ASFVdb The African Swine Fever Virus Database
Strain
Ukraine_Kyiv_2014 (Region: Ukraine;  Strain: ASFV/Kyiv/2016/131;  Date: 2014)
Gene
CP2475L
Description
Annotated in NCBI,  ASFV_Kyiv_2016_131_00148
GenBank Accession
Full name
Polyprotein pp220      
Alternative Name
220 kDa polyprotein
 

Sequence

CDS
ATGTACAATGAAAATACTTTTGGTGGAGTTAATCTTATTAGCGAGAACAGAGACGATAAACCCATTATAACAGCGGGAATAGGGATGAATGCAGTGTATTCGCTTCGTAAAACATTGCAAGACGTAATTTCCTTCGTGGAAAGCTCTTACCAAGAGGAGCAAATCAATCATATTCACAAAATAGTGTCGCCGAAAGGTCAAACACGCACTCTTGGCTCTAATAGAGAGCGCGAGCGCATATTTAACTTGTTTGATATGAATATTATACCTATCAATGTAAATGCGCTGATGCGATCTATACCACTTGCCAATATTTACAACTATGACTATAGTTTTGAAGAAATTGCTTGTCTTATGTACGGCATTTCGGCTGAAAAAGTACGATCTCTGGACACCACGGCTCCTCAACCAGATGTTGCAGAGGTATTAAACATTCCGAATCGTCCCCCCATAAATACTCGAGAATTTATGCTAAAACTTCTTATAAACCCCTATGTCTCGGTCTCTATTACTCAATATGGGAATGAGTTACTATCCAAAGGCAACGCCGGATACATGTCACGCATCTTTAGAGGGGACAACGCGCTAAATATGGGCCGCCCTAAATTTCTTTCTGACCAAATTTTCAATAAAGTGCTATTTGGAAGCCTTTATCCTACACAATTTGATTATGACGAGGCAGGTCCTAGTTTGGCCGCAGGTATTCAACGTGGACGTGAGCGGTGGGGCCATCCCATGTCAATATACATAAACCAGGCCTTACATGAAATTGTGCGTACTATACGATTGGCTGAAACAGTTCGAGGTTTAAGAAATGTTATTGATAGAAACCAAATTATAGGCGAGTTAAATGCATTTAGGACTCAGCTTGAAGATACACGAAGAGAAGTGAATAATCTAATACAAACACCTGAAATTCAAAACAATCCAACCCCTGAGATCATCGCTGCCATTCAAAACTGGGTACAACAATATCGAGGTCAAATAACCAATTTAATCGATCTTATAGGAAATGCCGGGCAAGCCAATTCGATGATAAATTTAATACAAAATATTACGCCCCAAACAGCCGGTGCACAATTAACCGCTTTATTCAACATACGTGGATTACCTGCCCCGCCTCCCCGTCAAGCATTACAAAATGATATTGAAGCAATGCAATGGTTTATGACAATGGTTATAAACCATCCACCTGTTTTAATAGCACCCTTCATGCTACTCGTAAATAACCTTAAGGAATTTTTAAATACGCTAGAACGATATGTTTATAAAACTCCACGATGGTTGGGTCCCGGTACAGCCCGAATTGCACAACCGCCAGTTGGAATGGCACCAGGTATTAATATGCGACATCATACCTCATATACAGAAAATAGTGTGCTGACCTATATCACGGAACAAAATCGGGAAGAAGGACCCTGGTCCATCGTTAAACAAGTGGGAGTTGGAATACAAAAGCCCACCTTAGTACAAATTGGAAAGGATCGCTTTGACACTCGCCTCATACGCAATCTAATATTTATTACAAATATACAGCGACTATTACGACTGCGTCTAAACCTAGAACTCTCGCAGTTCAGAAATGTGCTTGTCAGTCCTGACCACATTATAAACCCCAGCATTACAGAGTATGGGTTCTCCATCACAGGACCCAGTGAGACCTTCTCAGATAAACAGTATGATAGTGATATTCGGATTTTATAA
Protein
MYNENTFGGVNLISENRDDKPIITAGIGMNAVYSLRKTLQDVISFVESSYQEEQINHIHKIVSPKGQTRTLGSNRERERIFNLFDMNIIPINVNALMRSIPLANIYNYDYSFEEIACLMYGISAEKVRSLDTTAPQPDVAEVLNIPNRPPINTREFMLKLLINPYVSVSITQYGNELLSKGNAGYMSRIFRGDNALNMGRPKFLSDQIFNKVLFGSLYPTQFDYDEAGPSLAAGIQRGRERWGHPMSIYINQALHEIVRTIRLAETVRGLRNVIDRNQIIGELNAFRTQLEDTRREVNNLIQTPEIQNNPTPEIIAAIQNWVQQYRGQITNLIDLIGNAGQANSMINLIQNITPQTAGAQLTALFNIRGLPAPPPRQALQNDIEAMQWFMTMVINHPPVLIAPFMLLVNNLKEFLNTLERYVYKTPRWLGPGTARIAQPPVGMAPGINMRHHTSYTENSVLTYITEQNREEGPWSIVKQVGVGIQKPTLVQIGKDRFDTRLIRNLIFITNIQRLLRLRLNLELSQFRNVLVSPDHIINPSITEYGFSITGPSETFSDKQYDSDIRIL

