ASFVdb The African Swine Fever Virus Database
Strain
Uganda_N10_2015 (Region: Uganda, Tororo district;  Strain: N10;  Date: 2015)
Gene
pB646L
Description
Annotated in NCBI,  gene expression: late
GenBank Accession
Full name
Major capsid protein      
Alternative Name
p72
p73
 

Sequence

CDS
ATGGCATCAGGAGGAGCTTTTTGTCTTATTGCTAACGATGGGAAGGCCGACAAGATCATTTTGGCCCAAGACTTGCTTAATAGCAGGATCTCTAACATTAAAAATGTTAACAAAAGTTATGGGAAACCCGACCCCGAACCCACTTTGAGTCAAATCGAAGAAACACATATGGTGCATTTTAACGCACATTTTAAGCCTTACGTCCCAATAGGGTTTGAATACAATAAAGTACGTCCACATACGGGTACCCCCACATTGGGCAACAAGCTTACCTTTGGTATTCCCCAGTACGGAGACTTTTTCCATGATATGGTAGGCCACCATATATTGGGCGCGTGTCATTCCTCCTGGCAGGATGCTCCGATTCAGGGCTCATCCCAGATGGGGGCCCATGGTCAGCTTCAAACGTTTCCTCGCAACGGATATGACTGGGACAACCAAACACCTTTGGAGGGCGCCGTTTACACGCTTGTGGATCCTTTTGGGAGGCCCATTGTGCCCGGCACAAAGAATGCGTACCGAAACTTGGTTTACTACTGCGAATACCCCGGAGAACGGCTTTATGAAAATGTAAGATTCGATGTAAATGGAAACTCCCTGGACGAATATAGTTCGGATGTTACAACGCTTGTGCGTAAATTTTGCATCCCAGGAGATAAAATGACTGGATATAAGCACTTGGTTGGCCAGGAGGTATCGGTGGAGGGAACCAGTGGCCCTCTCCTATGCAACGTTCAAGATATGCACAAGCCGCACCAGAGCAAACCTATTCTTACCGATGAAAATGATACGCAGCGAACATGCACCCATACCAACCCGAAATTTCTTTCACAGCATTTTCCCGAGAACTCCCACAATATCCAAACAGCAGGTAAACAAGATATTACCCCTATTACGGACGCAACGTATCTGGACATAAGACGTAATGTTCATTACAGCTGTAATGGACCTCAAACCCCTAAATACTATCAGCCCCCTCTTGCGCTCTGGATTAAGCTGCGCTTTTGGTTTAATGAGAACGTGAACCTTGCTATTCCCTCGGTATCTATTCCCTTCGGCGAGCGCTTTATCACCATAAAGCTTGCATCGCAAAAGGATTTGGTGAATGAATTTCCCGGACTTTTTATCCGCCAGTCACGTTTTATACCTGGGCGCCCCAGTAGACGCAACATCCGCTTTAAACCATGGTTTATCCCAGGAGTCATTAGTGAAATCTCGCTCACGAATAATGAGCTTTACATCAATAACCTGTTTGTAACCCCTGAAATACACAATCTTTTTGTAAAACGCGTTCGATTTTCCCTGATACGTGTCCATAAAACGCAGGTGACCCACACGAACAATAACCATCACGATGAAAAACTAATGTCTGCTCTTAAATGGCCCATCGAATATATGTTTATAGGATTAAAACCCACCTGGAATATTTCCGACCAAAATCCTCATCAACACCGAGATTGGCACAAGTTCGGACATGTTGTTAACGCCATTATGCAGCCTACCCACCACGCAGAGGTAAGCTTTCAGGATAGAGATACAGCTCTTCCAGATGCATGTTCATCCATATCTGATATTACCCCCATTACTTATCCGATCACATTACCTATTATTAAAAACATTTCCGTTACTGCTCACGGTATCAATCTTATCGATAAATTTCCATCAAAGTTCTGCAGCTCTTACATACCCTTCCACTACGGAGGCAATTCGATTAAAACCCCCGACGATCCGGGCGCGATGATGATTACCTTTGCTTTGAAACCACGGGAGGAATACCAACCCAGCGGTCATATTAACGTATCCAGAGCAAGAGAATTTTATATTAGCTGGGACACAGATTATGTGGGGTCTATCACCACGGCTGATCTTGTGGTATCGGCATCCGCTATTAACTTTCTTCTTCTTCAGAATGGTTCAGCTGTGTTGCGTTACAGTACCTAA
Protein
MASGGAFCLIANDGKADKIILAQDLLNSRISNIKNVNKSYGKPDPEPTLSQIEETHMVHFNAHFKPYVPIGFEYNKVRPHTGTPTLGNKLTFGIPQYGDFFHDMVGHHILGACHSSWQDAPIQGSSQMGAHGQLQTFPRNGYDWDNQTPLEGAVYTLVDPFGRPIVPGTKNAYRNLVYYCEYPGERLYENVRFDVNGNSLDEYSSDVTTLVRKFCIPGDKMTGYKHLVGQEVSVEGTSGPLLCNVQDMHKPHQSKPILTDENDTQRTCTHTNPKFLSQHFPENSHNIQTAGKQDITPITDATYLDIRRNVHYSCNGPQTPKYYQPPLALWIKLRFWFNENVNLAIPSVSIPFGERFITIKLASQKDLVNEFPGLFIRQSRFIPGRPSRRNIRFKPWFIPGVISEISLTNNELYINNLFVTPEIHNLFVKRVRFSLIRVHKTQVTHTNNNHHDEKLMSALKWPIEYMFIGLKPTWNISDQNPHQHRDWHKFGHVVNAIMQPTHHAEVSFQDRDTALPDACSSISDITPITYPITLPIIKNISVTAHGINLIDKFPSKFCSSYIPFHYGGNSIKTPDDPGAMMITFALKPREEYQPSGHINVSRAREFYISWDTDYVGSITTADLVVSASAINFLLLQNGSAVLRYST

