Strain

Zambia_LIV_1983 (Region: Zambia;  Strain: LIV_5_40;  Date: 1983)

Gene

pEP153R

Description

Annotated in NCBI,  EP153R

Location

MN318203.1(+):70329-70655

GenBank Accession

QGM12719.1

Full name

Lectin-like protein EP153R      

CDS

ATGTTTTCTATCAAAAAGTACATACGTCTTATTGTCAAGTACTGTGCAAAAAAAATATTACATGTTTCTACTACAATACAAATTTGTTACATATTATTTGGAATATTATTCGGAACTATTATGTTATCTCTTATTTATATTTTCATATTTTGGGATATTTATATACAATGTATCCAAAATGTTGTTATATTGTTTTACTGTCCTATACATTGGGTTGGATATATTATTGTTTGTTATTATTTTACTATTACTATTGTTGCAAAAAATTATATGTATGCAAGTATTTATTGTATTACAAAAAATACCACGCTTGCTATTATTACATAA

Protein

MFSIKKYIRLIVKYCAKKILHVSTTIQICYILFGILFGTIMLSLIYIFIFWDIYIQCIQNVVILFYCPIHWVGYIIVCYYFTITIVAKNYMYASIYCITKNTTLAIIT

Function

Participates to viral hemadsorption, which may help viral spread (PubMed:10639320). Reduces the transactivating activity of host TP53, thus inhibiting apoptosis (PubMed:15262504). Non-essential for virus growth in swine macrophage cell cultures (By similarity).
Participates to viral hemadsorption, which may help viral spread. Reduces the transactivating activity of host TP53, thus inhibiting apoptosis (By similarity). Non-essential for virus growth in swine macrophage cell cultures (PubMed:10573162).
Participates to viral hemadsorption, which may help viral spread. Reduces the transactivating activity of host TP53, thus inhibiting apoptosis (By similarity). Non-essential for virus growth in swine macrophage cell cultures (By similarity).

Similarity

Belongs to the asfivirus lectin-like protein family.

Keywords

Complete proteome   Glycoprotein   Host membrane   Host-virus interaction   Lectin   Membrane   Modulation of host cell apoptosis by virus   Reference proteome   Signal-anchor   Transmembrane   Transmembrane helix   Late protein  

Feature

chain  Lectin-like protein EP153R

Uniprot

A0A0A7W6T2   A0A0C5B248   O89332   O89329   A0A0C5B2I5   O89336   + More
A0A0A7W576   Q8JSP0   A9JL06   D4I5P5   Q77Z14   Q65150   O89334   P0CA64   A0A0A7W6V6   O89333   O89331   A0A0A7W4Q4   A0A0A7W6S0   A0A0A7W4S6   O89335   Q4TZL7   A0A0A7W520   O89337  

Pubmed

25524164    25645905    10573162    19729182    18198370    25406173    + More
26618713    11831707    10639320    15262504   

EMBL

KM609340    KM609343    KM609344    KM609345    AJB28367.1    AJB28372.1    + More
AJB28374.1    AJB28376.1    KM111294    AJL34071.1    AF017033    AAC28418.1    AF017027    AAC28412.1    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34236.1    AXB49286.1    AXB49460.1    AXB49632.1    AXB49803.1    AXB49976.1    AF017037    AAC28422.1    KM609346    KM609347    AJB28377.1    AJB28379.1    AF481876    AAM90853.1    AM712239    CAN10157.1    FN557520    CBH29158.1    AF017030    AF017031    AF017032    AY463913    AY463915    AY463916    DQ026264    DQ026266    DQ026267    DQ026268    DQ026269    DQ026270    KM262844    KM609334    KM609337    KM609350    KM609351    KM609352    KM609355    KM102979    KP055815    KX354450    AAC28417.1    AAS45763.1    AAY44916.1    AAY44920.1    AAY44922.1    AAY44925.1    AAY44926.1    AAY44928.1    AIY22248.1    AJB28357.1    AJB28363.1    AJB28385.1    AJB28387.1    AJB28389.1    AJB28393.1    AJZ77151.1    AKO62739.1    AOO54389.1    U18466    AF017035    KM609354    AAC28420.1    AJB28391.1    AY261361    KM609361    AJB28404.1    AF017034    AAC28419.1    AF017029    AAC28414.1    KM609336    AJB28361.1    KM609335    AJB28359.1    KM609348    AJB28381.1    AY261363    AF017036    AF050111    DQ026265    AAY44918.1    KM609359    AJB28400.1    AF017038    AAC28423.1   

Proteomes

UP000105860    UP000101566    UP000130745    UP000101090    UP000117635    UP000142390    + More
UP000241813    UP000266411    UP000000624    UP000000860    UP000000859   

PRIDE

Q65150   

Pfam

PF05473   UL45

Interpro

IPR016186   C-type_lectin-like/link_sf
IPR016187   CTDL_fold
IPR008646   Herpes_UL45-like

SUPFAM

SSF56436   SSF56436

Gene 3D

3.10.100.10    

ProteinModelPortal

A0A0A7W6T2   A0A0C5B248   O89332   O89329   A0A0C5B2I5   O89336   + More
A0A0A7W576   Q8JSP0   A9JL06   D4I5P5   Q77Z14   Q65150   O89334   P0CA64   A0A0A7W6V6   O89333   O89331   A0A0A7W4Q4   A0A0A7W6S0   A0A0A7W4S6   O89335   Q4TZL7   A0A0A7W520   O89337  

PDB

6G4G     E-value=1.20922,     Score=77