Strain

Zambia_LIV_1983 (Region: Zambia;  Strain: LIV_5_40;  Date: 1983)

Gene

p104R

Description

With frameshift mutation but translatable,  p104R

Location

MN318203.1(+):45218-45991

GenBank Accession

QGM12896.1

Full name

Viral histone-like protein      

Alternative Name

Viral histone-like protein A104R
pA104R

CDS

ATGTTATACTCATCATCGTCATATTCTTCTTTATCATTATTATCTTCAATACATTTTTGCCAATCGAAATCGAATATATTCAGATCCTGGACATTTATATACTTATCATCGTACATTTTATTATATTTTATACATGTGTTATTGTCAAAAACTTTTATCGTTTTTGTTACAATCATTGTATGTATATTTTCCTTATTATGTGTTGCCGGAATATTACAAAGCCTATTTTTACGTACATCATTCATGTTATTACTATATTTACTATATATTGTTTCTTGTTTTTCTTTTGTTTCAAATATACGTTGTATGGTTATACGTTTTTCATTCAATGGTTTCTTTGTAGATATATACAATGTATATTCCGGTTTATACATATTTTTGCTTTCAATCGTGTTTCCATCTGCTTGTGCATATGCTATACCAGACCAAATATATCGGTCCACTATTACAATACAATTTACTTTATGTACTGCTGCAATTTCTGCGCTATATTCACTACGATGTTTTGTATATATTTTATGCAATTGTTCCGATGTCATTTCTATGGTTTTATTTATCACCTGCAATATATGGTCACCGGTGGTCGTGTCTGGATTACGAAAATGTATACATATACCATTATATTCCATGCATTCCAATGCCTTTTTTATTCTCATGGCCTGCGTGCTTTTTCCCACACCATTGTTTCCCTCGATGGCAATATGTATTCCACGCATGTTTATTACATGGGTACAAAGAATTCAGTTTTTATACAACATTGTACAACACTACATT

Protein

MLYSSSSYSSLSLLSSIHFCQSKSNIFRSWTFIYLSSYILLYFIHVLLSKTFIVFVTIIVCIFSLLCVAGILQSLFLRTSFMLLLYLLYIVSCFSFVSNIRCMVIRFSFNGFFVDIYNVYSGLYIFLLSIVFPSACAYAIPDQIYRSTITIQFTLCTAAISALYSLRCFVYILCNCSDVISMVLFITCNIWSPVVVSGLRKCIHIPLYSMHSNAFFILMACVLFPTPLFPSMAICIPRMFITWVQRIQFLYNIVQHYI

Function

DNA-binding protein that plays a critical role in viral DNA replication and gene expression. Binds to both ssDNA and dsDNA with a binding site covering about 15 nucleotides. Displays DNA-supercoiling activity only when associated with the viral DNA topoisomerase 2.

Miscellaneous

Host antibody response against A104R protein is higher in asymptomatic than in chronically infected hosts.

Similarity

Belongs to the bacterial histone-like protein family.

Keywords

Complete proteome   DNA replication   DNA-binding   Late protein   Reference proteome  

Feature

chain  Viral histone-like protein

Uniprot

P0C9E4   A9JKW9   D4I5M2   A9JLM4   E0WMH2   A0A0A1E0L7   + More
P0C9E3   P68743   P0C9E5   P68742   A0A2W4QNC4   A0A3N7B073   A0A3M1YAX0   A0A3D1R3U3  

Pubmed

18198370    21470447    25406173    26618713    25645905    8464748    + More
11831707    12029148    17698651    28381576    30148503   

EMBL

AY261366    AM712239    CAN10133.1    FN557520    CBH29135.1    AM712240    + More
CAN10382.1    FR682468    CBW46700.1    KM262844    KM262845    KM111294    KM111295    KM102979    KP055815    KX354450    MH025916    MH025917    MH025918    MH025919    MH025920    MG939583    MG939587    MG939588    LS478113    AIY22225.1    AIY22384.1    AJL34049.1    AJL34214.1    AJZ77172.1    AKO62716.1    AOO54361.1    AXB49263.1    AXB49437.1    AXB49609.1    AXB49780.1    AXB49953.1    AXZ95811.1    AXZ95999.1    AXZ96094.1    SPS73457.1    AY261363    L10066    AY261361    AY261360    U18466    QGUX01000020    PZN69528.1    QAJK01000120    RQO46266.1    RFGZ01000009    RMG75330.1    DPEG01000398    HCF59151.1   

Proteomes

UP000000858    UP000130745    UP000101090    UP000108903    UP000141072    UP000101566    + More
UP000105860    UP000110401    UP000117635    UP000142390    UP000241813    UP000266411    UP000000859    UP000000860    UP000000861    UP000000624    UP000249764   

Pfam

PF00216   Bac_DNA_binding

Interpro

IPR010992   IHF-like_DNA-bd_dom_sf
IPR020816   Histone-like_DNA-bd_CS
IPR000119   Hist_DNA-bd

SUPFAM

SSF47729   SSF47729

Gene 3D

4.10.520.10    

ProteinModelPortal

P0C9E4   A9JKW9   D4I5M2   A9JLM4   E0WMH2   A0A0A1E0L7   + More
P0C9E3   P68743   P0C9E5   P68742   A0A2W4QNC4   A0A3N7B073   A0A3M1YAX0   A0A3D1R3U3  

PANTHER

PTHR33175  

PDB

5YH1     E-value=2.83945,     Score=70