Strain

Benin_1997 (Region: Benin;  Strain: Benin 97/1;  Date: 1997)

Gene

Ribonucleotide reductase small subunit

Description

Annotated in NCBI,  Ribonucleotide reductase small subunit

Location

AM712239.1(-):50202-51185

GenBank Accession

CAN10143.1

Full name

Ribonucleoside-diphosphate reductase small chain       + More
Ribonucleoside-diphosphate reductase subunit beta      

Alternative Name

Ribonucleotide reductase small subunit

CDS

ATGGAGGAATTACTAATTGAAAATTCCCAACGTTTCACTATTTTTCCTATTCAGCACCCCGAATGTTGGAACTGGTATAAAAAATTAGAAAGTTTGACGTGGACGGCGCAGGAGGTAGACATGTGTAAGGACATTGATGATTGGGAAGCCATGCCAAAGCCACAGCGCGAATTTTATAAACAAATTTTAGCCTTCTTTGTTGTTGCCGACGAAATTGTTATCGAAAACCTTTTAACCAATTTTATGCGCGAAATTAAAGTAAAGGAAGTGTTATACTTTTATACAATGCAGGCTGCCCAAGAGTGTGTTCATAGTGAAGCCTACTCAATACAGGTAAAAACGCTGATCCCGGATGAGAAGGAACAACAGCGCATCTTTAGCGGCATTGAAAAACACCCTATCATAAAAAAAATGGCGCAGTGGGTGCGGCAGTGGATGGACCCCGACAGGAACACTCTGGGTGAGCGGCTGGTGGGCTTCGCCGCCGTAGAAGGCATTTTATTTCAAAACCACTTTGTGGCGATCCAGTTTCTTAAGGAACAGAATATTATGCCGGGGCTTGTAAGCTATAATGAGTTTATTTCACGCGATGAGGGGATGCACTGTAGTTTTGCGTGTTTTCTTATCTCGAATTACGTGTATAACATTCCCGAGGAAAAGATCATTCACAAAATTTTGAAGGAGGCTGTGGAGTTGGTGGATGAGTTCATTAACTATGCCTTTGACAAGGCAAGAGGAAGAGTTCCCGGTTTTTCAAAAGAAATGCTGTTTCAATATATACGCTACTTTACAGATAATTTGTGCTTCATGATGCAGTGCAAAAGTATTTATAAAGTGGGAAACCCTTTTCCTCAGATGACTAAATTCTTTCTTAATGAAGTAGAAAAAACCAACTTTTTCGAGTTAAGACCTACGCAGTATCAGAACTGTGTTAAGGATGATGCGTTTGCCTTCAAACTCTTTTTAAACGACGATGATTTTTAA

Protein

MEELLIENSQRFTIFPIQHPECWNWYKKLESLTWTAQEVDMCKDIDDWEAMPKPQREFYKQILAFFVVADEIVIENLLTNFMREIKVKEVLYFYTMQAAQECVHSEAYSIQVKTLIPDEKEQQRIFSGIEKHPIIKKMAQWVRQWMDPDRNTLGERLVGFAAVEGILFQNHFVAIQFLKEQNIMPGLVSYNEFISRDEGMHCSFACFLISNYVYNIPEEKIIHKILKEAVELVDEFINYAFDKARGRVPGFSKEMLFQYIRYFTDNLCFMMQCKSIYKVGNPFPQMTKFFLNEVEKTNFFELRPTQYQNCVKDDAFAFKLFLNDDDF

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic Activity

[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate

Cofactor

Fe cation

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).

Similarity

Belongs to the ribonucleoside diphosphate reductase small chain family.

Keywords

Complete proteome   DNA replication   Iron   Metal-binding   Oxidoreductase   Reference proteome  

