Strain

Poland_Pol16_20540_o10_2016-2017 (Region: Poland; Strain: Pol16_20540_o10; Date: 2016-2017)

Gene

IAP homolog

Description

Annoated by sequence mapping, putative product contains BIR motif of baculovirus IAP proteins

Location

MG939585.1(-):46328-47002

GenBank Accession

CAN10132.1

Full name

Inhibitor of apoptosis protein + More
IAP-like protein p27

CDS

ATGTTTCCTAAAATAAATACGATAGATCCATACATCTCTTTGCGATTATTTGAAGTAAAACCTAAATATGTAGGCTATAGCTCCATAGATGCACGAAATCAAAGCTTCGCAATCCATGACATAAAAAATTATGAAAAATTTTCGAATGCCGGATTATTCTATACATCCCCCACTGAAATAACATGCTACTGTTGCGGAATGAAATTTTGTAATTGGTTATATGAAAAGCACCCTTTACAGGTGCATGCTTTTTGGAGCAGAAACTGTGGCTTTATGCGTGCAACCTTGGGCATTATAGGACTTAAAAAAATGATTGATAGCTATAACGACTATTATAACAATGAAGTTTTTGTAAAACACCAAAATAGGGTTTATACCCACAAAAGATTAGAAGATATGGGTTTTTCCAAGCCTTTTATGCGATTTATTTTGGCAAATGCTTTCATTCCTCCTTATCGAAAATACATTCATAAGATCATTTTAAATGAAAGATATTTTACTTTTAAATTTGCGGCTCACTTACTTTCCTTTCATAAAGTTAATCTTGATAATCAAACAACATATTGTATGACATGTGGTATTGAACCAATTAAAAAAGATGAAAATTTCTGCAATGCATGCAAAACACTTAATTATAAACACTATAAAACACTGAATTTTAGTGTCAAACTTTGA

Protein

MFPKINTIDPYISLRLFEVKPKYVGYSSIDARNQSFAIHDIKNYEKFSNAGLFYTSPTEITCYCCGMKFCNWLYEKHPLQVHAFWSRNCGFMRATLGIIGLKKMIDSYNDYYNNEVFVKHQNRVYTHKRLEDMGFSKPFMRFILANAFIPPYRKYIHKIILNERYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL

Function

Prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation. Induces also the activation of host NF-kappaB.

Subunit

Interacts with subunit p17 of host CASP3.

Similarity

Belongs to the asfivirus IAP family.

Keywords

Activation of host NF-kappa-B by virus Complete proteome Host cytoplasm Host-virus interaction Inhibition of host caspases by virus Metal-binding Modulation of host cell apoptosis by virus Reference proteome Zinc Zinc-finger

Feature

chain Inhibitor of apoptosis protein

Uniprot

A9JKW7 D4I5M1 A9JLM2 D0Q0F0 P69180 P69184 + More
P69183 P69182 P69181 E0WMH0 A0A2X0THP1 O11452 P0C9X6 P0C9X5 P68765 P68763 P68764 O11451 O11453 A0A0C5BCK7 P0C9X4 A0A0C5BC53 A0A293M076 A0A293LGI3 A0A293MZW6 A0A147B6T0

Pubmed

18198370 19477086 25406173 26618713 11831707 8553574 + More
11222676 11907233 9143281 21470447 25645905

EMBL

AM712239 CAN10132.1 FN557520 CBH29134.1 AM712240 CAN10381.1 + More
FJ394332 KM262844 KM262845 KM102979 KP055815 KX354450 ACQ99372.1 AIY22224.1 AIY22383.1 AJZ77127.1 AKO62715.1 AOO54360.1 U18466 U91736 U91735 U91734 U91733 U91739 FR682468 CBW46698.1 MG939583 MG939587 MG939588 LS478113 AXZ95810.1 AXZ95998.1 AXZ96093.1 SPS73455.1 U91737 AY261366 AY261363 U91740 U91730 U91731 U91732 U91738 AY261361 KM111295 MH025916 MH025917 MH025918 MH025919 MH025920 AJL34213.1 AXB49262.1 AXB49436.1 AXB49608.1 AXB49779.1 AXB49952.1 AY261360 KM111294 AJL34048.1 GFWV01008699 MAA33428.1 GFWV01002211 MAA26941.1 GFWV01021654 MAA46382.1 GEIB01001940 JAR86493.1

