Strain

Poland_Pol17_04461_C210_2016-2017 (Region: Poland;  Strain: Pol17_04461_C210;  Date: 2016-2017)

Gene

E183L

Description

Annotated in NCBI,  E183L

Location

MG939588.1(-):162255-162809

GenBank Accession

AXZ96180.1

Full name

Envelope protein p54      

CDS

ATGGATTCTGAATTTTTTCAACCGGTTTATCCGCGGCATTATGGTGAGTGTTTGTCACCAGTCACTACACCAAGCTTCTTCTCCACACATATGTATACTATTCTCATTGCTATCGTGGTCTTAGTCATCATTATCATCGTTCTAATCTATCTATTCTCTTCAAGAAAGAAAAAAGCTGCTGCTATTGAGGAGGAAGATATACAGTTTATAAATCCTTATCAAGATCAGCAGTGGGTAGAAGTCACTCCACAACCAGGTACCTCTAAACCAGCTGGAGCGACTACAGCAAGTGTAGGCAAGCCAGTCACGGGCAGACCGGCAACAAACAGACCAGCAACAAACAAACCAGTTACGGACAACCCAGTTACGGACAGACTAGTCATGGCAACTGGCGGGCCGGCGGCCGCACCTGCGGCCGCGAGTGCTCCTGCTCATCCGGCTGAGCCTTACACGACAGTCACTACTCAGAACACTGCTTCACAAACAATGTCGGCTATTGAAAATTTACGACAAAGAAACACCTATACGCATAAAGACCTAGAAAACTCCTTGTAA

Protein

MDSEFFQPVYPRHYGECLSPVTTPSFFSTHMYTILIAIVVLVIIIIVLIYLFSSRKKKAAAIEEEDIQFINPYQDQQWVEVTPQPGTSKPAGATTASVGKPVTGRPATNRPATNKPVTDNPVTDRLVMATGGPAAAPAAASAPAHPAEPYTTVTTQNTASQTMSAIENLRQRNTYTHKDLENSL

Function

Envelope protein involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward viral factories. Seems to induce caspase-3 activation and apoptosis. Plays a role in virion morphogenesis by recruiting and transforming the host ER membranes into the precursors of the viral envelope.
Envelope protein involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward viral factories (PubMed:11559815). Seems to induce caspase-3 activation and apoptosis (PubMed:15225638). Plays a role in virion morphogenesis by recruiting and transforming the host ER membranes into the precursors of the viral envelope (PubMed:15047843).

Subunit

Interacts with the host light chain cytoplasmic dynein DYNLL1; this interaction is critical for intracellular microtubule-dependent virus transport toward viral factories.

Similarity

Belongs to the asfivirus envelope protein p54 family.

Keywords

Apoptosis   Complete proteome   Cytoplasmic inwards viral transport   Host cytoplasm   Host cytoskeleton   Host endoplasmic reticulum   Host membrane   Host-virus interaction   Membrane   Microtubular inwards viral transport   Repeat   Transmembrane   Transmembrane helix   Viral envelope protein   Virion   Virus entry into host cell   Reference proteome  

Feature

chain  Envelope protein p54

Uniprot

B9UNK6   E0WM75   A0A2Z6BDP3   A0A1Q2TSG0   B2MUM6   R4RWB9   + More
R4S7F0   B9UNI8   A0A059SS19   W5RPZ4   A0A146F0F5   A0A1Q2TSF1   A0A1Q2TSF2   A0A146F0G6   A0A1Q2TSG4   A0A1Q2TSF9   A0A146F0H9   B9UNL1   W8DM39   A0A059SQU0   A0A059SQY5   B9UNH0   A0A068EX60   B9UNJ6   W8DM87   W5RR64   W8DLZ4   A0A059SRA4   A0A059SS60   B9UNG2   Q65271   B9UNG8   B9UNG9   P0CA00   B9UNG1   P0C9Z9   A0A059SS95   B7TBE4   B9UNK3   A0A059SQT1   A0A059SS09   B9UNK1   B9UNL2   A0A059SRX9   B9UNJ4   B7TBE0   A0A059SQT9   B9UNE7   B9UNH1   B9UNG5   W8DMF5   B9UNH4   B9UNE8   A0A059SQS1   B9UNG4   A0A059SRX6   A0A059SRB8   A0A059SQX7   Q65270   A0A059SQR3   G0Y739   A0A1B3IHA3   A0A1B3IH83   B9UNE9   A0A0N7CU17   A9JLB2   D4I5E9   A9JM49   E0WMT0   Q4TWM1   Q65194   B9UNF0   Q65273   D9UBA6   Q65272   B9UNH2   D9UB98   B9UNG3   B9UNG7   D9UBA0   B9UNI3   A0A1B1MRZ7   A0A1B0V6C7   B9UNI5   A0A059SRZ0   B9UNI4   D9UBB6   A0A0C4K0H2   B9UNJ1   S5TJT9   A0A059SQX3   A0A059SRZ3   A0A059SS17   A0A059SS18   W5RQN4   A0A059SQT8   B9UNI2   P0C9Z8   W5RQB8   Q65275  

