ASFVdb The African Swine Fever Virus Database
Strain
Poland_Pol17_04461_C210_2016-2017 (Region: Poland;  Strain: Pol17_04461_C210;  Date: 2016-2017)
Gene
A240L
Description
Annotated in NCBI,  gene expression: early
Location
MG939588.1(-):47670-48380
GenBank Accession
AXZ96095.1
Full name
Thymidylate kinase       + More
Putative thymidylate kinase 251L      
Probable thymidylate kinase      
Alternative Name
dTMP kinase
 

Sequence

CDS
ATGCGTGGAATACTCATTGCCATCGAGGGAATCAATGGTGTGGGAAAAAGCACACAGGCAATGAAATTAAAAGAAACATTGGAATGCATGGATTATAATGCTATATGTATACATTTTCCTAATCCAGACACGACCACCGGTGATCTTATATTGCAGGTGTTAAATAAAACCATAGAAATGTCATCGGAACAATTACATAAATTATTTACAAAACATCGTAGTGAATTTATCGCAGAAATTGCAGTGCTACTTAAGCTAAATTATATTGTAATAGTGGACCGTTATATTTGGTCTGGTTTAGTATATGCTCAAGCAGATGGAATCACGATTGAAACCAAAAATACCTTTAAACCAGATTATACATTCTTTTTATCTTCAAAGAAACCATTGAACGAGAAACCTTTAACCTTACAACGTTTATTTGAAACAAAAGAAAAACAAGAAACAATTTTTACTAATTTTACTATTATCATGGATGATGTACCTAAAAATAGGTTTTGTATTATTCCGGCAACTCTTAATAAGGAAATTATTCATATGATAATTTTAACAAAAACGCTAAAAGTTTTTGACAACAACTCATGTTTAAATTATATTAAAATGTACGATGATAAGTATTTAAATGTCCAGGATCTGAATTTATTCGATTTCGATTGGCAAAAATATATTGAAGATAATAACGATAAAGAAGAATATGACTTTATAGTTTAG
Protein
MRGILIAIEGINGVGKSTQAMKLKETLECMDYNAICIHFPNPDTTTGDLILQVLNKTIEMSSEQLHKLFTKHRSEFIAEIAVLLKLNYIVIVDRYIWSGLVYAQADGITIETKNTFKPDYTFFLSSKKPLNEKPLTLQRLFETKEKQETIFTNFTIIMDDVPKNRFCIIPATLNKEIIHMIILTKTLKVFDNNSCLNYIKMYDDKYLNVQDLNLFDFDWQKYIEDNNDKEEYDFIV

