ASFVdb The African Swine Fever Virus Database
Strain
Russia_Georgia_2007 (Region: Russia;  Strain: Georgia 2007/1;  Date: 2007)
Gene
B119L
Description
Annotated in NCBI,  similar to S. cerevisiae ERV1 protein and Vaccinia virus E10R protein
Location
FR682468.1(-):94949-95308
GenBank Accession
CBW46740.1
Full name
Sulfhydryl oxidase       + More
FAD-linked sulfhydryl oxidase      
Alternative Name
p14
 

Sequence

CDS
ATGTTGCATTGGGGACCTAAATACTGGCGATCCTTGCATCTATATGCTATCTTTTTTTCAGACGCTCCTAGCTGGAAAGAAAAATATGAAGCCATCCAATGGATACTGAACTTTATCGAGTCTCTGCCATGCACCAGGTGCCAGCACCACGCCTTTTCGTATCTTACAAAAAATCCCTTGACATTAAACAACTCGGAGGACTTTCAGTACTGGACCTTCGCGTTCCATAACAACGTAAATAACCGGCTTAATAAAAAAATAATTTCTTGGTCAGAGTATAAAAATATTTATGAACAATCAATCCTTAAAACAATAGAATATGGGAAAACCGACTTTATTGGAGCCTGGTCATCTCTATAA
Protein
MLHWGPKYWRSLHLYAIFFSDAPSWKEKYEAIQWILNFIESLPCTRCQHHAFSYLTKNPLTLNNSEDFQYWTFAFHNNVNNRLNKKIISWSEYKNIYEQSILKTIEYGKTDFIGAWSSL

