ASFVdb The African Swine Fever Virus Database
Strain
Italy_26544_OG10_2010 (Region: Sardinian,Italy;  Strain: 26544/OG10;  Date: 2010)
Gene
A859L
Description
Annotated in NCBI,  member of helicase superfamily II group including hsdR subunits of type Ib restriction enzymes
Location
KM102979.1(-):45487-48066
GenBank Accession
AJZ77050.1
Full name
Probable helicase A859L      
 

Sequence

CDS
ATGTGCGCAGGATTTTACGTGGCGGTTCATCCCTGGCTGGAGGCCCAATCCTTACATAAAGTTGGGCACACAGGAAACTTGGCCGCTAGGCTCCATGATGGATCTTATACAACCTGTTTTACGGATGAATGGAAGTATTGTTTCACATTGGAAACATCTACAAAGAAGGATGCGCAAAAAATTGAAGCAGGGGTGTTGTATTGCGCACAGTTTTTTCGCGTCAAAAACAAAGAACTCGTATGTCTTTTACCCGAAAAAATAAAACAATTGGCTGAGGATGTTGCAAACTGTCTGGACATAAGCTATACTTTGTGTGATTCTCCCACTTATGAGATGAATGATTCCACGATAGTGGTTGAGCCATCTTTGCCCTCTGATCCGCTGATAAGCAAGGAGAAACTGAGACACCTGGTGATAACTCCTGTGGAAGATGAAGAACATTTCGCAGATGACGTATTATTTTTTTCTACAGATGAGACACGGACTGCAATCGAGGATCGGCTTTATCAGAAGGAGGCGGCCAATATGGGCTATCAGGAGCTGCGGCGAAGTGGAAGGGCCATTCTGCAGATGGCCTGCCGCTGCGGCAAAACTCGCGTCGCCTATCTTATCCTCTCCAATTATCTTCAAGGAAAAGTTTTGTACCTGGTGCCGGGCCTGTCCCTACTACGGCAGACTCTGGAAAAACTCTATCAGTATGGAATTTCTTTGAAGAACGTTTTGCTTGTGGGGTCTGACCAGACCCGCATTGTGCTAAATCACGACAATATAGAAATGACCACCAATCCTGTCTTTATTGCAAAACGGATACGGGAGGCCCCTTCTCTTCTTGTGATTGCCACCTACCAATCCTCCACGCTACTGGTGGATGATTTCGATCTTATTATTAGCGATGAATGTCACCGGATTTGCGGTGAATGGGAGACACGGCCCTTTACCCATGTGTTGCTCAACTTTAAAAAAGGGCACCGACTTTTTTTAACGGCAACGCCCAGGTACGACACCCCGCTTTCCATGAAAAATCGTGAACTTTTTGGCGGCGTTGCCTTTCGCTACTATCTGCGAGAAGGCATAGAGGCCGGCTATGTAAATGATTTTGAATTACAAATGGTAGCCGCGCCCAAATTGGCTCACCAACCGAGTAACAGAGAGGAGACCACGAAACAGATCATAGTAAAGCAAATTATAATGGCCTTAGCCTATTTAAAAACCAATATACCGGCTCCTAAAATGCTGGTATTCACCCGTGATATTAAACAGGCCAGGGAGCTATACGCGGAGTTGGTAGACCAAGGGGTCTATGCCCTGATAGCTCACTCAACCCTGCCGCGACAGGTTATCCTCAAAACATTTACAGAATTTTGTTCCTCAAAGGAACCCGTTATTTTATTAAACTGTCGACTCTTTCAAGAGGGCGTAGAGGTTCCGGAACTAAACGCGGTATTTTTTGCAGCGCCGCGTCATAGTCCTAGAGACATTATTCAAAGCATATGCAGACCGCTGAACAAGCAGGTTCAAAAGCCTCACGCAACCATTTTTCTACCTTTAGAAGTAAACACAGAAAACGTATGCCTAGACAGGTTTTCTAGTATTATCCCTTTTGCAGACGCCTTGGCGTCTGAAGATCCACGCTTTTACGAGCATCTTTTAAACCCTTCAGAGGTTGCCTATCCGATAAACTGGATCGGGGCCCACGGATCGGTGTCAGAATTGTTGCAATTGGCACGTCACGCCATACGCTATGGTACGCAGGGCAAAATAGACCGCCTTACCCGCAGCGAGAGACTTCCTTGGAAGGCCGCCTTTGCAGAACTCAAACGTACGGTTGAAATATGTTGCAGATATCCTAAAATCAACGACGGCTTTCACTTTGGAGGCGCCACGCTGCGGTTCGACACATGGTATAAATGGGTCATTAAATCCTATTTGCAGTACAAAAACAAGGAACCGTCTTCTTTAGAGCCTTACCAGGTGTCGGACCTGGAGTCCTTGCAAGATTGGACAACCCGTGGTGTTGGCGGGCCTTATCCCTGGGAAGAAAGCATGGCATTCTTGGAAACTTGGCTTGCCCAAAATAAAGGAGAGCTTGTTGCCATTGATATTCATCAGGGTGGATGGATAGGATTGGACGCGACGCCCATGGAAAGGCTGTCGGGCGTCCTAACCACTGTTTCGCAACGCGATGGCCGAAGCTATGGAAAAAATAAAAAGCTTCGACCTAAAAAGGGGTTTATGATCCCACCCCAGCAGGCCGAAGATCTTGACCGTATTTTTGGAAAGCACAATCTTAAGTGGAGAAAGGACAGGGTTAATGGCTTTTTAAAGGAAGATGAACACGGAAATTATACAGGCGAGCCTACCTGTATTCAAGAAGCCTATCGGACCTTTAAAGAATATGTAAAAACAAATCCCGAATATATCGAAAAATACTGGCCTGGATATGCCAAAGGCAAGCATAAACACCAAGAATTACCGCACATATGGGAAAGCGGCCTGGCTCCTCCCCGCTATAAGGCATTTAAAGATGGTAATAAACAGCTTATCCAAAGAAGTCCGAAAAAAAAGGACATTAAAAATTAA
Protein
MCAGFYVAVHPWLEAQSLHKVGHTGNLAARLHDGSYTTCFTDEWKYCFTLETSTKKDAQKIEAGVLYCAQFFRVKNKELVCLLPEKIKQLAEDVANCLDISYTLCDSPTYEMNDSTIVVEPSLPSDPLISKEKLRHLVITPVEDEEHFADDVLFFSTDETRTAIEDRLYQKEAANMGYQELRRSGRAILQMACRCGKTRVAYLILSNYLQGKVLYLVPGLSLLRQTLEKLYQYGISLKNVLLVGSDQTRIVLNHDNIEMTTNPVFIAKRIREAPSLLVIATYQSSTLLVDDFDLIISDECHRICGEWETRPFTHVLLNFKKGHRLFLTATPRYDTPLSMKNRELFGGVAFRYYLREGIEAGYVNDFELQMVAAPKLAHQPSNREETTKQIIVKQIIMALAYLKTNIPAPKMLVFTRDIKQARELYAELVDQGVYALIAHSTLPRQVILKTFTEFCSSKEPVILLNCRLFQEGVEVPELNAVFFAAPRHSPRDIIQSICRPLNKQVQKPHATIFLPLEVNTENVCLDRFSSIIPFADALASEDPRFYEHLLNPSEVAYPINWIGAHGSVSELLQLARHAIRYGTQGKIDRLTRSERLPWKAAFAELKRTVEICCRYPKINDGFHFGGATLRFDTWYKWVIKSYLQYKNKEPSSLEPYQVSDLESLQDWTTRGVGGPYPWEESMAFLETWLAQNKGELVAIDIHQGGWIGLDATPMERLSGVLTTVSQRDGRSYGKNKKLRPKKGFMIPPQQAEDLDRIFGKHNLKWRKDRVNGFLKEDEHGNYTGEPTCIQEAYRTFKEYVKTNPEYIEKYWPGYAKGKHKHQELPHIWESGLAPPRYKAFKDGNKQLIQRSPKKKDIKN