Summary

Function
Major capsid protein, one of the most immunogenic protein in natural infections. Plays an essential role in virion assembly.
Major capsid protein, one of the most immunogenic protein in natural infections. Plays an essential role in virion assembly (PubMed:9580160).
Subunit
Homomultimer. The membrane-bound form, but not the cytosolic one, assembles into large complexes.
Homomultimer (PubMed:9573294). The membrane-bound form, but not the cytosolic one, assembles into large complexes (PubMed:9573294).
Similarity
Belongs to the NCLDV major capsid protein family.
Keywords
Capsid protein   Complete proteome   Host cytoplasm   Host endoplasmic reticulum   Host membrane   Membrane   Virion   Direct protein sequencing   Reference proteome  
Feature
chain  Major capsid protein
EMBL
GQ427193    ADB28078.1    GQ427190    ADB28072.1    GQ427194    ADB28080.1    + More
GQ427192    ADB28076.1    GQ427191    ADB28074.1    L27498    AAA42721.1    KT795353    KT795354    KT795356    KT795358    KT795359    AMQ11000.1    AMQ11001.1    AMQ11003.1    AMQ11005.1    AMQ11006.1    KM111294    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34095.1    AJL34260.1    AXB49310.1    AXB49484.1    AXB49656.1    AXB49827.1    AXB50000.1    AY261360    AY578698    L27499    AAA42722.1    AY261361    L00966    S89966    AAN86724.1    EF121429    ABL67020.1    FR682468    CBW46748.1    AY578690    AY578691    AY578694    AY578696    AY578699    AY578701    AY578702    AY578703    AY578704    AY578707    KJ195685    MH713612    MG939583    MG939587    MG939588    LS478113    AAT84439.1    AAT84440.1    AAT84443.1    AAT84445.1    AAT84448.1    AAT84450.1    AAT84451.1    AAT84452.1    AAT84453.1    AAT84456.1    AHN94306.1    AXP99042.1    AXZ95856.1    AXZ96044.1    AXZ96139.1    SPS73505.1    AY578706    AY261366    AM712239    CAN10181.1    FN557520    CBH29183.1    AM712240    CAN10431.1    L76727    AAL40036.1    AY578692    AAT84441.1    EF121428    ABL67019.1    AY578689    AY578693    AY578695    AY578705    AY578708    KM262844    KM262845    KM102979    KP055815    KX354450    AAT84438.1    AAT84442.1    AAT84444.1    AAT84454.1    AAT84457.1    AIY22273.1    AIY22431.1    AJZ77054.1    AKO62763.1    AOO54423.1    M34142    U18466    AY578700    AAT84449.1    AY578697    AAT84446.1    KT795355    AMQ11002.1    KT795357    AMQ11004.1    AF159503    AAD49226.1    LT706986    SIP85932.1    GL376611    NYYR01000108    MAE21706.1   
Pfam
PF04451   Capsid_NCLDV
PF16903   Capsid_N
Interpro
IPR016112   VP_dsDNA_II
IPR007542   MCP_C
IPR038519   MCP_C_sf
IPR031654   Capsid_N
SUPFAM
SSF49749   SSF49749
Gene 3D
PDB
6KU9     E-value=0,     Score=3433