Feature

chain  Ribonucleoside-diphosphate reductase small chain

Uniprot

P0C8I2   A9JKY6   A0A1C6ZY12   P42492   D4I5N2   A9JLN9   + More
E0WMI2   A0A0A1E0M7   P26713   A0A0C5BCL6   P0C8I0   A0A0C5BC64   P0C8I1   A0A1A9Y0F4   A0A1B0BB24   M1JSJ7   D3TQH9   A0A1B0A7I9   A0A1B0FQN1   I4DQD3   A0A223FML1   A0A223FN71   A0A1A9UY57   A0A194QA43   H9JVE7   A0A212FIQ5   A0A2G1VVU8   A0A2G2J464   Q91BG2   A0A328B6Y1   A0A2E3F0Z3   W8EVA9   A0A0K8TMM2   A0A076HQM0   S4PCX5   A0A140HQZ1   I4AKY5   A0A2T5YT83   A0A3D9LHD1   A0A1I2TZW7   A0A182PIU1   A0A358Y5L0   A0A182FFL1   A4S0Z8   A0A2H1W8N5   G3EI98   A0A388LV04   A0A2V1ANI0   A0A2T2VQT0   A0A0L7LTX7   A0A1D8QNI3   A0A140HRH7   A0A2S1XBD3   A0A2W1BFZ9   A0A140HQG9   A0A0D3QW76   Q9YMK7   V9TIJ5   A0A1S5YDT4   A0A0A0YZ80   A0A1M7CGH5   R1BJX5   A0A1A9WBA5   A0A2D5N9I3   A0A1D8P8V2   A0A348TWD2   T1DRH5   A0A2A4JLF6   A0A142EIC8   A0A2M4ASK8   W5J0Z2   A0A1Z9P0K8   A0A182WMC5   A0A2T4WDU9   A0A388LUZ5   A0A1C9KC71   A0A182X294   A0A238WXR9   M7N2T7   A0A182I6F5   A0A372E4R8   A0A182K769   A0A2M4CHV7   A0A3D3XSL6   A0A3E0R1K9   A0A0N1PGL6   A0A364RJB2   A0A1B9E4J1   A0A1H1LZM2   A0A182L3Y8   A0A349NQK5   A0A142HF45   A0A314XTH4   A0A2E2Y6Z5   A0A1B2YMN9   A0A2D8F8H4   A0A182UUW7   A0A1C9KBJ1   A0A2E8VD36   A0A182TWD5  

EC Number

1.17.4.1

Pubmed

18198370    11831707    21470447    25406173    26618713    1871976    + More
25645905    23219924    20353571    22651552    28762208    26354079    19121390    24081323    24773378    22118469    29099490    11531416    26369729    23622113    30148503    17460045    21813608    30007417    26227816    26728722    28756777    25908142    9887315    24370838    28392286    25593255    23760476    29337314    27174266    20920257    23761445    27613417    23682146    20966253    27348854   

EMBL

AY261366    AM712239    CAN10143.1    KM102979    AJZ77097.1    U18466    + More
FN557520    CBH29145.1    AM712240    CAN10392.1    FR682468    CBW46710.1    KM262844    KM262845    KP055815    KX354450    MG939583    MG939587    MG939588    LS478113    AIY22235.1    AIY22394.1    AKO62726.1    AOO54374.1    AXZ95820.1    AXZ96008.1    AXZ96103.1    SPS73467.1    M64728    AY261361    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34223.1    AXB49273.1    AXB49447.1    AXB49619.1    AXB49790.1    AXB49963.1    AY261360    KM111294    AJL34058.1    AY261363    JXJN01011284    JX454574    AGE89912.1    EZ423681    ADD19957.1    CCAG010009454    AK404052    BAM20123.1    MF001304    AST09231.1    MF001305    AST09433.1    KQ459465    KPJ00301.1    BABH01036043    BABH01036044    BABH01036045    BABH01036046    AB703263    BAL72672.1    AGBW02008342    OWR53617.1    NQXA01000001    PHQ30906.1    NVVZ01000139    PHR93058.1    AF325155    AAL01745.1    QHKM01000012    RAK62657.1    PAPI01000004    MBA80142.1    CP007145    AHJ95667.1    GDAI01002180    JAI15423.1    CP006587    AII52115.1    GAIX01003906    JAA88654.1    KT626571    AMO27788.1    CP003345    AFM04620.1    QBKI01000001    PTX22513.1    QREG01000001    REE05914.1    FOOT01000003    SFG70422.1    DORI01000167    HBW86445.1    CP000588    ABO97569.1    ODYU01007043    SOQ49459.1    HQ849551    AEN03609.1    BFEA01000551    GBG86164.1    PKFO01000001    PVH19272.1    PXYR01000010    PSR08030.1    JTDY01000137    KOB78661.1    KX618634    AOW42794.1    KT626572    KU862282    AMO27974.1    AMO65605.1    MF311096    AWJ76733.1    KZ150213    PZC72157.1    KT626570    AMO27616.1    KP027546    AJR20393.1    AF081810    AAC70306.1    KF695050    AHC69623.1    KY249580    AQQ80135.1    KM386655    AIX47958.1    FRAS01000018    SHL66274.1    KB868468    EOD10158.1    NYXD01000037    MAD31098.1    CP017478    AOW21016.1    DMUC01000112    HAR22094.1    GAMD01000630    JAB00961.1    NWSH01001095    PCG72649.1    CP012836    AMQ54883.1    GGFK01010436    MBW43757.1    ADMH02002207    ETN57812.1    NHJR01000002    OUW85582.1    PZPJ01000019    PTM00115.1    GBG86154.1    KU749311    AOP31730.1    FZNS01000003    SNR51213.1    AODQ01000038    EMR02993.1    APCN01003635    QVLT01000002    RFP66798.1    GGFL01000736    MBW64914.1    DQCP01000240    HCP41863.1    QQUU01000034    QQVW01000121    REJ63551.1    REK60119.1    KQ460796    KPJ12174.1    QMDV01000001    RAU84328.1    LVEP01000019    OCB76849.1    LT629737    SDR79840.1    DMXF01000252    HAT65069.1    CP014771    AMR27503.1    PJQY01002342    PQP94497.1    PAND01000007    MAZ96499.1    KX158455    AOE05841.1    NZMM01000027    MAL51472.1    KU749310    AOP31519.1    PBWA01000026    MBR99338.1   