Summary

Function
FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation (By similarity). Involved in virion maturation.
FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Involved in virion maturation (By similarity).
FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Involved in virion maturation and virulence (By similarity).
Catalytic Activity
O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'
Cofactor
FAD
Subunit
Interacts with A151R.
Similarity
Belongs to the asfivirus B119L family.
Keywords
3D-structure   Complete proteome   Disulfide bond   FAD   Flavoprotein   Host cytoplasm   Late protein   Oxidoreductase   Reference proteome   Virulence  
Feature
chain  FAD-linked sulfhydryl oxidase
Uniprot
A9JL27   D4I5R2   E0WML2   Q71UJ8   Q65163   Q9JFM7   + More
Q9JFN0   Q9JFN2   A9JLW0   A0A0A1E126   Q9JFM8   Q9ICB8   P0C8G9   Q9JFN1   P0C8G8   Q9JFM9   M2XR87   A0A0F7U9P3   Q6XLY8   A0A2C6KM64   A0A086JF07   A0A086K2V9   A0A151H397   A0A139XKV7   S7VZ72   A0A086KFG0   A0A125YR09   A0A2T6IGY7   A0A086LMN5   A0A2G8XRI3   A0A086PGQ6   A0A125YR10   A0A2E3C6A4   A0A074SXN8   A0A086Q6H6   A0A0P0YN22   A0A3G5A8H8   A0A0K0DU75   D8M9I9   A0A2D5BE32   K8F290   A0A2A9M2Y2   A0A2T9Y9T5   A0A2A2KPB1   A0A2H4UUT2   A0A0N7KVR6   A0A0N4ZLU4   A0A0R3PLH2   W8W2H4   A4S5R1   A0A2L2YMN3   A0A2D5MUZ0   A0A1V0SDM5   A0A1I8MMR1   A0A1Q9ENP7   A0A0B1SRQ5   W8W2S2   A0A1I8BBZ3   F4PQC7   A0A1R2B5D6   A0A099NWV8   A0A1J4MJU0   B4NEH8   U6MMC4   A0A2E4HKW1   A0A1V0SC43   A0A2A2KV91   A0A3P7MWK8   A0A2A6CZA0   A0A293NIK7   A0A2D7JUT5   A0A1X7TZ25   Q75JQ5   A0A090LJC8   A0A0M4ETR2   A0A3P7KZ67   E3T5L5   G0T5G1   A0A2D5CG30   T1J897   S6DA40   W8W1X9   A0A1A9XX35   A0A1B0BQS1   B4JHR4   A0A2T9ZGW6   A0A1A9ZK03   A0A1B0G4I3   A0A1A9VS14   B4L6U5   A0A3G4ZSE5   H9BA18   Q29H00   A0A1V0SJ57   B4H0N3   A0A3P3YAU9   A0A2P0VN55   B4MA20   A0A2E1CG62  
EC Number
1.8.3.2
Pubmed
18198370    21470447    10627538    25406173    26618713    11831707    + More
16537584    25645905    23471408    25875305    14745530    28161402    26738725    25480939    29337314    26459929    29764946    17460045    26561354    25315136    24232916    18809916    21757610    17994087    18806794    12097910    15875012    20974979    21632757    23804567    22244352    15632085    29649682   
EMBL
AM712239    CAN10173.1    FN557520    CBH29175.1    FR682468    CBW46740.1    + More
AF081160    AF081164    AF081165    AF081166    AF081170    AF081171    AF081172    AF081177    AF081179    AF081181    KM262844    KM102979    KP055815    KX354450    MG939583    MG939587    MG939588    LS478113    AAF27960.1    AIY22265.1    AJZ77167.1    AKO62755.1    AOO54412.1    AXZ95848.1    AXZ96036.1    AXZ96131.1    SPS73497.1    U18466    AF081180    AAF27976.1    AF081169    AAF27965.1    AF081167    AAF27963.1    AM712240    CAN10423.1    KM262845    AIY22423.1    AF081178    AAF27974.1    AF081161    AF081162    AF081163    AF081173    AF081175    AF081176    AAF27972.1    AY261366    AF081168    KM111294    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AAF27964.1    AJL34087.1    AJL34252.1    AXB49302.1    AXB49476.1    AXB49648.1    AXB49819.1    AXB49992.1    AY261360    AF081174    L00966    AY261361    KB454586    EME26178.1    LN714478    CEL65350.1    AY225134    AAR26923.1    MIGC01004858    PHJ17585.1    AHZU02001596    KFG30725.1    AEYH02002462    KFG38727.1    AHZP02002511    KYK63831.1    AGQS02005750    KYF39413.1    AAQM03000279    EPR58303.1    AEYI02000968    KFG43128.1    KE138818    EPT31357.1    AFHV02003128    PUA84567.1    AFYV02002706    KFG57903.1    AGQR02003086    PIL97633.1    AEYJ02001829    KFG99537.1    LN714493    AAYL02000291    CEL72638.1    ESS29674.1    PAOZ01000008    MBA45251.1    KL544037    KEP64226.1    AEXC02002059    KFH08208.1    LC015648    BAT22424.1    MK072390    AYV83576.1    FN668688    CBK24728.2    NYTV01000001    MAB85690.1    FO082272    CCO66403.1    NWUJ01000011    PFH32299.1    MBFR01000340    PVU89090.1    LIAE01008038    PAV75804.1    MF782455    ATZ80682.1    LC015647    BAT22065.1    UYYA01003882    