Strain

South_Africa_2_2008 (Region: South Africa;  Strain: RSA_2_2008;  Date: 2008)

Gene

pEP153R

Description

Annotated in NCBI,  EP153R

Location

MN336500.1(+):71975-74410

GenBank Accession

QGM12837.1

Full name

Lectin-like protein EP153R       + More

CDS

ATGTATTTTACGAAAAAGTACATCGGTCTTATTGTTACGAACTGTGCAAAAAAAATATTACATGTTTGTACTACAATACAAATTTGTTACATATTATTTGGAATATTGTTTGGAACTATTATGTTATCTCTTATTTATATTTTCATATTTTGGGAGAATTATATACAATGTTACCGAAATATTGTTACAATGTTTTACTGTCCTATTGTTTGGGTTGGATATATTATTGTTTGTTACTATTTTACTATTGGTACTTTTTCTACAAATTATACAGCTGCTACTATTTCTTGTATACAATTATATACTACACTTGCTATTATTGTTACTATTTTATTATATCTATCTACAATATATATTATTCAATCTATGTATTGGGTTATCAATTCTATATTATGTCAATATATATTACAACATATGTATTACTATATTTGGACAAAAAAATTATTTACACAGTACAACTATTACAATCTGTTGTTTCCCCAACTATTACATATATTTGTACTATTTCTTTATTATCATGTACAAATATTATTGGGACAAATGTTATTATATATTTATTTATTATTATTACAATTGTTATTATTACTATTGGAGATATCCTTATTTATTATTGGAATGGTATTATTATTTTTACAGCTACATGTATGTTTATTATTACAATTACTTCATTGTATGCAACAGAAAATATATATTGTACTTATCCAATATTACATTCATATCAAAATTATTTTACAATATTTATACATTATTTTATATCATATTTTTTATTGTGTGTGGATTATTATTACGTATTTTTATTTCAATCATATCTGTATTGTCTATACGAAGAAAAAGAAAAACCCATGCAGAAATACAAAGTCCACCACCATCTGTATCTATTGCAGAAGACATTTCTCATCATGTCACCACTTCCATACATGTACCATCTCCCAGAGAGCCATTACTTCCTATACCATATACTCGTTATCAGTATATTACACCTATTTACTACATGCGTCCCTCAACACAACCACTCAATCCATTTCCCCTACCTATACCGTGTCCTCCACCTATACCGTGCCCGCCACCCAAACCATGCCCGCCACCTATACCATGTCCTCCACCTATACCGTGCCCGCCACCCAAACCATGCCCGCCACCTATACCATGTCCTCCACCTATACCATGTTCTTCACCTGTATCATATTCTCCACCCAAACCACTACCTACTATCCCGCTGCTACCCAATATCCCGCCATTATCTACACAAAATATTTCGCTTATTCATGTACATACAATTATTTAATCTTTCAAGCTGGTCTTCATTTAAATTTAAAATCCACTAATAAAAAATGTATTTTCTACTACCAGATCATCGAGAACATCATGTGTTTCCTTTTCTTACAACCGATTTTCATCACATGCATCAAAATCCTATACAAAAAAATCAAGCTCCCCTACAAATCAAGCAGCTTTTTACCGGAGATTATCTCATCTGCAAAAGCCCTTCCACGATTCTGGCCTGTATTGTACGAAAAACCTACAAAGACTTTGCGGCTTCTTTGCAAGATGGACGTTATACAAATCGCCAAAAAATGCTATCGCTGCGAGAACAAACCAACTGTCAACTTTATTTTTTTGTACAAGGCCCGGCATTTCCTAACCCTCAAAAAAAAATTATTCACATTGCCTATGCAAGCATTATTACTGCTATGTCGCATCTTATGGTTACAGATCATATGTTTGTCATTCAAACGAAAAATGTGGCCCACAGTTCCCAAAAGCTTGTGCAGCTTTTTTATGCCTTTTCTATGGAAATGGTGTGCGTCGTTCCCACCTCCCTCACCCCCACGGATGCAGAGCTATGCACCAAGCTATGGTCTTCTCTTTCTGGTATTTCAGGCGTGTTACGTACAATCTTGGCAAACACTTGTTCCGTACCTCATTTGGTTACTGGAAAGCTTTCATCGCAGAATATTGTTCAGTTACAAACCCCCTCCAACCGGCCATTCCCCAAAAAAGTACAACGTATGCTTATATGCATTACCAAAGGAAATACAGAGTTACAAATACAATTGCTCTCGGGGGTTCCCAATATCGGGAAAAAATTACCTGCCGAAATTTTACAAGATCATGCGCTTCTTTTTTTTCTATATCAGCCCGTACAATGCTTGGCAAATATACAAATCGCTCAAAAAACCCGTACGATTATGTTGGGAATGCAGCGAGCCGAAGCGATTCATTATTTTTTATACTGGTGTGGGTCTGTCCATGTATCCGATGTTACCCAAAATATCACAAAGACGTCGCGGCCCACAATGCAGGTCGCGACGCAGCCCGCTGCAACGCAGCCCATTGCACGAAGTATCAGATGATGCATCATCTAATGCATCAGATGCTTCATCACCCACAGGGCATCAAACATTATCTAAAGAAATGCCATTGAACACAGCCTGA