Proteomes

UP000000858    UP000130745    UP000117635    UP000000624    UP000101090    UP000108903    + More
UP000141072    UP000110401    UP000142390    UP000241813    UP000266411    UP000000860    UP000101566    UP000000861    UP000105860    UP000000859    UP000092443    UP000092460    UP000232896    UP000092445    UP000092444    UP000217350    UP000217248    UP000078200    UP000053268    UP000005204    UP000007151    UP000229433    UP000202667    UP000248553    UP000230854    UP000019423    UP000028590    UP000006054    UP000244225    UP000256779    UP000198724    UP000075885    UP000069272    UP000001568    UP000164653    UP000265515    UP000244309    UP000242248    UP000037510    UP000203997    UP000183947    UP000013827    UP000091820    UP000176050    UP000218220    UP000073816    UP000000673    UP000075920    UP000243445    UP000203649    UP000076407    UP000198310    UP000011910    UP000075840    UP000262520    UP000075881    UP000256824    UP000053240    UP000251692    UP000093510    UP000199552    UP000075882    UP000075086    UP000075903    UP000201873    UP000075902   

PRIDE

H9JVE7   

Pfam

PF00268   Ribonuc_red_sm

Interpro

IPR000358   RNR_small_fam
IPR030475   RNR_small_AS
IPR009078   Ferritin-like_SF
IPR033909   RNR_small
IPR012348   RNR-like

SUPFAM

SSF47240   SSF47240

Gene 3D

1.10.620.20    

CDD

cd01049  RNRR2

ProteinModelPortal

P0C8I2   A9JKY6   A0A1C6ZY12   P42492   D4I5N2   A9JLN9   + More
E0WMI2   A0A0A1E0M7   P26713   A0A0C5BCL6   P0C8I0   A0A0C5BC64   P0C8I1   A0A1A9Y0F4   A0A1B0BB24   M1JSJ7   D3TQH9   A0A1B0A7I9   A0A1B0FQN1   I4DQD3   A0A223FML1   A0A223FN71   A0A1A9UY57   A0A194QA43   H9JVE7   A0A212FIQ5   A0A2G1VVU8   A0A2G2J464   Q91BG2   A0A328B6Y1   A0A2E3F0Z3   W8EVA9   A0A0K8TMM2   A0A076HQM0   S4PCX5   A0A140HQZ1   I4AKY5   A0A2T5YT83   A0A3D9LHD1   A0A1I2TZW7   A0A182PIU1   A0A358Y5L0   A0A182FFL1   A4S0Z8   A0A2H1W8N5   G3EI98   A0A388LV04   A0A2V1ANI0   A0A2T2VQT0   A0A0L7LTX7   A0A1D8QNI3   A0A140HRH7   A0A2S1XBD3   A0A2W1BFZ9   A0A140HQG9   A0A0D3QW76   Q9YMK7   V9TIJ5   A0A1S5YDT4   A0A0A0YZ80   A0A1M7CGH5   R1BJX5   A0A1A9WBA5   A0A2D5N9I3   A0A1D8P8V2   A0A348TWD2   T1DRH5   A0A2A4JLF6   A0A142EIC8   A0A2M4ASK8   W5J0Z2   A0A1Z9P0K8   A0A182WMC5   A0A2T4WDU9   A0A388LUZ5   A0A1C9KC71   A0A182X294   A0A238WXR9   M7N2T7   A0A182I6F5   A0A372E4R8   A0A182K769   A0A2M4CHV7   A0A3D3XSL6   A0A3E0R1K9   A0A0N1PGL6   A0A364RJB2   A0A1B9E4J1   A0A1H1LZM2   A0A182L3Y8   A0A349NQK5   A0A142HF45   A0A314XTH4   A0A2E2Y6Z5   A0A1B2YMN9   A0A2D8F8H4   A0A182UUW7   A0A1C9KBJ1   A0A2E8VD36   A0A182TWD5  

PANTHER

PTHR23409  

PDB

1XSM     E-value=1.16382e-65,     Score=634