Strain

Spain_E75_1975 (Region: Spain; Strain: E75; Date: 1975)

Gene

BA71V-DP71L (l14L, NLS)

Description

Annotated in NCBI, product is similar to mouse protein MyD116, Swiss-Prot Accession Number P17564, protein encoded by Cricetulus longicaudatus GADD34 gene, GenBank Accession Number L28147, HSV1 infected-cell protein (ICP34.5), Swiss-Prot Accession Number P37319, and a partial protein sequence from Amsacta moorei entomopoxvirus, encoded by GenBank Accession Number M77182

Location

FN557520.1(-):177771-177986

GenBank Accession

CBH29256.1

Full name

Protein DP71L

Alternative Name

MyD116 homolog

CDS

ATGGGGGGGCGGCGGCGCAAAAAACGGACGAATGACACGAAGCACGTCCGCTTTGCTGCAGCCGTCGAGGTATGGGAAGCCGACGACATCGAGCGCAAGGGTCCCTGGGAGCAGGTGGCGGTCGATCGGTTCCGCTTCCAGCGCCGGATCGCGAGCGTGGAGGAGCTCCTATCCACGGTGCTCCTGCGGCAAAAAAAGCTACTGGAGCAGCAGTAA

Protein

MGGRRRKKRTNDTKHVRFAAAVEVWEADDIERKGPWEQVAVDRFRFQRRIASVEELLSTVLLRQKKLLEQQ

Function

Interacts with the host phosphatase PP1 catalytic subunit (PPP1CB) and recruits it to dephosphorylate EIF2S1/eIF2alpha and therefore restores the host translation that has been shut-down by the host. Also inhibits the EIF2S1/eIF2alpha-ATF4-DDIT3/CHOP pathway.

Subunit

Interacts (via C-terminus) with host PPP1CB.

Similarity

Belongs to the asfivirus DP71L family.

Keywords

Complete proteome Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host interferon signaling pathway by virus Modulation of host PP1 activity by virus Reference proteome Viral immunoevasion

Feature

chain Protein DP71L

Uniprot

D4I5I0 A9JM96 Q76SC7 Q65212 A9JLG5 A0A1C6ZY93 + More
P87510 P0C753 P0C756 P87511 P90496 A0A2S1KM50 E0WMA7 A0A2S1KM36 A0A2S1KM42 A0A2S1KM30 A0A2S1KM38 H1A4D9 A0A1B6MLH5 Q5U232 A0A1L8FH48 Q5U4R3 D2H8S4 A0A194PSV8 A0A3M0JKL1 A0A3M0JJM0

Pubmed

18198370 8971015 25406173 26618713 11831707 17215279 + More
20702639 28189088 21470447 20360741 27762356 20010809 26354079

EMBL

FN557520 CBH29256.1 AM712240 CAN10505.1 U73711 U73712 + More
U73713 U73714 U73715 U73719 KM262844 KM262845 KP055815 MF589621 MF589622 AAB40127.1 AAB40128.1 AAB40129.1 AAB40130.1 AAB40131.1 AAB40135.1 AIY22346.1 AIY22505.1 AKO62836.1 AWF94056.1 AWF94057.1 U18466 AM712239 CAN10254.1 KM102979 AJZ77187.1 U73717 AAB40133.1 AY261366 AY261363 U73720 AAB40136.1 U73716 U73718 AAB40132.1 AAB40134.1 MF589624 MF589625 MF589626 MF589627 AWF94059.1 AWF94060.1 AWF94061.1 AWF94062.1 FR682468 CBW46823.1 MF589623 MG939583 MG939588 LS478113 AWF94058.1 AXZ95926.1 AXZ96209.1 SPS73423.1 SPS73579.1 MF589630 AWF94065.1 MF589620 AWF94055.1 MF589628 AWF94063.1 ABQF01065043 ABQF01065044 ABQF01065045 ABQF01065046 GEBQ01003248 JAT36729.1 BC086299 AAH86299.1 CM004479 OCT70913.1 BC084983 AAH84983.1 ACTA01128427 GL192583 EFB17061.1 KQ459593 KPI96397.1 QRBI01000149 RMB99229.1 RMB99243.1

