Strain

Ukraine_Kyiv_2014 (Region: Ukraine; Strain: ASFV/Kyiv/2016/131; Date: 2014)

Gene

hypothetical protein ASFV_Kyiv_2016_131_00059

Description

Annotated in NCBI, ASFV_Kyiv_2016_131_00059

Location

MN194591.1(-):52144-54678

GenBank Accession

QED21595.1

Full name

Probable helicase A859L + More
Helicase ATP-binding domain-containing protein

CDS

ATGACCACCAATCCTGTCTTTATTGCAAAACGGATACGGGAGGCCCCTTCTCTTCTTGTGATTGCCACCTACCAATCCTCCACGCTACTGGTGGATGATTTCGATCTTATTATTAGCGATGAATGTCACCGGATTTGCGGCGAATGGGAGACACGGCCCTTTACCCACGTGTTGCTCAACTTTAAAAAAGGGCACCGACTTTTTTTAACGGCAACGCCCAGGTACGACACCCCGCTTTCCATGAAAAATCGTGAACTTTTTGGCGGCGTTGCCTTTCGCTACTATCTGCGAGAAGGCATAGAGGCCGGCTATGTAAATGATTTTGAATTGCAGATGGTAGCCGCGCCTAAATTGGCCCACCAACCGAGTACCAAAGAGGAGACCACGAAACAGATCATAGTAAAGCAAATTATAATGGCCTTAGCCTATTTAAAAACCAATATACCGGCTCCTAAAATGCTGGTATTTACCCGTGATATTAAACAGGCCAAGGAGCTATACGCGGCGTTGGTAGACCAAGGGGTCTATGCCCTGATAGCTCACTCAACCCTGCCGCGACAGGTTATCCTCAAAACATTTACAGAATTTTGTTCCTCAAAGGAACCCGTTATTTTATTAAACTGTCGACTCTTTCAAGAGGGCGTAGAGGTTCCAGAACTAAACGCGGTATTTTTTGCAGCGCCGCGACATAGTCCTAGAGACATTATTCAAAGCATATGCAGACCGCTGAACAAGCAGGTTCAAAAGCCTCACGCAACCATTTTTCTACCTTTAGAAGTAAACACAGAAAACGTATGTCTAGACAGGTTTTCTAGCATTATCCCCTTTGCAGACGCCTTGGCATCTGAAGATCCACGCTTTTACGAGCATCTTTTAAACCCTTCGGAGGTTGCCTATCCGATAAACTGGATCGGGGCCCACGGATCGGTGTCAGAATTGTTGCAATTGGCACGACATGCCATACGCTATGGCACGCAGGGCAAAATAGACCGTCTTACCCGCAGCGAAAGACTTCCTTGGAAGGCCGCTTTTGCAGAACTCAAACGTACGGTTGAAATATGTTGCAGATATCCTAAAATCAACGACGGCTTTCACTTTGGAGGCGCCACGCTGCGGTTCGACACATGGTATAAATGGGTCATTAAATCTTATTTGCAGTACAAAAACAAGGAACCGTCTTCTTTAGAGCCTTACCAGGTGTCGGACCTGGAGTCCTTGCAAGATTGGACAACCCGTGGTGTTGGCGGGCCTTATCCCTGGGAAGAAAGCATGGCATTCTTGGAAACTTGGCTTGCCCAAAATAAAGGAGAGCTTGTTGCCATTGATATTCATCAGGGTGGATGGATAGGATTAGATGCGACGCCCATGGAAAGACTATCAGGCGTCCTAACCACTGTTTCGCAACGCGATGGCCGAAGCTATGGAAAAAATAAAAAGCTTCGACCTAAAAAGGGATTTATGATTCCACCCCAGCAGGCGCAAGATCTTGATCGCATTTTTGGAAAGCACAATCTTAAGTGGAGAAAGGACAGGGTTAATGGCTTTTTAAAGGAAGATGAACATGGAAATTATACCGGTGAGCCTACCTGTATTCAAGAAGCCTATCGGACCTTTAAAGAATACGTAAAAACAAACCCTGAATATATCGAAAAATACTGGCCTGGTTATGCCAAAGGCAAGCATAAACACCAAGAATTACCGCACATATGGGAAAAGGGCCTGGCTCCTCCCCGCTATAAGGCATTTAAAGATGGTAATAAACAGCTTATCCAAAGAAGTCCGAAAAAAAGGACATTAAAAATTAAAGGAGTAAAATCATATAGTGGAGTAGGGGCGACATTCAAAATGGAACACATGTTTCCAGAAAGGGAGATAGAAAACTTGTTTGTTAAATGGATTAAAAAACATATTAGAAATGGGAATCTTACACTATTTGAGGAATTTTTTAAAACAGATCCGTGGATTGTCAATAGATGCGATAAAAATGGATCCTCGGTATTCATGTGGATATGCATCTACGGACGTATAGACTTTTTAAAATTTCTTTTTGAACAAGAATCTTATCCTGGAGAAATAATTAACCCTCATAGGAGGGATAAAGATGGAAACTCTGCTTTACATTATTTAGCTGAGAAAAAAAATCATTTAATCCTGGAAGGGGTGTTGGGCTATTTCGGAAAAAATGGGACCAGAATTTGTTTACCGAATTTTAATGGGATGACTCCTGTGATGAAGGCCGCAATACGGGGCCGTTCTTTAAATATGCTTTCTCTCATAAAATTTGGAGCAGATCCAACTCAAAAAGACTATCATAGAGGTTTTACTGCTTGGGACTGGGCAGTCTTTACAGGAAACATGGAGTTAGTCAAATCTCTTAACCATGACTACCAAAACCTCTCTACATGCATTTCCCTCTTTACAAGCTGGATGTTTTCCACCGGTGGTTTAAGAAAAAGCCCAAAATTATTATTACTGGCTGTAAACATAATGTCTATGAAAAACTTCCTGAACAGAATCCAAAGTTCCTGTGTGTAA