VDM57193.1    HF920636    CCV02210.1    CP000592    ABO99109.1    IAAA01034264    LAA09398.1    NYWG01000249    MAD25995.1    KY684087    ARF09817.1    LSRX01000105    OLQ09042.1    KN556632    KHJ88003.1    HF920635    CCV02034.1    GL883009    EGG22590.1    MPUH01000938    OMJ72003.1    CP028773    JQFK01000039    MQVM01000016    NHMM01000007    AWU74331.1    KGK37313.1    ONH73086.1    OUT20639.1    LRBP01000017    OII73284.1    CH964239    EDW82147.2    HG722920    CDJ64223.1    PAVG01000034    MBE17959.1    KY684084    ARF09234.1    LIAE01007639    PAV77895.1    UYRV01118730    VDN31310.1    ABKE03000008    PDM83554.1    PAAB01000072    MAA53526.1    NZFV01000046    MAJ01713.1    AAFI01000020    EAL71267.1    LN609529    CEF69813.1    CP012528    ALC49011.1    ALC49014.1    UYYB01095806    VDM75765.1    GU244497    ADO67478.1    GQ918152    ADO00479.1    NYTR01000170    MAB98621.1    JH431950    HF920633    CCV01693.1    HF920634    CCV01861.1    JXJN01018759    CH916369    EDV93903.1    MBFS01000188    PVV03828.1    CCAG010020456    CH933812    EDW06091.2    MK072018    AYV77234.1    JN987605    HG674741    AET50828.1    CDJ39867.1    CH379064    EAL31959.3    KY684109    ARF11750.1    CH479200    EDW29828.1    OVEO01000007    SPQ97296.1    KY322437    AUF82328.1    CH940655    EDW66079.2    PACS01000016    MAU36366.1   
Proteomes
UP000130745    UP000101090    UP000141072    UP000117635    UP000142390    UP000241813    + More
UP000266411    UP000000624    UP000108903    UP000110401    UP000000858    UP000101566    UP000105860    UP000000861    UP000000860    UP000030680    UP000005641    UP000001529    UP000002226    UP000027470    UP000202573    UP000035681    UP000218231    UP000240325    UP000204088    UP000038045    UP000050601    UP000136450    UP000001568    UP000095301    UP000097612    UP000095281    UP000007797    UP000007798    UP000007879    UP000002195    UP000035682    UP000092553    UP000029781    UP000112896    UP000014500    UP000154968    UP000141616    UP000092443    UP000092460    UP000001070    UP000092445    UP000092444    UP000078200    UP000009192    UP000001819    UP000008744    UP000244773    UP000008792    UP000226882   
Pfam
PF04777   Evr1_Alr
PF04998   RNA_pol_Rpb1_5
PF00069   Pkinase
PF00432   Prenyltrans
PF04805   Pox_E10
PF02650   HTH_WhiA
Interpro
IPR039799   ALR/ERV
IPR017905   ERV/ALR_sulphydryl_oxidase
IPR036774   ERV/ALR_sulphydryl_oxid_sf
IPR007081   RNA_pol_Rpb1_5
IPR008271   Ser/Thr_kinase_AS
IPR008930   Terpenoid_cyclase/PrenylTrfase
IPR001330   PFTB_repeat
IPR000719   Prot_kinase_dom
IPR011009   Kinase-like_dom_sf
IPR017441   Protein_kinase_ATP_BS
IPR026873   Ptb1
IPR023054   Sporulation_regulator_WhiA_C
IPR006890   Sulphydryl_Oase_FAD-link_ERV1
SUPFAM
SSF69000   SSF69000
SSF56112   SSF56112
SSF48239   SSF48239
Gene 3D
1.20.120.310    
CDD
cd02894  GGTase-II
ProteinModelPortal
A9JL27   D4I5R2   E0WML2   Q71UJ8   Q65163   Q9JFM7   + More
Q9JFN0   Q9JFN2   A9JLW0   A0A0A1E126   Q9JFM8   Q9ICB8   P0C8G9   Q9JFN1   P0C8G8   Q9JFM9   M2XR87   A0A0F7U9P3   Q6XLY8   A0A2C6KM64   A0A086JF07   A0A086K2V9   A0A151H397   A0A139XKV7   S7VZ72   A0A086KFG0   A0A125YR09   A0A2T6IGY7   A0A086LMN5   A0A2G8XRI3   A0A086PGQ6   A0A125YR10   A0A2E3C6A4   A0A074SXN8   A0A086Q6H6   A0A0P0YN22   A0A3G5A8H8   A0A0K0DU75   D8M9I9   A0A2D5BE32   K8F290   A0A2A9M2Y2   A0A2T9Y9T5   A0A2A2KPB1   A0A2H4UUT2   A0A0N7KVR6   A0A0N4ZLU4   A0A0R3PLH2   W8W2H4   A4S5R1   A0A2L2YMN3   A0A2D5MUZ0   A0A1V0SDM5   A0A1I8MMR1   A0A1Q9ENP7   A0A0B1SRQ5   W8W2S2   A0A1I8BBZ3   F4PQC7   A0A1R2B5D6   A0A099NWV8   A0A1J4MJU0   B4NEH8   U6MMC4   A0A2E4HKW1   A0A1V0SC43   A0A2A2KV91   A0A3P7MWK8   A0A2A6CZA0   A0A293NIK7   A0A2D7JUT5   A0A1X7TZ25   Q75JQ5   A0A090LJC8   A0A0M4ETR2   A0A3P7KZ67   E3T5L5   G0T5G1   A0A2D5CG30   T1J897   S6DA40   W8W1X9   A0A1A9XX35   A0A1B0BQS1   B4JHR4   A0A2T9ZGW6   A0A1A9ZK03   A0A1B0G4I3   A0A1A9VS14   B4L6U5   A0A3G4ZSE5   H9BA18   Q29H00   A0A1V0SJ57   B4H0N3   A0A3P3YAU9   A0A2P0VN55   B4MA20   A0A2E1CG62  
PANTHER
PTHR12645  
PDB
3GWL     E-value=3.3527e-48,     Score=477

