Strain

South_Africa_Warmbaths_1987 (Region: South Africa, Warmbaths; Strain: Warmbaths; Date: 1987)

Gene

Helicase

Description

Annoated by sequence mapping, Member of helicase superfamily II group including human ERCC-3, vaccinia A18R and bacteriophage T5 D10

Location

AY261365.1(-):158921-160450

GenBank Accession

CAN10222.1

Full name

Putative ATP-dependent RNA helicase QP509L

CDS

ATGGAGGCCATTATATCCTTTGCTGGAATAGGAATAAATTATAAGAGGCTACAAAGTAAATTACAACATGATTTCGGGCGCCTTCTTAAGGCGCTCACCGTTACGGCGCGGGCATTACCTGGGCAGCCAAAGCACATAGCCATAAGACAGGAAACTGCCTTCACGCTGCAGGGGGAATACATTTATTTTCCCATATTGCTGCGAAAGCAGTTTGAAATGTTTAACATGGTTTACACGGCGCGCCCCGTGTCGCTGCGGGCCCTCCCATGCGTTGAAACAGAATTTCCACTATTTAACTACCAGCAAGAAATGGTCGATAAGATTCATAAAAAGCTCCTGTCCCCCTATGGGCGCTTTTACCTACATCTAAATACCGGTTTGGGGAAAACGCGTATTGCGATCAGTATTATTCAAAAACTTTTGTACCCTACCCTAGTCATCGTGCCCACCAAGGCGATTCAAGTACAGTGGATCGACGAGCTAACATTGCTCCTGCCCCACCTACGTGTAGCTGCTTACAATAATGCAGCGTGCAAGAAAAAGGACATGACGAGTAAAGAGTACGACGTCATCGTGGGAATCATTAATACCCTGCGCAAGAAGCCTGAGCAGTTCTTTGAGCCCTTCGGTCTAGTCGTGTTAGATGAGGCACATGAATTACACTCGCCGGAAAATTACAAAATTTTTTGGAAAATACAACTGAGTCGGATATTAGGACTGTCCGCTACACCCCTGGACCGGCCCGATGGTATGGACAAGATTATTATTCACCATCTAGGACAGCCCCAGAGGACTGTAAGTCCCACCACAACCTTTTCCGGGTACGTGAGGGAAATCGAATATCAGGGACATCCTGACTTTGTCAGCCCTGTGTGTATTAATGAAAAGGTATCGGCCATTGCCACCATTGATAAACTACTTCAAGATCCTTCGCGTATACAGCTTGTCGTAAATGAGGCAAAGCGGCTTTACTCCCTGCATACCGCTGAACCTCACAAATGGGGGACCGATGAGCCGTATGGCATCATCATTTTCGTGGAATTTCGTAAACTTTTAGAAATTTTTTATCAGGCGCTTTCCAAAGAATTCAAAGATGTTCAAATTATCGTTCCGGAGGTGGCGCTCCTATGCGGCGGGGTTTCAAATACCGCTCTTTCTCAGGCACACAGCGCTTCCATTATCTTGCTGACCTATGGCTACGGGCGGAGAGGCATTTCCTTCAAGCATATGACATCGATCATCATGGCAACGCCCCGCAGAAACAACATGGAGCAAATCTTGGGACGTATTACCCGGCAGGGATCGGATGAAAAAAAGGTACGCATCGTCGTGGACATTAAAGATACACTAAGCCCGCTTTCTAGCCAGGTCTACGACAGGCACCGGATTTACAAGAAAAAGGGCTACCCCATTTTTAAGTGCAGCGCCAGTTATCAGCAGCCCTATTCTTCTAATGAAGTTTTAATATGGGATCCTTATAACGAGTCATGTCTTGCGTGCACAACAACACCTCCTTCCCCGTCCAAACAG

Protein

MEAIISFAGIGINYKRLQSKLQHDFGRLLKALTVTARALPGQPKHIAIRQETAFTLQGEYIYFPILLRKQFEMFNMVYTARPVSLRALPCVETEFPLFNYQQEMVDKIHKKLLSPYGRFYLHLNTGLGKTRIAISIIQKLLYPTLVIVPTKAIQVQWIDELTLLLPHLRVAAYNNAACKKKDMTSKEYDVIVGIINTLRKKPEQFFEPFGLVVLDEAHELHSPENYKIFWKIQLSRILGLSATPLDRPDGMDKIIIHHLGQPQRTVSPTTTFSGYVREIEYQGHPDFVSPVCINEKVSAIATIDKLLQDPSRIQLVVNEAKRLYSLHTAEPHKWGTDEPYGIIIFVEFRKLLEIFYQALSKEFKDVQIIVPEVALLCGGVSNTALSQAHSASIILLTYGYGRRGISFKHMTSIIMATPRRNNMEQILGRITRQGSDEKKVRIVVDIKDTLSPLSSQVYDRHRIYKKKGYPIFKCSASYQQPYSSNEVLIWDPYNESCLACTTTPPSPSKQ

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Similarity

Belongs to the DEAD box helicase family. DEAH subfamily.

