ASFVdb The African Swine Fever Virus Database
Strain
Lithuania_LT14_2014 (Region: Lithuania;  Strain: ASFV/LT14/1490;  Date: 2014)
Gene
MGF_110-4L
Description
Annotated in NCBI,  NA
GenBank Accession
Full name
Protein MGF 110-4L       + More
Protein LIS 124-2      
Protein LIS 124-1      
Protein MGF 110-3L      
Protein MGF 110-6L      
Protein V118      
Protein MGF 110-5L      
Protein LIS 121-1      
Protein LIS 137      
Protein MGF 110-7L      
Protein LIS 117      
Protein MGF 110-13L      
Protein MGF 110-9L      
Protein MGF 110-11L      
Protein LIS 290      
Protein MGF 360-1L      
Protein LIS 119-1      
 

Sequence

CDS
ATGTTGGTAGTCTTCTTGGGAATTCTTGGCCTGCTGGCCAATCAGGTCGTAGGACTACCTACTCAGGCAGGAGGGCATCTTCGTTCAACGGATAATCCTCCACAAGAAGAACTTGGATACTGGTGCACTTACATGGAAAGGTGCAAGTTTTGCTGGGAATGTGCACATGGAATTTGCAAGAACAAGGTGAATAATAGCATGCCATTGATTATTGAAAACAGCTACTTGACAACATGTGAGGTTTCTCGCTGGTATAACCAGTGTACATATGGTGAAGGAAATGGGCATTACCATGTTATGGATTGTTCTGATCCAGTACCTCACAACCGCCCCTACCAATTGTTAATGAAAATTTATGAAAAGAAAGATCTGTGA
Protein
MLVVFLGILGLLANQVVGLPTQAGGHLRSTDNPPQEELGYWCTYMERCKFCWECAHGICKNKVNNSMPLIIENSYLTTCEVSRWYNQCTYGEGNGHYHVMDCSDPVPHNRPYQLLMKIYEKKDL

Summary

Function
Causes the redistribution of lumenal ER protein to an enlarged ERGIC compartment.
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
Similarity
Belongs to the asfivirus MGF 110 family.
Belongs to the asfaviruses V110 family.
Keywords
Complete proteome   Early protein   Glycoprotein   Signal   Virion   Reference proteome   Host membrane   Membrane   Transmembrane   Transmembrane helix   Host endoplasmic reticulum   Repeat  
Feature
chain  Protein MGF 110-4L
EMBL
FR682468    CBW46655.1    MG939583    MG939586    MG939587    MG939588    + More
AXZ95777.1    AXZ95957.1    AXZ95974.1    AXZ96069.1    AY261363    KP055815    AKO62692.1    M36467    U18466    KM111294    AJL34015.1    M58155    CBW46653.1    AXZ95776.1    AXZ95956.1    AXZ95973.1    AXZ96068.1    AY261366    KM262845    AIY22361.1    AM712240    CAN10359.1    AY261361    CAN10358.1    U81365    AAC40560.1    AIY22360.1    AY261360    KM111295    MH025916    MH025917    MH025918    MH025919    MH025920    AJL34180.1    AXB49229.1    AXB49402.1    AXB49576.1    AXB49748.1    AXB49919.1    AJL34014.1    AJL34179.1    AXB49228.1    AXB49401.1    AXB49575.1    AXB49747.1    AXB49918.1    AJL34016.1    AJL34181.1    AXB49230.1    AXB49403.1    AXB49577.1    AXB49749.1    AXB49920.1    AJL34017.1    AKO62694.1    AJL34182.1    AXB49231.1    AXB49404.1    AXB49578.1    AXB49750.1    AXB49921.1    AKO62693.1    AXB49232.1    AXB49405.1    AXB49579.1    AXB49751.1    AXB49922.1    CBW46657.1    AXZ95779.1    AXZ95959.1    AXZ95976.1    AXZ96071.1    AJL34018.1    AXB49236.1    AXB49410.1    AXB49755.1    AXB49926.1    LR536725    VFV47934.1    AJL34023.1    AJL34186.1    KX354450    AOO54322.1    MK628478    QEY87807.1    AJL34022.1    AJL34185.1    KM262844    AIY22199.1    AM712239    CAN10107.1    AOO54321.1    AXB49235.1    AXB49409.1    AXB49582.1    AXB49754.1    AXB49925.1    KM102979    AJZ77135.1    CBW46662.1    AXZ95782.1    AXZ95962.1    AXZ95979.1    AXZ96074.1    AXB49583.1    MG939584    AXZ95940.1    MH910496    AZP54211.1    LR722600    VVW94007.1    MN194591    QED21559.1    MH910495    AZP54032.1    CBW46668.1    AXZ95787.1    AXB49239.1    AXB49413.1    AXB49585.1    AXB49758.1    AXB49929.1    AJL34189.1    AJL34026.1    AJL34178.1    VFV47930.1    CBW46664.1    AXZ95784.1    AXZ95937.1    AXZ95964.1    AXZ95981.1    AXZ96076.1    QED21554.1   
Pfam
PF01639   v110
Interpro
IPR004848   V110_vir

