Strain

Kenya_1950 (Region: Kenya ;  Strain: Kenya 1950;  Date: 1950)

Gene

BA71V-A238L (5EL)

Description

Pseudogene,  similar to African swine fever virus E75 strain E75 of INSD accession FN557520

Location

AY261360.1(-):53593-54312

GenBank Accession

AJL34053.1

Full name

IkB-like protein      

Alternative Name

Ankyrin repeat domain-containing protein A238L
p28

CDS

ATGGATACGGTAGGCCTGTTTTCAGCCGAGGTAGAACACTTGTTTATTGAGTGGATTAAAAAACATATCAAAAAAGGAGACCTTACACTATTTGAGAGATTTTTTAAAGCAGATCCATGGATTGTCAATAGATGCGATCGAAGTAAAATCACGGTATTTATGTGGATATGCATCTATGGACGTTTAGACTTTTTAAGATTTCTTTTTAAACAAGAATCCTATCCCGGGGAAATAATAAGCCATTATAGAAGGGATAAAGATGGAAATTCTGTTTGGCATTATTTGGCGGAAAAAAAGAATCATCTCCTTTTGGAAGAAGTGCTGGAATATTTTGGAAAAATTGGCATCAAAGTTTGTTTTCGGAATTTTAATGGGATTACGCCCGTTATGAAGGCTGCAATGCGGGGTCGTACTCTAAGTGTCCTTTCTCTCATAAAATATGGAGCAAATCCGAACCAAAAAGACTATCTTAAAGGATTTAATACTTGGGATTGGGCAGTCTTTACAGGACACGCAGATTTAGTTAAATCTCTGAACAAGGACTACCAAAAACCCCTCTTCATGCATTTCCCTCTTTACAAACTGGATGTTTTCCATCGCAGGCACAAGAAAAAACCTAAAATTATTATCACTAGCTGTGAAGATAATGTCTATGAAAAACTTCCTGAACAGAATCCAAACTTTCTATGTGTAAAAAAACTTAACAAGTATGGTAAGTAG

Protein

Not available

Function

IkB-like protein that inhibits the binding of NF-kappa-B to DNA, thereby downregulating proinflammatory cytokine production (By similarity). Forms a heterodimer with the NF-kappa-B subunit RELA/p65 and prevents the activation of the NF-kappa-B transcription factor (By similarity). Inhibits calcineurin function, which is required for the induction of nuclear factor of activated T cells (NFAT)-dependent immune response genes. Prevents the binding of substrates to calcineurin without affecting the phosphatase activity (By similarity). Does not contain the serine residues that are phosphorylated by host IkB kinase and thus is not degraded following stimulation of the NFkB pathway (By similarity).
IkB-like protein that inhibits the binding of NF-kappa-B to DNA, thereby downregulating proinflammatory cytokine production (PubMed:8970976). Forms a heterodimer with the NF-kappa-B subunit RELA/p65 and prevents the activation of the NF-kappa-B transcription factor (By similarity). Inhibits calcineurin function, which is required for the induction of nuclear factor of activated T cells (NFAT)-dependent immune response genes (PubMed:23468591, PubMed:9677199). Prevents the binding of substrates to calcineurin without affecting the phosphatase activity (PubMed:23468591). Does not contain the serine residues that are phosphorylated by host IkB kinase and thus is not degraded following stimulation of the NFkB pathway (By similarity).

Subunit

Interacts with host PPIA. Interacts with host PPP3CA/Calcineurin (By similarity). Interacts with host RELA/p65; interaction of the 32 kDa form with host RELA results in the formation of a stable complex with NF-kappa-B (By similarity). Interacts with host PPP3R1 (By similarity). Interacts with host EP300; this interaction inhibits the association of host EP300 with host RELA, JUN and NFATC2 (By similarity).
Interacts with host PPIA (PubMed:9677199). Interacts with host PPP3CA/Calcineurin (PubMed:9677199, PubMed:11000210, PubMed:23468591). Interacts with host RELA/p65; interaction of the 32 kDa form with host RELA results in the formation of a stable complex with NF-kappa-B (By similarity). Interacts with host PPP3R1 (PubMed:23468591). Interacts with host EP300; this interaction inhibits the association of host EP300 with host RELA, JUN and NFATC2 (By similarity).

Similarity

Belongs to the asfivirus A238L family.

Keywords

ANK repeat   Complete proteome   Host cytoplasm   Host nucleus   Host-virus interaction   Inhibition of host NF-kappa-B by virus   Repeat   Ubl conjugation   3D-structure  

Feature

chain  IkB-like protein

Uniprot

A0A0C5BC58   P0C965   A0A0C5BCL1   O36972   O36975   O36971   + More

Pubmed

25645905    9281518    8970976    9677199    11000210    23468591    + More

EMBL

KM111294    AJL34053.1    AY261360    KM111295    MH025916    MH025917    + More
MH025918    MH025919    MH025920    AJL34218.1    AXB49268.1    AXB49442.1    AXB49614.1    AXB49785.1    AXB49958.1    AF014479    AY261361    AF014484    AAB71366.1    AF014478    AAB71360.1   

Proteomes

UP000105860    UP000000861    UP000101566    UP000000860   

Pfam

PF00023   Ank

Interpro

IPR020683   Ankyrin_rpt-contain_dom
IPR002110   Ankyrin_rpt
IPR036770   Ankyrin_rpt-contain_sf

SUPFAM

SSF48403   SSF48403

Gene 3D

1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

A0A0C5BC58   P0C965   A0A0C5BCL1   O36972   O36975   O36971   + More

PDB

4F0Z     E-value=3.42605e-09,     Score=145