Protein

MTTNPVFIAKRIREAPSLLVIATYQSSTLLVDDFDLIISDECHRICGEWETRPFTHVLLNFKKGHRLFLTATPRYDTPLSMKNRELFGGVAFRYYLREGIEAGYVNDFELQMVAAPKLAHQPSTKEETTKQIIVKQIIMALAYLKTNIPAPKMLVFTRDIKQAKELYAALVDQGVYALIAHSTLPRQVILKTFTEFCSSKEPVILLNCRLFQEGVEVPELNAVFFAAPRHSPRDIIQSICRPLNKQVQKPHATIFLPLEVNTENVCLDRFSSIIPFADALASEDPRFYEHLLNPSEVAYPINWIGAHGSVSELLQLARHAIRYGTQGKIDRLTRSERLPWKAAFAELKRTVEICCRYPKINDGFHFGGATLRFDTWYKWVIKSYLQYKNKEPSSLEPYQVSDLESLQDWTTRGVGGPYPWEESMAFLETWLAQNKGELVAIDIHQGGWIGLDATPMERLSGVLTTVSQRDGRSYGKNKKLRPKKGFMIPPQQAQDLDRIFGKHNLKWRKDRVNGFLKEDEHGNYTGEPTCIQEAYRTFKEYVKTNPEYIEKYWPGYAKGKHKHQELPHIWEKGLAPPRYKAFKDGNKQLIQRSPKKRTLKIKGVKSYSGVGATFKMEHMFPEREIENLFVKWIKKHIRNGNLTLFEEFFKTDPWIVNRCDKNGSSVFMWICIYGRIDFLKFLFEQESYPGEIINPHRRDKDGNSALHYLAEKKNHLILEGVLGYFGKNGTRICLPNFNGMTPVMKAAIRGRSLNMLSLIKFGADPTQKDYHRGFTAWDWAVFTGNMELVKSLNHDYQNLSTCISLFTSWMFSTGGLRKSPKLLLLAVNIMSMKNFLNRIQSSCV

Similarity

Belongs to the asfivirus helicase A859L family.

Keywords

ATP-binding Complete proteome Helicase Hydrolase Nucleotide-binding Reference proteome