Pubmed

21470447    25148518    7730797    19009341    21801650    26618713    + More
18198370    25406173    11831707    7933107    11559815    15047843    15225638    20686048    9603333    27211823    24996815   

EMBL

EU874377    ACJ61636.1    FR682468    CBW46791.1    LC322015    BBD14109.1    + More
LC174765    BAW94565.1    EU620681    EU620682    EU620683    EU620684    EU620685    EU874376    EU874380    EU874384    JN582354    JN582355    JN582356    JN582357    JN582358    JQ771681    JQ771682    JQ771683    JQ771684    JQ771685    JQ771686    JX857494    JX857495    JX857496    JX857497    JX857498    JX857499    JX857500    JX857501    JX857502    JX857503    JX857504    JX857505    JX857506    JX857507    KC610531    KC610532    KC610533    KC610534    KC610535    KC610536    KC610538    KC610539    KC535555    KF015965    KF015966    KF015967    KF015977    KF015978    KF015979    KF015980    KF015982    KF015983    KF015984    KF015985    KC662387    KF834194    KJ380910    KJ627186    KJ627187    KJ627188    KJ627189    KJ627190    KJ627191    KJ627192    KJ627193    KJ627194    KJ627195    KJ627196    MH717102    MG939583    MG939588    MH735140    AM999765    LS478113    ACC95838.1    ACC95839.1    ACC95840.1    ACC95841.1    ACC95842.1    ACJ61635.1    ACJ61639.1    ACJ61643.1    AEX07905.1    AEX07906.1    AEX07907.1    AEX07908.1    AEX07909.1    AFD34343.1    AFD34344.1    AFD34345.1    AFD34346.1    AFD34347.1    AFD34348.1    AFY22678.1    AFY22679.1    AFY22680.1    AFY22681.1    AFY22682.1    AFY22683.1    AFY22684.1    AFY22685.1    AFY22686.1    AFY22687.1    AFY22688.1    AFY22689.1    AFY22690.1    AFY22691.1    AGL93190.1    AGL93191.1    AGL93192.1    AGL93193.1    AGL93194.1    AGL93195.1    AGL93197.1    AGL93198.1    AHA58720.1    AHA58872.1    AHA58873.1    AHA58874.1    AHA58884.1    AHA58885.1    AHA58886.1    AHA58887.1    AHA58889.1    AHA58890.1    AHA58891.1    AHA58892.1    AHA58940.1    AHH83723.1    AHN94307.1    AII03113.1    AII03114.1    AII03115.1    AII03116.1    AII03117.1    AII03118.1    AII03119.1    AII03120.1    AII03121.1    AII03122.1    AII03123.1    AXL65963.1    AXZ95897.1    AXZ96180.1    AYD60221.1    CAQ53724.1    SPS73548.1    KC610530    AGL93189.1    KC610537    AGL93196.1    EU874359    EU874381    KF015960    ACJ61618.1    ACJ61640.1    AHA58867.1    KF736430    AHA58911.1    KC535550    AHA58715.1    LC088174    BAU68265.1    LC174759    BAW94559.1    LC174758    BAW94558.1    LC088175    BAU68266.1    LC174763    BAW94563.1    LC174764    BAW94564.1    LC088176    BAU68267.1    EU874382    KF015928    KF015929    KF015930    KF015931    ACJ61641.1    AHA58835.1    AHA58836.1    AHA58837.1    AHA58838.1    KF015861    KF015975    KF015981    KC662391    AHA58768.1    AHA58882.1    AHA58888.1    AHA58944.1    KF015932    AHA58839.1    KF015974    KF015976    AHA58881.1    AHA58883.1    EU874341    KF015857    KF015862    KF015863    ACJ61600.1    AHA58764.1    AHA58769.1    AHA58770.1    KJ671541    AID55013.1    EU874367    KF015859    KF015968    