ASFVdb The African Swine Fever Virus Database
Strain
Ukraine_Kyiv_2014 (Region: Ukraine;  Strain: ASFV/Kyiv/2016/131;  Date: 2014)
Gene
B646L
Description
Annotated in NCBI,  ASFV_Kyiv_2016_131_00129
Location
MN194591.1(-):105256-105492
GenBank Accession
QED21665.1
Full name
Major capsid protein      
Alternative Name
p72
p73
 

Sequence

CDS
ATGCGATTTAAAACCCCCGATGATCCGGGTGCGATGATGATTACCTTTGCTTTGAAGCCACGGGAGGAATACCAACCCAGTGGTCATATTAACGTATCCAGAGCAAGAGAATTTTATATTAGTTGGGACACGGATTACGTGGGGTCTATCACTACGGCTGATCTTGTGGTATCGGCATCTGCTATTAACTTTCTTCTTCTTCAGAACGGTTCAGCTGTGCTGCGTTACAGTACCTAA
Protein
MRFKTPDDPGAMMITFALKPREEYQPSGHINVSRAREFYISWDTDYVGSITTADLVVSASAINFLLLQNGSAVLRYST

Summary

Function
Major capsid protein, one of the most immunogenic protein in natural infections. Plays an essential role in virion assembly.
Major capsid protein, one of the most immunogenic protein in natural infections. Plays an essential role in virion assembly (PubMed:9580160).
Subunit
Homomultimer. The membrane-bound form, but not the cytosolic one, assembles into large complexes.
Homomultimer (PubMed:9573294). The membrane-bound form, but not the cytosolic one, assembles into large complexes (PubMed:9573294).
Similarity
Belongs to the NCLDV major capsid protein family.
Keywords
Capsid protein   Complete proteome   Host cytoplasm   Host endoplasmic reticulum   Host membrane   Membrane   Virion   Direct protein sequencing   Reference proteome  
Feature
chain  Major capsid protein
Uniprot
A0A5B8XAB1   Q5IZK1   A1EC49   A9JL40   D4I5S0   A9JLW9   + More
E0WMM0   Q5IZK2   Q5IZK0   Q5IZI7   P22776   Q8UY56   Q5IZJ6   Q5IZJ3   Q8V9S6   A0A0C5AZH0   Q5IZJ5   A1EC50   Q9QQ83   Q65282   A0A1S6YJH7   A0A1S6YJI3   X5FVZ0   E0WMS8   E0WMS9   D5HT64   A0A1S6YJG3   A0A1S6YJF9   A0A1S6YJI4   A0A1S6YJH4   A0A1S6YJI6   A0A0C4K1W5   A0A0C4K0H5   A0A0C4K445   A0A0C4K087   A0A0B4L734   J7KJX0   J7KDD5   J7KIT3   J7KGS5   J7KJW5   J7JVL6   J7KBN3   J7JZC6   A0A5B9Y0X1   A0A068F1B1   Q4TWN6   A0A1B0V1C2   Q4TWN5   Q4TWN3   Q4TWN1   Q4TWN0   Q4TWN8   Q4TWN2   Q4TWN4   Q4TWN7   A0A1Q2TSE6   A0A2Z6BDP5   A0A146F0D3   A0A1Q2TSE4   A0A146F0B8   A0A1Q2TSE9   A0A2Z6BDM9   A0A1Q2TSF4   A0A146F0E6   A0A1Q2TSG3   A0A1Q2TSG2   A0A1Q2TSE8   A0A1Q2TSF0   A0A5C0ZTL9   A0A5C0ZTI9   A0A5C0ZWX0   A0A2H4V685   A0A1B0V1V1   A0A4Y5RDH8   A0A1B0V1B5   A0A1B0VAK7   A0A1B0VC42   Q65281  
Pubmed
15634958    18198370    21470447    30102848    25406173    26618713    + More
2327074    11831707    8970959    9580160    9573294    8893801    25645905    10872875    21214868    24996815    23171814    27211823   
EMBL
MN194591    QED21665.1    AY578692    AAT84441.1    EF121428    ABL67019.1    + More
AM712239    CAN10181.1    FN557520    CBH29183.1    AM712240    CAN10431.1    FR682468    CBW46748.1    AY578690    AY578691    AY578694    AY578696    AY578699    AY578701    AY578702    AY578703    AY578704    AY578707    KJ195685    MH713612    MG939583    MG939587    MG939588    LS478113    AAT84439.1    AAT84440.1    AAT84443.1    AAT84445.1    AAT84448.1    AAT84450.1    AAT84451.1    AAT84452.1    AAT84453.1    AAT84456.1    AHN94306.1    AXP99042.1    AXZ95856.1    AXZ96044.1    AXZ96139.1    SPS73505.1    AY578689    AY578693    AY578695    AY578705    AY578708    KM262844    KM262845    KM102979    KP055815    KX354450    AAT84438.1    AAT84442.1    AAT84444.1    AAT84454.1    AAT84457.1    AIY22273.1    AIY22431.1    AJZ77054.1    