Strain

South_Africa_2_2008 (Region: South Africa;  Strain: RSA_2_2008;  Date: 2008)

Gene

pEP402R

Description

Annotated in NCBI,  EP402R

Location

MN336500.1(+):72367-73299

GenBank Accession

QGM12838.1

Full name

CD2 homolog       + More

Alternative Name

5HL
CD2v
PEP402R
T-lymphocyte CD2 receptor-like protein
5HL
CD2v
PEP402R
T-lymphocyte CD2 receptor-like protein

CDS

ATGTCAATATATATTACAACATATGTATTACTATATTTGGACAAAAAAATTATTTACACAGTACAACTATTACAATCTGTTGTTTCCCCAACTATTACATATATTTGTACTATTTCTTTATTATCATGTACAAATATTATTGGGACAAATGTTATTATATATTTATTTATTATTATTACAATTGTTATTATTACTATTGGAGATATCCTTATTTATTATTGGAATGGTATTATTATTTTTACAGCTACATGTATGTTTATTATTACAATTACTTCATTGTATGCAACAGAAAATATATATTGTACTTATCCAATATTACATTCATATCAAAATTATTTTACAATATTTATACATTATTTTATATCATATTTTTTATTGTGTGTGGATTATTATTACGTATTTTTATTTCAATCATATCTGTATTGTCTATACGAAGAAAAAGAAAAACCCATGCAGAAATACAAAGTCCACCACCATCTGTATCTATTGCAGAAGACATTTCTCATCATGTCACCACTTCCATACATGTACCATCTCCCAGAGAGCCATTACTTCCTATACCATATACTCGTTATCAGTATATTACACCTATTTACTACATGCGTCCCTCAACACAACCACTCAATCCATTTCCCCTACCTATACCGTGTCCTCCACCTATACCGTGCCCGCCACCCAAACCATGCCCGCCACCTATACCATGTCCTCCACCTATACCGTGCCCGCCACCCAAACCATGCCCGCCACCTATACCATGTCCTCCACCTATACCATGTTCTTCACCTGTATCATATTCTCCACCCAAACCACTACCTACTATCCCGCTGCTACCCAATATCCCGCCATTATCTACACAAAATATTTCGCTTATTCATGTACATACAATTATTTAATCTTTCAAGCTGGTCTTCATTTAAATTTAAAATCCACTAA

Protein

MSIYITTYVLLYLDKKIIYTVQLLQSVVSPTITYICTISLLSCTNIIGTNVIIYLFIIITIVIITIGDILIYYWNGIIIFTATCMFIITITSLYATENIYCTYPILHSYQNYFTIFIHYFISYFLLCVDYYYVFLFQSYLYCLYEEKEKPMQKYKVHHHLYLLQKTFLIMSPLPYMYHLPESHYFLYHILVISILHLFTTCVPQHNHSIHFPYLYRVLHLYRARHPNHARHLYHVLHLYRARHPNHARHLYHVLHLYHVLHLYHILHPNHYLLSRCYPISRHYLHKIFRLFMYIQLFNLSSWSSFKFKIHX

Function

May play an immunosuppressive role by inhibiting lymphocyte proliferation and subsequently facilitating viral replication and generalization of infection (By similarity). Responsible for viral hemadsorption, which may help viral spread (PubMed:8102411, PubMed:8615037). Increases virus replication in the tick vector at the step of virus uptake or replication in the tick gut (PubMed:19729182). May play a role in the host Golgi reorganization to yield viral factories (PubMed:25915900).

Subunit

Both glycosylated and nonglycosylated forms interact (via C-terminus) with the host AP-1 complex.
Both glycosylated and nonglycosylated forms interact (via C-terminus) with the host AP-1 complex.

Similarity

Belongs to the asfivirus CD2 homolog protein family.