KF736433    ACJ61626.1    AHA58766.1    AHA58875.1    AHA58913.1    KF015860    KC662379    KC662385    AHA58767.1    AHA58933.1    AHA58938.1    KC535554    KF015878    AHA58719.1    AHA58785.1    KF015869    KF015891    KC662382    AHA58776.1    AHA58798.1    AHA58935.1    KF015915    KF015916    KF015917    KF015918    KF015943    KF736426    AHA58822.1    AHA58823.1    AHA58824.1    AHA58825.1    AHA58850.1    AHA58907.1    KF015890    AHA58797.1    EU874333    ACJ61592.1    FJ174420    FJ174423    FJ174424    FJ174427    FJ174428    FJ174429    HQ645949    KF015899    KF015907    KF015924    KF015952    KF015970    KF015971    KC662389    MG596460    MG596461    MG596462    MG596465    MG596467    X84890    ACJ39039.1    ACJ39042.1    ACJ39043.1    ACJ39046.1    ACJ39047.1    ACJ39048.1    AEM23928.1    AHA58806.1    AHA58814.1    AHA58831.1    AHA58859.1    AHA58877.1    AHA58878.1    AHA58942.1    AYE67011.1    AYE67012.1    AYE67013.1    AYE67016.1    AYE67018.1    CAA59316.1    EU874339    ACJ61598.1    EU874340    EU874369    EU874370    KF015944    KC662390    ACJ61599.1    ACJ61628.1    ACJ61629.1    AHA58851.1    AHA58943.1    AY261366    EU874332    KF015956    ACJ61591.1    AHA58863.1    AY261363    KF736415    AHA58897.1    FJ174426    ACJ39045.1    EU874374    ACJ61633.1    KF015871    KF015873    AHA58778.1    AHA58780.1    KF015969    AHA58876.1    EU874372    EU874373    ACJ61631.1    ACJ61632.1    EU874383    ACJ61642.1    KF015874    AHA58781.1    EU874365    KF015865    KF015866    ACJ61624.1    AHA58772.1    AHA58773.1    FJ174422    EU874371    ACJ39041.1    ACJ61630.1    KF015886    AHA58793.1    EU874318    ACJ61577.1    EU874342    EU874344    EU874378    EU874379    ACJ61601.1    ACJ61603.1    ACJ61637.1    ACJ61638.1    EU874336    ACJ61595.1    KC662384    AHA58937.1    EU874345    ACJ61604.1    EU874319    ACJ61578.1    KF015892    KF015973    AHA58799.1    AHA58880.1    EU874335    EU874358    EU874375    KF015870    KF736427    KC662380    KC662383    ACJ61594.1    ACJ61617.1    ACJ61634.1    AHA58777.1    AHA58908.1    AHA58934.1    AHA58936.1    KF015864    AHA58771.1    KF736413    AHA58895.1    KF015961    KF736435    AHA58868.1    AHA58914.1    X84888    CAA59314.1    KF015867    AHA58774.1    HQ645948    KF015881    KX121485    KX121486    KX121487    KX121488    KX121492    KX121493    KX121497    KX121498    KX121499    KX121500    KX121501    KX121502    KX121503    KX121504    KX121508    KX121509    KX121520    KX121521    KX121522    KX121523    KX121524    KX121525    KX121526    KX121527    KX121528    KX121529    KX121530    KX121536    AEM23927.1    AHA58788.1    AOF39538.1    AOF39539.1    AOF39540.1    AOF39541.1    AOF39545.1    AOF39546.1    AOF39550.1    AOF39551.1    AOF39552.1    AOF39553.1    AOF39554.1    AOF39555.1    AOF39556.1    AOF39557.1    AOF39561.1    AOF39573.1    AOF39574.1    AOF39575.1    AOF39576.1    AOF39577.1    AOF39578.1    AOF39579.1    AOF39580.1    AOF39581.1    AOF39582.1    AOF39583.1    AOF39589.1    KX121484    KX121515    KX121516    