Strain

Russia_Georgia_2007 (Region: Russia; Strain: Georgia 2007/1; Date: 2007)

Gene

R298L

Description

Annotated in NCBI, structural protein

Location

FR682468.1(-):156057-156953

GenBank Accession

CBW46786.1

Full name

Serine/threonine-protein kinase 1

CDS

ATGTCCAGGCCGGAACAACAGCTTAAAAAAATGTTAAAAAATCCCCAGGCACAATATGCGTTTTATCCTACAGCAAAGGTGGAAAGGATCTCCACAACGCAGCACATGTATTTCATTGCGACGAGACCCATGTTTGAGGGTGGCAGAAATAACGTCTTTTTGGGTCATCAAGTAGGGCAACCCATTATATTTAAGTACGTTTCTAAAAAAGAAATTCCAGGAAATGAAGTCATCGTGTTGAAAGCCCTGCAAGATACTCCCGGTGTTATTAAGCTTATCGAATATACCGAAAATGCTATGTATCATATACTAATCATAGAATATATTCCAAATAGTGTTGATCTACTTCATTATCATTACTTTAAAAAACTTGAGGAAACCGAAGCCAAAAAAATAATATTCCAGCTTATTCTTATTATACAAAACATTTATGAGAAGGGCTTTATCCATGGGGATATTAAGGATGAGAACCTTATTATAGACATAAATCAAAAGATCATTAAGGTCATTGACTTTGGAAGCGCTGTTAGATTAGACGAAACCCGTCCCCAATATAATATGTTTGGAACATGGGAATACGTGTGTCCAGAATTTTATTATTATGGTTATTACTACCAGCTTCCTTTAACCGTGTGGACGATAGGTATGGTCGCGGTTAATCTTTTTAGATTTCGTGCAGAAAATTTTTATTTAAATGATATCCTGAAACGGGAAAATTATATTCCCGAGAACATTTCAGAGACGGGAAAACAGTTTATCACGGAATGTTTAACAATTAATGAAAATAAGCGGCTTTCCTTTAAGAGTCTTGTATCACATCCTTGGTTTAAAGGACTTAAAAAAGAAATTCAGCCTATTTCGGAACTAGGAGTAGACTATAAAAATGTTATTACTTAG

Protein

MSRPEQQLKKMLKNPQAQYAFYPTAKVERISTTQHMYFIATRPMFEGGRNNVFLGHQVGQPIIFKYVSKKEIPGNEVIVLKALQDTPGVIKLIEYTENAMYHILIIEYIPNSVDLLHYHYFKKLEETEAKKIIFQLILIIQNIYEKGFIHGDIKDENLIIDINQKIIKVIDFGSAVRLDETRPQYNMFGTWEYVCPEFYYYGYYYQLPLTVWTIGMVAVNLFRFRAENFYLNDILKRENYIPENISETGKQFITECLTINENKRLSFKSLVSHPWFKGLKKEIQPISELGVDYKNVIT

Function

Essential for viral replication. It may mediate the virus' progression through DNA replication (By similarity).
Essential for viral replication. It may mediate the virus' progression through DNA replication.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Keywords

ATP-binding Complete proteome Host cytoplasm Kinase Nucleotide-binding Reference proteome Transferase Virion

Feature

chain Serine/threonine-protein kinase 1

Uniprot

E0WM70 A0A2X0SE42 D4I5E4 A9JM39 A0A0A1E0V9 P42493 + More
P0C8F3 P0C8F2 P34206 A0A2Z5DG21 A0A0C5BCU2 A0A0C5BCC8 P0C8F4

Pubmed

21470447 18198370 25406173 26618713 11831707 8331722 + More
8397501 8021596 25645905

EMBL

FR682468 CBW46786.1 MG939583 MG939588 LS478113 AXZ95893.1 + More
AXZ96176.1 SPS73543.1 FN557520 CBH29220.1 AM712240 CAN10469.1 KM262844 KM262845 KP055815 AIY22311.1 AIY22469.1 AKO62801.1 U18466 AY261366 AY261363 X72954 M88275 X71982 AY261361 MH025916 MH025917 MH025918 MH025919 MH025920 AXB49349.1 AXB49523.1 AXB49695.1 AXB49866.1 AXB50039.1 KM111295 AJL34298.1 KM111294 AJL34133.1 AY261360