Summary

Function
Catalyzes the conversion of dTMP to dTDP.
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Catalytic Activity
ATP + dTMP = ADP + dTDP
Similarity
Belongs to the thymidylate kinase family.
Keywords
ATP-binding   Complete proteome   Kinase   Nucleotide biosynthesis   Nucleotide-binding   Transferase   Reference proteome  
Feature
chain  Thymidylate kinase
Uniprot
E0WMH3   A0A2X0RUU2   P0C8G2   P0C8G1   A0A0N6WHZ1   A9JKX1   + More
D4I5M3   A9JLM6   A0A0A1E300   P42490   A0A0C5AZC7   P0C8F9   A0A2Z5DGC8   D6WW08   A0A1Y3BL63   C4WTA6   A0A0L8HLB6   A0A0L8G043   Q91FS1   A0A0P4VS64   T1HFS6   R4FN90   A0A0V0GB06   A0A2H8TXE8   J9K470   A0A023F7Z7   A0A224XKB1   A0A3M7QN55   A0A069DQQ3   B4KNS9   A0A286UJZ7   A0A212EPA4   V5GJC1   A0A1V9XDP3   A0A1W4XS65   A0A267HA90   A0A1I8GGD6   A0A3P3YJU7   A0A267DTH8   A0A2P0VN24   E4URU8   A0A163EG61   A0A1Q2YEY2   V8NMQ6   A0A0H5QIM5   F2UA04   A0A2B7Z168   G5E3F1   A0A1B6EFI8   A0A2U3CHU8   R9PAR2   A0A177TS54   A0A177UW63   D8Q2T6   A0A0W0CHT6   Q6FSB3   A0A068S3V0   A0A2H1VL46   A0A2C5ZA62   A0A1I8HW21   A0A0F7Z299   W1QBD2   D8Q2T3   A0A2D4FVS7   D0AB90   A0A2J8IPB7   A0A2J8RPT4   G5E9E9   G3QFV9   A0A1B6K446   A9UNQ0   A0A2G9Z0Z9   A0A1E3NPC9   H2TXQ6   A0A212CGJ5   A0A0P4WLI0   A0A1B0CN11   A0A2A4JCZ2   L5KUE7   A0A1L8DXV4   A0A077X4V8   F2RNV5   A0A067REX9   A0A3F2Y7Z2   A0A166JFD7   A0A3B3U8P7   A0A2Y9SP80   A0A1B2J889   A0A3P8TZ48   A0A2K6B2U5   A0A220T6K7   A0A1B7P8T1   A0A2K5TJ98   A0A2K5KA98   L7X3W4   F7H337   G1SQ07   A0A3M0K5D9   G7N9E6  
EC Number
2.7.4.9
Pubmed
21470447    26618713    18198370    25406173    8393914    11831707    + More
25645905    18362917    19820115    11448171    17239238    27129103    25474469    30375419    26334808    17994087    22118469    28327890    26392545    29649682    22951933    24297900    23814110    20622885    15229592    24279325    11181995    15815621    19413330    21269460    25944712    18273011    27535936    21551351    23258410    24845553    26659563    28685222    23674305    17431167    21993624    22002653   
EMBL
FR682468    CBW46701.1    MG939583    MG939587    MG939588    LS478113    + More
AXZ95812.1    AXZ96000.1    AXZ96095.1    SPS73458.1    AY261366    AY261363    KP055815    AKO62717.1    AM712239    CAN10134.1    FN557520    CBH29136.1    AM712240    CAN10383.1    KM262844    KM262845    KM102979    KX354450    AIY22226.1    AIY22385.1    AJZ77121.1    AOO54362.1    Z19544    U18466    KM111294    AJL34050.1    AY261360    MH025916    MH025917    MH025918    MH025919    MH025920    AXB49264.1    AXB49438.1    AXB49610.1    AXB49781.1    AXB49954.1    KQ971361    EFA08206.2    MUJZ01016332    OTF80847.1    AK340538    BAH71126.1    KQ417858    KOF90031.1    KQ424852    KOF70367.1    AF303741    GDKW01001174    JAI55421.1    ACPB03001438    ACPB03001439    GAHY01001394    JAA76116.1    GECL01000844    JAP05280.1    GFXV01006666    MBW18471.1    ABLF02029968    GBBI01001330    JAC17382.1    GFTR01003511    JAW12915.1    REGN01005694    RNA12425.1    GBGD01002927    JAC85962.1    CH933808    EDW08974.1    NBII01000004    PAV19943.1    AGBW02013517    OWR43287.1    GALX01006754    JAB61712.1    MNPL01014534    OQR71462.1    NIVC01000010    PAA94462.1    OVEO01000013    SPR00040.1    NIVC01003210    NIVC01001800    NIVC01000199    PAA52608.1    PAA63936.1    PAA88241.1    KY322437    AUF82317.1    DS989824    EFR01220.1    KV441026    KV440973    OAD67069.1    OAD78460.1    BDGI01000057    GAV28126.1    AZIM01002690    ETE63544.1    HACM01001055    CRZ01497.1    GL832966    EGD73579.1    PDNA01000009    PGH27150.1    JP287915    AEQ17250.1    GEDC01000601    JAS36697.1    NJBF01000011    PWI48607.1    DF238791    GAC95180.1    LWDF01000026    OAJ06127.1    LWDG01000052    OAJ19869.1    GL377305    