KX121537    AOF39537.1    AOF39568.1    AOF39569.1    AOF39590.1    KX121496    AOF39549.1    EU874320    ACJ61579.1    KP055815    AKO62806.1    AM712239    CAN10225.1    FN557520    CBH29225.1    AM712240    CAN10474.1    FR686763    CBW52780.1    DQ028315    DQ028316    DQ028317    DQ028318    DQ028319    DQ028320    DQ028321    DQ028323    FJ238534    FJ238535    FJ238536    FJ174384    FJ174385    FJ174386    FJ174387    FJ174388    FJ174389    FJ174390    FJ174391    FJ174392    FJ174393    FJ174394    FJ174395    FJ174396    FJ174397    FJ174398    FJ174399    FJ174400    FJ174401    FJ174402    FJ174403    FJ174404    FJ174405    FJ174406    FJ174407    FJ174408    FJ174409    FJ174410    FJ174411    FJ174412    FJ174413    FJ174414    FJ174415    FJ174416    FJ174417    FJ174418    FJ174419    FJ174421    EU874322    EU874323    EU874324    EU874325    EU874326    EU874327    EU874328    KC535549    KF015868    KF015877    KF015879    KF015893    KF015894    KF015895    KF015903    KF015904    KF015905    KF015906    KF015945    KF015953    KF015954    KF015955    KF015962    KF015972    KF736411    KF736429    KF736432    KC662386    KC662388    KC662392    KC662393    KM262844    KM262845    KM102979    KT150945    KT150946    KT150947    KT150948    KT150949    KT150950    KT150951    KT150952    KT150953    KT150954    KT150955    KT150956    KT150957    KT150958    KT150959    KT150960    KT150961    KT150962    KT150963    KT150964    KT150965    KT150966    KT150967    KT150968    KT150969    KT150970    KT150971    KT150972    KT150973    KX354450    KT961344    KT961345    KT961346    KT961347    KT961348    KT961349    KT961350    KT961351    KT961352    KT961353    KT961354    KT961355    KT961356    KT961357    KT961358    KT961359    KT961360    KT961361    KT961362    KT961363    MG674298    MG674299    MG596439    MG596440    MG596441    MG596442    MG596443    MG596444    MG596445    MG596446    MG596447    MG596448    MG596449    MG596450    MG596451    MG596452    MG596453    MG596454    MG596455    MG596456    MG596457    MG596458    MG596459    MG596463    MG596464    MG596466    MG596468    FR668247    FR668248    FR668249    FR668250    FR668251    FR668252    FR668253    FR668254    FR668271    FR681820    FR681828    FR681833    FR681837    AAY46101.1    AAY46102.1    AAY46103.1    AAY46104.1    AAY46105.1    AAY46106.1    AAY46107.1    AAY46109.1    ACJ37444.1    ACJ37445.1    ACJ37446.1    ACJ39003.1    ACJ39004.1    ACJ39005.1    ACJ39006.1    ACJ39007.1    ACJ39008.1    ACJ39009.1    ACJ39010.1    ACJ39011.1    ACJ39012.1    ACJ39013.1    ACJ39014.1    ACJ39015.1    ACJ39016.1    ACJ39017.1    ACJ39018.1    ACJ39019.1    ACJ39020.1    ACJ39021.1    ACJ39022.1    ACJ39023.1    ACJ39024.1    ACJ39025.1    ACJ39026.1    ACJ39027.1    ACJ39028.1    ACJ39029.1    ACJ39030.1    ACJ39031.1    ACJ39032.1    ACJ39033.1    ACJ39034.1    ACJ39035.1    ACJ39036.1    ACJ39037.1    ACJ39038.1    ACJ39040.1    ACJ61581.1    ACJ61582.1    ACJ61583.1    ACJ61584.1    ACJ61585.1    ACJ61586.1    ACJ61587.1    