Strain

Kenya_Tk1_2005 (Region: Kenya; Strain: Ken05/Tk1; Date: 2005)

Gene

BA71V-EP364R

Description

Annotated in NCBI, similar to African swine fever virus E75 strain E75 of INSD accession FN557520

Location

KM111294.1(+):75340-76467

GenBank Accession

AJL34073.1

Full name

ERCC4 domain-containing protein EP364R

CDS

ATGTATTTTCTAGTAGCGGATCATCGAGAGCATCATGTGATTCCTTTTCTCAAAACCGATCTTCATCATATATATCAAAATCCTACCCAAAAAAAACAAATTCCCCTGGAAATCAAGCAGCTTTTTACCGGAGATTATCTTATATGCAAAAGCCCTTCTACGATTCTGGCCTGTATTGAACGAAAAACCTACAAAGACTTTGCCGCTTCTTTGAAAGATGGACGCTATAAAAATCGCCAAAAAATGCTGTCGCTGCGAGAACAAACCAAATGTCAACTTTATTTTTTTGTAGAAGGCCCGGCATTTCCTAACCCTCAAAAAAAAATTAATCACGTTGCCTATGCGAGCATTATTACGGCTATGACGCATCTTATGGTTAGAGATCATATTTTTGTCATTCAAACGAAGAATGAGGCCCACAGCTCCCAAAAACTGGTGCAGCTTTTTTATGCCTTTTCTAAGGAAATGGTGTGCATCGTTCCCACCTCCCTCACCCCCACGGATGAAGAGCTATGCATCAAACTATGGTCTTCTCTTTCTGGTATTTCAGGCGTGATAGGTAAAATCTTGGCAAACACTTGTTCAGTAGCTCATTTGGTTAGTGGGCAGCTTCCACCGCAGAATATTGATCAGTTAAAAACCCCATCCAACCGGCCATTCCCCAAAAAAGTAAAACGTATGCTTATAAGCATTAGCAAAGGAAATAAGGAATTAGAAATAAAATTACTCTCGGGGGTTCCCAATATTGGGAAAAAATTAGCTGCCGAAATTTTAAAAGACCATGCGCTTCTTTTTTTTCTAAATCAGCCCGTAGATTGTTTGGCAAATATACAAATCGCCCAAAAAACCCGTACGATTAAGTTGGGAATGAAGCGAGCCGAAGCGATTCATTATTTTTTAAACTGGTGTGGGTCTGCCCGTGTAACAGTGGATAGCCAAAATATCACAGAGACATCACGGCCCGCCACAATACAGGCCACCGCGACGCAAGCCGTTGCAACGCAGCCCGCTGCAACGCAGTCATTGCACGAAATATCAAATGAAGCATCAAATGATGCATCAAATGATGCAACAGATAAAGCATCAAATGAAGTCACTCACACAGGGCATCAAACATTATTTATCTAA

Protein

MYFLVADHREHHVIPFLKTDLHHIYQNPTQKKQIPLEIKQLFTGDYLICKSPSTILACIERKTYKDFAASLKDGRYKNRQKMLSLREQTKCQLYFFVEGPAFPNPQKKINHVAYASIITAMTHLMVRDHIFVIQTKNEAHSSQKLVQLFYAFSKEMVCIVPTSLTPTDEELCIKLWSSLSGISGVIGKILANTCSVAHLVSGQLPPQNIDQLKTPSNRPFPKKVKRMLISISKGNKELEIKLLSGVPNIGKKLAAEILKDHALLFFLNQPVDCLANIQIAQKTRTIKLGMKRAEAIHYFLNWCGSARVTVDSQNITETSRPATIQATATQAVATQPAATQSLHEISNEASNDASNDATDKASNEVTHTGHQTLFI

Catalytic Activity

L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine

Similarity

Belongs to the asfivirus EP364R family.

