ASFVdb The African Swine Fever Virus Database
Strain
Benin_1997 (Region: Benin;  Strain: Benin 97/1;  Date: 1997)
Gene
Structural protein p72
Description
Annotated in NCBI,  similar to Chlorella virus PBCV-1 major capsid protein, PIR Accession Number A40245
Location
AM712239.1(-):98226-100166
GenBank Accession
CAN10181.1
Full name
Major capsid protein       + More
Alternative Name
p72
p73
p72
p73
 

Sequence

CDS
ATGGCATCAGGAGGAGCTTTTTGTCTTATTGCTAACGATGGGAAGGCCGACAAGATTATATTGGCCCAAGACTTGCTTAATAGCAGGATTTCTAACATTAAAAATGTGAACAAAAGTTATGGGAAACCCGACCCCGAACCCACTTTGAGTCAAATCGAAGAAACACATTTGGTTCATTTTAATGCGCATTTTAAGCCTTATGTTCCAGTAGGGTTTGAATACAATAAAGTACGCCCGCATACGGGTACCCCCACCTTGGGAAACAAGCTTACCTTTGGTATTCCCCAGTACGGAGACTTTTTCCATGATATGGTGGGCCACCATATATTGGGTGCATGTCATTCGTCCTGGCAGGATGCTCCGATTCAGGGCACGGCCCAGATGGGGGCCCATGGTCAGCTTCAAACGTTTCCTCGCAACGGATATGACTGGGACAACCAAACACCTTTAGAGGGCGCCGTTTACACGCTTGTAGATCCCTTTGGAAGACCTATTGTACCCGGCACAAAGAATGCGTACCGAAACTTGGTTTACTACTGCGAATACCCCGGAGAACGACTTTATGAAAACGTAAGATTCGATGTAAATGGAAATTCCCTGGACGAATATAGTTCGGATGTCACAACGCTTGTGCGCAAATTTTGCATCCCAGGGGATAAAATGACTGGATATAAGCACTTGGTCGGCCAGGAGGTATCGGTGGAGGGAACTAGTGGCCCTCTCCTATGCAACATTCATGATTTGCACAAGCCGCACCAAAGCAAACCTATTCTTACCGATGAAAATGATACGCAGCGAACGTGCAGCCATACCAACCCGAAATTCCTTTCACAACATTTTCCCGAGAACTCTCACAATATCCAAACAGCAGGTAAACAAGATATTACTCCTATTACGGACGCAACGTATCTGGACATAAGACGTAATGTTCATTACAGCTGTAATGGACCTCAAACCCCTAAATACTATCAGCCCCCTCTTGCGCTCTGGATTAAGCTGCGCTTTTGGTTTAACGAGAACGTGAACCTTGCTATTCCCTCGGTATCCATTCCCTTCGGCGAGCGCTTTATCACCATAAAGCTTGCATCGCAAAAGGATTTGGTGAATGAATTTCCTGGACTTTTTATACGCCAGTCGCGTTTTATACCTGGACGCCCCAGTAGACGCAATATACGCTTTAAACCATGGTTTATCCCAGGAGTCATTAATGAAATCTCGCTCACGAATAATGAACTTTACATCAATAACCTGTTTGTAACCCCTGAAATACACAACCTTTTTGTAAAACGCGTTCGATTTTCCCTGATACGTGTCCATAAAACGCAGGTGACCCACACCAACAATAACCACCACGATGAAAAACTAATGTCTGCTCTTAAATGGCCCATTGAATATATGTTTATAGGATTAAAACCTACCTGGAACATCTCCGATCAAAATCCTCATCAACACCGAGATTGGCACAAGTTCGGACATGTTGTTAACGCCATTATGCAGCCTACTCACCACGCAGAGATAAGCTTTCAGGATAGAGATACAGCTCTTCCAGACGCATGTTCATCTATATCGGATATTAGCCCCGTTACGTATCCGATCACATTACCTATTATTAAAAACATTTCCGTAACTGCTCATGGTATCAATCTTATCGATAAGTTTCCATCAAAGTTCTGCAGCTCTTACATACCCTTCCACTACGGAGGCAATGCAATTAAAACCCCCGATGATCCGGGTGCGATGATGATTACCTTTGCTTTGAAGCCACGGGAGGAATACCAACCCAGTGGTCATATTAACGTATCCAGAGCAAGAGAATTTTATATTAGTTGGGACACGGATTACGTGGGGTCTATCACTACGGCTGATCTTGTGGTATCGGCATCTGCTATTAACTTTCTTCTTCTTCAGAACGGTTCAGCTGTGCTGCGTTACAGTACCTAA
Protein
MASGGAFCLIANDGKADKIILAQDLLNSRISNIKNVNKSYGKPDPEPTLSQIEETHLVHFNAHFKPYVPVGFEYNKVRPHTGTPTLGNKLTFGIPQYGDFFHDMVGHHILGACHSSWQDAPIQGTAQMGAHGQLQTFPRNGYDWDNQTPLEGAVYTLVDPFGRPIVPGTKNAYRNLVYYCEYPGERLYENVRFDVNGNSLDEYSSDVTTLVRKFCIPGDKMTGYKHLVGQEVSVEGTSGPLLCNIHDLHKPHQSKPILTDENDTQRTCSHTNPKFLSQHFPENSHNIQTAGKQDITPITDATYLDIRRNVHYSCNGPQTPKYYQPPLALWIKLRFWFNENVNLAIPSVSIPFGERFITIKLASQKDLVNEFPGLFIRQSRFIPGRPSRRNIRFKPWFIPGVINEISLTNNELYINNLFVTPEIHNLFVKRVRFSLIRVHKTQVTHTNNNHHDEKLMSALKWPIEYMFIGLKPTWNISDQNPHQHRDWHKFGHVVNAIMQPTHHAEISFQDRDTALPDACSSISDISPVTYPITLPIIKNISVTAHGINLIDKFPSKFCSSYIPFHYGGNAIKTPDDPGAMMITFALKPREEYQPSGHINVSRAREFYISWDTDYVGSITTADLVVSASAINFLLLQNGSAVLRYST

