Strain

Uganda_R25_2015 (Region: Uganda, Tororo district; Strain: R25; Date: 2015)

Gene

p360-3L

Description

Annotated in NCBI, hypothetical protein

Location

MH025918.1(-):3969-5030

GenBank Accession

AXB49572.1

Full name

Protein MGF 360-3L       + More
Protein MGF 360-1L
Protein MGF 360-2L
Protein MGF 360-19R
Protein MGF 360-21R
Protein MGF 360-22R
Protein MGF 360-18R
Protein MGF 360-11L
Protein MGF 360-10L
Protein MGF 360-13L
Protein MGF 360-9L

Sequence

CDS

ATGCAGCCATCGACTTTACAAACACTTACCAAAAGGGTATTGGCCACACAGCACGTCTCTAAAGATGATTATTGTATTTTAAAGCGTTGTGGTTTATGGTGGCATGATGCTCCTATCACACTTTATACAGATGGTGAACAAATATTAATAAAAACGCCATGCTATAAAGAAGGTATAAAGCTTAATACTGCATTAGTGTTGGCGGTCAAAGAAAATAATTATGACCTGATTGTGTTGTTTACTGAATGGGGTGCAAATATTAATTATGGGTTACTTTCTGTTAATAAGGAGCATACTCGAAACCTATGCCGAAAATTGGGAGCCAAAGAAGGTCTTGAAGCAAGTGAAGTTTTACGATTTTTCTTTGAAACAAAGCGTCATAAAACAAGTAGTAATATCATTTTGTGTCATAAATTATTTTCTAATAATCCGTTTTTACAAAATGTCAACATGGTGGAATTAAGGATGATAATTTATTGGGAGTTGAAGGATTTAACAACAAATCTTATAGTAAATGAGTCCTCATTTACTGAGATGTTAACTAAATATTGGTATGGGATTGCAGTAAAATATAATCTTAAAGAAGCTATTCAATATTTCTGTCAAGAATATGAACATCTTAATGAGTGGCGCTTAATTTGTGCACTTTCTTTTAATAACGTATTTGAGCTTCATGAGATATGTAACACAATGAATATGAATATTAATAAAATGATGCAACTGGCCTGTATGCGTGACAACAATTTTTTAACTATTTACTATTGTTTTGCATTGGGGGCCGACATCAATTGCGCAATGTATGACTCAGTATCAAACTTTCGTATTGAAAATATGTTCTTTTGTATGGATTTAGGGGCTGATGCCTTTGAAGAGAGTTTAGAATTAGCAGAACTACACGGTTATTCTGTAATAGTTGATATATTATCTTTAAAAATTTATAAAGCGAATCCTATCTTATTAGCAAAAGAGACTGATCCTGAAAAAATTAATACTTTACTAAAAAACTATTATCCGAAAAATATGTTAGCTTATGATATTTGCAATGTTGATAATTATCTTTAA

Protein

MQPSTLQTLTKRVLATQHVSKDDYCILKRCGLWWHDAPITLYTDGEQILIKTPCYKEGIKLNTALVLAVKENNYDLIVLFTEWGANINYGLLSVNKEHTRNLCRKLGAKEGLEASEVLRFFFETKRHKTSSNIILCHKLFSNNPFLQNVNMVELRMIIYWELKDLTTNLIVNESSFTEMLTKYWYGIAVKYNLKEAIQYFCQEYEHLNEWRLICALSFNNVFELHEICNTMNMNINKMMQLACMRDNNFLTIYYCFALGADINCAMYDSVSNFRIENMFFCMDLGADAFEESLELAELHGYSVIVDILSLKIYKANPILLAKETDPEKINTLLKNYYPKNMLAYDICNVDNYL

Summary

Function

Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.

Similarity

Belongs to the asfivirus MGF 360 family.