AKO62763.1    AOO54423.1    AY578706    AY261366    M34142    U18466    L76727    AAL40036.1    AY578697    AAT84446.1    AY578700    AAT84449.1    AY261361    L00966    KM111294    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34095.1    AJL34260.1    AXB49310.1    AXB49484.1    AXB49656.1    AXB49827.1    AXB50000.1    AY261360    AY578698    EF121429    ABL67020.1    AF159503    AAD49226.1    L27499    AAA42722.1    KY611354    AQX45489.1    KY611351    AQX45486.1    KJ496127    AHW85122.1    FR686761    CBW52778.1    FR686762    CBW52779.1    GQ410765    ADD62405.1    KY611352    AQX45487.1    KY611350    AQX45485.1    KY611358    AQX45493.1    KY611355    AQX45490.1    KY611357    AQX45492.1    KF706361    AHJ10471.1    KF706363    AHJ10473.1    KF706362    AHJ10472.1    KF706360    AHJ10470.1    KF834193    AHH83722.1    JX391992    AFQ95562.1    JX391991    AFQ95561.1    JX391989    AFQ95559.1    JX391990    AFQ95560.1    JX391987    AFQ95557.1    JX235334    AFQ60160.1    JX391988    AFQ95558.1    JX235333    AFQ60159.1    MN199633    QEH60629.1    KJ671549    AID55012.1    DQ028308    AAY46094.1    KT795360    AMQ11007.1    DQ028309    AAY46095.1    DQ028311    AAY46097.1    DQ028313    AAY46099.1    DQ028314    AAY46100.1    DQ028306    AAY46092.1    DQ028312    AAY46098.1    DQ028310    AAY46096.1    DQ028307    AAY46093.1    LC174750    BAW94550.1    LC322016    BBD14110.1    LC088172    BAU68263.1    LC174751    BAW94551.1    LC088171    BAU68262.1    LC174754    BAW94554.1    LC322012    BBD14106.1    LC174755    BAW94555.1    LC088173    BAU68264.1    LC174756    BAW94556.1    LC174757    BAW94557.1    LC174753    BAW94553.1    LC174752    BAW94552.1    MK850404    QEL09060.1    MK850402    QEL09058.1    MK850403    QEL09059.1    KY963545    AUB45119.1    KT795361    AMQ11008.1    MK189425    QCZ25052.1    KT795353    KT795354    KT795356    KT795358    KT795359    AMQ11000.1    AMQ11001.1    AMQ11003.1    AMQ11005.1    AMQ11006.1    KT795357    AMQ11004.1    KT795355    AMQ11002.1    L27498    AAA42721.1   
Proteomes
UP000321214    UP000130745    UP000101090    UP000108903    UP000141072    UP000110401    + More
UP000117635    UP000142390    UP000241813    UP000266411    UP000000858    UP000000624    UP000000860    UP000101566    UP000105860    UP000000861   
Pfam
PF04451   Capsid_NCLDV
Interpro
IPR007542   MCP_C
IPR038519   MCP_C_sf
IPR016112   VP_dsDNA_II
SUPFAM
SSF49749   SSF49749
Gene 3D
2.70.9.20    
ProteinModelPortal
A0A5B8XAB1   Q5IZK1   A1EC49   A9JL40   D4I5S0   A9JLW9   + More
E0WMM0   Q5IZK2   Q5IZK0   Q5IZI7   P22776   Q8UY56   Q5IZJ6   Q5IZJ3   Q8V9S6   A0A0C5AZH0   Q5IZJ5   A1EC50   Q9QQ83   Q65282   A0A1S6YJH7   A0A1S6YJI3   X5FVZ0   E0WMS8   E0WMS9   D5HT64   A0A1S6YJG3   A0A1S6YJF9   A0A1S6YJI4   A0A1S6YJH4   A0A1S6YJI6   A0A0C4K1W5   A0A0C4K0H5   A0A0C4K445   A0A0C4K087   A0A0B4L734   J7KJX0   J7KDD5   J7KIT3   J7KGS5   J7KJW5   J7JVL6   J7KBN3   J7JZC6   A0A5B9Y0X1   A0A068F1B1   Q4TWN6   A0A1B0V1C2   Q4TWN5   Q4TWN3   Q4TWN1   Q4TWN0   Q4TWN8   Q4TWN2   Q4TWN4   Q4TWN7   A0A1Q2TSE6   A0A2Z6BDP5   A0A146F0D3   A0A1Q2TSE4   A0A146F0B8   A0A1Q2TSE9   A0A2Z6BDM9   A0A1Q2TSF4   A0A146F0E6   A0A1Q2TSG3   A0A1Q2TSG2   A0A1Q2TSE8   A0A1Q2TSF0   A0A5C0ZTL9   A0A5C0ZTI9   A0A5C0ZWX0   A0A2H4V685   A0A1B0V1V1   A0A4Y5RDH8   A0A1B0V1B5   A0A1B0VAK7   A0A1B0VC42   Q65281  
PDB
6KU9     E-value=0,     Score=3433