Protein

MYFTKKYIGLIVTNCAKKILHVCTTIQICYILFGILFGTIMLSLIYIFIFWENYIQCYRNIVTMFYCPIVWVGYIIVCYYFTIGTFSTNYTAATISCIQLYTTLAIIVTILLYLSTIYIIQSMYWVINSILCQYILQHMYYYIWTKKLFTQYNYYNLLFPQLLHIFVLFLYYHVQILLGQMLLYIYLLLLQLLLLLLEISLFIIGMVLLFLQLHVCLLLQLLHCMQQKIYIVLIQYYIHIKIILQYLYIILYHIFYCVWIIITYFYFNHICIVYTKKKKNPCRNTKSTTICIYCRRHFSSCHHFHTCTISQRAITSYTIYSLSVYYTYLLHASLNTTTQSISPTYTVSSTYTVPATQTMPATYTMSSTYTVPATQTMPATYTMSSTYTMFFTCIIFSTQTTTYYPAATQYPAIIYTKYFAYSCTYNYLIFQAGLHLNLKSTNKKCIFYYQIIENIMCFLFLQPIFITCIKILYKKIKLPYKSSSFLPEIISSAKALPRFWPVLYEKPTKTLRLLCKMDVIQIAKKCYRCENKPTVNFIFLYKARHFLTLKKKLFTLPMQALLLLCRILWLQIICLSFKRKMWPTVPKSLCSFFMPFLWKWCASFPPPSPPRMQSYAPSYGLLFLVFQACYVQSWQTLVPYLIWLLESFHRRILFSYKPPPTGHSPKKYNVCLYALPKEIQSYKYNCSRGFPISGKNYLPKFYKIMRFFFFYISPYNAWQIYKSLKKPVRLCWECSEPKRFIIFYTGVGLSMYPMLPKISQRRRGPQCRSRRSPLQRSPLHEVSDDASSNASDASSPTGHQTLSKEMPLNTAX

Function

Participates to viral hemadsorption, which may help viral spread (PubMed:10639320). Reduces the transactivating activity of host TP53, thus inhibiting apoptosis (PubMed:15262504). Non-essential for virus growth in swine macrophage cell cultures (By similarity).
Participates to viral hemadsorption, which may help viral spread. Reduces the transactivating activity of host TP53, thus inhibiting apoptosis (By similarity). Non-essential for virus growth in swine macrophage cell cultures (By similarity).
Participates to viral hemadsorption, which may help viral spread. Reduces the transactivating activity of host TP53, thus inhibiting apoptosis (By similarity). Non-essential for virus growth in swine macrophage cell cultures (PubMed:10573162).

Similarity

Belongs to the asfivirus lectin-like protein family.

Keywords

Complete proteome   Glycoprotein   Host membrane   Host-virus interaction   Lectin   Membrane   Modulation of host cell apoptosis by virus   Reference proteome   Signal-anchor   Transmembrane   Transmembrane helix   Late protein  

Feature

chain  Lectin-like protein EP153R

Uniprot

O89333   O89336   Q8JSP0   A9JL06   D4I5P5   Q77Z14   + More
Q65150   O89332   A0A0C5B248   A0A0C5B2I5   O89335   A0A0A7W6V6   A0A0A7W6T2   O89329   O89334   P0CA64   Q4TZL7   O89331   A0A0A7W576   A0A0A7W4Q4   A0A0A7W4S6   A0A0A7W6S0   A0A0A7W520   O89337  

Pubmed

10573162    19729182    18198370    25406173    25524164    26618713    + More
11831707    10639320    15262504    25645905   

EMBL

AF017034    AAC28419.1    AF017037    AAC28422.1    AF481876    AAM90853.1    + More
AM712239    CAN10157.1    FN557520    CBH29158.1    AF017030    AF017031    AF017032    AY463913    AY463915    AY463916    DQ026264    DQ026266    DQ026267    DQ026268    DQ026269    DQ026270    KM262844    KM609334    KM609337    KM609350    KM609351    KM609352    KM609355    KM102979    KP055815    KX354450    AAC28417.1    AAS45763.1    AAY44916.1    AAY44920.1    AAY44922.1    AAY44925.1    AAY44926.1    AAY44928.1    AIY22248.1    AJB28357.1    AJB28363.1    AJB28385.1    AJB28387.1    AJB28389.1    AJB28393.1    AJZ77151.1    AKO62739.1    AOO54389.1    U18466    AF017033    AAC28418.1    KM111294    AJL34071.1    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34236.1    AXB49286.1    AXB49460.1    AXB49632.1    AXB49803.1    AXB49976.1    AY261363    AF017036    AF050111    KM609361    AJB28404.1    KM609340    KM609343    KM609344    KM609345    AJB28367.1    AJB28372.1    AJB28374.1    AJB28376.1    AF017027    AAC28412.1    AF017035    KM609354    AAC28420.1    AJB28391.1    AY261361    DQ026265    AAY44918.1    AF017029    AAC28414.1    KM609346    KM609347    AJB28377.1    AJB28379.1    KM609336    AJB28361.1    KM609348    AJB28381.1    KM609335    AJB28359.1    KM609359    AJB28400.1    AF017038    AAC28423.1   

Proteomes

UP000130745    UP000101090    UP000117635    UP000142390    UP000241813    UP000266411    + More
UP000000624    UP000105860    UP000101566    UP000000859    UP000000860   

PRIDE

Q65150   

Pfam

PF05473   UL45

Interpro

IPR016187   CTDL_fold
IPR008646   Herpes_UL45-like
IPR016186   C-type_lectin-like/link_sf

SUPFAM

SSF56436   SSF56436

Gene 3D

3.10.100.10     3.10.100.10    

ProteinModelPortal

O89333   O89336   Q8JSP0   A9JL06   D4I5P5   Q77Z14   + More
Q65150   O89332   A0A0C5B248   A0A0C5B2I5   O89335   A0A0A7W6V6   A0A0A7W6T2   O89329   O89334   P0CA64   Q4TZL7   O89331   A0A0A7W576   A0A0A7W4Q4   A0A0A7W4S6   A0A0A7W6S0   A0A0A7W520   O89337  

PDB

6G4G     E-value=1.20922,     Score=77