Feature

chain Probable helicase A859L

Uniprot

E0WMH8 A0A385KMI0 P0C8H2 P0C8H3 A0A2X0SDV7 A9JKX8 + More
D4I5M8 A9JLN7 A0A0A1E304 Q65143 A0A5B8XA67 P0C8H1 A0A0C5AW97 P0C8H0 A0A0C5AWM3 A0A2Z5DFT6 G0UY07 W6KWA5 A0A3P3ZDB3 A0A088RX71 A0A1E1J2G5 A4HIX1 E9B1F5 A0A3Q8IF99 A0A5K1V5S9 A4I6A0 A0A504WY43 E9BMD0 A0A504X3C3 S9VVA9 K2N7A9 S9VG44 A0A0M9FQI1 A0A2V2V286 Q4Q6Q7 A0A1X0P8K5 A0A2V2UZK3 V5B0I9 Q4CVA8 A0A2V2W8E1 A0A422QAD5 A0A3R7KPC7 Q4D326 A0A3L6KYF2 D0A541 A0A1G4I059 Q389B2 A0A061J8L4 A0A0N1I3J1 S9UAM1 S9U4B4 W6LCV2 G0U3Z4 A0A2K4YAM4 A0A4V2RKV7 A0A552ZIJ3 A0A100ZNW4 A0A260MWW2 A2BTY5 A0A150A2K1 A0A3D9TS91 X7YQE2 A0A498QR07 A0A1A0V3S0 A0A1P8XF02 A0A1A2BD48 A0A0U0W7V0 I0WG10 A0A523YUR4 A0A259XM75 A0A1S1M1F6 A0A0A2ADH2 A0A498PJD7 A0A1A3BPM7 A0A481Z4U3 A0A1U9PGQ8 A0A424HZD6 A0A0D6J306 A0A1X2LFP7 A0A557XC56 A0A260MYB1 A0A238VZB5 A0A4Z0NA41 A0A1X0BPD4 A0A1A3KSX4 A0A1U9PKG7 A0A1T4J0N7 A0A1A3GDI7 A0A1Z8SVB0 A0A424RA97 A0A1A1WE99 A0A2S8KKE5 A0A022LAC5 A0A1T4J0D6 J4JUX8 A0A260PYZ5 A0A0F2P7N8

Pubmed

21470447 18198370 25406173 26618713 11831707 25645905 + More
22331916 24516393 25707621 17572675 22038252 30409989 22038251 23560078 23035642 29708484 16020728 24482508 16020725 30355302 20404998 16020726 26317207 26203337 18159947 26804932 22689233 25977791 30837339 28713657 23661480 21952541

EMBL

FR682468 CBW46706.1 MG939583 MG939587 MG939588 AXZ95816.1 + More
AXZ96004.1 AXZ96099.1 AY261363 AY261366 LS478113 SPS73463.1 AM712239 CAN10139.1 FN557520 CBH29141.1 AM712240 CAN10388.1 KM262844 KM262845 KM102979 KP055815 KX354450 AIY22231.1 AIY22390.1 AJZ77050.1 AKO62722.1 AOO54370.1 U18466 MN194591 QED21595.1 AY261361 KM111294 AJL34054.1 AY261360 KM111295 AJL34219.1 MH025916 MH025917 MH025918 MH025919 MH025920 AXB49269.1 AXB49443.1 AXB49615.1 AXB49786.1 AXB49959.1 HE575323 CCC94274.1 HF955125 CCW65814.1 LS997630 SYZ68202.1 CP009400 AIO00599.1 CALQ01001382 CCM17777.1 FR799006 CAM42427.1 FR799583 CBZ29061.1 CP029530 AYU81185.1 UINB01000031 SUZ44206.1 FR796463 CAM70323.1 RHLD01000005 TPP41621.1 FR799618 CBZ36408.1 RHLC01000006 TPP42773.1 ATMG01010879 EPY27205.1 AHKC01011967 EKF30546.1 ATMG01003987 EPY39939.1 LGTL01000032 KPA74015.1 PRFC01000359 PWU90645.1 FR796427 CAJ08152.1 NBCO01000003 ORC92770.1 PRFA01000058 PWU89540.1 AYLP01000041 ESS66650.1 AAHK01001763 EAN84209.1 PRFC01000144 PWV04781.1 MKKU01000023 RNF26928.1 MKGL01000442 RNE98701.1 AAHK01001120 EAN86926.1 QSBY01000010 RHW69379.1 FN554973 CBH16385.1 CZPT02000209 SCU65038.1 CM000208 EAN78608.1 AUPL01000464 ESL11778.1 LJSK01000007 KPI90361.1 ATMH01009351 ATMH01006855 ATMH01006372 ATMH01002372 ATMH01000607 EPY19648.1 EPY25075.1 EPY25998.1 EPY33256.1 EPY36395.1 ATMH01007630 EPY23604.1 HF955212 CCW71644.1 HE573026 CCC52156.1 FXEG02000002 SOX53839.1 SLVY01000006 TCN53370.1 VKAA01000022 TRW79285.1 LQIL01000001 KUH91864.1 NOZH01000002 OZE43162.1 CP000552 ABM71246.1 LTCZ01000066 KXX60900.1 QTTW01000006 REF15038.1 JANZ01000008 EUA08625.1 UPHU01000001 VBA48749.1 LZSW01000010 OBB77877.1 CP019420 AQA04894.1 LZIF01000074 OBF65975.1 CSTD01000002 CPR10900.1 AJJH01000157 EID75326.1 SOIG01000498 TET95271.1 NOYA01000035 OZC55568.1 MLIS01000001 OHU77030.1 JNAM01000002 KGF98901.1 UPHL01000125 VAZ85581.1 LZKP01000161 OBI75882.1 MK500433 QBK89660.1 CP019882 AQT80276.1 NHBZ02000014 RPF84212.1 LN831039 CKI51574.1 NCXO01000032 OSC32810.1 VMQU01000158 TVS83096.1 OZE43160.1 FZNT01000002 SNR39223.1 SRLQ01000003 TGD89224.1 MVHN01000025 ORA44543.1 LZLK01000077 OBJ87468.1 AQT81508.1 FTQU01000001 SIU03354.1 LZLB01000010 OBJ34102.1 NHCQ01000092 OUU26378.1 NHJG02000010 RPG88344.1 LZHT01000041 OBF05342.1 PUTX01001013 PQP39737.1 AOSR01000043 EYT60945.1 SIU03352.1 AFVW02000004 EJO88062.1 NOZM01000005 OZE68040.1 LADQ01000260 KJS08562.1

