Strain

Kenya_Tk1_2005 (Region: Kenya;  Strain: Ken05/Tk1;  Date: 2005)

Gene

BA71V-F334L

Description

Annotated in NCBI,  similar to African swine fever virus E75 strain E75 of INSD accession FN557520

Location

KM111294.1(-):56665-57648

GenBank Accession

AJL34058.1

Full name

Ribonucleoside-diphosphate reductase small chain       + More
Ribonucleoside-diphosphate reductase subunit beta      

Alternative Name

Ribonucleotide reductase small subunit

CDS

ATGGAGGAATTACTAATTGAAGATTCCCAACGTTTCACTATTTTTCCTATTCAGCACCCAGAATGTTGGAACTGGTACAAAAAATTAGAAAGTTTGACGTGGACGGCGCAGGAGGTGGACATGTGTAAGGACATAGATGATTGGGAAGCGATGCCAAAACCGCAGCGTGAATTTTATAAACAAATCTTAGCCTTCTTTGTCGTTGCCGACGAAATTGTTATCGAAAACCTTTTAACCAACTTTATGCGCGAAATTAAAGTAAAGGAAGTGCTATACTTTTATACAATGCAGGCTGCCCAAGAGTGCGTTCACAGCGAGGCCTACTCAATACAAGTAAAAACGCTGATCCCGGATGAGAAGGAACAACAGCGCATCTTTAGCGGTATTGAAAAACATCCTATCATAAGAAAAATGGCTCAATGGGTGCAGCAGTGGATGGACCCCGTCAAGAACAGTCTGGGCGAACGACTTGTGGGCTTTGCCGCCGTGGAGGGCATTTTATTTCAAAACCACTTTGTGGCGATCCAGTTTCTTAAGGAACAAAATATTATGCCGGGGCTTGTAAGCTATAATGAGTTTATTTCACGCGATGAGGGGATGCATTGTAGCTTTGCGTGTTTTCTTATCTCGAATTATCTGTATAACATCCCCGAGGAAAAAATCATTCACAAAATTTTGAAGGAGGCCGTGGAACTGGTAGATGAGTTTATTAGCTATGCCTTTGACAAGGCAAGGGGAAGAGTTCCCGGTTTTTCAAAAGAAATGCTATTTCAATATATACGCTACTTTACTGATAATCTGTGCTTCATGCTGCAGTGCAAAAGTATTTATAAGGTGGAAAACCCTTTTCCTCAGATGACTAAATTCTTTCTTAATGAAGTAGAAAAAACCAACTTTTTCGAGTTAAGACCTACGCAGTATCAGAACTGTGTTAAGGATGATGCGTTTGCCTTCAAACTCTTTTTAAACGACGATGATTTTTAA

Protein

MEELLIEDSQRFTIFPIQHPECWNWYKKLESLTWTAQEVDMCKDIDDWEAMPKPQREFYKQILAFFVVADEIVIENLLTNFMREIKVKEVLYFYTMQAAQECVHSEAYSIQVKTLIPDEKEQQRIFSGIEKHPIIRKMAQWVQQWMDPVKNSLGERLVGFAAVEGILFQNHFVAIQFLKEQNIMPGLVSYNEFISRDEGMHCSFACFLISNYLYNIPEEKIIHKILKEAVELVDEFISYAFDKARGRVPGFSKEMLFQYIRYFTDNLCFMLQCKSIYKVENPFPQMTKFFLNEVEKTNFFELRPTQYQNCVKDDAFAFKLFLNDDDF

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic Activity

[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate

Cofactor

Fe cation

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).

Similarity

Belongs to the ribonucleoside diphosphate reductase small chain family.

Keywords

Complete proteome   DNA replication   Iron   Metal-binding   Oxidoreductase   Reference proteome  

