Strain

China_wbBS01_2018 (Region: China, Jilin; Strain: ASFV-wbBS01; Date: 2018)

Gene

E248R

Description

Annotated in NCBI, E248R

Location

MK645909.1(+):167028-167774

GenBank Accession

QDL88162.1

Full name

Protein E248R

CDS

ATGGGAGGCTCTACAAGCAAAAATTCCTTTAAAAATACGACCAACATTATCAGCAATTCCATTTTCAATCAGATGCAAAGTTGTATTTCCATGTTGGATGGCAAAAATTACATAGGCGTATTCGGTGATGGAAATATTTTAAACCACGTTTTCCAGGATTTAAACTTATCATTAAACACAAGTTGCGTGCAAAAGCACGTAAACGAGGAAAATTTCATTACAAATCTTTCGAACCAAATTACTCAAAATTTAAAAGACCAAGAAGTTGCGTTAACCCAATGGATGGACGCAGGAACTCACGATCAGAAAACGGATATAGAAGAAAATATAAAGGTAAACTTAACAACCACACTTATTCAAAACTGCGTTTCATCCCTGTCGGGTATGAACGTGCTGGTGGTGAAGGGGAATGGCAACATTGTTGAAAACGCAACTCAGAAGCAGTCGCAGCAAATCATCTCTAACTGCTTGCAGGGGAGCAAGCAGGCCATAGACACCACAACCGGCATCACTAACACGGTAAATCAGTACTCACACTACACCTCAAAAAACTTTTTTGACTTCATTGCAGACGCAATTTCGGCTGTTTTTAAAAACATCATGGTCGCGGCTGTAGTTATCGTTCTAATCATCGTAGGGTTTATAGCCGTCTTTTACTTTTTGCATTCACGGCACCGCCATGAGGAGGAAGAAGAAGCTGAACCACTCATAAGCAACAAGGTATTAAAAAATGCTGCCGTTTCGTAA

Protein

MGGSTSKNSFKNTTNIISNSIFNQMQSCISMLDGKNYIGVFGDGNILNHVFQDLNLSLNTSCVQKHVNEENFITNLSNQITQNLKDQEVALTQWMDAGTHDQKTDIEENIKVNLTTTLIQNCVSSLSGMNVLVVKGNGNIVENATQKQSQQIISNCLQGSKQAIDTTTGITNTVNQYSHYTSKNFFDFIADAISAVFKNIMVAAVVIVLIIVGFIAVFYFLHSRHRHEEEEEAEPLISNKVLKNAAVS

Function

Probably plays a role in an early post-entry event.

Subunit

Interacts with A151R.

Similarity

Belongs to the asfivirus E248R family.

Keywords

Capsid inner membrane protein Complete proteome Host membrane Lipoprotein Membrane Myristate Signal-anchor Transmembrane Transmembrane helix Virion Reference proteome

Feature

chain Protein E248R

Uniprot

A0A5B8XAF7 E0WM81 A0A2X0TKP6 P0CAB1 A0A0C5AWF7 Q65244 + More
A0A0C5AWW7 P0CAB2 A9JLC3 D4I5F5 A9JM61 A0A0A1DYK1 Q65200 P0CAB0

Pubmed

21470447 25645905 8021596 18198370 25406173 26618713 + More
11831707 16537584 19793823

EMBL

MN194591 QED21744.1 FR682468 CBW46797.1 MG939583 MG939588 + More
LS478113 AXZ95903.1 AXZ96186.1 SPS73554.1 AY261363 KM111294 AJL34144.1 X71982 AY261361 KM111295 MH025916 MH025917 MH025918 MH025919 MH025920 AJL34309.1 AXB49360.1 AXB49534.1 AXB49706.1 AXB49877.1 AXB50050.1 AY261366 AM712239 CAN10231.1 FN557520 CBH29231.1 AM712240 CAN10480.1 KM262844 KM262845 KM102979 KP055815 KX354450 AIY22322.1 AIY22480.1 AJZ77119.1 AKO62812.1 AOO54501.1 U18466 AY261360

Proteomes

UP000321214 UP000141072 UP000000859 UP000105860 UP000000860 UP000101566 + More
UP000000858 UP000130745 UP000101090 UP000108903 UP000110401 UP000117635 UP000142390 UP000241813 UP000266411 UP000000624 UP000000861