Proteomes

UP000141072 UP000000859 UP000000858 UP000130745 UP000101090 UP000108903 + More
UP000110401 UP000117635 UP000142390 UP000241813 UP000266411 UP000000624 UP000321214 UP000000860 UP000105860 UP000000861 UP000101566 UP000007258 UP000007259 UP000274082 UP000255414 UP000008153 UP000318821 UP000008980 UP000318447 UP000000542 UP000002296 UP000002316 UP000008524 UP000015354 UP000236318 UP000295305 UP000320222 UP000054385 UP000216746 UP000001589 UP000075580 UP000257142 UP000268285 UP000092013 UP000188050 UP000091887 UP000198875 UP000006447 UP000216115 UP000179441 UP000030445 UP000279331 UP000092151 UP000189653 UP000196051 UP000062612 UP000193577 UP000320513 UP000198384 UP000297600 UP000192556 UP000093974 UP000190894 UP000093933 UP000196085 UP000196760 UP000092144 UP000239797 UP000019757 UP000006455 UP000216557 UP000050680

PRIDE

P0C8H2 P0C8H3 Q65143 P0C8H1 P0C8H0

Pfam

PF00271   Helicase_C
PF04851   ResIII
PF10544   T5orf172
PF03457   HA
PF13156   Mrr_cat_2
PF18135   Type_ISP_C
PF02384   N6_Mtase

Interpro

IPR018306   Phage_T5_Orf172_DNA-bd
IPR027417   P-loop_NTPase
IPR001650   Helicase_C
IPR014001   Helicase_ATP-bd
IPR006935   Helicase/UvrB_N
IPR036770   Ankyrin_rpt-contain_sf
IPR020683   Ankyrin_rpt-contain_dom
IPR002110   Ankyrin_rpt
IPR005114   Helicase_assoc
IPR011335   Restrct_endonuc-II-like
IPR039442   Mrr-like_dom
IPR002052   DNA_methylase_N6_adenine_CS
IPR041635   Type_ISP_LLaBIII_C
IPR029063   SAM-dependent_MTases
IPR003356   DNA_methylase_A-5

SUPFAM

SSF52540   SSF52540
SSF48403   SSF48403
SSF52980   SSF52980
SSF53335   SSF53335

Gene 3D

1.25.40.20 1.25.40.20

CDD

cd00079 HELICc
cd00079 HELICc

ProteinModelPortal

E0WMH8 A0A385KMI0 P0C8H2 P0C8H3 A0A2X0SDV7 A9JKX8 + More
D4I5M8 A9JLN7 A0A0A1E304 Q65143 A0A5B8XA67 P0C8H1 A0A0C5AW97 P0C8H0 A0A0C5AWM3 A0A2Z5DFT6 G0UY07 W6KWA5 A0A3P3ZDB3 A0A088RX71 A0A1E1J2G5 A4HIX1 E9B1F5 A0A3Q8IF99 A0A5K1V5S9 A4I6A0 A0A504WY43 E9BMD0 A0A504X3C3 S9VVA9 K2N7A9 S9VG44 A0A0M9FQI1 A0A2V2V286 Q4Q6Q7 A0A1X0P8K5 A0A2V2UZK3 V5B0I9 Q4CVA8 A0A2V2W8E1 A0A422QAD5 A0A3R7KPC7 Q4D326 A0A3L6KYF2 D0A541 A0A1G4I059 Q389B2 A0A061J8L4 A0A0N1I3J1 S9UAM1 S9U4B4 W6LCV2 G0U3Z4 A0A2K4YAM4 A0A4V2RKV7 A0A552ZIJ3 A0A100ZNW4 A0A260MWW2 A2BTY5 A0A150A2K1 A0A3D9TS91 X7YQE2 A0A498QR07 A0A1A0V3S0 A0A1P8XF02 A0A1A2BD48 A0A0U0W7V0 I0WG10 A0A523YUR4 A0A259XM75 A0A1S1M1F6 A0A0A2ADH2 A0A498PJD7 A0A1A3BPM7 A0A481Z4U3 A0A1U9PGQ8 A0A424HZD6 A0A0D6J306 A0A1X2LFP7 A0A557XC56 A0A260MYB1 A0A238VZB5 A0A4Z0NA41 A0A1X0BPD4 A0A1A3KSX4 A0A1U9PKG7 A0A1T4J0N7 A0A1A3GDI7 A0A1Z8SVB0 A0A424RA97 A0A1A1WE99 A0A2S8KKE5 A0A022LAC5 A0A1T4J0D6 J4JUX8 A0A260PYZ5 A0A0F2P7N8