Keywords

Complete proteome Reference proteome

Feature

chain ERCC4 domain-containing protein EP364R

Uniprot

A0A0C5BCN1 A0A0C5BC74 A0A2Z5DF02 P0CAF6 E0WMJ7 A0A2X0RTV5 + More
P0CAF9 P0CAF8 P0CAF7 A9JL08 D4I5P7 A9JLS7 A0A0A1DXX9 Q65151 A0A3G1EUY8 A0A1X6WEZ8 A0A2E0EN87 A0A1X7QG79 A0A2P4UWK1 A0A2P4UWJ4 E3MGJ6 A0A2E1CFQ1 A0A2D5VNT6 A8XF20 A0A2G5VI71 P91153 A0A2H2IEP6 A0A260ZXK6 A0A260YN47 A0A2E0E2B7 A0A1B1ISH1 A0A141ZKL1 X0UX66 A0A1E5R2Z8 A0A1X7BZE5 A0A0H3TP64 A0A1L0CN70

Pubmed

25645905 21470447 18198370 25406173 26618713 11831707 + More
29337314 26114425 26394399 14624247 9851916 26903952 24624126 25878099

EMBL

KM111295 AJL34238.1 KM111294 AJL34073.1 MH025916 MH025917 + More
MH025918 MH025919 MH025920 AXB49288.1 AXB49462.1 AXB49634.1 AXB49805.1 AXB49978.1 AY261360 FR682468 CBW46725.1 MG939583 MG939587 MG939588 LS478113 AXZ95834.1 AXZ96022.1 AXZ96117.1 SPS73482.1 AY261366 AY261363 AY261361 AM712239 CAN10159.1 FN557520 CBH29160.1 AM712240 CAN10407.1 KM262844 KM262845 KM102979 KP055815 AIY22250.1 AIY22409.1 AJZ77081.1 AKO62741.1 U18466 KX354450 AOO54392.1 LT706986 SIP85889.1 NZXR01000083 MAR56918.1 CZDJ02000003 SMH63297.1 LFJK02001496 POM29413.1 POM29414.1 DS268443 EFP01534.1 PACS01000004 MAU35889.1 NYYR01000118 MAE21843.1 HE600958 CAP31242.1 PDUG01000001 PIC51499.1 BX284601 CCD65150.1 NIPN01000313 OZF90428.1 NMWX01000912 OZF74828.1 NZZO01000005 MAR49587.1 KT997790 ANS04265.1 KU702949 KU702951 KU556803 AMN83779.1 AMN84555.1 AMP44302.1 BARS01018308 GAF93015.1 LPNL01000009 OEJ81272.1 LT839607 SME64803.1 KJ614390 KU702948 KU702950 KU702952 AIB51844.1 AMN83077.1 AMN84060.1 AMN85046.1 FQNF01000032 SGZ39865.1

Proteomes

UP000101566 UP000105860 UP000000861 UP000141072 UP000000858 UP000000859 + More
UP000000860 UP000130745 UP000101090 UP000108903 UP000110401 UP000117635 UP000142390 UP000241813 UP000000624 UP000266411 UP000201921 UP000237256 UP000008281 UP000226882 UP000008549 UP000230233 UP000001940 UP000005237 UP000216463 UP000216624 UP000244556 UP000244783 UP000244814 UP000244303 UP000244713 UP000244774 UP000244833

Pfam

PF02732   ERCC4
PF00397   WW
PF17907   AWS
PF00856   SET

Interpro

IPR006166   ERCC4_domain
IPR011335   Restrct_endonuc-II-like
IPR003583   Hlx-hairpin-Hlx_DNA-bd_motif
IPR027421   DNA_pol_lamdba_lyase_dom_sf
IPR003616   Post-SET_dom
IPR001214   SET_dom
IPR036020   WW_dom_sf
IPR001202   WW_dom
IPR006560   AWS_dom
IPR036388   WH-like_DNA-bd_sf

