ASFVdb The African Swine Fever Virus Database
Strain
Poland_Pol16_20540_o10_2016-2017 (Region: Poland;  Strain: Pol16_20540_o10;  Date: 2016-2017)
Gene
MGF 110-1L
Description
With frameshift mutation but translatable,  similar to African swine fever virus E75 strain E75 of INSD accession FN557520
GenBank Accession
Full name
Protein MGF 110-1L       + More
Protein MGF 360-3L      
Protein LIS 117      
Protein MGF 110-13L      
Protein MGF 110-11L      
Protein MGF 360-1L      
Protein LIS 119-1      
Protein LIS 124-1      
Protein MGF 110-14L      
Protein LIS 121-2      
Protein MGF 110-4L      
Protein LIS 124-2      
 

Sequence

CDS
ATGCTTGGTCTGCAAATATTTACTTTACTATCCATTCCAACTCTTCTTTATACATATGAGCTAGAGCTCCTGGATCTAACAAGAACCCCTCCTGAAAAGGAGCTTGAATACTGGTGCACCTATGCAAATCATTGTAGGTTCTGTTGGGACTGTCAAGATGGCATCTGTAAGAATAAGGTCTTTGAAAACCATTCTCCCATTCTTGAAAATGACTACATAGCTAACTGCAGTGTTTTTCGTCACAATGAATTCTGTACCTACTATGTAACTTCTATAAAGCCTCATGAAGTTTACCGAACAGAATGCCCACAACACAACCATGAATGGCACGAGGCTGTCATACGAAAATGGCAAAAGTTATTAACTTATGGATTTTACCTTGTGGGTTGTGTTTTAGTTGCAAATTACATTCGCAAACGTAGTTTGCAGACTATTATATATTTAATGGTTCTCCTGGTAATCTTCTTTCTGCTTTCCCAACTGATGTTGTACAGAGAGTTAGAAGCTAAAAAACATAAAATTGGCAGCATTCCTCCCGAAAGAGAGCTTGAACATTGGTGTACTCATGGAAAATATTGTGACTTTTGCTAG
Protein
MLGLQIFTLLSIPTLLYTYELELLDLTRTPPEKELEYWCTYANHCRFCWDCQDGICKNKVFENHSPILENDYIANCSVFRHNEFCTYYVTSIKPHEVYRTECPQHNHEWHEAVIRKWQKLLTYGFYLVGCVLVANYIRKRSLQTIIYLMVLLVIFFLLSQLMLYRELEAKKHKIGSIPPERELEHWCTHGKYCDFC

Summary

Function
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
Causes the redistribution of lumenal ER protein to an enlarged ERGIC compartment.
Similarity
Belongs to the asfivirus MGF 110 family.
Belongs to the asfaviruses V110 family.
Keywords
Complete proteome   Early protein   Glycoprotein   Host membrane   Membrane   Repeat   Transmembrane   Transmembrane helix   Reference proteome   Signal   Virion  
Feature
chain  Protein MGF 110-1L
EMBL
KM111294    AJL34012.1    AM712239    CAN10104.1    FN557520    CBH29105.1    + More
KM262845    AIY22358.1    KM102979    KP055815    KX354450    AJZ77110.1    AKO62690.1    AOO54316.1    KM262844    AIY22195.1    AM712240    CAN10356.1    AY261361    M36467    U18466    KM111295    AJL34177.1    MH025919    AXB49745.1    MH025916    MH025917    MH025918    MH025920    AXB49226.1    AXB49399.1    AXB49573.1    AXB49916.1    AY261360    MG939583    MG939586    MG939587    MG939588    AXZ95774.1    AXZ95954.1    AXZ95971.1    AXZ96066.1    AY261366    FR682468    CBW46650.1    AY261363    CAN10107.1    AIY22199.1    AOO54322.1    AJZ77135.1    AOO54321.1    M58155    AJL34167.1    AXB49239.1    AXB49413.1    AXB49585.1    AXB49758.1    AXB49929.1    AJL34189.1    MG939584    AXZ95940.1    CBW46668.1    AXZ95787.1    AJL34026.1    AXB49236.1    AXB49410.1    AXB49755.1    AXB49926.1    AJL34186.1    CBW46664.1    AXZ95784.1    AXZ95937.1    AXZ95964.1    AXZ95981.1    AXZ96076.1    AIY22366.1    CAN10364.1    AJL34023.1    AXB49583.1    AIY22367.1    CAN10358.1    U81365    AAC40560.1    AIY22360.1    LS478113    SPS73426.1    AKO62692.1    CAN10365.1    AJL34015.1    CAN10108.1    AIY22200.1    CBH29109.1    CBW46653.1    AXZ95776.1    AXZ95956.1    AXZ95973.1    AXZ96068.1    CAN10359.1    AIY22361.1    AJZ77154.1    AOO54323.1    AJL34179.1    AXB49228.1    AXB49401.1    AXB49575.1    AXB49747.1    AXB49918.1    CBW46655.1    AXZ95777.1    AXZ95957.1    AXZ95974.1    AXZ96069.1    CBH29106.1    CAN10105.1    AOO54318.1    AIY22196.1   
Pfam
PF01639   v110
Interpro
IPR004848   V110_vir

