Strain

Uganda_R25_2015 (Region: Uganda, Tororo district; Strain: R25; Date: 2015)

Gene

p505-3R

Description

Annotated in NCBI, Member of multigene family 505 (A280R)

Location

MH025918.1(+):34974-35822

GenBank Accession

AXB49602.1

Full name

Protein MGF 505-3R       + More
Protein MGF 505-1R
Protein MGF 505-4R
Protein MGF 505-2R
Protein MGF 505-10R
Protein MGF 505-5R
Protein MGF 505-7R
Protein MGF 505-6R

CDS

ATGTCCTCTTCCCTTCAGGAACTTTGCCGAAAAAACTTACCCGACCACATACTTCCAGAGTTCTTTGACGACTATATATTGCAACTATTAGGACTGCACTGGCAAGATCATGGTTCTCTTCAGCGTACCGAGAAGAATCAGGTACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTAAAAGTGGCAGCATCAGAAGGAAACTACGAAATAGTAGAGCTGTTGTTGTCATGGAAGGCAGACCCCCGATACGCTGTCGTAGGAGCGCTAGAAAGCAAATACTATGACCTCGTTTACAAATATTACGACCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATCCAAAATTCGGAAACATTCGAAAGATGTCATGAGTTGAACAATTGTTCTCTTAAATGCTTATTCAAGCATGCTGTGATATATGACAAGCTGCCGATTCTTCAAAAATATGCAAGCTATCTGGATGGGTGGCCGTATTGCAACCAGATGCTGTTCGAGTTGGCATGTAAAAAACAAAAATATAACATGGCTGTATGGATAGAGGGAGTCCTGGGCGTCGGCAACTTCACAATTCTTTTCACGATTGCGATTATCAAAAGAGACCTACAGCTGTATTCCCTGGGCTACTCAATGATTCTTGAGAAAATGTACTCCTGTGGATACGACCCTACGTTTTTACTAAATCATTATCTGCGAATCGTTTCAACAAAGGGGCTTCTGCCCTTTGTGCTGAAAACCATAGAATATGGTGGAAGCAAAGAGATAGCCATCACTTTGGCTAAAAAGTATCAGCATGAAAATATTTTGAGATACTTCGAAACCAGGAAAACCCAAGAGTGCTAA

Protein

MSSSLQELCRKNLPDHILPEFFDDYILQLLGLHWQDHGSLQRTEKNQVLVQQEPIHINEALKVAASEGNYEIVELLLSWKADPRYAVVGALESKYYDLVYKYYDQVKDCHDILPLIQNSETFERCHELNNCSLKCLFKHAVIYDKLPILQKYASYLDGWPYCNQMLFELACKKQKYNMAVWIEGVLGVGNFTILFTIAIIKRDLQLYSLGYSMILEKMYSCGYDPTFLLNHYLRIVSTKGLLPFVLKTIEYGGSKEIAITLAKKYQHENILRYFETRKTQEC

Function

Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.

Similarity

Belongs to the asfivirus MGF 505 family.

Keywords

Complete proteome Reference proteome ANK repeat Repeat

Feature

chain Protein MGF 505-3R

Uniprot

A0A0C5AZ75 A0A0C5AYU7 P0C740 P0C9T0 A9JKV4 D4I5L4 + More
A0A0A1DXH8 Q89642 E0WMG2 A0A2X0RVK8 P0C9T1 A0A1C6ZY20 Q65129 A9JKU5 D4I5K9 A0A1C6ZXX7 A0A0A1DXH2 A0A0C5AYU4 A0A0C5B2F2 A0A2Z5DGS0 P0C9S5 P0C9S6 Q65124 E0WMF6 A0A2X0RTR5 P0C9S4 A9JKV6 D4I5L5 A9JLL3 A0A0A1E0I1 Q89768 A0A2Z5DEF5 A0A0C5BCK1 P0C9T3 A0A0C5BC47 P0C9T5 P0C9T2 P0C9T4 A0A385KLZ6 E0WMG4 A0A2X0RVA3 A0A2Z5DEX1 A0A0C5B2F7 P0C9S7 A0A0C5AW92 A0A0C5AWL2 D4I5M0 A9JLM1 A0A0A1DY08 A0A0A1E0I6 Q89869 A0A1C6ZXX4 A9JKW5 E0WMG5 A0A2X0TC45 A0A385KLZ1 A0A0C5AYV0 P0C9V0 A0A2Z5DF55 A0A0C5AZ79 P0C9T6 P0C9V1 P0C9V2 A9JLL5 A0A0A1E0Y6 P0C9T8 A9JKV8 D4I5L6 A0A0A1E043 Q89777 E0WMG9 A0A2X0TKE5 P0C9T7 P0C9S8 Q89702 P0C9S9 A9JKV3 E0WMG1 A0A2X0RU65 A0A0A1E2Z4 D4I5L3 Q65114 A0A2Z5DFS5 A0A0C5AZV5 Q65128 P0C9T9 P0C9U2 A0A0C5AZC1 P0C9U3 P0C9U1 A0A0C5B227 E0WMG6 A0A2X0S742 Q89925 D4I5L7 A9JLL7 A0A0A1E0L2 A9JKW0 P0C9U0 E0WMG7