Feature

chain  Ribonucleoside-diphosphate reductase small chain

Uniprot

A0A0C5BC64   P0C8I0   P0C8I2   D4I5N2   A9JLN9   E0WMI2   + More
A0A0A1E0M7   P42492   A9JKY6   A0A1C6ZY12   P26713   A0A0C5BCL6   P0C8I1   A0A1B0BB24   A0A1A9Y0F4   M1JSJ7   D3TQH9   A0A1B0A7I9   A0A1B0FQN1   A0A223FML1   I4DQD3   A0A223FN71   A0A1A9UY57   A0A194QA43   A0A212FIQ5   Q91BG2   H9JVE7   A0A2G1VVU8   A0A2G2J464   A0A328B6Y1   A0A372FCY6   A0A076HQM0   A0A2E3F0Z3   A0A2D9G786   W8EVA9   A0A0K8TMM2   I4AKY5   S4PCX5   A0A140HQZ1   A0A2T5YT83   A0A1I2TZW7   A0A358Y5L0   G3EI98   A0A3D9LHD1   A0A2V1ANI0   A0A182FFL1   A0A182PIU1   A0A2H1W8N5   A0A388LV04   A0A257IRD7   A0A061D1L3   A4S0Z8   A0A1D8QNI3   A0A140HRH7   A0A2T2VQT0   A0A2S1XBD3   A0A0D3QW76   A0A0L7LTX7   A0A140HQG9   A0A327HP63   V9TIJ5   A0A2W1BFZ9   Q9YMK7   A0A1M7CGH5   R1BJX5   A0A1S5YDT4   A0A0A0YZ80   A0A2N4XJ92   A0A1Z9P0K8   A0A1C9KC71   A0A142EIC8   A0A369I595   A0A344TPX6   A0A238WXR9   A0A1D8P8V2   A0A1A9WBA5   A0A348TWD2   A0A2D5N9I3   A0A2T4WDU9   A0A2N1KNJ4   A0A2M4ASK8   A0A388LUZ5   T1DRH5   A0A142HF45   A0A182WMC5   W5J0Z2   A0A2A4JLF6   A0A372E4R8   M7N2T7   A0A182X294   A0A0L6WWI0   A0A364RJB2   A0A182I6F5   A0A1B9E4J1   A0A2M4CHV7   A0A182K769   A0A0N1PGL6   A0A3E0R1K9   A0A087SHF3   A0A3D3XSL6  

EC Number

1.17.4.1

Pubmed

25645905    18198370    21470447    25406173    26618713    11831707    + More
1871976    23219924    20353571    28762208    22651552    26354079    22118469    11531416    19121390    24081323    24773378    29099490    29337314    26369729    23622113    30148503    21813608    30007417    17460045    26728722    25908142    26227816    24370838    28756777    9887315    23760476    28392286    25593255    27613417    27174266    20920257    23761445    23682146    25012212   

EMBL

KM111294    AJL34058.1    AY261360    AY261366    FN557520    CBH29145.1    + More
AM712240    CAN10392.1    FR682468    CBW46710.1    KM262844    KM262845    KP055815    KX354450    MG939583    MG939587    MG939588    LS478113    AIY22235.1    AIY22394.1    AKO62726.1    AOO54374.1    AXZ95820.1    AXZ96008.1    AXZ96103.1    SPS73467.1    U18466    AM712239    CAN10143.1    KM102979    AJZ77097.1    M64728    AY261361    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34223.1    AXB49273.1    AXB49447.1    AXB49619.1    AXB49790.1    AXB49963.1    AY261363    JXJN01011284    JX454574    AGE89912.1    EZ423681    ADD19957.1    CCAG010009454    MF001304    AST09231.1    AK404052    BAM20123.1    MF001305    AST09433.1    KQ459465    KPJ00301.1    AGBW02008342    OWR53617.1    AF325155    AAL01745.1    BABH01036043    BABH01036044    BABH01036045    BABH01036046    AB703263    BAL72672.1    NQXA01000001    PHQ30906.1    NVVZ01000139    PHR93058.1    QHKM01000012    RAK62657.1    QVMT01000002    RFS17607.1    CP006587    AII52115.1    PAPI01000004    MBA80142.1    NZRR01000009    MAO69553.1    CP007145    AHJ95667.1    GDAI01002180    JAI15423.1    CP003345    AFM04620.1    GAIX01003906    JAA88654.1    KT626571    AMO27788.1    QBKI01000001    PTX22513.1    FOOT01000003    SFG70422.1    DORI01000167    HBW86445.1    HQ849551    AEN03609.1    QREG01000001    REE05914.1    PKFO01000001    PVH19272.1    ODYU01007043    SOQ49459.1    BFEA01000551    GBG86164.1    NKJF01000038    OYU65363.1    LK391707    CDR94533.1    CP000588    ABO97569.1    KX618634    AOW42794.1    KT626572    KU862282    AMO27974.1    AMO65605.1    PXYR01000010    PSR08030.1    MF311096    AWJ76733.1    KP027546    AJR20393.1    JTDY01000137    KOB78661.1    KT626570    AMO27616.1    PBGP02000006    RAH15640.1    KF695050    AHC69623.1    KZ150213    PZC72157.1    AF081810    AAC70306.1    FRAS01000018    SHL66274.1    KB868468    EOD10158.1    KY249580    AQQ80135.1    KM386655    AIX47958.1    PKRS01000001    PLK46514.1    NHJR01000002    OUW85582.1    KU749311    AOP31730.1    CP012836    AMQ54883.1    QPIW01000013    RDB04899.1    CP030850    AXE20697.1    FZNS01000003    SNR51213.1    CP017478    AOW21016.1    DMUC01000112    HAR22094.1    NYXD01000037    MAD31098.1    PZPJ01000019    PTM00115.1    NHPP01000007    PKK36666.1    GGFK01010436    MBW43757.1    GBG86154.1    GAMD01000630    JAB00961.1    CP014771    AMR27503.1    ADMH02002207    ETN57812.1    NWSH01001095    PCG72649.1    QVLT01000002    RFP66798.1    AODQ01000038    EMR02993.1    KQ412282    KNZ79910.1    QMDV01000001    RAU84328.1    APCN01003635    LVEP01000019    OCB76849.1    GGFL01000736    MBW64914.1    KQ460796    KPJ12174.1    QQUU01000034    QQVW01000121    REJ63551.1    REK60119.1    KL662112    QOKY01000195    KFM25157.1    RMZ53768.1    DQCP01000240    HCP41863.1   