SUPFAM

SSF52980   SSF52980
SSF47802   SSF47802
SSF51045   SSF51045

Gene 3D

1.10.150.110 1.10.10.10

CDD

cd00201 WW

ProteinModelPortal

A0A0C5BCN1 A0A0C5BC74 A0A2Z5DF02 P0CAF6 E0WMJ7 A0A2X0RTV5 + More
P0CAF9 P0CAF8 P0CAF7 A9JL08 D4I5P7 A9JLS7 A0A0A1DXX9 Q65151 A0A3G1EUY8 A0A1X6WEZ8 A0A2E0EN87 A0A1X7QG79 A0A2P4UWK1 A0A2P4UWJ4 E3MGJ6 A0A2E1CFQ1 A0A2D5VNT6 A8XF20 A0A2G5VI71 P91153 A0A2H2IEP6 A0A260ZXK6 A0A260YN47 A0A2E0E2B7 A0A1B1ISH1 A0A141ZKL1 X0UX66 A0A1E5R2Z8 A0A1X7BZE5 A0A0H3TP64 A0A1L0CN70

PDB

2BHN E-value=0.000690214, Score=101

Ontologies

KEGG

vg:22220289

GO

GO:0003677  F:DNA binding
GO:0004518  F:nuclease activity
GO:0006281  P:DNA repair
GO:0009792  P:embryo development ending in birth or egg hatching
GO:0040019  P:positive regulation of embryonic development
GO:0000712  P:resolution of meiotic recombination intermediates
GO:0000724  P:double-strand break repair via homologous recombination
GO:0019899  F:enzyme binding
GO:0002164  P:larval development
GO:0006355  P:regulation of transcription, DNA-templated
GO:0046975  F:histone methyltransferase activity (H3-K36 specific)
GO:0000785  C:chromatin
GO:0005634  C:nucleus
GO:0048257  F:3'-flap endonuclease activity
GO:0000727  P:double-strand break repair via break-induced replication
GO:0048476  C:Holliday junction resolvase complex
GO:0031573  P:intra-S DNA damage checkpoint
GO:0018024  F:histone-lysine N-methyltransferase activity
GO:0004519  F:endonuclease activity

Subcellular Location

From MSLVP

Nucleus

From Uniprot

Nucleus

Topology

Length:

375

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0898200000000001

Exp number, first 60 AAs:

0.00057

Total prob of N-in:

0.01182

outside

1 - 375

Population Genetic Test Statistics

Pi

0.0348359

Theta

0.0443727

Tajima's D

-1.1188163

CLR

0.159301

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971
China_AnhuiXCGQ_2018
China_ASFV-SY18_2018
Poland_Pol16_20186_o7_2016-2017
Poland_Pol16_20538_o9_2016-2017
Poland_Pol16_20540_o10_2016-2017
Poland_Pol16_29413_o23_2016-2017
Poland_Pol17_03029_C201_2016-2017
Poland_Pol17_04461_C210_2016-2017
Poland_Pol17_05838_C220_2016-2017
Poland_ASFV_POL_Podlaskie_2015
Uganda_R8_2015
Uganda_R7_2015
Uganda_R25_2015
Uganda_N10_2015
Uganda_R35_2015
Estonia_2014
Italy_26544_OG10_2010
Italy_47_Ss_2008_2008
Portugal_OURT_88.3_1988
Spain_E75_1975
Russia_Georgia_2007
Kenya_Tk1_2005	Protein	AJL34073.1
Kenya_Bus_2006
Russia_Odintsovo_2014
Portugal_L60_1960
Portugal_NHV_1968
Russia_Kashino_2013
Benin_1997
South_Africa_KNP_Pretorisuskop_1996
South_Africa_MGR_Mkuzi_1979
Malawi_Lil_1983
Kenya_1950
Namibia_Warthog_1980
South_Africa_Warmbaths_1987
Malawi_Tengani_1962
China_HLJ_2018
China_LN_2018
China_wbBS01_2018
Ukraine_Kyiv_2014
Belgium_Etalle_wb_2018
Lithuania_LT14_2014
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983	Protein	QGM12721.1

Sequence