Proteomes

UP000101090 UP000108903 UP000110401 UP000142390 UP000241813 UP000000624 + More
UP000130745 UP000117635 UP000000858 UP000000859 UP000141072 UP000007754 UP000186698 UP000008912 UP000053268

Pfam

PF10488 PP1c_bdg
PF10472 CReP_N

Interpro

IPR019523 Prot_Pase1_reg-su15A/B_C
IPR019512 Prot_Pase1_reg-su15B_N

ProteinModelPortal

D4I5I0 A9JM96 Q76SC7 Q65212 A9JLG5 A0A1C6ZY93 + More
P87510 P0C753 P0C756 P87511 P90496 A0A2S1KM50 E0WMA7 A0A2S1KM36 A0A2S1KM42 A0A2S1KM30 A0A2S1KM38 H1A4D9 A0A1B6MLH5 Q5U232 A0A1L8FH48 Q5U4R3 D2H8S4 A0A194PSV8 A0A3M0JKL1 A0A3M0JJM0

PDB

4V0U E-value=0.120805, Score=75

Ontologies

KEGG

vg:22220380

GO

GO:0039502  P:suppression by virus of host type I interferon-mediated signaling pathway
GO:0039586  P:modulation by virus of host PP1 activity
GO:0019888  F:protein phosphatase regulator activity
GO:1903912  P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0042542  P:response to hydrogen peroxide
GO:0006983  P:ER overload response
GO:0000164  C:protein phosphatase type 1 complex
GO:0070262  P:peptidyl-serine dephosphorylation

Subcellular Location

From MSLVP

Host nucleus > host nucleolus. Host cytoplasm. Secreted.

Topology

Length:

71

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00015

Exp number, first 60 AAs:

0.00011

Total prob of N-in:

0.89960

inside

1 - 71

Population Genetic Test Statistics

Pi

0.0955811

Theta

0.089363

Tajima's D

0.2101064

CLR

0

Interpretation

Possibly Balancing Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62836.1
China_AnhuiXCGQ_2018	Protein	AYW34126.1
China_ASFV-SY18_2018	Genetic Remain	AKO62836.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95926.1
Poland_Pol16_20538_o9_2016-2017
Poland_Pol16_20540_o10_2016-2017
Poland_Pol16_29413_o23_2016-2017
Poland_Pol17_03029_C201_2016-2017
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96209.1
Poland_Pol17_05838_C220_2016-2017
Poland_ASFV_POL_Podlaskie_2015
Uganda_R8_2015
Uganda_R7_2015
Uganda_R25_2015
Uganda_N10_2015
Uganda_R35_2015
Estonia_2014	Protein Protein	SPS73423.1 SPS73579.1
Italy_26544_OG10_2010	Protein	AJZ77187.1
Italy_47_Ss_2008_2008
Portugal_OURT_88.3_1988	Protein	CAN10505.1
Spain_E75_1975	Protein	CBH29256.1
Russia_Georgia_2007	Protein	CBW46823.1
Kenya_Tk1_2005
Kenya_Bus_2006
Russia_Odintsovo_2014
Portugal_L60_1960	Protein	AIY22346.1
Portugal_NHV_1968	Protein	AIY22505.1
Russia_Kashino_2013
Benin_1997	Protein Protein	CAN10254.1 CAN10254.1
South_Africa_KNP_Pretorisuskop_1996
South_Africa_MGR_Mkuzi_1979
Malawi_Lil_1983
Kenya_1950
Namibia_Warthog_1980
South_Africa_Warmbaths_1987
Malawi_Tengani_1962	Protein	CAN10254.1
China_HLJ_2018	Protein	QBH90644.1
China_LN_2018	Protein	QBH90829.1
China_wbBS01_2018	Protein	QDL88187.1
Ukraine_Kyiv_2014	Protein	QED21776.1
Belgium_Etalle_wb_2018	Protein	QED90599.1
Lithuania_LT14_2014	Protein	QEY87961.1
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983

Sequence