Ontologies

KEGG

Subcellular Location

From MSLVP
Capsid
From Uniprot
Virion   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host endoplasmic reticulum membrane   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host cytoplasm   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host cytosol   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.

Topology

Length:
646
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.98282
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00013
outside
1  -  646
 
 

Population Genetic Test Statistics

Pi
0.0270466
Theta
0.0352706
Tajima's D
-0.8651392
CLR
0
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62763.1
China_AnhuiXCGQ_2018 Protein
AYW34053.1
China_ASFV-SY18_2018 Protein
AKO62763.1
Poland_Pol16_20186_o7_2016-2017 Protein
AXZ95856.1
Poland_Pol16_20538_o9_2016-2017 Protein
CAN10181.1
Poland_Pol16_20540_o10_2016-2017 Protein
CAN10181.1
Poland_Pol16_29413_o23_2016-2017 Protein
CAN10181.1
Poland_Pol17_03029_C201_2016-2017 Protein
AXZ96044.1
Poland_Pol17_04461_C210_2016-2017 Protein
AXZ96139.1
Poland_Pol17_05838_C220_2016-2017 Protein
CAN10181.1
Poland_ASFV_POL_Podlaskie_2015 Protein
CAN10181.1
Uganda_R8_2015 Protein
AXB49310.1
Uganda_R7_2015 Protein
AXB49484.1
Uganda_R25_2015 Protein
AXB49656.1
Uganda_N10_2015 Protein
AXB49827.1
Uganda_R35_2015 Protein
AXB50000.1
Estonia_2014 Protein
SPS73505.1
Italy_26544_OG10_2010 Protein
AJZ77054.1
Italy_47_Ss_2008_2008 Protein
AOO54423.1
Portugal_OURT_88.3_1988 Protein
CAN10431.1
Spain_E75_1975 Protein
CBH29183.1
Russia_Georgia_2007 Protein
CBW46748.1
Kenya_Tk1_2005 Protein
AJL34095.1
Kenya_Bus_2006 Protein
AJL34260.1
Russia_Odintsovo_2014 Protein
CAN10181.1
Portugal_L60_1960 Protein
AIY22273.1
Portugal_NHV_1968 Protein
AIY22431.1
Russia_Kashino_2013 Protein
CAN10181.1
Benin_1997 Protein
Protein
CAN10181.1
CAN10181.1
South_Africa_KNP_Pretorisuskop_1996 Protein
CAN10181.1
South_Africa_MGR_Mkuzi_1979 Protein
CAN10181.1
Malawi_Lil_1983 Protein
CAN10181.1
Kenya_1950 Protein
CAN10181.1
Namibia_Warthog_1980 Protein
CAN10181.1
South_Africa_Warmbaths_1987 Protein
CAN10181.1
Malawi_Tengani_1962 Protein
CAN10181.1
China_HLJ_2018 Protein
QBH90570.1
China_LN_2018 Protein
QBH90755.1
China_wbBS01_2018 Protein
QDL88113.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
QED21665.1
QED21666.1
QED21668.1
Belgium_Etalle_wb_2018 Protein
QED90525.1
Lithuania_LT14_2014 Protein
QEY87888.1
South_Africa_1985    
South_Africa_2_2008    
Zambia_LIV_1983    
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