Keywords

ANK repeat Complete proteome Reference proteome Glycoprotein Host membrane Membrane Transmembrane Transmembrane helix

Feature

chain Protein MGF 360-3L

Uniprot

P0C9M7 A0A0C5B205 A0A0C5B2C9 P0C9M5 P0C9M4 A9JLI0 + More
A0A0A1DXY2 P23165 A0A0N7CUQ6 E0WMC0 A0A385KN20 A0A3G1EV18 P0C9M6 P0C9M0 A0A2Z5DG36 E0WMB5 P0C9M2 A0A1C6ZY43 A0A0C5B200 P0C9L8 A0A0C5BCX7 E0WMB1 A0A2X0RUQ2 P0C9M1 P0C9R9 P23167 P0C9S1 A9JKQ6 A9JLH2 Q65278 A0A0C5AYS7 A0A1C6ZY17 D4I5I2 Q65269 A0A2X0RU57 A9JKQ8 A9JLH4 A0A0A1E0W1 P23166 A9JLG8 A0A0N7CVN2 P23164 A0A0A1E0V6 D4I5I7 A9JM99 A0A0A1DYF6 E0WMB6 A0A385KN21 A0A385KN43 A0A2Z5DFL9 A0A0C5AZU1 A0A0C5AZ39 A0A0C5B223 P0C9S2 P0C9R7 P0C9M3 P0C9P7 P0C9S0 P0C9P6 P0C9P8 P0C9R8 P0C9R5 Q65123 P0C9L9 P0C9P3 A9JKU4 D4I5K8 A0A0A1E2Z0 A0A0C5AZB2 P0C9P4 E0WMF7 A0A2X0S729 A0A385KMG1 E0WMF5 A0A2X0TC36 A9JKU2 D4I5K7 A0A0A1DXU3 P0C9P5 A0A0C5AWK0 A0A2Z5DGQ9 A0A0C5B2C7 A0A0C5AZ90 P0C9Q2 P0C9Q4 Q65122 E0WMF9 A0A2X0TKD5 A9JKU7 D4I5L1 A0A0A1E036 A0A2X0RV94 A9JKU0 D4I5K6 A0A0A1E031 E0WMF4 A0A0C5AW86 A0A0C5BCJ3 Q65121 E0WMF8

Pubmed

25645905 18198370 25406173 2325203 11831707 26618713 + More
21470447 11238833 14747550 14963141 8030278 8409937 8021596 8030263

EMBL

AY261361 KM111294 AJL34011.1 KM111295 MH025916 MH025917 + More
MH025918 MH025919 MH025920 AJL34176.1 AXB49225.1 AXB49398.1 AXB49572.1 AXB49744.1 AXB49915.1 AY261360 AY261366 AM712240 CAN10355.1 KM262844 KM262845 AIY22194.1 AIY22357.1 M57546 U18466 KP055815 AKO62689.1 FR682468 CBW46648.1 MG939583 MG939586 MG939587 MG939588 AXZ95773.1 AXZ95953.1 AXZ95970.1 AXZ96065.1 KX354450 AOO54315.1 AY261363 AXB49385.1 AXB49559.1 AXB49731.1 AXB49902.1 AXB50075.1 CBW46643.1 KM102979 AJZ77131.1 AOO54309.1 AJL34006.1 AJL34333.1 CBW46827.1 LS478113 AXZ95930.1 AXZ96213.1 SPS73418.1 SPS73584.1 AM712239 CAN10098.1 CAN10350.1 L28109 AAA50851.1 AIY22189.1 AIY22352.1 AKO62684.1 AJL34007.1 AJZ77102.1 FN557520 CBH29258.1 X71982 SPS73420.1 SPS73582.1 CAN10099.1 CAN10351.1 AIY22190.1 AIY22353.1 AKO62685.1 AOO54310.1 CAN10256.1 AJZ77082.1 AKO62838.1 AOO54535.1 M57545 AIY22348.1 CBH29100.1 CAN10507.1 AIY22507.1 CBW46644.1 MG939584 AXZ95934.1 AXZ95945.1 AXZ95965.1 AXZ96059.1 AXZ96217.1 MG939585 MG939589 AXZ95947.1 AXZ96221.1 AXB49386.1 AXB49560.1 AXB49732.1 AXB49903.1 AXB50076.1 AJL34200.1 AXB49250.1 AXB49424.1 AXB49596.1 AXB49769.1 AXB49940.1 AJL34172.1 AJL34036.1 U03762 CAN10119.1 CBH29121.1 AIY22211.1 AJZ77088.1 AKO62702.1 AOO54337.1 AJL34035.1 CBW46684.1 AXZ95797.1 AXZ95985.1 AXZ96080.1 SPS73441.1 AXZ95796.1 AXZ95984.1 AXZ96079.1 CBW46683.1 SPS73440.1 CAN10118.1 CBH29120.1 AIY22210.1 AJZ77085.1 AKO62701.1 AOO54336.1 AJL34199.1 AXB49249.1 AXB49423.1 AXB49595.1 AXB49768.1 AXB49939.1 AJL34171.1 AJL34005.1 CBW46687.1 AXZ95800.1 AXZ95988.1 AXZ96083.1 SPS73444.1 CAN10122.1 CBH29124.1 AIY22214.1 AJZ77087.1 AKO62705.1 AOO54345.1 AXZ95795.1 AXZ95983.1 AXZ96078.1 SPS73439.1 CAN10117.1 CBH29119.1 AIY22209.1 AJZ77090.1 AKO62700.1 AOO54335.1 CBW46682.1 AJL34034.1 AJL34198.1 AXB49248.1 AXB49422.1 AXB49594.1 AXB49767.1 AXB49938.1 CBW46686.1