Pfam

PF02442 L1R_F9L

Interpro

IPR003472 Virion_mem_poxvirus_L1

ProteinModelPortal

A0A5B8XAF7 E0WM81 A0A2X0TKP6 P0CAB1 A0A0C5AWF7 Q65244 + More
A0A0C5AWW7 P0CAB2 A9JLC3 D4I5F5 A9JM61 A0A0A1DYK1 Q65200 P0CAB0

PDB

1TX9 E-value=9.31191, Score=64

Ontologies

KEGG

vg:22220360

GO

GO:0016021  C:integral component of membrane
GO:0039641  C:viral inner membrane
GO:0033644  C:host cell membrane

Subcellular Location

From MSLVP

Single-Pass Membrane

From Uniprot

Host membrane Probably part of the virion inner membrane. With evidence from 1 publications.
Virion Probably part of the virion inner membrane. With evidence from 1 publications.

Topology

Length:

248

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.47342

Exp number, first 60 AAs:

0.00775

Total prob of N-in:

0.15818

outside

1 - 198

TMhelix

199 - 221

inside

222 - 248

Population Genetic Test Statistics

Pi

0.0252726

Theta

0.0352706

Tajima's D

-0.6108826

CLR

0.330805

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62812.1
China_AnhuiXCGQ_2018	Protein	AYW34102.1
China_ASFV-SY18_2018	Protein	AKO62812.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95903.1
Poland_Pol16_20538_o9_2016-2017	Protein	AJL34144.1
Poland_Pol16_20540_o10_2016-2017	Protein	AJL34144.1
Poland_Pol16_29413_o23_2016-2017	Protein	AJL34144.1
Poland_Pol17_03029_C201_2016-2017	Protein	AJL34144.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96186.1
Poland_Pol17_05838_C220_2016-2017	Protein	AJL34144.1
Poland_ASFV_POL_Podlaskie_2015	Protein	AJL34144.1
Uganda_R8_2015	Protein	AXB49360.1
Uganda_R7_2015	Protein	AXB49534.1
Uganda_R25_2015	Protein	AXB49706.1
Uganda_N10_2015	Protein	AXB49877.1
Uganda_R35_2015	Protein	AXB50050.1
Estonia_2014	Protein	SPS73554.1
Italy_26544_OG10_2010	Protein	AJZ77119.1
Italy_47_Ss_2008_2008	Protein	AOO54501.1
Portugal_OURT_88.3_1988	Protein	CAN10480.1
Spain_E75_1975	Protein	CBH29231.1
Russia_Georgia_2007	Protein	CBW46797.1
Kenya_Tk1_2005	Protein Protein	AJL34144.1 AJL34144.1
Kenya_Bus_2006	Protein	AJL34309.1
Russia_Odintsovo_2014	Protein	AJL34144.1
Portugal_L60_1960	Protein	AIY22322.1
Portugal_NHV_1968	Protein	AIY22480.1
Russia_Kashino_2013	Protein	AJL34144.1
Benin_1997	Protein	CAN10231.1
South_Africa_KNP_Pretorisuskop_1996	Protein	AJL34144.1
South_Africa_MGR_Mkuzi_1979	Protein	AJL34144.1
Malawi_Lil_1983	Protein	AJL34144.1
Kenya_1950	Protein	AJL34144.1
Namibia_Warthog_1980	Protein	AJL34144.1
South_Africa_Warmbaths_1987	Protein	AJL34144.1
Malawi_Tengani_1962	Protein	AJL34144.1
China_HLJ_2018	Protein	QBH90619.1
China_LN_2018	Protein	QBH90804.1
China_wbBS01_2018	Protein	QDL88162.1
Ukraine_Kyiv_2014	Protein Protein	QED21744.1 QED21745.1
Belgium_Etalle_wb_2018	Protein	QED90574.1
Lithuania_LT14_2014	Protein	QEY87937.1
South_Africa_1985	Protein	QGM12943.1
South_Africa_2_2008	Protein	QGM12869.1
Zambia_LIV_1983	Protein	QGM12764.1

Sequence