Ontologies

KEGG
vg:22220311    
GO
GO:0005198  F:structural molecule activity
 GO:0019028  C:viral capsid
 GO:0016020  C:membrane
 GO:0044167  C:host cell endoplasmic reticulum membrane
 GO:0044164  C:host cell cytosol

Subcellular Location

From MSLVP
Capsid
From Uniprot
Virion   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host endoplasmic reticulum membrane   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host cytoplasm   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host cytosol   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.

Topology

Length:
78
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
9.53162
Exp number, first 60 AAs:
5.90567
Total prob of N-in:
0.19570
outside
1  -  78
 
 

Population Genetic Test Statistics

Pi
0.0291515
Theta
0.0441383
Tajima's D
-1.068457
CLR
0
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
 AKO62763.1
China_AnhuiXCGQ_2018 Protein
 AYW34053.1
China_ASFV-SY18_2018 Protein
 AKO62763.1
Poland_Pol16_20186_o7_2016-2017 Protein
 AXZ95856.1
Poland_Pol16_20538_o9_2016-2017 Protein
 CAN10181.1
Poland_Pol16_20540_o10_2016-2017 Protein
 CAN10181.1
Poland_Pol16_29413_o23_2016-2017 Protein
 CAN10181.1
Poland_Pol17_03029_C201_2016-2017 Protein
 AXZ96044.1
Poland_Pol17_04461_C210_2016-2017 Protein
 AXZ96139.1
Poland_Pol17_05838_C220_2016-2017 Protein
 CAN10181.1
Poland_ASFV_POL_Podlaskie_2015 Protein
 CAN10181.1
Uganda_R8_2015 Protein
 AXB49310.1
Uganda_R7_2015 Protein
 AXB49484.1
Uganda_R25_2015 Protein
 AXB49656.1
Uganda_N10_2015 Protein
 AXB49827.1
Uganda_R35_2015 Protein
 AXB50000.1
Estonia_2014 Protein
 SPS73505.1
Italy_26544_OG10_2010 Protein
 AJZ77054.1
Italy_47_Ss_2008_2008 Protein
 AOO54423.1
Portugal_OURT_88.3_1988 Protein
 CAN10431.1
Spain_E75_1975 Protein
 CBH29183.1
Russia_Georgia_2007 Protein
 CBW46748.1
Kenya_Tk1_2005 Protein
 AJL34095.1
Kenya_Bus_2006 Protein
 AJL34260.1
Russia_Odintsovo_2014 Protein
 CAN10181.1
Portugal_L60_1960 Protein
 AIY22273.1
Portugal_NHV_1968 Protein
 AIY22431.1
Russia_Kashino_2013 Protein
 CAN10181.1
Benin_1997 Protein
Protein
 CAN10181.1
CAN10181.1
South_Africa_KNP_Pretorisuskop_1996 Protein
 CAN10181.1
South_Africa_MGR_Mkuzi_1979 Protein
 CAN10181.1
Malawi_Lil_1983 Protein
 CAN10181.1
Kenya_1950 Protein
 CAN10181.1
Namibia_Warthog_1980 Protein
 CAN10181.1
South_Africa_Warmbaths_1987 Protein
 CAN10181.1
Malawi_Tengani_1962 Protein
 CAN10181.1
China_HLJ_2018 Protein
 QBH90570.1
China_LN_2018 Protein
 QBH90755.1
China_wbBS01_2018 Protein
 QDL88113.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
 QED21665.1
QED21666.1
QED21668.1
Belgium_Etalle_wb_2018 Protein
 QED90525.1
Lithuania_LT14_2014 Protein
 QEY87888.1
South_Africa_1985    
South_Africa_2_2008    
Zambia_LIV_1983    
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