Summary

Similarity
Belongs to the asfivirus helicase A859L family.
Keywords
ATP-binding   Complete proteome   Helicase   Hydrolase   Nucleotide-binding   Reference proteome  
Feature
chain  Probable helicase A859L
Uniprot
A9JKX8   D4I5M8   A9JLN7   A0A0A1E304   Q65143   E0WMH8   + More
A0A385KMI0   A0A2X0SDV7   P0C8H3   P0C8H2   A0A0C5AW97   P0C8H0   A0A0C5AWM3   A0A2Z5DFT6   P0C8H1   A0A2V2UZK3   A0A2V2W8E1   V5B0I9   Q4D326   A0A2V2V286   A4I6A0   K2N7A9   Q4Q6Q7   E9BMD0   A0A3P3ZDB3   A4HIX1   A0A088RX71   A0A1E1J2G5   A0A061J8L4   A0A0M9FQI1   E9B1F5   W6KWA5   A0A0N1I3J1   A0A0S4JTG1   A0A1X0P8K5   A0A1G4I059   D0A541   Q389B2   A0A3L6KYF2   S9UAM1   G0UY07   G0U3Z4   S9VVA9  
Pubmed
18198370    25406173    26618713    11831707    21470447    25645905    + More
29708484    24482508    16020725    17572675    22038252    23035642    16020728    22038251    25707621    24516393    26317207    20404998    16020726    23560078    22331916   
EMBL
AM712239    CAN10139.1    FN557520    CBH29141.1    AM712240    CAN10388.1    + More
KM262844    KM262845    KM102979    KP055815    KX354450    AIY22231.1    AIY22390.1    AJZ77050.1    AKO62722.1    AOO54370.1    U18466    FR682468    CBW46706.1    MG939583    MG939587    MG939588    AXZ95816.1    AXZ96004.1    AXZ96099.1    LS478113    SPS73463.1    AY261366    AY261363    KM111294    AJL34054.1    AY261360    KM111295    AJL34219.1    MH025916    MH025917    MH025918    MH025919    MH025920    AXB49269.1    AXB49443.1    AXB49615.1    AXB49786.1    AXB49959.1    AY261361    PRFA01000058    PWU89540.1    PRFC01000144    PWV04781.1    AYLP01000041    ESS66650.1    AAHK01001120    EAN86926.1    PRFC01000359    PWU90645.1    FR796463    UINB01000031    CAM70323.1    SUZ44206.1    AHKC01011967    EKF30546.1    FR796427    CAJ08152.1    FR799618    CBZ36408.1    LS997630    SYZ68202.1    FR799006    CAM42427.1    CP009400    AIO00599.1    CALQ01001382    CCM17777.1    AUPL01000464    ESL11778.1    LGTL01000032    KPA74015.1    FR799583    CBZ29061.1    HF955125    CCW65814.1    LJSK01000007    KPI90361.1    CYKH01002159    CUG93533.1    NBCO01000003    ORC92770.1    CZPT02000209    SCU65038.1    FN554973    CBH16385.1    CM000208    EAN78608.1    QSBY01000010    RHW69379.1    ATMH01009351    ATMH01006855    ATMH01006372    ATMH01002372    ATMH01000607    EPY19648.1    EPY25075.1    EPY25998.1    EPY33256.1    EPY36395.1    HE575323    CCC94274.1    HE573026    CCC52156.1    ATMG01010879    EPY27205.1   
Proteomes
UP000130745    UP000101090    UP000108903    UP000110401    UP000117635    UP000142390    + More
UP000241813    UP000266411    UP000000624    UP000141072    UP000000858    UP000000859    UP000105860    UP000000861    UP000101566    UP000000860    UP000002296    UP000008153    UP000000542    UP000008980    UP000007258    UP000007259    UP000002316    UP000008524   
PRIDE
Q65143    P0C8H3    P0C8H2    P0C8H0    P0C8H1   
Pfam
PF10544   T5orf172
PF00271   Helicase_C
PF04851   ResIII
Interpro
IPR014001   Helicase_ATP-bd
IPR006935   Helicase/UvrB_N
IPR001650   Helicase_C
IPR018306   Phage_T5_Orf172_DNA-bd
IPR027417   P-loop_NTPase
SUPFAM
SSF52540   SSF52540
CDD
cd00079  HELICc
ProteinModelPortal
A9JKX8   D4I5M8   A9JLN7   A0A0A1E304   Q65143   E0WMH8   + More
A0A385KMI0   A0A2X0SDV7   P0C8H3   P0C8H2   A0A0C5AW97   P0C8H0   A0A0C5AWM3   A0A2Z5DFT6   P0C8H1   A0A2V2UZK3   A0A2V2W8E1   V5B0I9   Q4D326   A0A2V2V286   A4I6A0   K2N7A9   Q4Q6Q7   E9BMD0   A0A3P3ZDB3   A4HIX1   A0A088RX71   A0A1E1J2G5   A0A061J8L4   A0A0M9FQI1   E9B1F5   W6KWA5   A0A0N1I3J1   A0A0S4JTG1   A0A1X0P8K5   A0A1G4I059   D0A541   Q389B2   A0A3L6KYF2   S9UAM1   G0UY07   G0U3Z4   S9VVA9  
PDB
5FFJ     E-value=9.67346e-18,     Score=225

Ontologies

KEGG
vg:22220422    
GO
GO:0003677  F:DNA binding
 GO:0005524  F:ATP binding
 GO:0004386  F:helicase activity
 GO:0016787  F:hydrolase activity
 GO:0016021  C:integral component of membrane
 GO:0043138  F:3'-5' DNA helicase activity
 GO:0006367  P:transcription initiation from RNA polymerase II promoter
 GO:0006366  P:transcription by RNA polymerase II
 GO:0033683  P:nucleotide-excision repair, DNA incision
 GO:0000112  C:nucleotide-excision repair factor 3 complex
 GO:0020023  C:kinetoplast
 GO:0009411  P:response to UV
 GO:0004003  F:ATP-dependent DNA helicase activity
 GO:0005675  C:transcription factor TFIIH holo complex
 GO:0006468  P:protein phosphorylation
 GO:0097550  C:transcriptional preinitiation complex
 GO:0008134  F:transcription factor binding

