Strain

Italy_47_Ss_2008_2008 (Region: Sardinia, Italy;  Strain: 47/Ss/2008;  Date: 2008)

Gene

A179L

Description

Annotated in NCBI,  apoptosis regulator Bcl-2-like protein

Location

KX354450.1(-):49332-49871

GenBank Accession

AOO54371.1

Full name

Apoptosis regulator Bcl-2 homolog      

Alternative Name

LMH-5W

CDS

ATGGAGGGAGAAGAGTTAATATATCATAATATCATTAATGAAATACTAGTGGGTTATATTAAATATTACATTAATGATATTTCAGAGCATGAGCTTAGCCCATATCAACAACAAATAAAAAAAATTTTAACCTATTATGATGAGTGTTTGAACAAACAGGTTACAATTACCTTTTCTCTTACGAGTGTCCAAGAAATTAAAACCCAGTTTACTGGGGTTGTGACTGAGCTGTTTAAGGATCTTATCAACTGGGGTAGAATTTGTGGATTTATCGTCTTTTCTGCCAAGATGGCAAAGTATTGCAAAGACGCCAATAACCATCTGGAGTCCACGGTGATCACTACGGCATACAACTTCATGAAACACAACCTACTACCCTGGATGATTTCCCACGGCGGTCAAGAGGAGTTTTTGGCTTTCTCTCTACACAGTGACATGTATTCCGTGATTTTTAATATTAAATATTTCTTATCTAAATTTTGTAATCACATGTTTTTCAGATCCTGTGTACAGTTATTAAGAAACTGCAATTTGATATAG

Protein

MEGEELIYHNIINEILVGYIKYYINDISEHELSPYQQQIKKILTYYDECLNKQVTITFSLTSVQEIKTQFTGVVTELFKDLINWGRICGFIVFSAKMAKYCKDANNHLESTVITTAYNFMKHNLLPWMISHGGQEEFLAFSLHSDMYSVIFNIKYFLSKFCNHMFFRSCVQLLRNCNLI

Function

Suppresses apoptosis in host cell and thus facilitates production of progeny virions (PubMed:9123849, PubMed:18329683). Has the ability to potentially bind to all the members of the proapoptotic Bcl-2 family (PubMed:28053104, PubMed:18329683).
Suppresses apoptosis in host cell and thus facilitates production of progeny virions. Has the ability to potentially bind to all the members of the proapoptotic Bcl-2 family.

Subunit

Interacts with host BECN1 (PubMed:23228131). Interacts with host BID (PubMed:28053104). dInteracts with host BAX (PubMed:28053104).
Interacts with host BECN1. Interacts with host BID. Interacts with host BAX.

Miscellaneous

Expressed early and late in the infection cycle.

Similarity

Belongs to the Bcl-2 family.

Keywords

3D-structure   Apoptosis   Complete proteome   Host-virus interaction   Inhibition of host apoptosis by viral BCL2-like protein   Modulation of host cell apoptosis by virus   Reference proteome  

Feature

chain  Apoptosis regulator Bcl-2 homolog

Uniprot

D4I5M9   A9JLP1   E0WMH9   D0Q0E8   P42485   Q07818   + More
P0C8H6   P0C8H5   A9JKY0   Q07819   A0A0C5AZD3   P0C8H4   A0A0C5AZX0  

Pubmed

18198370    21470447    25406173    26618713    11831707    9123849    + More
18329683    23228131    28053104    8389936    25645905   

EMBL

FN557520    CBH29142.1    AM712240    CAN10389.1    FR682468    CBW46707.1    + More
FJ394330    FJ394331    KM262844    KM262845    KM102979    KP055815    KX354450    MG939583    MG939587    MG939588    LS478113    ACQ99370.1    ACQ99371.1    AIY22232.1    AIY22391.1    AJZ77140.1    AKO62723.1    AOO54371.1    AXZ95817.1    AXZ96005.1    AXZ96100.1    SPS73464.1    U18466    AY261366    AY261363    AM712239    CAN10140.1    L09548    AY261361    KM111294    AJL34055.1    AY261360    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34220.1    AXB49270.1    AXB49444.1    AXB49616.1    AXB49787.1    AXB49960.1   

Proteomes

UP000101090    UP000108903    UP000141072    UP000110401    UP000117635    UP000142390    + More
UP000241813    UP000266411    UP000000624    UP000000858    UP000000859    UP000130745    UP000000860    UP000105860    UP000000861    UP000101566   

Pfam

PF00452   Bcl-2

Interpro

IPR036834   Blc2-like_sf
IPR026298   Blc2_fam
IPR020717   Bcl2_BH1_motif_CS
IPR002475   Bcl2-like
IPR020726   Bcl2_BH2_motif_CS

SUPFAM

SSF56854   SSF56854

Gene 3D

1.10.437.10    

ProteinModelPortal

D4I5M9   A9JLP1   E0WMH9   D0Q0E8   P42485   Q07818   + More
P0C8H6   P0C8H5   A9JKY0   Q07819   A0A0C5AZD3   P0C8H4   A0A0C5AZX0  

PANTHER

PTHR11256  

PDB

5UA5     E-value=5.16993e-78,     Score=736