Proteomes

UP000105860    UP000000861    UP000000858    UP000101090    UP000108903    UP000141072    + More
UP000110401    UP000142390    UP000241813    UP000266411    UP000000624    UP000130745    UP000117635    UP000000860    UP000101566    UP000000859    UP000092460    UP000092443    UP000232896    UP000092445    UP000092444    UP000217350    UP000217248    UP000078200    UP000053268    UP000007151    UP000202667    UP000005204    UP000229433    UP000248553    UP000263688    UP000028590    UP000230854    UP000019423    UP000006054    UP000244225    UP000198724    UP000164653    UP000256779    UP000244309    UP000069272    UP000075885    UP000265515    UP000215757    UP000001568    UP000242248    UP000037510    UP000203997    UP000183947    UP000013827    UP000234203    UP000203649    UP000073816    UP000253141    UP000251993    UP000198310    UP000176050    UP000091820    UP000243445    UP000075086    UP000075920    UP000000673    UP000218220    UP000262520    UP000011910    UP000076407    UP000053712    UP000251692    UP000075840    UP000093510    UP000075881    UP000053240    UP000256824    UP000028924   

PRIDE

H9JVE7   

Pfam

PF00268   Ribonuc_red_sm

Interpro

IPR009078   Ferritin-like_SF
IPR000358   RNR_small_fam
IPR033909   RNR_small
IPR012348   RNR-like
IPR030475   RNR_small_AS

SUPFAM

SSF47240   SSF47240

Gene 3D

1.10.620.20    

CDD

cd01049  RNRR2

ProteinModelPortal

A0A0C5BC64   P0C8I0   P0C8I2   D4I5N2   A9JLN9   E0WMI2   + More
A0A0A1E0M7   P42492   A9JKY6   A0A1C6ZY12   P26713   A0A0C5BCL6   P0C8I1   A0A1B0BB24   A0A1A9Y0F4   M1JSJ7   D3TQH9   A0A1B0A7I9   A0A1B0FQN1   A0A223FML1   I4DQD3   A0A223FN71   A0A1A9UY57   A0A194QA43   A0A212FIQ5   Q91BG2   H9JVE7   A0A2G1VVU8   A0A2G2J464   A0A328B6Y1   A0A372FCY6   A0A076HQM0   A0A2E3F0Z3   A0A2D9G786   W8EVA9   A0A0K8TMM2   I4AKY5   S4PCX5   A0A140HQZ1   A0A2T5YT83   A0A1I2TZW7   A0A358Y5L0   G3EI98   A0A3D9LHD1   A0A2V1ANI0   A0A182FFL1   A0A182PIU1   A0A2H1W8N5   A0A388LV04   A0A257IRD7   A0A061D1L3   A4S0Z8   A0A1D8QNI3   A0A140HRH7   A0A2T2VQT0   A0A2S1XBD3   A0A0D3QW76   A0A0L7LTX7   A0A140HQG9   A0A327HP63   V9TIJ5   A0A2W1BFZ9   Q9YMK7   A0A1M7CGH5   R1BJX5   A0A1S5YDT4   A0A0A0YZ80   A0A2N4XJ92   A0A1Z9P0K8   A0A1C9KC71   A0A142EIC8   A0A369I595   A0A344TPX6   A0A238WXR9   A0A1D8P8V2   A0A1A9WBA5   A0A348TWD2   A0A2D5N9I3   A0A2T4WDU9   A0A2N1KNJ4   A0A2M4ASK8   A0A388LUZ5   T1DRH5   A0A142HF45   A0A182WMC5   W5J0Z2   A0A2A4JLF6   A0A372E4R8   M7N2T7   A0A182X294   A0A0L6WWI0   A0A364RJB2   A0A182I6F5   A0A1B9E4J1   A0A2M4CHV7   A0A182K769   A0A0N1PGL6   A0A3E0R1K9   A0A087SHF3   A0A3D3XSL6  

PANTHER

PTHR23409  

PDB

1XSM     E-value=1.16382e-65,     Score=634