Strain

Kenya_Tk1_2005 (Region: Kenya; Strain: Ken05/Tk1; Date: 2005)

Gene

I12R

Description

Annotated in NCBI, I12R

Location

KM111294.1(+):185688-185963

GenBank Accession

AJL34167.1

Full name

Protein MGF 110-1L + More
Protein MGF 110-4L

CDS

ATGTTTGTCCAGCAGGTCATGCAATTATTTGTTTCGCAAGTAATCTCAGTCTTATATGCGTATAATAAGATACATTACTTACAGCAAACTATTAAACCTCCTAGCAAGAAGCTTGGGTACTGGCGTACCTATACAAACCATCATAGATTCTGTTGGGATTGTCAAGATGTCATCTGTAGGAACAAGGTCTTTAATAATCATGTTTCTATAGTTAAGGACCTTAATACAGATAAATATTTGACGTTACATCGGTTTAATGGAGCATCTACCAAATAA

Protein

MFVQQVMQLFVSQVISVLYAYNKIHYLQQTIKPPSKKLGYWRTYTNHHRFCWDCQDVICRNKVFNNHVSIVKDLNTDKYLTLHRFNGASTK

Function

Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
Causes the redistribution of lumenal ER protein to an enlarged ERGIC compartment.

Similarity

Belongs to the asfivirus MGF 110 family.

Keywords

Complete proteome Early protein Glycoprotein Host membrane Membrane Repeat Transmembrane Transmembrane helix Signal Virion

Feature

chain Protein MGF 110-1L

Uniprot

A0A0C5AZ33 Q65267 A0A0C5B0D7 A0A2Z5DF99 A0A2Z5DG74 A0A0C5AZ45 + More
A0A0C5AYS9 P0C9G2 A9JLI7 A0A0A1E3D3 P0C9H0

Pubmed

25645905 8409937 18198370 25406173

EMBL

KM111294 AJL34167.1 X71982 CAA50864.1 KM111295 MH025916 + More
MH025917 MH025918 MH025919 MH025920 AJL34330.1 AXB49382.1 AXB49556.1 AXB49728.1 AXB49899.1 AXB50072.1 AXB49226.1 AXB49399.1 AXB49573.1 AXB49916.1 AXB49745.1 AJL34177.1 AJL34012.1 AY261360 AM712240 CAN10359.1 KM262845 AIY22361.1 AY261366

Proteomes

UP000105860 UP000101566 UP000000861 UP000108903 UP000110401 UP000000858 + More

Pfam

PF01639 v110

Interpro

IPR004848 V110_vir

ProteinModelPortal

A0A0C5AZ33 Q65267 A0A0C5B0D7 A0A2Z5DF99 A0A2Z5DG74 A0A0C5AZ45 + More
A0A0C5AYS9 P0C9G2 A9JLI7 A0A0A1E3D3 P0C9H0

PDB

5C2W E-value=4.19763, Score=62

Ontologies

GO

GO:0004386  F:helicase activity
GO:0016021  C:integral component of membrane
GO:0033644  C:host cell membrane
GO:0019012  C:virion
GO:0044172  C:host cell endoplasmic reticulum-Golgi intermediate compartment

Subcellular Location

From MSLVP

Single-Pass Membrane

From Uniprot

Host membrane
Virion
Host endoplasmic reticulum-Golgi intermediate compartment

Topology

Length:

91

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.32875

Exp number, first 60 AAs:

1.32875

Total prob of N-in:

0.13452

outside

1 - 91

Population Genetic Test Statistics

Pi

0.1398563

Theta

0.147086

Tajima's D

-0.3178918

CLR

17.848519

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971
China_AnhuiXCGQ_2018
China_ASFV-SY18_2018
Poland_Pol16_20186_o7_2016-2017
Poland_Pol16_20538_o9_2016-2017
Poland_Pol16_20540_o10_2016-2017
Poland_Pol16_29413_o23_2016-2017
Poland_Pol17_03029_C201_2016-2017
Poland_Pol17_04461_C210_2016-2017
Poland_Pol17_05838_C220_2016-2017
Poland_ASFV_POL_Podlaskie_2015
Uganda_R8_2015	Protein	AXB49382.1
Uganda_R7_2015	Protein	AXB49556.1
Uganda_R25_2015	Protein	AXB49728.1
Uganda_N10_2015	Protein	AXB49899.1
Uganda_R35_2015	Protein	AXB50072.1
Estonia_2014
Italy_26544_OG10_2010
Italy_47_Ss_2008_2008
Portugal_OURT_88.3_1988
Spain_E75_1975
Russia_Georgia_2007
Kenya_Tk1_2005	Protein	AJL34167.1
Kenya_Bus_2006	Protein Protein	AJL34330.1 AJL34330.1
Russia_Odintsovo_2014
Portugal_L60_1960
Portugal_NHV_1968
Russia_Kashino_2013
Benin_1997
South_Africa_KNP_Pretorisuskop_1996
South_Africa_MGR_Mkuzi_1979
Malawi_Lil_1983
Kenya_1950
Namibia_Warthog_1980
South_Africa_Warmbaths_1987
Malawi_Tengani_1962
China_HLJ_2018
China_LN_2018
China_wbBS01_2018
Ukraine_Kyiv_2014
Belgium_Etalle_wb_2018
Lithuania_LT14_2014
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983

Sequence