PDB

5FFJ E-value=7.2654e-14, Score=191

Ontologies

KEGG

vg:22220422

GO

GO:0003677  F:DNA binding
GO:0005524  F:ATP binding
GO:0016787  F:hydrolase activity
GO:0004386  F:helicase activity
GO:0016021  C:integral component of membrane
GO:0043138  F:3'-5' DNA helicase activity
GO:0006367  P:transcription initiation from RNA polymerase II promoter
GO:0006366  P:transcription by RNA polymerase II
GO:0033683  P:nucleotide-excision repair, DNA incision
GO:0000112  C:nucleotide-excision repair factor 3 complex
GO:0020023  C:kinetoplast
GO:0009411  P:response to UV
GO:0004003  F:ATP-dependent DNA helicase activity
GO:0005675  C:transcription factor TFIIH holo complex
GO:0006468  P:protein phosphorylation
GO:0097550  C:transcriptional preinitiation complex
GO:0008134  F:transcription factor binding
GO:0003678  F:DNA helicase activity
GO:0004519  F:endonuclease activity
GO:0008168  F:methyltransferase activity
GO:0032259  P:methylation
GO:0006306  P:DNA methylation
GO:0008170  F:N-methyltransferase activity

Subcellular Location

From MSLVP

Nucleus

Topology

Length:

844

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1152

Exp number, first 60 AAs:

0.01512

Total prob of N-in:

0.00384

Length:

844

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1152

Exp number, first 60 AAs:

0.01512

Total prob of N-in:

0.00384

outside

1 - 844

outside

1 - 844

Population Genetic Test Statistics

Pi

0.0343836

Theta

0.0409595

Tajima's D

-0.5658299

CLR

0

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62721.1
China_AnhuiXCGQ_2018	Protein	AYW34011.1
China_ASFV-SY18_2018	Protein	AKO62721.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95815.1
Poland_Pol16_20538_o9_2016-2017
Poland_Pol16_20540_o10_2016-2017
Poland_Pol16_29413_o23_2016-2017
Poland_Pol17_03029_C201_2016-2017	Protein	AXZ96003.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96098.1
Poland_Pol17_05838_C220_2016-2017
Poland_ASFV_POL_Podlaskie_2015
Uganda_R8_2015
Uganda_R7_2015
Uganda_R25_2015
Uganda_N10_2015
Uganda_R35_2015
Estonia_2014	Protein	SPS73462.1
Italy_26544_OG10_2010	Protein	AJZ77124.1
Italy_47_Ss_2008_2008	Protein	AOO54366.1
Portugal_OURT_88.3_1988	Protein	CAN10387.1
Spain_E75_1975	Protein	CBH29140.1
Russia_Georgia_2007	Protein	CBW46705.1
Kenya_Tk1_2005
Kenya_Bus_2006
Russia_Odintsovo_2014
Portugal_L60_1960	Protein	AIY22230.1
Portugal_NHV_1968	Protein	AIY22389.1
Russia_Kashino_2013
Benin_1997	Protein	CAN10138.1
South_Africa_KNP_Pretorisuskop_1996
South_Africa_MGR_Mkuzi_1979
Malawi_Lil_1983
Kenya_1950
Namibia_Warthog_1980
South_Africa_Warmbaths_1987
Malawi_Tengani_1962
China_HLJ_2018	Protein	QBH90527.1
China_LN_2018	Protein	QBH90712.1
China_wbBS01_2018	Protein	QDL88070.1
Ukraine_Kyiv_2014	Protein Protein	QED21595.1 QED21595.1
Belgium_Etalle_wb_2018	Protein	QED90482.1
Lithuania_LT14_2014	Protein	QEY87845.1
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983

Sequence