Strain

Ukraine_Kyiv_2014 (Region: Ukraine; Strain: ASFV/Kyiv/2016/131; Date: 2014)

Gene

MGF_110-9L

Description

Annotated in NCBI, ASFV_Kyiv_2016_131_00018

Location

MN194591.1(-):13311-13877

GenBank Accession

QED21554.1

Full name

Protein LIS 290 + More
Protein MGF 110-9L

Sequence

CDS

ATGAGCTGTACAAATCCCACATATTATGATTGGTTTGATGAGTTAATGCAAATAAAGGAGGATAGGGTCATTGACACTGAGAATATCAAACATACTTGTCTTTGTATGATAGCTACCATTGCTCTCATAAGCTATGTTCGCAAACAATACTCACGAATGCGAATGCAAGCCGCTACAAGACTGCTTATCTTTCTTGGCTTCTATGTTCTTTTAGGAATTTTGATGACGAACATAATAATGAACCTACCTCTTTCCACAGATAATCCGATGCAAATGCGTAGGCCTCCTGAAAGGGATCTCAAGTTCTGGTGCACCTATGCAAAACACTGTGACTTCTGCTGGACCTGTAAAGATGGAATGTGTAAAAATAAAGTGTTTAGTGACCACCCTATTATTACGCAAAATGATTATATTGTTAATTGTACAGTTTCCCGGTGGCATGACCGGTGTATGTATGAAGCTCACTTTAGGATACACTATCAACATAACATGAATTGTTCACAACCCAAAGATTTAGAATGGTTCATTGAGTTAAAACGACATGTGATTAATCAAGATGATTTGTAA

Protein

MSCTNPTYYDWFDELMQIKEDRVIDTENIKHTCLCMIATIALISYVRKQYSRMRMQAATRLLIFLGFYVLLGILMTNIIMNLPLSTDNPMQMRRPPERDLKFWCTYAKHCDFCWTCKDGMCKNKVFSDHPIITQNDYIVNCTVSRWHDRCMYEAHFRIHYQHNMNCSQPKDLEWFIELKRHVINQDDL

Summary

Function

Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.

Similarity

Belongs to the asfaviruses V110 family.
Belongs to the asfivirus MGF 110 family.

Keywords

Early protein Repeat Signal Complete proteome Glycoprotein Host membrane Membrane Transmembrane Transmembrane helix

Feature

chain Protein LIS 290

Uniprot

A0A5B8XA24 E0WMD4 A0A385KMQ4 P26710 A0A0A1DY81 A9JLJ4 + More
P0C9J1 P0C9I9 P0C9J0 A0A2Z5DGN8 A0A0C5AZS1 A0A0C5AYT5

Pubmed

21470447 2219721 25406173 18198370 25645905

EMBL

MN194591 QED21554.1 FR682468 CBW46662.1 MG939583 MG939586 + More
MG939587 MG939588 AXZ95782.1 AXZ95962.1 AXZ95979.1 AXZ96074.1 M58155 KM262845 AIY22365.1 AM712240 CAN10363.1 AY261363 AY261366 AY261360 MH025916 MH025917 MH025918 MH025919 MH025920 AXB49235.1 AXB49409.1 AXB49582.1 AXB49754.1 AXB49925.1 KM111295 AJL34185.1 KM111294 AJL34022.1

Proteomes

UP000321214 UP000141072 UP000110401 UP000108903 UP000000859 UP000000858 + More
UP000000861 UP000101566 UP000105860

PRIDE

P26710 P0C9I9

Pfam

PF01639 v110

Interpro

IPR004848 V110_vir

ProteinModelPortal

A0A5B8XA24 E0WMD4 A0A385KMQ4 P26710 A0A0A1DY81 A9JLJ4 + More
P0C9J1 P0C9I9 P0C9J0 A0A2Z5DGN8 A0A0C5AZS1 A0A0C5AYT5

Ontologies

GO:0016021 C:integral component of membrane
GO:0033644 C:host cell membrane

Subcellular Location

From MSLVP

Multi-Pass Membrane

From Uniprot

Host membrane

Topology

Length:

188

Number of predicted TMHs:

Exp number of AAs in TMHs:

26.71377

Exp number, first 60 AAs:

5.30755

Total prob of N-in:

0.79519

inside

1 - 60

TMhelix

61 - 83

outside

84 - 188

Population Genetic Test Statistics

0.1899393

Theta

0.3072367

Tajima's D

-1.3971982

CLR

1.249386

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971
China_AnhuiXCGQ_2018	Protein	AYW33964.1
China_ASFV-SY18_2018	Protein	CAN10363.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95782.1
Poland_Pol16_20538_o9_2016-2017	Protein	CBW46662.1
Poland_Pol16_20540_o10_2016-2017	Protein	CBW46662.1
Poland_Pol16_29413_o23_2016-2017	Protein	AXZ95962.1
Poland_Pol17_03029_C201_2016-2017	Protein	AXZ95979.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96074.1
Poland_Pol17_05838_C220_2016-2017	Protein	CBW46662.1
Poland_ASFV_POL_Podlaskie_2015	Protein	CBW46662.1
Uganda_R8_2015	Protein	AXB49235.1
Uganda_R7_2015	Protein	AXB49409.1
Uganda_R25_2015	Protein	AXB49582.1
Uganda_N10_2015	Protein	AXB49754.1
Uganda_R35_2015	Protein	AXB49925.1
Estonia_2014
Italy_26544_OG10_2010
Italy_47_Ss_2008_2008
Portugal_OURT_88.3_1988	Protein	CAN10363.1
Spain_E75_1975
Russia_Georgia_2007	Protein Protein	CBW46662.1 CBW46662.1
Kenya_Tk1_2005	Protein	AJL34022.1
Kenya_Bus_2006	Protein	AJL34185.1
Russia_Odintsovo_2014	Protein	CBW46662.1
Portugal_L60_1960
Portugal_NHV_1968	Protein	AIY22365.1
Russia_Kashino_2013	Protein	CBW46662.1
Benin_1997
South_Africa_KNP_Pretorisuskop_1996	Protein	CBW46662.1
South_Africa_MGR_Mkuzi_1979	Protein	CBW46662.1
Malawi_Lil_1983
Kenya_1950	Protein	CBW46662.1
Namibia_Warthog_1980	Protein	CBW46662.1
South_Africa_Warmbaths_1987	Protein	CBW46662.1
Malawi_Tengani_1962	Protein	CBW46662.1
China_HLJ_2018	Protein	QBH90485.1
China_LN_2018	Protein	QBH90670.1
China_wbBS01_2018	Protein	QDL88027.1
Ukraine_Kyiv_2014	Protein	QED21554.1
Belgium_Etalle_wb_2018	Protein	QED90442.1
Lithuania_LT14_2014	Protein	QEY87801.1
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983