ASFVdb The African Swine Fever Virus Database
Strain
Poland_Pol17_04461_C210_2016-2017 (Region: Poland;  Strain: Pol17_04461_C210;  Date: 2016-2017)
Gene
A104R
Description
Annotated in NCBI,  pA104R
GenBank Accession
Full name
Viral histone-like protein       + More
Integration host factor subunit alpha      
Alternative Name
Viral histone-like protein A104R
pA104R
 

Sequence

CDS
ATGTCGACAAAAAAAAAGCCCACAATTACCAAGCAAGAGCTTTACTCCTTAGTAGCGGCAGATACCCAGTTAAATAAAGCATTGATTGAAAGAATCTTTACAAGTCAGCAAAAAATAATACAAAATGCTTTAAAGCACAATCAAGAAGTTATTATACCACCCGGAATCAAGTTCACCGTCGTTACGGTGAAAGCTAAACCTGCTCGCCAGGGCCATAATCCCGCCACAGGAGAGCCTATTCAAATTAAAGCTAAACCTGAACATAAAGCCGTAAAGATACGAGCATTGAAACCTGTCCATGATATGTTAAACTAA
Protein
MSTKKKPTITKQELYSLVAADTQLNKALIERIFTSQQKIIQNALKHNQEVIIPPGIKFTVVTVKAKPARQGHNPATGEPIQIKAKPEHKAVKIRALKPVHDMLN

Summary

Function
DNA-binding protein that plays a critical role in viral DNA replication and gene expression. Binds to both ssDNA and dsDNA with a binding site covering about 15 nucleotides. Displays DNA-supercoiling activity only when associated with the viral DNA topoisomerase 2.
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
Subunit
Heterodimer of an alpha and a beta chain.
Miscellaneous
Host antibody response against A104R protein is higher in asymptomatic than in chronically infected hosts.
Similarity
Belongs to the bacterial histone-like protein family.
Keywords
Complete proteome   DNA replication   DNA-binding   Late protein   Reference proteome  
Feature
chain  Viral histone-like protein
EMBL
AM712239    CAN10133.1    FN557520    CBH29135.1    AM712240    CAN10382.1    + More
FR682468    CBW46700.1    KM262844    KM262845    KM111294    KM111295    KM102979    KP055815    KX354450    MH025916    MH025917    MH025918    MH025919    MH025920    MG939583    MG939587    MG939588    LS478113    AIY22225.1    AIY22384.1    AJL34049.1    AJL34214.1    AJZ77172.1    AKO62716.1    AOO54361.1    AXB49263.1    AXB49437.1    AXB49609.1    AXB49780.1    AXB49953.1    AXZ95811.1    AXZ95999.1    AXZ96094.1    SPS73457.1    AY261363    L10066    AY261361    AY261360    U18466    AY261366    NVQC01000022    PTL35892.1    QAJK01000120    RQO46266.1    PDTV01000002    PIE83704.1    RFGZ01000009    RMG75330.1    NVSN01000052    NVSN01000010    PCI10869.1    PCI13345.1    NVQC01000009    PTL36979.1    NCVR01000008    OUC51380.1    AGEJ01000010    EMD17177.1    NSIT01000079    PJE79297.1    LJTO01000079    KPK52215.1    DPEG01000398    HCF59151.1    APNK01000005    KEZ78395.1    CP029488    AWN16629.1    QZWD01000008    RJS93135.1    NZYJ01000001    MAS08467.1    LMEV01000017    KQX87553.1    PBNT01000017    MBN50342.1    NYTP01000027    MAA70777.1    PBJS01000002    MBK30680.1    DNSV01000162    HBH11309.1    LKHV01000003    KRG19285.1    NVVB01000013    PCJ19420.1    CBDJ010000050    CDB29026.1    MAAD01000178    OUR66727.1    DMWI01000034    HAS50358.1    PDKU01000005    PPI86327.1    LT629785    SDU04005.1    PALP01000003    MAY37473.1    BDSZ01000037    GBD98817.1    CBTJ020000088    CDI03975.1    DOCA01000219    HBN23244.1    FNTJ01000003    SED27615.1    DMDB01000022    HAF66333.1    JOJP01000001    KEI71678.1    LMCQ01000019    KQU85111.1    ADZZ01000348    EFK08844.1    CP017887    APC19465.1    LXSQ01000028    OAM37504.1    LXSG01000026    OAM20060.1    FMUN01000001    SCX76108.1    CP001230    ACO03940.1    QWEZ01000001    RRJ84901.1    LMDW01000002    KQW63500.1    MGWS01000026    OGS90833.1    JOPL01000087    OUJ12748.1    FNDR01000018    SDJ66927.1    LQNP01000034    KZE85222.1    PKBZ01000001    PLV41645.1    MGDD01000280    OGL43321.1    CP001614    ACR13101.2    QLMD01000007    RAJ96874.1    PDKS01000005    PPI87015.1    MTBD01000030    PRP69567.1    NZIR01000008    MAJ56826.1    PAKT01000110    MAY36977.1    JOKH01000006    KEQ16139.1    BAFH01000003    GAB62838.1    MGYH01000015    OGT63014.1    QBLY01000003    PZO10069.1    JPLS01000010    KFX72155.1    CP007142    AJQ95847.1    CP002511    AEA81319.1    LGQY01000058    PWC92980.1    FOYD01000002    SFQ67925.1    JOKG01000001    KEQ15972.1    CP013251    AMO56293.1    MIAQ01000151    OHD24115.1    PHBR01000043    PKN81475.1    LFTY01000001    KMW60764.1    FNBP01000005    SDG18150.1    UOFR01000014    VAW92379.1    CZQC01000004    CUS40155.1    HF680312    CCU72269.1    CP017810    APR67066.1    CP006829    AHK15784.1    NVTA01000010    PHQ88092.1    NVTO01000016    PCI47580.1    NHGL01000013    OUV87522.1    MVYU01000100    OSY18416.1    LUKF01000017    LUKD01000005    KYG61155.1    KYG65183.1    ADAC02000001    EMH79903.1    NYVZ01000006    MAD13593.1   
Pfam
PF00216   Bac_DNA_binding
Interpro
IPR020816   Histone-like_DNA-bd_CS
IPR000119   Hist_DNA-bd
IPR010992   IHF-like_DNA-bd_dom_sf
IPR005684   IHF_alpha
SUPFAM
SSF47729   SSF47729
Gene 3D
PDB
5YH1     E-value=2.83945,     Score=70