Keywords

Complete proteome   Disulfide bond   Glycoprotein   Host membrane   Late protein   Membrane   Receptor   Reference proteome   Signal   Transmembrane   Transmembrane helix  

Feature

chain  CD2 homolog

Uniprot

A0A0A7WCE6   A0A0A7W539   A0A0A7W6X7   A0A0A7W4V8   A0A0A7W4X5   A0A0A7WCF1   + More
A0A0A7W5B1   A0A0A7W532   A0A0A1E110   A9JLS5   Q6JHT7   Q6JHT1   A0A3G1EUZ7   D4I5P6   Q4TZL0   A9JL07   Q76VU8   Q89501   A0A0N7CVF4   Q8JSP1  

Pubmed

25524164    25406173    18198370    19729182    8102411    11831707    + More
8615037    25915900    26618713   

EMBL

KM609377    AJB28423.1    KM609369    AJB28415.1    KM609385    AJB28429.1    + More
KM609365    AJB28411.1    KM609380    AJB28426.1    KM609384    AJB28428.1    KM609366    AJB28412.1    KM609364    AJB28410.1    KM262845    AIY22408.1    AM712240    CAN10406.1    AY463914    AAS45768.1    AY463915    AY463916    AAS45774.1    KX354450    AOO54390.1    FN557520    CBH29159.1    DQ026268    AAY44924.1    AM712239    CAN10158.1    L16864    DQ026264    DQ026265    DQ026266    DQ026267    DQ026269    DQ026270    KM609337    KM609350    KM609351    KM609352    KM609355    KM102979    AAA42691.1    AAY44917.1    AAY44919.1    AAY44921.1    AAY44923.1    AAY44927.1    AAY44929.1    AJB28364.1    AJB28386.1    AJB28388.1    AJB28390.1    AJB28394.1    AJZ77076.1    U18466    KP055815    AKO62740.1    AF481875    AAM90851.1   

Proteomes

UP000110401    UP000108903    UP000266411    UP000101090    UP000130745    UP000117635    + More
UP000000624    UP000241813   

Interpro

IPR013783   Ig-like_fold
IPR036179   Ig-like_dom_sf

SUPFAM

SSF48726   SSF48726

Gene 3D

2.60.40.10     2.60.40.10    

ProteinModelPortal

A0A0A7WCE6   A0A0A7W539   A0A0A7W6X7   A0A0A7W4V8   A0A0A7W4X5   A0A0A7WCF1   + More
A0A0A7W5B1   A0A0A7W532   A0A0A1E110   A9JLS5   Q6JHT7   Q6JHT1   A0A3G1EUZ7   D4I5P6   Q4TZL0   A9JL07   Q76VU8   Q89501   A0A0N7CVF4   Q8JSP1  

KEGG

vg:22220440    

GO

GO:0016021  C:integral component of membrane
GO:0033644  C:host cell membrane

From MSLVP

Single-Pass Membrane

From Uniprot

Host membrane   Localizes around the cytoplasmic viral factories which are probably derived from the host Golgi membrane (PubMed:25915900). Both proteolytic fragments localize to membrane compartements (By similarity).   With evidence from 2 publications.
Host membrane   Localizes around the cytoplasmic viral factories which are probably derived from the host Golgi membrane (PubMed:25915900). Both proteolytic fragments localize to membrane compartements (By similarity).   With evidence from 2 publications.

Length:

311

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

122.27836

Exp number, first 60 AAs:

30.99855

Total prob of N-in:

0.40323

POSSIBLE N-term signal

sequence

Length:

310

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

122.27664

Exp number, first 60 AAs:

30.99851

Total prob of N-in:

0.40322

POSSIBLE N-term signal

sequence

outside

1  -  19

TMhelix

20  -  42

inside

43  -  50

TMhelix

51  -  73

outside

74  -  76

TMhelix

77  -  99

inside

100  -  111

TMhelix

112  -  134

outside

135  -  183

TMhelix

184  -  206

inside

207  -  311

outside

1  -  19

TMhelix

20  -  42

inside

43  -  50

TMhelix

51  -  73

outside

74  -  76

TMhelix

77  -  99

inside

100  -  111

TMhelix

112  -  134

outside

135  -  183

TMhelix

184  -  206

inside

207  -  310

 

 

Pi

0.079894

Theta

0.0908801

Tajima's D

-0.6698157

CLR

0.90093

Interpretation

No evidence of Selection