Summary

Function
Polyprotein pp220 is essential for the core assembly. Its myristoyl moiety may function as a membrane-anchoring signal to bind the developing core shell to the inner viral envelope (By similarity).
The structural protein p34 is a component of the virus core shell.
The structural protein p14 is a component of the virus core shell.
The structural protein p37 is a component of the virus core shell.
The structural protein p150 is a component of the virus core shell.
Similarity
Belongs to the asfivirus polyprotein pp220 family.
Keywords
Coiled coil   Complete proteome   Host cytoplasm   Host nucleus   Late protein   Lipoprotein   Myristate   Reference proteome   Virion  
Feature
chain  Polyprotein pp220
PDB
6OGE     E-value=0.502924,     Score=85

Ontologies

KEGG

Subcellular Location

From MSLVP
Capsid
From Uniprot
  
Virion  
Host cytoplasm  
Host perinuclear region  
Host nucleus  

Topology

Length:
567
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.73661
Exp number, first 60 AAs:
0.00556
Total prob of N-in:
0.00623
outside
1  -  567
 
 

Population Genetic Test Statistics

Pi
0.092367
Theta
0.0762557
Tajima's D
0.2931673
CLR
0.699687
Interpretation
Possibly Balancing Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62773.1
China_AnhuiXCGQ_2018 Protein
AYW34063.1
China_ASFV-SY18_2018 Protein
AKO62773.1
Poland_Pol16_20186_o7_2016-2017 Protein
AXZ95866.1
Poland_Pol16_20538_o9_2016-2017 Protein
AJL34270.1
Poland_Pol16_20540_o10_2016-2017 Genetic Remain
AJL34270.1
Poland_Pol16_29413_o23_2016-2017 Genetic Remain
AJL34270.1
Poland_Pol17_03029_C201_2016-2017 Protein
AXZ96054.1
Poland_Pol17_04461_C210_2016-2017 Protein
AXZ96149.1
Poland_Pol17_05838_C220_2016-2017 Genetic Remain
AJL34270.1
Poland_ASFV_POL_Podlaskie_2015 Genetic Remain
AJL34270.1
Uganda_R8_2015 Protein
AXB49320.1
Uganda_R7_2015 Protein
AXB49494.1
Uganda_R25_2015 Protein
AXB49666.1
Uganda_N10_2015 Protein
AXB49837.1
Uganda_R35_2015 Protein
AXB50010.1
Estonia_2014 Protein
SPS73515.1
Italy_26544_OG10_2010 Protein
AJZ77038.1
Italy_47_Ss_2008_2008 Protein
AOO54441.1
Portugal_OURT_88.3_1988 Protein
CAN10441.1
Spain_E75_1975 Protein
CBH29192.1
Russia_Georgia_2007 Protein
CBW46758.1
Kenya_Tk1_2005 Protein
AJL34105.1
Kenya_Bus_2006 Protein
Protein
AJL34270.1
AJL34270.1
Russia_Odintsovo_2014 Genetic Remain
AJL34270.1
Portugal_L60_1960 Protein
AIY22283.1
Portugal_NHV_1968 Protein
AIY22441.1
Russia_Kashino_2013 Genetic Remain
AJL34270.1
Benin_1997 Protein
CAN10191.1
South_Africa_KNP_Pretorisuskop_1996 Genetic Remain
AJL34270.1
South_Africa_MGR_Mkuzi_1979 Genetic Remain
AJL34270.1
Malawi_Lil_1983 Protein
AJL34270.1
Kenya_1950 Protein
AJL34270.1
Namibia_Warthog_1980 Genetic Remain
AJL34270.1
South_Africa_Warmbaths_1987 Genetic Remain
AJL34270.1
Malawi_Tengani_1962 Genetic Remain
AJL34270.1
China_HLJ_2018 Protein
QBH90580.1
China_LN_2018 Protein
QBH90765.1
China_wbBS01_2018 Protein
QDL88123.1
Ukraine_Kyiv_2014 Protein
Protein
Protein
QED21684.1
QED21685.1
QED21686.1
Belgium_Etalle_wb_2018 Protein
QED90535.1
Lithuania_LT14_2014 Protein
QEY87898.1
South_Africa_1985    
South_Africa_2_2008    
Zambia_LIV_1983    
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