Proteomes

UP000130745 UP000101090 UP000108903 UP000110401 UP000117635 UP000142390 + More
UP000241813 UP000266411 UP000000624 UP000141072 UP000000858 UP000000859 UP000000860 UP000101566 UP000000861 UP000105860

PRIDE

P69181 O11452 P68764 O11451

Pfam

PF00653 BIR
PF06556 ASFV_p27

Interpro

IPR001370 BIR_rpt
IPR010549 ASFV_p27_C

CDD

cd00022 BIR

ProteinModelPortal

A9JKW7 D4I5M1 A9JLM2 D0Q0F0 P69180 P69184 + More
P69183 P69182 P69181 E0WMH0 A0A2X0THP1 O11452 P0C9X6 P0C9X5 P68765 P68763 P68764 O11451 O11453 A0A0C5BCK7 P0C9X4 A0A0C5BC53 A0A293M076 A0A293LGI3 A0A293MZW6 A0A147B6T0

PDB

1Q4Q E-value=0.00241937, Score=94

Ontologies

KEGG

vg:22220415

GO

GO:0039650  P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
GO:0046872  F:metal ion binding
GO:0039652  P:activation by virus of host NF-kappaB transcription factor activity
GO:0030430  C:host cell cytoplasm
GO:0016874  F:ligase activity

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host cytoplasm Probably accumulates in the cytoplasmic viral factories. With evidence from 5 publications.

Topology

Length:

224

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1079

Exp number, first 60 AAs:

0.00727

Total prob of N-in:

0.04128

outside

1 - 224

Population Genetic Test Statistics

Pi

0.0359264

Theta

0.0409595

Tajima's D

-0.6398028

CLR

0.153789

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62715.1
China_AnhuiXCGQ_2018	Protein	AYW34004.1
China_ASFV-SY18_2018	Protein	AKO62715.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95810.1
Poland_Pol16_20538_o9_2016-2017	Protein	CAN10132.1
Poland_Pol16_20540_o10_2016-2017	Protein	CAN10132.1
Poland_Pol16_29413_o23_2016-2017	Protein	CAN10132.1
Poland_Pol17_03029_C201_2016-2017	Protein	AXZ95998.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96093.1
Poland_Pol17_05838_C220_2016-2017	Protein	CAN10132.1
Poland_ASFV_POL_Podlaskie_2015	Protein	CAN10132.1
Uganda_R8_2015	Protein	AXB49262.1
Uganda_R7_2015	Protein	AXB49436.1
Uganda_R25_2015	Protein	AXB49608.1
Uganda_N10_2015	Protein	AXB49779.1
Uganda_R35_2015	Protein	AXB49952.1
Estonia_2014	Protein	SPS73455.1
Italy_26544_OG10_2010	Protein	AJZ77127.1
Italy_47_Ss_2008_2008	Protein	AOO54360.1
Portugal_OURT_88.3_1988	Protein	CAN10381.1
Spain_E75_1975	Protein	CBH29134.1
Russia_Georgia_2007	Protein	CBW46698.1
Kenya_Tk1_2005	Protein	AJL34048.1
Kenya_Bus_2006	Protein	AJL34213.1
Russia_Odintsovo_2014	Protein	CAN10132.1
Portugal_L60_1960	Protein	AIY22224.1
Portugal_NHV_1968	Protein	AIY22383.1
Russia_Kashino_2013	Protein	CAN10132.1
Benin_1997	Protein Protein	CAN10132.1 CAN10132.1
South_Africa_KNP_Pretorisuskop_1996	Protein	CAN10132.1
South_Africa_MGR_Mkuzi_1979	Protein	CAN10132.1
Malawi_Lil_1983	Protein	CAN10132.1
Kenya_1950	Protein	CAN10132.1
Namibia_Warthog_1980	Protein	CAN10132.1
South_Africa_Warmbaths_1987	Protein	CAN10132.1
Malawi_Tengani_1962	Protein	CAN10132.1
China_HLJ_2018	Protein	QBH90520.1
China_LN_2018	Protein	QBH90705.1
China_wbBS01_2018	Protein	QDL88063.1
Ukraine_Kyiv_2014	Protein	QED21590.1
Belgium_Etalle_wb_2018	Protein	QED90475.1
Lithuania_LT14_2014	Protein	QEY87838.1
South_Africa_1985
South_Africa_2_2008	Protein	CAN10132.1
Zambia_LIV_1983

Sequence