Ontologies

KEGG

Subcellular Location

From MSLVP
Host nucleus > host nucleolus. Host cytoplasm. Secreted.

Topology

Length:
104
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00139
Exp number, first 60 AAs:
0.00123
Total prob of N-in:
0.63419
inside
1  -  104
 
 

Population Genetic Test Statistics

Pi
0.035248
Theta
0.0466483
Tajima's D
-0.8456648
CLR
0
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62716.1
China_AnhuiXCGQ_2018 Protein
AYW34006.1
China_ASFV-SY18_2018 Protein
AKO62716.1
Poland_Pol16_20186_o7_2016-2017 Protein
AXZ95811.1
Poland_Pol16_20538_o9_2016-2017    
Poland_Pol16_20540_o10_2016-2017    
Poland_Pol16_29413_o23_2016-2017    
Poland_Pol17_03029_C201_2016-2017 Protein
AXZ95999.1
Poland_Pol17_04461_C210_2016-2017 Protein
AXZ96094.1
Poland_Pol17_05838_C220_2016-2017    
Poland_ASFV_POL_Podlaskie_2015    
Uganda_R8_2015 Protein
AXB49263.1
Uganda_R7_2015 Protein
AXB49437.1
Uganda_R25_2015 Protein
AXB49609.1
Uganda_N10_2015 Protein
AXB49780.1
Uganda_R35_2015 Protein
AXB49953.1
Estonia_2014 Protein
SPS73457.1
Italy_26544_OG10_2010 Protein
AJZ77172.1
Italy_47_Ss_2008_2008 Protein
AOO54361.1
Portugal_OURT_88.3_1988 Protein
CAN10382.1
Spain_E75_1975 Protein
CBH29135.1
Russia_Georgia_2007 Protein
CBW46700.1
Kenya_Tk1_2005 Protein
AJL34049.1
Kenya_Bus_2006 Protein
AJL34214.1
Russia_Odintsovo_2014    
Portugal_L60_1960 Protein
AIY22225.1
Portugal_NHV_1968 Protein
AIY22384.1
Russia_Kashino_2013    
Benin_1997 Protein
CAN10133.1
South_Africa_KNP_Pretorisuskop_1996    
South_Africa_MGR_Mkuzi_1979    
Malawi_Lil_1983    
Kenya_1950    
Namibia_Warthog_1980    
South_Africa_Warmbaths_1987    
Malawi_Tengani_1962    
China_HLJ_2018 Protein
QBH90522.1
China_LN_2018 Protein
QBH90707.1
China_wbBS01_2018 Protein
QDL88065.1
Ukraine_Kyiv_2014    
Belgium_Etalle_wb_2018 Protein
QED90477.1
Lithuania_LT14_2014 Protein
QEY87840.1
South_Africa_1985 Protein
Protein
Protein
QGM12896.1
QGM12896.1
QGM12897.1
South_Africa_2_2008 Protein
Protein
QGM12896.1
QGM12822.1
Zambia_LIV_1983 Protein
Protein
QGM12896.1
QGM12701.1
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