EFI97581.1    LLZZ01000149    KTA99005.1    CR380954    CAG59814.1    CBTN010000039    CDH56665.1    ODYU01003152    SOQ41543.1    NJEU01000301    PHH76763.1    GBEX01003485    JAI11075.1    AEOI02000009    ESW97643.1    EFI97579.1    IACJ01093317    LAA51595.1    FP102340    CBH09285.1    NBAG03000666    PNI12345.1    NDHI03003662    PNJ10537.1    AC133528    CH471063    EAW71286.1    CABD030019471    CABD030019472    GECU01003532    GECU01001488    JAT04175.1    JAT06219.1    CH991543    EDQ92738.1    PCRS01000004    PIP25152.1    KV454002    ODQ47916.1    MKHE01000020    OWK05065.1    GDRN01063553    GDRN01063552    GDRN01063551    GDRN01063550    GDRN01063549    JAI64965.1    AJWK01019616    NWSH01001832    PCG69967.1    KB030575    ELK14418.1    GFDF01002845    JAV11239.1    LK023386    CDS14534.1    GG698478    EGD93011.1    KK852730    KDR17511.1    LS990928    VAX57769.1    KV424479    KZV74510.1    CP014584    ANZ74196.1    KY747497    ASK51348.1    LGUA01000010    OAX85408.1    AQIA01016515    KC469893    AGC92695.1    JSUE03010009    QRBI01000134    RMC02287.1    CM001264    EHH21846.1   
Proteomes
UP000141072    UP000000858    UP000000859    UP000241813    UP000130745    UP000101090    + More
UP000108903    UP000110401    UP000117635    UP000142390    UP000266411    UP000000624    UP000105860    UP000000861    UP000007266    UP000053454    UP000001359    UP000015103    UP000007819    UP000009192    UP000217199    UP000007151    UP000192247    UP000192223    UP000215902    UP000095280    UP000244773    UP000002669    UP000077315    UP000007799    UP000224634    UP000245584    UP000014071    UP000077521    UP000078113    UP000007431    UP000054886    UP000002428    UP000027586    UP000224854    UP000008673    UP000005640    UP000001519    UP000001357    UP000005226    UP000092461    UP000218220    UP000010552    UP000009172    UP000027135    UP000077086    UP000261500    UP000248484    UP000094565    UP000233120    UP000217428    UP000091918    UP000233080    UP000006718    UP000001811   
PRIDE
P0C8G2    P0C8G1    P42490    G5E9E9   
Pfam
PF02223   Thymidylate_kin
PF00183   HSP90
Interpro
IPR039430   Thymidylate_kin_like_dom
IPR027417   P-loop_NTPase
IPR018095   Thymidylate_kin_CS
IPR018094   Thymidylate_kinase
IPR037196   HSP90_C
IPR020575   Hsp90_N
IPR036890   HATPase_C_sf
IPR001404   Hsp90_fam
IPR003594   HATPase_C
IPR020568   Ribosomal_S5_D2-typ_fold
SUPFAM
SSF52540   SSF52540
SSF55874   SSF55874
SSF54211   SSF54211
SSF110942   SSF110942
Gene 3D
1.20.120.790     3.30.565.10    
CDD
cd00075  HATPase_c
ProteinModelPortal
E0WMH3   A0A2X0RUU2   P0C8G2   P0C8G1   A0A0N6WHZ1   A9JKX1   + More
D4I5M3   A9JLM6   A0A0A1E300   P42490   A0A0C5AZC7   P0C8F9   A0A2Z5DGC8   D6WW08   A0A1Y3BL63   C4WTA6   A0A0L8HLB6   A0A0L8G043   Q91FS1   A0A0P4VS64   T1HFS6   R4FN90   A0A0V0GB06   A0A2H8TXE8   J9K470   A0A023F7Z7   A0A224XKB1   A0A3M7QN55   A0A069DQQ3   B4KNS9   A0A286UJZ7   A0A212EPA4   V5GJC1   A0A1V9XDP3   A0A1W4XS65   A0A267HA90   A0A1I8GGD6   A0A3P3YJU7   A0A267DTH8   A0A2P0VN24   E4URU8   A0A163EG61   A0A1Q2YEY2   V8NMQ6   A0A0H5QIM5   F2UA04   A0A2B7Z168   G5E3F1   A0A1B6EFI8   A0A2U3CHU8   R9PAR2   A0A177TS54   A0A177UW63   D8Q2T6   A0A0W0CHT6   Q6FSB3   A0A068S3V0   A0A2H1VL46   A0A2C5ZA62   A0A1I8HW21   A0A0F7Z299   W1QBD2   D8Q2T3   A0A2D4FVS7   D0AB90   A0A2J8IPB7   A0A2J8RPT4   G5E9E9   G3QFV9   A0A1B6K446   A9UNQ0   A0A2G9Z0Z9   A0A1E3NPC9   H2TXQ6   A0A212CGJ5   A0A0P4WLI0   A0A1B0CN11   A0A2A4JCZ2   L5KUE7   A0A1L8DXV4   A0A077X4V8   F2RNV5   A0A067REX9   A0A3F2Y7Z2   A0A166JFD7   A0A3B3U8P7   A0A2Y9SP80   A0A1B2J889   A0A3P8TZ48   A0A2K6B2U5   A0A220T6K7   A0A1B7P8T1   A0A2K5TJ98   A0A2K5KA98   L7X3W4   F7H337   G1SQ07   A0A3M0K5D9   G7N9E6  
PANTHER
PTHR11528  
PDB
1E9F     E-value=3.06859e-12,     Score=171