AHA58714.1    AHA58775.1    AHA58784.1    AHA58786.1    AHA58800.1    AHA58801.1    AHA58802.1    AHA58810.1    AHA58811.1    AHA58812.1    AHA58813.1    AHA58852.1    AHA58860.1    AHA58861.1    AHA58862.1    AHA58869.1    AHA58879.1    AHA58893.1    AHA58910.1    AHA58912.1    AHA58939.1    AHA58941.1    AHA58945.1    AHA58946.1    AIY22316.1    AIY22474.1    AJZ77139.1    ANP38952.1    ANP38953.1    ANP38954.1    ANP38955.1    ANP38956.1    ANP38957.1    ANP38958.1    ANP38959.1    ANP38960.1    ANP38961.1    ANP38962.1    ANP38963.1    ANP38964.1    ANP38965.1    ANP38966.1    ANP38967.1    ANP38968.1    ANP38969.1    ANP38970.1    ANP38971.1    ANP38972.1    ANP38973.1    ANP38974.1    ANP38975.1    ANP38976.1    ANP38977.1    ANP38978.1    ANP38979.1    ANP38980.1    AOO54494.1    APA62506.1    APA62507.1    APA62508.1    APA62509.1    APA62510.1    APA62511.1    APA62512.1    APA62513.1    APA62514.1    APA62515.1    APA62516.1    APA62517.1    APA62518.1    APA62519.1    APA62520.1    APA62521.1    APA62522.1    APA62523.1    APA62524.1    APA62525.1    AXY94498.1    AXY94499.1    AYE66990.1    AYE66991.1    AYE66992.1    AYE66993.1    AYE66994.1    AYE66995.1    AYE66996.1    AYE66997.1    AYE66998.1    AYE66999.1    AYE67000.1    AYE67001.1    AYE67002.1    AYE67003.1    AYE67004.1    AYE67005.1    AYE67006.1    AYE67007.1    AYE67008.1    AYE67009.1    AYE67010.1    AYE67014.1    AYE67015.1    AYE67017.1    AYE67019.1    CBV98086.1    CBV98087.1    CBV98088.1    CBV98089.1    CBV98090.1    CBV98091.1    CBV98092.1    CBV98093.1    CBV98110.1    CBW45563.1    CBW45571.1    CBW45576.1    CBW45580.1    U18466    EU874321    ACJ61580.1    X84892    CAA59318.1    FR681825    CBW45568.1    X84889    EU874343    ACJ61602.1    FR681817    CBW45560.1    EU874334    EU874337    ACJ61593.1    ACJ61596.1    EU874338    ACJ61597.1    FR681819    CBW45562.1    EU874354    ACJ61613.1    KT795363    KT795364    KT795365    KT795368    KT795369    KT795370    KU291452    KU291453    AMQ11010.1    AMQ11011.1    AMQ11012.1    AMQ11015.1    AMQ11016.1    AMQ11017.1    ANS71339.1    ANS71340.1    KT795362    KT795366    KT795367    AMQ11009.1    AMQ11013.1    AMQ11014.1    EU874356    ACJ61615.1    KF015908    KF015909    AHA58815.1    AHA58816.1    EU874355    KF015947    ACJ61614.1    AHA58854.1    FR681835    CBW45578.1    KF706356    KF706357    KF706358    KF706359    AHJ10466.1    AHJ10467.1    AHJ10468.1    AHJ10469.1    EU874362    KF015897    KF015920    KF015948    KF015949    KF015950    KF015951    ACJ61621.1    AHA58804.1    AHA58827.1    AHA58855.1    AHA58856.1    AHA58857.1    AHA58858.1    KC896388    KF015942    AGS41515.1    AHA58849.1    KF736423    AHA58904.1    KF015919    AHA58826.1    KF736420    AHA58901.1    KF736425    AHA58906.1    KC535551    KF015926    AHA58716.1    AHA58833.1    KF015927    AHA58834.1    EU874353    ACJ61612.1    AY261360    KC535553    KF015896    KF015922    KF015933    AHA58718.1    AHA58803.1    AHA58829.1    AHA58840.1    FJ174430    X84893    ACJ39049.1    CAA59319.1   