Pubmed

25645905 18198370 25406173 26618713 2325202 11831707 + More
21470447 8030263

EMBL

KM111295 MH025916 MH025917 MH025918 MH025919 MH025920 + More
AJL34207.1 AXB49256.1 AXB49430.1 AXB49602.1 AXB49774.1 AXB49946.1 KM111294 AJL34042.1 AY261360 AY261363 AM712239 CAN10125.1 FN557520 CBH29127.1 KM262844 KP055815 AIY22217.1 AKO62708.1 U02468 U18466 FR682468 CBW46690.1 MG939583 MG939587 MG939588 LS478113 AXZ95803.1 AXZ95991.1 AXZ96086.1 SPS73447.1 AY261366 KM102979 KX354450 AJZ77106.1 AOO54351.1 U03762 AY261361 CAN10120.1 CBH29122.1 AJZ77058.1 AOO54340.1 AIY22212.1 AKO62703.1 AJL34037.1 AJL34201.1 AXB49251.1 AXB49425.1 AXB49597.1 AXB49770.1 AXB49941.1 CBW46685.1 AXZ95798.1 AXZ95986.1 AXZ96081.1 SPS73442.1 CAN10126.1 CBH29128.1 AM712240 CAN10375.1 KM262845 AIY22218.1 AIY22377.1 AJZ77065.1 AKO62709.1 AOO54353.1 AXB49257.1 AXB49431.1 AXB49603.1 AXB49947.1 AJL34208.1 AJL34043.1 AXZ95805.1 CBW46692.1 AXZ95993.1 AXZ96088.1 SPS73449.1 AXB49255.1 AXB49429.1 AXB49601.1 AXB49773.1 AXB49945.1 AJL34206.1 AJL34044.1 AJL34209.1 AXB49258.1 AXB49432.1 AXB49604.1 AXB49775.1 AXB49948.1 CBH29133.1 CAN10380.1 AIY22382.1 AIY22223.1 AKO62714.1 AJZ77055.1 AOO54359.1 CAN10131.1 CBW46693.1 SPS73450.1 AXZ95806.1 AXZ95994.1 AXZ96089.1 AJL34047.1 AXB49261.1 AXB49435.1 AXB49607.1 AXB49778.1 AXB49951.1 AJL34212.1 CAN10376.1 AIY22378.1 CAN10127.1 CBH29129.1 AIY22219.1 AJZ77066.1 AKO62710.1 AOO54354.1 CBW46697.1 AXZ95809.1 AXZ95997.1 AXZ96092.1 SPS73454.1 CAN10124.1 CBW46689.1 AXZ95802.1 AXZ95990.1 AXZ96085.1 SPS73446.1 AIY22216.1 AJZ77062.1 AKO62707.1 AOO54349.1 CBH29126.1 U03761 AXB49259.1 AXB49433.1 AXB49605.1 AXB49776.1 AXB49949.1 AJL34210.1 AJL34045.1 AJL34041.1 CBW46694.1 AXZ95807.1 AXZ95995.1 AXZ96090.1 SPS73451.1 CBH29130.1 CAN10377.1 AIY22220.1 AIY22379.1 AJZ77060.1 AKO62711.1 AOO54355.1 CAN10128.1 CBW46695.1

Proteomes

UP000101566 UP000105860 UP000000861 UP000000859 UP000130745 UP000101090 + More
UP000142390 UP000241813 UP000000624 UP000141072 UP000000858 UP000117635 UP000266411 UP000000860 UP000108903 UP000110401