Proteomes

UP000141072 UP000101090 UP000108903 UP000110401 UP000142390 UP000241813 + More
UP000000624 UP000000858 UP000000859 UP000000860 UP000101566 UP000105860 UP000000861

PRIDE

P42493 P0C8F2

Pfam

PF00069 Pkinase

Interpro

IPR000719   Prot_kinase_dom
IPR008271   Ser/Thr_kinase_AS
IPR011009   Kinase-like_dom_sf
IPR016254   Ser/Thr_kinase_asfivir

SUPFAM

SSF56112 SSF56112

ProteinModelPortal

E0WM70 A0A2X0SE42 D4I5E4 A9JM39 A0A0A1E0V9 P42493 + More
P0C8F3 P0C8F2 P34206 A0A2Z5DG21 A0A0C5BCU2 A0A0C5BCC8 P0C8F4

PDB

4X7Q E-value=2.74151e-22, Score=259

Ontologies

KEGG

vg:22220350

GO

GO:0016032  P:viral process
GO:0004674  F:protein serine/threonine kinase activity
GO:0005524  F:ATP binding
GO:0019012  C:virion
GO:0030430  C:host cell cytoplasm
GO:0004672  F:protein kinase activity

Subcellular Location

From MSLVP

Cytoplasm

From Uniprot

Virion
Host cytoplasm

Topology

Length:

298

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

17.47509

Exp number, first 60 AAs:

0.0058

Total prob of N-in:

0.29006

outside

1 - 298

Population Genetic Test Statistics

Pi

0.0363435

Theta

0.047786

Tajima's D

-0.6975067

CLR

0

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62801.1
China_AnhuiXCGQ_2018	Protein	AYW34091.1
China_ASFV-SY18_2018	Protein	AKO62801.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95893.1
Poland_Pol16_20538_o9_2016-2017	Protein	AJL34133.1
Poland_Pol16_20540_o10_2016-2017	Protein	AJL34133.1
Poland_Pol16_29413_o23_2016-2017	Protein	AJL34133.1
Poland_Pol17_03029_C201_2016-2017	Protein	AJL34133.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96176.1
Poland_Pol17_05838_C220_2016-2017	Protein	AJL34133.1
Poland_ASFV_POL_Podlaskie_2015	Protein	AJL34133.1
Uganda_R8_2015	Protein	AXB49349.1
Uganda_R7_2015	Protein	AXB49523.1
Uganda_R25_2015	Protein	AXB49695.1
Uganda_N10_2015	Protein	AXB49866.1
Uganda_R35_2015	Protein	AXB50039.1
Estonia_2014	Protein	SPS73543.1
Italy_26544_OG10_2010	Protein	AJZ77115.1
Italy_47_Ss_2008_2008	Protein	AOO54486.1
Portugal_OURT_88.3_1988	Protein	CAN10469.1
Spain_E75_1975	Protein	CBH29220.1
Russia_Georgia_2007	Protein	CBW46786.1
Kenya_Tk1_2005	Protein Protein	AJL34133.1 AJL34133.1
Kenya_Bus_2006	Protein	AJL34298.1
Russia_Odintsovo_2014	Protein	AJL34133.1
Portugal_L60_1960	Protein	AIY22311.1
Portugal_NHV_1968	Protein	AIY22469.1
Russia_Kashino_2013	Protein	AJL34133.1
Benin_1997	Protein	CAN10220.1
South_Africa_KNP_Pretorisuskop_1996	Protein	AJL34133.1
South_Africa_MGR_Mkuzi_1979	Protein	AJL34133.1
Malawi_Lil_1983	Protein	AJL34133.1
Kenya_1950	Protein	AJL34133.1
Namibia_Warthog_1980	Protein	AJL34133.1
South_Africa_Warmbaths_1987	Protein	AJL34133.1
Malawi_Tengani_1962	Protein	AJL34133.1
China_HLJ_2018	Protein	QBH90608.1
China_LN_2018	Protein	QBH90793.1
China_wbBS01_2018	Protein	QDL88151.1
Ukraine_Kyiv_2014	Protein Protein	QED21729.1 QED21730.1
Belgium_Etalle_wb_2018	Protein	QED90563.1
Lithuania_LT14_2014	Protein	QEY87926.1
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983

Sequence