Ontologies

KEGG

Subcellular Location

From MSLVP
Multi-Pass Membrane
From Uniprot
Host membrane  
Membrane  
Virion  
Host endoplasmic reticulum-Golgi intermediate compartment  

Topology

Length:
196
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
38.87144
Exp number, first 60 AAs:
0.84106
Total prob of N-in:
0.20989
outside
1  -  119
TMhelix
120  -  137
inside
138  -  143
TMhelix
144  -  163
outside
164  -  196
 
 

Population Genetic Test Statistics

Pi
0.1041941
Theta
0.2005773
Tajima's D
-1.7710496
CLR
17.086605
Interpretation
Possibly Positive selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62690.1
China_AnhuiXCGQ_2018 Protein
AYW33957.1
China_ASFV-SY18_2018 Genetic Remain
CBW46650.1
Poland_Pol16_20186_o7_2016-2017 Protein
AXZ95774.1
Poland_Pol16_20538_o9_2016-2017 Protein
AJL34012.1
Poland_Pol16_20540_o10_2016-2017 Protein
AJL34012.1
Poland_Pol16_29413_o23_2016-2017 Protein
AXZ95954.1
Poland_Pol17_03029_C201_2016-2017 Protein
AXZ95971.1
Poland_Pol17_04461_C210_2016-2017 Protein
AXZ96066.1
Poland_Pol17_05838_C220_2016-2017 Protein
AJL34012.1
Poland_ASFV_POL_Podlaskie_2015 Protein
AJL34012.1
Uganda_R8_2015 Protein
AXB49226.1
Uganda_R7_2015 Protein
AXB49399.1
Uganda_R25_2015 Protein
AXB49573.1
Uganda_N10_2015 Protein
AXB49745.1
Uganda_R35_2015 Protein
AXB49916.1
Estonia_2014    
Italy_26544_OG10_2010 Protein
AJZ77110.1
Italy_47_Ss_2008_2008 Protein
AOO54316.1
Portugal_OURT_88.3_1988 Protein
CAN10356.1
Spain_E75_1975 Protein
CBH29105.1
Russia_Georgia_2007 Protein
CBW46650.1
Kenya_Tk1_2005 Protein
Protein
AJL34012.1
AJL34012.1
Kenya_Bus_2006 Protein
AJL34177.1
Russia_Odintsovo_2014 Protein
AJL34012.1
Portugal_L60_1960 Protein
AIY22195.1
Portugal_NHV_1968 Protein
AIY22358.1
Russia_Kashino_2013 Protein
AJL34012.1
Benin_1997 Protein
CAN10104.1
South_Africa_KNP_Pretorisuskop_1996 Protein
AJL34012.1
South_Africa_MGR_Mkuzi_1979 Protein
AJL34012.1
Malawi_Lil_1983 Genetic Remain
AJL34012.1
Kenya_1950    
Namibia_Warthog_1980 Protein
AJL34012.1
South_Africa_Warmbaths_1987 Protein
AJL34012.1
Malawi_Tengani_1962 Protein
AJL34012.1
China_HLJ_2018 Protein
QBH90473.1
China_LN_2018 Protein
QBH90658.1
China_wbBS01_2018 Protein
QDL88016.1
Ukraine_Kyiv_2014 Protein
QED21546.1
Belgium_Etalle_wb_2018 Protein
QED90430.1
Lithuania_LT14_2014 Protein
QEY87789.1
South_Africa_1985    
South_Africa_2_2008    
Zambia_LIV_1983    
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