PRIDE

P0C740 P0C9T1 P0C9S5 P0C9S6 Q65124 P0C9S7 + More
P0C9V0 P0C9V1 P0C9V2 Q89702 Q65114 Q65128 P0C9U2 Q89925 P0C9U0

Pfam

PF03158 DUF249

Interpro

IPR004858 MGF_505
IPR036770 Ankyrin_rpt-contain_sf

SUPFAM

SSF48403 SSF48403

Gene 3D

1.25.40.20

ProteinModelPortal

A0A0C5AZ75 A0A0C5AYU7 P0C740 P0C9T0 A9JKV4 D4I5L4 + More
A0A0A1DXH8 Q89642 E0WMG2 A0A2X0RVK8 P0C9T1 A0A1C6ZY20 Q65129 A9JKU5 D4I5K9 A0A1C6ZXX7 A0A0A1DXH2 A0A0C5AYU4 A0A0C5B2F2 A0A2Z5DGS0 P0C9S5 P0C9S6 Q65124 E0WMF6 A0A2X0RTR5 P0C9S4 A9JKV6 D4I5L5 A9JLL3 A0A0A1E0I1 Q89768 A0A2Z5DEF5 A0A0C5BCK1 P0C9T3 A0A0C5BC47 P0C9T5 P0C9T2 P0C9T4 A0A385KLZ6 E0WMG4 A0A2X0RVA3 A0A2Z5DEX1 A0A0C5B2F7 P0C9S7 A0A0C5AW92 A0A0C5AWL2 D4I5M0 A9JLM1 A0A0A1DY08 A0A0A1E0I6 Q89869 A0A1C6ZXX4 A9JKW5 E0WMG5 A0A2X0TC45 A0A385KLZ1 A0A0C5AYV0 P0C9V0 A0A2Z5DF55 A0A0C5AZ79 P0C9T6 P0C9V1 P0C9V2 A9JLL5 A0A0A1E0Y6 P0C9T8 A9JKV8 D4I5L6 A0A0A1E043 Q89777 E0WMG9 A0A2X0TKE5 P0C9T7 P0C9S8 Q89702 P0C9S9 A9JKV3 E0WMG1 A0A2X0RU65 A0A0A1E2Z4 D4I5L3 Q65114 A0A2Z5DFS5 A0A0C5AZV5 Q65128 P0C9T9 P0C9U2 A0A0C5AZC1 P0C9U3 P0C9U1 A0A0C5B227 E0WMG6 A0A2X0S742 Q89925 D4I5L7 A9JLL7 A0A0A1E0L2 A9JKW0 P0C9U0 E0WMG7

PDB

5K66 E-value=5.09508, Score=67

Ontologies

KEGG

vg:22220409 vg:22220410 vg:22220414 vg:22220411 vg:22220408 vg:22220412

GO

GO:0016021 C:integral component of membrane

Subcellular Location

From MSLVP

Nucleus

Topology

Length:

282

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.1599

Exp number, first 60 AAs:

0.00095

Total prob of N-in:

0.81777

inside

1 - 177

TMhelix

178 - 200

outside

201 - 282

Population Genetic Test Statistics

Pi

0.0882808

Theta

0.1491953

Tajima's D

-1.6198152

CLR

2.85164

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62708.1
China_AnhuiXCGQ_2018	Protein	AYW33996.1
China_ASFV-SY18_2018	Protein Protein	CAN10374.1 AKO62708.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95803.1
Poland_Pol16_20538_o9_2016-2017
Poland_Pol16_20540_o10_2016-2017
Poland_Pol16_29413_o23_2016-2017
Poland_Pol17_03029_C201_2016-2017	Protein	AXZ95991.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96086.1
Poland_Pol17_05838_C220_2016-2017
Poland_ASFV_POL_Podlaskie_2015
Uganda_R8_2015	Protein	AXB49256.1
Uganda_R7_2015	Protein	AXB49430.1
Uganda_R25_2015	Protein	AXB49602.1
Uganda_N10_2015	Protein	AXB49774.1
Uganda_R35_2015	Protein	AXB49946.1
Estonia_2014	Protein	SPS73447.1
Italy_26544_OG10_2010	Protein	AJZ77106.1
Italy_47_Ss_2008_2008	Protein	AOO54351.1
Portugal_OURT_88.3_1988	Protein	CAN10374.1
Spain_E75_1975	Protein	CBH29127.1
Russia_Georgia_2007	Protein	CBW46690.1
Kenya_Tk1_2005	Protein Protein	AJL34042.1 AJL34042.1
Kenya_Bus_2006	Protein	AJL34207.1
Russia_Odintsovo_2014
Portugal_L60_1960	Protein	AIY22217.1
Portugal_NHV_1968	Protein	AIY22376.1
Russia_Kashino_2013
Benin_1997	Protein	CAN10125.1
South_Africa_KNP_Pretorisuskop_1996
South_Africa_MGR_Mkuzi_1979
Malawi_Lil_1983
Kenya_1950	Protein	AJL34042.1
Namibia_Warthog_1980
South_Africa_Warmbaths_1987
Malawi_Tengani_1962
China_HLJ_2018	Protein	QBH90512.1
China_LN_2018	Protein	QBH90697.1
China_wbBS01_2018	Protein	QDL88055.1
Ukraine_Kyiv_2014	Protein	QED21581.1
Belgium_Etalle_wb_2018	Protein	QED90467.1
Lithuania_LT14_2014	Protein	QEY87830.1
South_Africa_1985	Protein	QGM12890.1
South_Africa_2_2008	Protein	QGM12815.1
Zambia_LIV_1983

Sequence