Subcellular Location

From MSLVP
Nucleus

Topology

Length:
859
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.784089999999996
Exp number, first 60 AAs:
0.00015
Total prob of N-in:
0.03522
outside
1  -  859
 
 

Population Genetic Test Statistics

Pi
0.0299864
Theta
0.0364084
Tajima's D
-0.6043324
CLR
0
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
Protein
 QED21595.1
AKO62722.1
China_AnhuiXCGQ_2018 Protein
Protein
 QED21595.1
AYW34012.1
China_ASFV-SY18_2018 Protein
 AKO62722.1
Poland_Pol16_20186_o7_2016-2017 Protein
Protein
 QED21595.1
AXZ95816.1
Poland_Pol16_20538_o9_2016-2017 Protein
Protein
 CAN10139.1
QED21595.1
Poland_Pol16_20540_o10_2016-2017 Protein
Protein
 CAN10139.1
QED21595.1
Poland_Pol16_29413_o23_2016-2017 Protein
Protein
 CAN10139.1
QED21595.1
Poland_Pol17_03029_C201_2016-2017 Protein
Protein
 QED21595.1
AXZ96004.1
Poland_Pol17_04461_C210_2016-2017 Protein
Protein
 QED21595.1
AXZ96099.1
Poland_Pol17_05838_C220_2016-2017 Protein
Protein
 CAN10139.1
QED21595.1
Poland_ASFV_POL_Podlaskie_2015 Protein
Protein
 CAN10139.1
QED21595.1
Uganda_R8_2015 Protein
Protein
 QED21595.1
AXB49269.1
Uganda_R7_2015 Protein
Protein
 QED21595.1
AXB49443.1
Uganda_R25_2015 Protein
Protein
 QED21595.1
AXB49615.1
Uganda_N10_2015 Protein
Protein
 QED21595.1
AXB49786.1
Uganda_R35_2015 Protein
Protein
 QED21595.1
AXB49959.1
Estonia_2014 Protein
Protein
 QED21595.1
SPS73463.1
Italy_26544_OG10_2010 Protein
Protein
 QED21595.1
AJZ77050.1
Italy_47_Ss_2008_2008 Protein
Protein
 QED21595.1
AOO54370.1
Portugal_OURT_88.3_1988 Protein
Protein
 QED21595.1
CAN10388.1
Spain_E75_1975 Protein
Protein
 QED21595.1
CBH29141.1
Russia_Georgia_2007 Protein
Protein
 QED21595.1
CBW46706.1
Kenya_Tk1_2005 Protein
Protein
 QED21595.1
AJL34054.1
Kenya_Bus_2006 Protein
Protein
 QED21595.1
AJL34219.1
Russia_Odintsovo_2014 Protein
Protein
 CAN10139.1
QED21595.1
Portugal_L60_1960 Protein
Protein
 QED21595.1
AIY22231.1
Portugal_NHV_1968 Protein
Protein
 QED21595.1
AIY22390.1
Russia_Kashino_2013 Protein
Protein
 CAN10139.1
QED21595.1
Benin_1997 Protein
Protein
Protein
 CAN10139.1
QED21595.1
CAN10139.1
South_Africa_KNP_Pretorisuskop_1996 Protein
Protein
 CAN10139.1
QED21595.1
South_Africa_MGR_Mkuzi_1979 Protein
Protein
 CAN10139.1
QED21595.1
Malawi_Lil_1983 Protein
 CAN10139.1
Kenya_1950 Protein
Protein
 CAN10139.1
QED21595.1
Namibia_Warthog_1980 Protein
Protein
 CAN10139.1
QED21595.1
South_Africa_Warmbaths_1987 Protein
Protein
 CAN10139.1
QED21595.1
Malawi_Tengani_1962 Protein
Protein
 CAN10139.1
QED21595.1
China_HLJ_2018 Protein
Protein
 QED21595.1
QBH90528.1
China_LN_2018 Protein
Protein
 QED21595.1
QBH90713.1
China_wbBS01_2018 Protein
Protein
 QED21595.1
QDL88071.1
Ukraine_Kyiv_2014 Protein
 QED21596.1
Belgium_Etalle_wb_2018 Protein
Protein
 QED21595.1
QED90483.1
Lithuania_LT14_2014 Protein
Protein
 QED21595.1
QEY87846.1
South_Africa_1985 Protein
 CAN10139.1
South_Africa_2_2008 Protein
 CAN10139.1
Zambia_LIV_1983 Protein
 CAN10139.1
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