Ontologies

KEGG
vg:22220417     vg:1733213    
GO
GO:0004798  F:thymidylate kinase activity
 GO:0006235  P:dTTP biosynthetic process
 GO:0005524  F:ATP binding
 GO:0016301  F:kinase activity
 GO:0006233  P:dTDP biosynthetic process
 GO:0009041  F:uridylate kinase activity
 GO:0004550  F:nucleoside diphosphate kinase activity
 GO:0006227  P:dUDP biosynthetic process
 GO:0005737  C:cytoplasm
 GO:0005739  C:mitochondrion
 GO:0005634  C:nucleus
 GO:0005829  C:cytosol
 GO:0051082  F:unfolded protein binding
 GO:0006457  P:protein folding
 GO:0071363  P:cellular response to growth factor stimulus

Subcellular Location

From MSLVP
Single-Pass Membrane

Topology

Length:
236
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.23656
Exp number, first 60 AAs:
0.00033
Total prob of N-in:
0.02906
outside
1  -  236
 
 

Population Genetic Test Statistics

Pi
0.081592
Theta
0.0932965
Tajima's D
-0.5155585
CLR
0.138611
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
 AKO62717.1
China_AnhuiXCGQ_2018 Protein
 AYW34007.1
China_ASFV-SY18_2018 Protein
 AKO62717.1
Poland_Pol16_20186_o7_2016-2017 Protein
 AXZ95812.1
Poland_Pol16_20538_o9_2016-2017 Genetic Remain
 CAN10134.1
Poland_Pol16_20540_o10_2016-2017 Genetic Remain
 CAN10134.1
Poland_Pol16_29413_o23_2016-2017 Genetic Remain
 CAN10134.1
Poland_Pol17_03029_C201_2016-2017 Protein
 AXZ96000.1
Poland_Pol17_04461_C210_2016-2017 Protein
 AXZ96095.1
Poland_Pol17_05838_C220_2016-2017 Genetic Remain
 CAN10134.1
Poland_ASFV_POL_Podlaskie_2015 Genetic Remain
 CAN10134.1
Uganda_R8_2015    
Uganda_R7_2015    
Uganda_R25_2015    
Uganda_N10_2015    
Uganda_R35_2015    
Estonia_2014 Protein
 SPS73458.1
Italy_26544_OG10_2010 Protein
 AJZ77121.1
Italy_47_Ss_2008_2008 Protein
 AOO54362.1
Portugal_OURT_88.3_1988 Protein
 CAN10383.1
Spain_E75_1975 Protein
 CBH29136.1
Russia_Georgia_2007 Protein
 CBW46701.1
Kenya_Tk1_2005    
Kenya_Bus_2006 Protein
 AJL34215.1
Russia_Odintsovo_2014 Genetic Remain
 CAN10134.1
Portugal_L60_1960 Protein
 AIY22226.1
Portugal_NHV_1968 Protein
 AIY22385.1
Russia_Kashino_2013 Genetic Remain
 CAN10134.1
Benin_1997 Protein
Protein
 CAN10134.1
CAN10134.1
South_Africa_KNP_Pretorisuskop_1996 Genetic Remain
 CAN10134.1
South_Africa_MGR_Mkuzi_1979 Protein
 CAN10134.1
Malawi_Lil_1983 Protein
 CAN10134.1
Kenya_1950    
Namibia_Warthog_1980 Genetic Remain
 CAN10134.1
South_Africa_Warmbaths_1987 Protein
 CAN10134.1
Malawi_Tengani_1962 Protein
 CAN10134.1
China_HLJ_2018 Protein
 QBH90523.1
China_LN_2018 Protein
 QBH90708.1
China_wbBS01_2018 Protein
 QDL88066.1
Ukraine_Kyiv_2014 Protein
 QED21592.1
Belgium_Etalle_wb_2018 Protein
 QED90478.1
Lithuania_LT14_2014 Protein
 QEY87841.1
South_Africa_1985 Genetic Remain
 CAN10134.1
South_Africa_2_2008 Protein
 CAN10134.1
Zambia_LIV_1983 Genetic Remain
 CAN10134.1
Copyright@ 2018-2023    Any Comments and suggestions mail to:  zhuzl@cqu.edu.cn, mg@cau.edu.cn   渝ICP备19006517号

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