Proteomes

UP000000860 UP000105860 UP000101566 UP000000861 UP000000858 UP000108903 + More
UP000110401 UP000142390 UP000000624 UP000241813 UP000141072 UP000266411 UP000000859 UP000117635 UP000130745 UP000101090

PRIDE

P0C9M4 P23165 P0C9M0 P0C9M2 Q65269 P23164 + More
P0C9P7 Q65122 Q65121

Pfam

PF01671 ASFV_360
PF13606 Ank_3

Interpro

IPR002595   ASFV_MGF360
IPR036770   Ankyrin_rpt-contain_sf
IPR020683   Ankyrin_rpt-contain_dom
IPR002110   Ankyrin_rpt

SUPFAM

SSF48403 SSF48403

ProteinModelPortal

Ontologies

KEGG

vg:22220389 vg:22220392 vg:22220393 vg:22220382

GO:0042330  P:taxis
GO:0033644  C:host cell membrane
GO:0016021  C:integral component of membrane

Subcellular Location

From MSLVP

Single-Pass Membrane

From Uniprot

Host membrane

Topology

Length:

353

Number of predicted TMHs:

Exp number of AAs in TMHs:

2.01493

Exp number, first 60 AAs:

0.00022

Total prob of N-in:

0.06663

outside

1 - 353

Population Genetic Test Statistics

0.079189

Theta

0.1429184

Tajima's D

-1.6517378

CLR

196.09539

Interpretation

Possibly Positive selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62689.1
China_AnhuiXCGQ_2018	Protein	AYW33956.1
China_ASFV-SY18_2018	Genetic Remain Protein Protein	AOO54315.1 CAN10103.1 AKO62689.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95773.1
Poland_Pol16_20538_o9_2016-2017
Poland_Pol16_20540_o10_2016-2017
Poland_Pol16_29413_o23_2016-2017	Protein	AXZ95953.1
Poland_Pol17_03029_C201_2016-2017	Protein	AXZ95970.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96065.1
Poland_Pol17_05838_C220_2016-2017
Poland_ASFV_POL_Podlaskie_2015
Uganda_R8_2015	Protein	AXB49225.1
Uganda_R7_2015	Protein	AXB49398.1
Uganda_R25_2015	Protein	AXB49572.1
Uganda_N10_2015	Protein	AXB49744.1
Uganda_R35_2015	Protein	AXB49915.1
Estonia_2014
Italy_26544_OG10_2010	Protein	AJZ77112.1
Italy_47_Ss_2008_2008	Protein Protein	AOO54314.1 AOO54315.1
Portugal_OURT_88.3_1988	Protein	CAN10355.1
Spain_E75_1975	Protein	CBH29104.1
Russia_Georgia_2007	Protein	CBW46648.1
Kenya_Tk1_2005	Protein Protein	AJL34011.1 AJL34011.1
Kenya_Bus_2006	Protein	AJL34176.1
Russia_Odintsovo_2014
Portugal_L60_1960	Protein	AIY22194.1
Portugal_NHV_1968	Protein	AIY22357.1
Russia_Kashino_2013
Benin_1997	Protein	CAN10103.1
South_Africa_KNP_Pretorisuskop_1996
South_Africa_MGR_Mkuzi_1979
Malawi_Lil_1983	Protein	AJL34011.1
Kenya_1950	Protein Protein	AJL34006.1 AJL34011.1
Namibia_Warthog_1980
South_Africa_Warmbaths_1987
Malawi_Tengani_1962
China_HLJ_2018	Protein	QBH90471.1
China_LN_2018	Protein	QBH90656.1
China_wbBS01_2018	Protein	QDL88015.1
Ukraine_Kyiv_2014	Protein	QED21545.1
Belgium_Etalle_wb_2018	Protein	QED90429.1
Lithuania_LT14_2014	Protein	QEY87788.1
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983