Ontologies

KEGG
vg:22220303     vg:26101130     vg:26101252     vg:18501210     vg:18501388     vg:9887847     vg:10963857     vg:16414355     vg:18501567    
GO
GO:0016971  F:flavin-linked sulfhydryl oxidase activity
 GO:0030430  C:host cell cytoplasm
 GO:0009405  P:pathogenesis
 GO:0045927  P:positive regulation of growth
 GO:0006351  P:transcription, DNA-templated
 GO:0003677  F:DNA binding
 GO:0003899  F:DNA-directed 5'-3' RNA polymerase activity
 GO:0016972  F:thiol oxidase activity
 GO:0016021  C:integral component of membrane
 GO:0050660  F:flavin adenine dinucleotide binding
 GO:0005739  C:mitochondrion
 GO:0042802  F:identical protein binding
 GO:0042246  P:tissue regeneration
 GO:0018344  P:protein geranylgeranylation
 GO:0005524  F:ATP binding
 GO:0004663  F:Rab geranylgeranyltransferase activity
 GO:0004672  F:protein kinase activity
 GO:0015035  F:protein disulfide oxidoreductase activity
 GO:0003743  F:translation initiation factor activity

Subcellular Location

From MSLVP
Cytoplasm
From Uniprot
Host cytoplasm  

Topology

Length:
119
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00174
Exp number, first 60 AAs:
0.00159
Total prob of N-in:
0.21601
outside
1  -  119
 
 

Population Genetic Test Statistics

Pi
0.029779
Theta
0.0375481
Tajima's D
-0.8562148
CLR
0
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
 AKO62755.1
China_AnhuiXCGQ_2018 Protein
 AYW34045.1
China_ASFV-SY18_2018 Protein
 AKO62755.1
Poland_Pol16_20186_o7_2016-2017 Protein
 AXZ95848.1
Poland_Pol16_20538_o9_2016-2017 Protein
 CAN10173.1
Poland_Pol16_20540_o10_2016-2017 Protein
 CAN10173.1
Poland_Pol16_29413_o23_2016-2017 Protein
 CAN10173.1
Poland_Pol17_03029_C201_2016-2017 Protein
 AXZ96036.1
Poland_Pol17_04461_C210_2016-2017 Protein
 AXZ96131.1
Poland_Pol17_05838_C220_2016-2017 Protein
 CAN10173.1
Poland_ASFV_POL_Podlaskie_2015 Protein
 CAN10173.1
Uganda_R8_2015 Protein
 AXB49302.1
Uganda_R7_2015 Protein
 AXB49476.1
Uganda_R25_2015 Protein
 AXB49648.1
Uganda_N10_2015 Protein
 AXB49819.1
Uganda_R35_2015 Protein
 AXB49992.1
Estonia_2014 Protein
 SPS73497.1
Italy_26544_OG10_2010 Protein
 AJZ77167.1
Italy_47_Ss_2008_2008 Protein
 AOO54412.1
Portugal_OURT_88.3_1988 Protein
 CAN10423.1
Spain_E75_1975 Protein
 CBH29175.1
Russia_Georgia_2007 Protein
 CBW46740.1
Kenya_Tk1_2005 Protein
 AJL34087.1
Kenya_Bus_2006 Protein
 AJL34252.1
Russia_Odintsovo_2014 Protein
 CAN10173.1
Portugal_L60_1960 Protein
 AIY22265.1
Portugal_NHV_1968 Protein
 AIY22423.1
Russia_Kashino_2013 Protein
 CAN10173.1
Benin_1997 Protein
Protein
 CAN10173.1
CAN10173.1
South_Africa_KNP_Pretorisuskop_1996 Protein
 CAN10173.1
South_Africa_MGR_Mkuzi_1979    
Malawi_Lil_1983 Protein
 CAN10173.1
Kenya_1950 Protein
 CAN10173.1
Namibia_Warthog_1980 Protein
 CAN10173.1
South_Africa_Warmbaths_1987 Protein
 CAN10173.1
Malawi_Tengani_1962 Protein
 CAN10173.1
China_HLJ_2018 Protein
 QBH90562.1
China_LN_2018 Protein
 QBH90747.1
China_wbBS01_2018 Protein
 QDL88105.1
Ukraine_Kyiv_2014 Protein
 QED21651.1
Belgium_Etalle_wb_2018 Protein
 QED90517.1
Lithuania_LT14_2014 Protein
 QEY87880.1
South_Africa_1985 Protein
 CAN10173.1
South_Africa_2_2008 Protein
 CAN10173.1
Zambia_LIV_1983    
Copyright@ 2018-2023    Any Comments and suggestions mail to:  zhuzl@cqu.edu.cn, mg@cau.edu.cn   渝ICP备19006517号

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