Proteomes

UP000141072    UP000000858    UP000000859    UP000241813    UP000130745    UP000101090    + More
UP000108903    UP000110401    UP000117635    UP000142390    UP000266411    UP000000624    UP000000861   

Pfam

PF05568   ASFV_J13L

Interpro

IPR008385   ASFV_j13L

ProteinModelPortal

B9UNK6   E0WM75   A0A2Z6BDP3   A0A1Q2TSG0   B2MUM6   R4RWB9   + More
R4S7F0   B9UNI8   A0A059SS19   W5RPZ4   A0A146F0F5   A0A1Q2TSF1   A0A1Q2TSF2   A0A146F0G6   A0A1Q2TSG4   A0A1Q2TSF9   A0A146F0H9   B9UNL1   W8DM39   A0A059SQU0   A0A059SQY5   B9UNH0   A0A068EX60   B9UNJ6   W8DM87   W5RR64   W8DLZ4   A0A059SRA4   A0A059SS60   B9UNG2   Q65271   B9UNG8   B9UNG9   P0CA00   B9UNG1   P0C9Z9   A0A059SS95   B7TBE4   B9UNK3   A0A059SQT1   A0A059SS09   B9UNK1   B9UNL2   A0A059SRX9   B9UNJ4   B7TBE0   A0A059SQT9   B9UNE7   B9UNH1   B9UNG5   W8DMF5   B9UNH4   B9UNE8   A0A059SQS1   B9UNG4   A0A059SRX6   A0A059SRB8   A0A059SQX7   Q65270   A0A059SQR3   G0Y739   A0A1B3IHA3   A0A1B3IH83   B9UNE9   A0A0N7CU17   A9JLB2   D4I5E9   A9JM49   E0WMT0   Q4TWM1   Q65194   B9UNF0   Q65273   D9UBA6   Q65272   B9UNH2   D9UB98   B9UNG3   B9UNG7   D9UBA0   B9UNI3   A0A1B1MRZ7   A0A1B0V6C7   B9UNI5   A0A059SRZ0   B9UNI4   D9UBB6   A0A0C4K0H2   B9UNJ1   S5TJT9   A0A059SQX3   A0A059SRZ3   A0A059SS17   A0A059SS18   W5RQN4   A0A059SQT8   B9UNI2   P0C9Z8   W5RQB8   Q65275  

KEGG

vg:22220355    

GO

GO:0016021  C:integral component of membrane
GO:0044163  C:host cytoskeleton
GO:0019031  C:viral envelope
GO:0075521  P:microtubule-dependent intracellular transport of viral material towards nucleus
GO:0046718  P:viral entry into host cell
GO:0044167  C:host cell endoplasmic reticulum membrane
GO:0055036  C:virion membrane

From MSLVP

Single-Pass Membrane

From Uniprot

Virion membrane   Detected mainly on membrane-like structures within viral factories. Present in mature extracellular virions. Host DYNLL1 and viral p54 interact at the microtubular organizing center.   With evidence from 2 publications.
Host cytoplasm   Detected mainly on membrane-like structures within viral factories. Present in mature extracellular virions. Host DYNLL1 and viral p54 interact at the microtubular organizing center.   With evidence from 2 publications.
Host cytoskeleton   Detected mainly on membrane-like structures within viral factories. Present in mature extracellular virions. Host DYNLL1 and viral p54 interact at the microtubular organizing center.   With evidence from 2 publications.
Host endoplasmic reticulum membrane   Detected mainly on membrane-like structures within viral factories. Present in mature extracellular virions. Host DYNLL1 and viral p54 interact at the microtubular organizing center.   With evidence from 2 publications.

Length:

184

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.55467

Exp number, first 60 AAs:

22.53251

Total prob of N-in:

0.00148

POSSIBLE N-term signal

sequence

outside

1  -  29

TMhelix

30  -  52

inside

53  -  184

 

 

Pi

0.0528241

Theta

0.0668445

Tajima's D

-0.9246496

CLR

0

Interpretation

No evidence of Selection