO27788.1    PYFQ01000018    PSK35182.1    GGFL01000736    MBW64914.1    BFEA01000551    GBG86164.1    FRAS01000018    SHL66274.1    KB868468    EOD10158.1    JTDY01000137    KOB78661.1    AAAB01008807    EAA04227.4    FZNS01000003    SNR51213.1    QVLT01000002    RFP66798.1    QKZU01000025    PZX50113.1    KX618634    AOW42794.1    MF311096    AWJ76733.1    KT626572    KU862282    AMO27974.1    AMO65605.1    KP027546    AJR20393.1    KT626570    AMO27616.1    KM386655    AIX47958.1    AF081810    AAC70306.1    QMDV01000001    RAU84328.1    KF695050    AHC69623.1    CP014771    AMR27503.1    NHJR01000002    OUW85582.1    KY249580    AQQ80135.1    CP012836    AMQ54883.1    PKFP01000004    PVH15832.1    GBG86154.1    MNPL01019961    OQR69756.1    PXYR01000010    PSR08030.1    AODQ01000038    EMR02993.1    MTSE01000003    OUJ74825.1    FYEW01000002    SNC76623.1    HQ849551    AEN03609.1    DMXF01000252    HAT65069.1    KQ460796    KPJ12174.1    KL662112    QOKY01000195    KFM25157.1    RMZ53768.1    LVEP01000019    OCB76849.1    KX158455    AOE05841.1    LT629737    SDR79840.1    GDKF01003601    JAT75021.1    CAID01000008    KZ155780    CEG01353.1    OUS46811.1   

Proteomes

UP000101566    UP000000858    UP000000624    UP000130745    UP000117635    UP000101090    + More
UP000108903    UP000141072    UP000110401    UP000142390    UP000241813    UP000266411    UP000000860    UP000105860    UP000000861    UP000000859    UP000232896    UP000092445    UP000092444    UP000078200    UP000092443    UP000092460    UP000217350    UP000217248    UP000248553    UP000053268    UP000229433    UP000006054    UP000005204    UP000075885    UP000007151    UP000069272    UP000202667    UP000244309    UP000001568    UP000019423    UP000028590    UP000230854    UP000075920    UP000256779    UP000218220    UP000000673    UP000076407    UP000244225    UP000198724    UP000075881    UP000075840    UP000241107    UP000265515    UP000183947    UP000075882    UP000013827    UP000037510    UP000075902    UP000075903    UP000007062    UP000198310    UP000262520    UP000249115    UP000076408    UP000091820    UP000203997    UP000251692    UP000075086    UP000073816    UP000244406    UP000192247    UP000242248    UP000075900    UP000011910    UP000194873    UP000198131    UP000164653    UP000053240    UP000028924    UP000093510    UP000199552    UP000009170   

PRIDE

H9JVE7   

Pfam

PF00268   Ribonuc_red_sm

Interpro

IPR012348   RNR-like
IPR033909   RNR_small
IPR030475   RNR_small_AS
IPR000358   RNR_small_fam
IPR009078   Ferritin-like_SF

SUPFAM

SSF47240   SSF47240

Gene 3D

1.10.620.20    

CDD

cd01049  RNRR2

ProteinModelPortal

A0A0C5BCL6   P0C8I2   P42492   A9JKY6   A0A1C6ZY12   D4I5N2   + More
A9JLN9   E0WMI2   A0A0A1E0M7   P26713   A0A0C5BC64   P0C8I0   P0C8I1   M1JSJ7   D3TQH9   A0A1B0A7I9   A0A1B0FQN1   A0A1A9UY57   A0A1A9Y0F4   A0A1B0BB24   I4DQD3   A0A223FML1   A0A223FN71   A0A0K8TMM2   A0A328B6Y1   A0A194QA43   A0A2G1VVU8   A0A2G2J464   I4AKY5   H9JVE7   A0A182PIU1   A0A212FIQ5   A0A182FFL1   Q91BG2   A0A2V1ANI0   A4S0Z8   W8EVA9   A0A076HQM0   A0A2E3F0Z3   A0A2W1BFZ9   T1DRH5   A0A182WMC5   A0A3D9LHD1   A0A2A4JLF6   S4PCX5   A0A2M4ASK8   W5J0Z2   A0A182X294   A0A2T5YT83   A0A1I2TZW7   A0A182K769   A0A182I6F5   A0A358Y5L0   A0A2H1W8N5   A0A140HQZ1   A0A2P7YGT9   A0A2M4CHV7   A0A388LV04   A0A1M7CGH5   A0A182L3Y8   R1BJX5   A0A0L7LTX7   A0A182TWD5   A0A182UUW7   Q7QIF4   A0A238WXR9   A0A372E4R8   A0A2W7QNQ1   A0A1D8QNI3   A0A2S1XBD3   A0A140HRH7   A0A182Y867   A0A0D3QW76   A0A140HQG9   A0A1A9WBA5   A0A0A0YZ80   Q9YMK7   A0A364RJB2   V9TIJ5   A0A142HF45   A0A1Z9P0K8   A0A1S5YDT4   A0A142EIC8   A0A2V1ADM0   A0A388LUZ5   A0A1V9X8M1   A0A2T2VQT0   A0A182RUY6   M7N2T7   A0A243WHX6   A0A212UEL1   G3EI98   A0A349NQK5   A0A0N1PGL6   A0A087SHF3   A0A1B9E4J1   A0A1B2YMN9   A0A1H1LZM2   A0A1D2A7I1   A0A090M877  

PANTHER

PTHR23409  

PDB

1XSM     E-value=1.16382e-65,     Score=634