Keywords

ATP-binding Complete proteome Helicase Hydrolase Nucleotide-binding Reference proteome

Feature

chain Putative ATP-dependent RNA helicase QP509L

Uniprot

A9JLA7 D4I5E6 A9JM43 A0A0A1E3R1 Q65191 P0C9A8 + More
E0WM72 A0A2X0THX2 P0C9A9 A0A0C5AZK8 A0A2Z5DGN2 A0A0C5B095 Q65277 Q89576 P0C9B0

Pubmed

18198370 25406173 26618713 11831707 21470447 25645905 + More
8397501 8021596 8376971

EMBL

AM712239 CAN10222.1 FN557520 CBH29222.1 AM712240 CAN10471.1 + More
KM262844 KM262845 KM102979 KP055815 KX354450 AIY22313.1 AIY22471.1 AJZ77063.1 AKO62803.1 AOO54489.1 U18466 AY261363 FR682468 CBW46788.1 MG939583 MG939588 LS478113 AXZ95895.1 AXZ96178.1 SPS73545.1 AY261366 KM111294 AJL34135.1 MH025919 AXB49868.1 KM111295 MH025916 MH025917 MH025918 MH025920 AJL34300.1 AXB49351.1 AXB49525.1 AXB49697.1 AXB50041.1 M88275 AAA03223.1 X71982 X72953 AY261361 AY261360

Proteomes

UP000130745 UP000101090 UP000108903 UP000110401 UP000117635 UP000142390 + More
UP000241813 UP000266411 UP000000624 UP000000859 UP000141072 UP000000858 UP000105860 UP000101566 UP000000860 UP000000861

PRIDE

P0C9A8 Q89576 P0C9B0

Pfam

PF04851 ResIII

Interpro

IPR027417   P-loop_NTPase
IPR006935   Helicase/UvrB_N
IPR014001   Helicase_ATP-bd

SUPFAM

SSF52540 SSF52540

ProteinModelPortal

A9JLA7 D4I5E6 A9JM43 A0A0A1E3R1 Q65191 P0C9A8 + More
E0WM72 A0A2X0THX2 P0C9A9 A0A0C5AZK8 A0A2Z5DGN2 A0A0C5B095 Q65277 Q89576 P0C9B0

PDB

2FWR E-value=1.2205e-07, Score=135

Ontologies

KEGG

vg:22220352

GO

GO:0003677  F:DNA binding
GO:0005524  F:ATP binding
GO:0004386  F:helicase activity
GO:0016787  F:hydrolase activity

Subcellular Location

From MSLVP

Capsid

Topology

Length:

510

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.08863

Exp number, first 60 AAs:

0.00167

Total prob of N-in:

0.00166

outside

1 - 510

Population Genetic Test Statistics

Pi

0.0258154

Theta

0.0364084

Tajima's D

-0.9085267

CLR

0.007012

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62803.1
China_AnhuiXCGQ_2018	Protein	AYW34093.1
China_ASFV-SY18_2018	Protein	AKO62803.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95895.1
Poland_Pol16_20538_o9_2016-2017	Protein	CAN10222.1
Poland_Pol16_20540_o10_2016-2017	Protein	CAN10222.1
Poland_Pol16_29413_o23_2016-2017	Protein	CAN10222.1
Poland_Pol17_03029_C201_2016-2017	Protein	CAN10222.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96178.1
Poland_Pol17_05838_C220_2016-2017	Protein	CAN10222.1
Poland_ASFV_POL_Podlaskie_2015	Protein	CAN10222.1
Uganda_R8_2015	Protein	AXB49351.1
Uganda_R7_2015	Protein	AXB49525.1
Uganda_R25_2015	Protein	AXB49697.1
Uganda_N10_2015	Protein	AXB49868.1
Uganda_R35_2015	Protein	AXB50041.1
Estonia_2014	Protein	SPS73545.1
Italy_26544_OG10_2010	Protein	AJZ77063.1
Italy_47_Ss_2008_2008	Protein	AOO54489.1
Portugal_OURT_88.3_1988	Protein	CAN10471.1
Spain_E75_1975	Protein	CBH29222.1
Russia_Georgia_2007	Protein	CBW46788.1
Kenya_Tk1_2005	Protein	AJL34135.1
Kenya_Bus_2006	Protein	AJL34300.1
Russia_Odintsovo_2014	Protein	CAN10222.1
Portugal_L60_1960	Protein	AIY22313.1
Portugal_NHV_1968	Protein	AIY22471.1
Russia_Kashino_2013	Protein	CAN10222.1
Benin_1997	Protein Protein	CAN10222.1 CAN10222.1
South_Africa_KNP_Pretorisuskop_1996	Protein	CAN10222.1
South_Africa_MGR_Mkuzi_1979	Protein	CAN10222.1
Malawi_Lil_1983	Protein	CAN10222.1
Kenya_1950	Protein	CAN10222.1
Namibia_Warthog_1980	Protein	CAN10222.1
South_Africa_Warmbaths_1987	Protein	CAN10222.1
Malawi_Tengani_1962	Protein	CAN10222.1
China_HLJ_2018	Protein	QBH90610.1
China_LN_2018	Protein	QBH90795.1
China_wbBS01_2018	Protein	QDL88153.1
Ukraine_Kyiv_2014	Protein Protein	QED21733.1 QED21734.1
Belgium_Etalle_wb_2018	Protein	QED90565.1
Lithuania_LT14_2014	Protein	QEY87928.1
South_Africa_1985	Protein	CAN10222.1
South_Africa_2_2008	Protein	CAN10222.1
Zambia_LIV_1983	Protein	CAN10222.1

Sequence