Summary

Function
Major capsid protein, one of the most immunogenic protein in natural infections. Plays an essential role in virion assembly.
Major capsid protein, one of the most immunogenic protein in natural infections. Plays an essential role in virion assembly (PubMed:9580160).
Subunit
Homomultimer. The membrane-bound form, but not the cytosolic one, assembles into large complexes.
Homomultimer (PubMed:9573294). The membrane-bound form, but not the cytosolic one, assembles into large complexes (PubMed:9573294).
Homomultimer. The membrane-bound form, but not the cytosolic one, assembles into large complexes.
Homomultimer (PubMed:9573294). The membrane-bound form, but not the cytosolic one, assembles into large complexes (PubMed:9573294).
Similarity
Belongs to the NCLDV major capsid protein family.
Keywords
Capsid protein   Complete proteome   Host cytoplasm   Host endoplasmic reticulum   Host membrane   Membrane   Virion   Direct protein sequencing   Reference proteome  
Feature
chain  Major capsid protein
Uniprot
D2WPI9   D2WPI3   D2WPJ1   D2WPI7   D2WPI5   Q8B389   + More
E0WMM0   Q5IZK2   Q8UY56   Q5IZI7   A9JL40   D4I5S0   A9JLW9   Q5IZK1   Q5IZJ6   A1EC49   Q5IZK0   P22776   Q5IZJ3   Q65281   A0A1B0V1B5   Q8V9S6   A0A0C5AZH0   Q5IZJ5   Q65282   A1EC50   A0A1B0VC42   A0A1B0VAK7   Q9QQ83   A0A1X6WF55   K3X3E3   A0A2D5VNF6  
Pubmed
20052526    1550491    21470447    15634958    30102848    8893801    + More
18198370    25406173    26618713    2327074    11831707    8970959    9580160    9573294    27211823    25645905    10872875    29337314   
EMBL
GQ427193    ADB28078.1    GQ427190    ADB28072.1    GQ427194    ADB28080.1    + More
GQ427192    ADB28076.1    GQ427191    ADB28074.1    S89966    AAN86724.1    FR682468    CBW46748.1    AY578690    AY578691    AY578694    AY578696    AY578699    AY578701    AY578702    AY578703    AY578704    AY578707    KJ195685    MH713612    MG939583    MG939587    MG939588    LS478113    AAT84439.1    AAT84440.1    AAT84443.1    AAT84445.1    AAT84448.1    AAT84450.1    AAT84451.1    AAT84452.1    AAT84453.1    AAT84456.1    AHN94306.1    AXP99042.1    AXZ95856.1    AXZ96044.1    AXZ96139.1    SPS73505.1    L76727    AAL40036.1    AY578706    AY261366    AM712239    CAN10181.1    FN557520    CBH29183.1    AM712240    CAN10431.1    AY578692    AAT84441.1    AY578697    AAT84446.1    EF121428    ABL67019.1    AY578689    AY578693    AY578695    AY578705    AY578708    KM262844    KM262845    KM102979    KP055815    KX354450    AAT84438.1    AAT84442.1    AAT84444.1    AAT84454.1    AAT84457.1    AIY22273.1    AIY22431.1    AJZ77054.1    AKO62763.1    AOO54423.1    M34142    U18466    AY578700    AAT84449.1    L27498    AAA42721.1    KT795353    KT795354    KT795356    KT795358    KT795359    AMQ11000.1    AMQ11001.1    AMQ11003.1    AMQ11005.1    AMQ11006.1    AY261361    L00966    KM111294    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34095.1    AJL34260.1    AXB49310.1    AXB49484.1    AXB49656.1    AXB49827.1    AXB50000.1    AY261360    AY578698    L27499    AAA42722.1    EF121429    ABL67020.1    KT795355    AMQ11002.1    KT795357    AMQ11004.1    AF159503    AAD49226.1    LT706986    SIP85932.1    GL376611    NYYR01000108    MAE21706.1   
Proteomes
UP000141072    UP000000858    UP000130745    UP000101090    UP000108903    UP000110401    + More
UP000117635    UP000142390    UP000241813    UP000266411    UP000000624    UP000000860    UP000101566    UP000105860    UP000000861    UP000201921    UP000019132   
Pfam
PF04451   Capsid_NCLDV
PF16903   Capsid_N
Interpro
IPR016112   VP_dsDNA_II
IPR038519   MCP_C_sf
IPR007542   MCP_C
IPR031654   Capsid_N
SUPFAM
SSF49749   SSF49749
Gene 3D
2.70.9.20     2.70.9.20    
ProteinModelPortal
D2WPI9   D2WPI3   D2WPJ1   D2WPI7   D2WPI5   Q8B389   + More
E0WMM0   Q5IZK2   Q8UY56   Q5IZI7   A9JL40   D4I5S0   A9JLW9   Q5IZK1   Q5IZJ6   A1EC49   Q5IZK0   P22776   Q5IZJ3   Q65281   A0A1B0V1B5   Q8V9S6   A0A0C5AZH0   Q5IZJ5   Q65282   A1EC50   A0A1B0VC42   A0A1B0VAK7   Q9QQ83   A0A1X6WF55   K3X3E3   A0A2D5VNF6  
PDB
6KU9     E-value=0,     Score=3433