Ontologies

Subcellular Location

From MSLVP
Single-Pass Membrane
From Uniprot
Virion  
Host endoplasmic reticulum-Golgi intermediate compartment  
Host membrane  
Host endoplasmic reticulum lumen  

Topology

Length:
124
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
2.67155
Exp number, first 60 AAs:
2.67118
Total prob of N-in:
0.13840
outside
1  -  124
 
 

Population Genetic Test Statistics

Pi
0.1535491
Theta
0.1768668
Tajima's D
-0.3099464
CLR
10.819715
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62692.1
China_AnhuiXCGQ_2018 Protein
Protein
AYW33962.1
AYW33963.1
China_ASFV-SY18_2018 Protein
Protein
AKO62692.1
CBW46655.1
Poland_Pol16_20186_o7_2016-2017 Protein
Protein
AXZ95776.1
AXZ95777.1
Poland_Pol16_20538_o9_2016-2017 Protein
CAN10358.1
Poland_Pol16_20540_o10_2016-2017 Protein
CAN10358.1
Poland_Pol16_29413_o23_2016-2017 Protein
Protein
AXZ95956.1
AXZ95957.1
Poland_Pol17_03029_C201_2016-2017 Protein
Protein
AXZ95973.1
AXZ95974.1
Poland_Pol17_04461_C210_2016-2017 Protein
Protein
AXZ96068.1
AXZ96069.1
Poland_Pol17_05838_C220_2016-2017 Protein
CAN10358.1
Poland_ASFV_POL_Podlaskie_2015 Protein
CAN10358.1
Uganda_R8_2015 Protein
Protein
AXB49228.1
AXB49229.1
Uganda_R7_2015 Protein
Protein
AXB49401.1
AXB49402.1
Uganda_R25_2015 Protein
Protein
AXB49575.1
AXB49576.1
Uganda_N10_2015 Protein
Protein
AXB49747.1
AXB49748.1
Uganda_R35_2015 Protein
Protein
AXB49918.1
AXB49919.1
Estonia_2014    
Italy_26544_OG10_2010    
Italy_47_Ss_2008_2008    
Portugal_OURT_88.3_1988 Protein
Protein
Protein
CAN10358.1
CAN10358.1
CAN10359.1
Spain_E75_1975    
Russia_Georgia_2007 Protein
Protein
CBW46653.1
CBW46655.1
Kenya_Tk1_2005 Protein
Protein
AJL34014.1
AJL34015.1
Kenya_Bus_2006 Protein
Protein
AJL34179.1
AJL34180.1
Russia_Odintsovo_2014 Protein
CAN10358.1
Portugal_L60_1960    
Portugal_NHV_1968 Protein
Protein
AIY22360.1
AIY22361.1
Russia_Kashino_2013 Protein
CAN10358.1
Benin_1997    
South_Africa_KNP_Pretorisuskop_1996    
South_Africa_MGR_Mkuzi_1979 Protein
CAN10358.1
Malawi_Lil_1983 Protein
CAN10358.1
Kenya_1950 Protein
CAN10358.1
Namibia_Warthog_1980 Protein
CAN10358.1
South_Africa_Warmbaths_1987 Protein
CAN10358.1
Malawi_Tengani_1962 Protein
CAN10358.1
China_HLJ_2018 Protein
Protein
QBH90476.1
QBH90478.1
China_LN_2018 Protein
Protein
QBH90661.1
QBH90663.1
China_wbBS01_2018 Protein
Protein
QDL88019.1
QDL88021.1
Ukraine_Kyiv_2014 Protein
Protein
QED21548.1
QED21549.1
Belgium_Etalle_wb_2018 Protein
Protein
QED90433.1
QED90435.1
Lithuania_LT14_2014 Protein
Protein
QEY87792.1
QEY87794.1
South_Africa_1985 Protein
CAN10358.1
South_Africa_2_2008 Protein
CAN10358.1
Zambia_LIV_1983 Protein
CAN10358.1
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