Ontologies

KEGG
vg:22220311    
GO
GO:0019028  C:viral capsid
 GO:0005198  F:structural molecule activity
 GO:0016020  C:membrane
 GO:0044167  C:host cell endoplasmic reticulum membrane
 GO:0044164  C:host cell cytosol

Subcellular Location

From MSLVP
Capsid
From Uniprot
Virion   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host endoplasmic reticulum membrane   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host cytoplasm   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host cytosol   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Virion   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host endoplasmic reticulum membrane   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host cytoplasm   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.
Host cytosol   Present in the external surfaces of intracellular virus particles.   With evidence from 1 publications.

Topology

Length:
646
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.97669
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00013
Length:
646
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.97669
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00013
outside
1  -  646
outside
1  -  646
 
 

Population Genetic Test Statistics

Pi
0.0266697
Theta
0.0364084
Tajima's D
-0.8680452
CLR
0.003635
Interpretation
No evidence of Selection

Genomic alignment in the CDS region

 
 

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
 AKO62763.1
China_AnhuiXCGQ_2018 Protein
 AYW34053.1
China_ASFV-SY18_2018 Protein
 AKO62763.1
Poland_Pol16_20186_o7_2016-2017 Protein
 AXZ95856.1
Poland_Pol16_20538_o9_2016-2017 Protein
 CAN10181.1
Poland_Pol16_20540_o10_2016-2017 Protein
 CAN10181.1
Poland_Pol16_29413_o23_2016-2017 Protein
 CAN10181.1
Poland_Pol17_03029_C201_2016-2017 Protein
 AXZ96044.1
Poland_Pol17_04461_C210_2016-2017 Protein
 AXZ96139.1
Poland_Pol17_05838_C220_2016-2017 Protein
 CAN10181.1
Poland_ASFV_POL_Podlaskie_2015 Protein
 CAN10181.1
Uganda_R8_2015 Protein
 AXB49310.1
Uganda_R7_2015 Protein
 AXB49484.1
Uganda_R25_2015 Protein
 AXB49656.1
Uganda_N10_2015 Protein
 AXB49827.1
Uganda_R35_2015 Protein
 AXB50000.1
Estonia_2014 Protein
 SPS73505.1
Italy_26544_OG10_2010 Protein
 AJZ77054.1
Italy_47_Ss_2008_2008 Protein
 AOO54423.1
Portugal_OURT_88.3_1988 Protein
 CAN10431.1
Spain_E75_1975 Protein
 CBH29183.1
Russia_Georgia_2007 Protein
 CBW46748.1
Kenya_Tk1_2005 Protein
 AJL34095.1
Kenya_Bus_2006 Protein
 AJL34260.1
Russia_Odintsovo_2014 Protein
 CAN10181.1
Portugal_L60_1960 Protein
 AIY22273.1
Portugal_NHV_1968 Protein
 AIY22431.1
Russia_Kashino_2013 Protein
 CAN10181.1
Benin_1997 Protein
Protein
 CAN10181.1
CAN10181.1
South_Africa_KNP_Pretorisuskop_1996 Protein
 CAN10181.1
South_Africa_MGR_Mkuzi_1979 Protein
 CAN10181.1
Malawi_Lil_1983 Protein
 CAN10181.1
Kenya_1950 Protein
 CAN10181.1
Namibia_Warthog_1980 Protein
 CAN10181.1
South_Africa_Warmbaths_1987 Protein
 CAN10181.1
Malawi_Tengani_1962 Protein
 CAN10181.1
China_HLJ_2018 Protein
 QBH90570.1
China_LN_2018 Protein
 QBH90755.1
China_wbBS01_2018 Protein
 QDL88113.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
 QED21665.1
QED21666.1
QED21668.1
Belgium_Etalle_wb_2018 Protein
 QED90525.1
Lithuania_LT14_2014 Protein
 QEY87888.1
South_Africa_1985    
South_Africa_2_2008    
Zambia_LIV_1983    
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