ASFVdb The African Swine Fever Virus Database
Strain
Spain_E75_1975 (Region: Spain;  Strain: E75;  Date: 1975)
Gene
BA71V-EP402R (CD2v)
Description
Annotated in NCBI,  membrane protein
GenBank Accession
Full name
CD2 homolog      
Alternative Name
5HL
CD2v
PEP402R
T-lymphocyte CD2 receptor-like protein
 

Sequence

CDS
ATGTGTTTAAAAATAGTTTTAAACAATATTATAATATGGAGTACTTTAAATCAAACTGTATTTTTAAATAATATTTTTACAATTAATGATACATATGGTGGTCTATTTTGGAATACATATTATGATAATAATCGTAGTAATTTTACTTATTGTGGAATAGCAGGAAATTATTGTTCATGTTGTGGTCATAACATATCATTGTATAATACAACAAATAATTGTAGTTTAATTATTTTTCCTAACAATACAGAAATATTTAATAGAACATATGAATTAGTATATTTGGACAAAAAAATTAATTATACAGTAAAACTATTAAAATCTGTTGATTCCCCAACTATTACATATAATTGTACTAATTCTTTAATAACATGTAAAAATAATAATGGGACAAATGTTAATATATATTTAATTATTAACAATACAATTGTTAATGATACTAATGGAGATATCCTTAATTATTATTGGAATGGTAATAATAATTTTACAGCTACATGTATGATTAATAATACAATTAGTTCATTGAATGAAACAGAAAATATAAATTGTACTAATCCAATATTAAAATATCAAAATTATTTATCCACATTATTTTATATCATAATTTTTATTGTGAGTGGATTAATAATAGGTATTTTTATTTCAATCATATCTGTATTATCTATACGAAGAAAAAGAAAAAAACATGTTGAAGAAATAGAAAGTCCACCACCCTCTGAATCTAATGAAGAAGATATTTCTCACGATGACACCACTTCCATACATGAACCATCTCCCAGAGAACCATTACTTCCTAAGCCTTACAGTCGTTATCAGTATAATACACCTATTTACTACATGCGTCCCTCAACACAACCACTCAACCCATTTCCCCTACCTAAACCATGCCCGCCACCTAAACCATGTCCTCCACCCAAGCCATGCCCGCCACCCAAACCATGTCCTCCACCTAAACCGTGTTCTCCACCCAAACCGTGTCGTCCACCTAAACCATGTCCTCCACCTAAACCATGTCCTCCACCTAAACCATGTCCTCCACCTAAACCATGTCCTCCATCCAAACCATGTCCTTCACCTGAATCCTATTCTCCACCCAAACCACTACCTAGTATCCCGTTACTACCCAATATCCCGCCATTATCTACACAAAATATTTCGCTTATTCATGTAGATAGAATTATTTAA
Protein
MCLKIVLNNIIIWSTLNQTVFLNNIFTINDTYGGLFWNTYYDNNRSNFTYCGIAGNYCSCCGHNISLYNTTNNCSLIIFPNNTEIFNRTYELVYLDKKINYTVKLLKSVDSPTITYNCTNSLITCKNNNGTNVNIYLIINNTIVNDTNGDILNYYWNGNNNFTATCMINNTISSLNETENINCTNPILKYQNYLSTLFYIIIFIVSGLIIGIFISIISVLSIRRKRKKHVEEIESPPPSESNEEDISHDDTTSIHEPSPREPLLPKPYSRYQYNTPIYYMRPSTQPLNPFPLPKPCPPPKPCPPPKPCPPPKPCPPPKPCSPPKPCRPPKPCPPPKPCPPPKPCPPPKPCPPSKPCPSPESYSPPKPLPSIPLLPNIPPLSTQNISLIHVDRII

Summary

Function
May play an immunosuppressive role by inhibiting lymphocyte proliferation and subsequently facilitating viral replication and generalization of infection (By similarity). Responsible for viral hemadsorption, which may help viral spread (PubMed:8102411, PubMed:8615037). Increases virus replication in the tick vector at the step of virus uptake or replication in the tick gut (PubMed:19729182). May play a role in the host Golgi reorganization to yield viral factories (PubMed:25915900).
May play an immunosuppressive role by inhibiting lymphocyte proliferation and subsequently facilitating viral replication and generalization of infection (By similarity). Responsible for viral hemadsorption, which may help viral spread. Increases virus replication in the tick vector at the step of virus uptake or replication in the tick gut. May play a role in the host Golgi reorganization to yield viral factories (By similarity).
Subunit
Both glycosylated and nonglycosylated forms interact (via C-terminus) with the host AP-1 complex.
Similarity
Belongs to the asfivirus CD2 homolog protein family.
Keywords
Complete proteome   Disulfide bond   Glycoprotein   Host membrane   Late protein   Membrane   Receptor   Reference proteome   Signal   Transmembrane   Transmembrane helix  
Feature
chain  CD2 homolog
EMBL
AY463913    AAS45764.1    KM262844    AIY22249.1    AF481876    AAM90854.1    + More
KX354450    AOO54390.1    FN557520    CBH29159.1    AM712239    CAN10158.1    L16864    DQ026264    DQ026265    DQ026266    DQ026267    DQ026269    DQ026270    KM609337    KM609350    KM609351    KM609352    KM609355    KM102979    AAA42691.1    AAY44917.1    AAY44919.1    AAY44921.1    AAY44923.1    AAY44927.1    AAY44929.1    AJB28364.1    AJB28386.1    AJB28388.1    AJB28390.1    AJB28394.1    AJZ77076.1    U18466    KP055815    AKO62740.1    DQ026268    AAY44924.1    KM609334    AJB28358.1    AY463915    AY463916    AAS45774.1    KM609335    AJB28360.1    KM609348    AJB28382.1    KM609336    AJB28362.1    KM609361    AJB28405.1    KM609346    KM609347    AJB28378.1    AJB28380.1    AY261366    KM609357    AJB28398.1    KM609341    AJB28369.1    KM609349    AJB28384.1    KM609339    AJB28366.1    KM609356    AJB28396.1    FR682468    CBW46724.1    KM609363    AJB28409.1    KM609342    KM609360    KM609362    MG939583    MG939587    MG939588    LS478113    AJB28371.1    AJB28403.1    AJB28407.1    AXZ95833.1    AXZ96021.1    AXZ96116.1    SPS73481.1    KM609358    AJB28399.1    AY261360    KM111294    AJL34072.1   
Interpro
IPR036179   Ig-like_dom_sf
IPR013783   Ig-like_fold
SUPFAM
SSF48726   SSF48726
Gene 3D
PDB
1HNG     E-value=0.000874314,     Score=101

Ontologies

KEGG

Subcellular Location

From MSLVP
Single-Pass Membrane
From Uniprot
Host membrane   Localizes around the cytoplasmic viral factories which are probably derived from the host Golgi membrane (PubMed:25915900). Both proteolytic fragments localize to membrane compartements (By similarity).   With evidence from 2 publications.

Topology

Length:
394
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
32.9671
Exp number, first 60 AAs:
9.32378
Total prob of N-in:
0.45669
outside
1  -  197
TMhelix
198  -  220
inside
221  -  394
 
 

Population Genetic Test Statistics

Pi
0.1496046
Theta
0.1726942
Tajima's D
-0.8713958
CLR
1.301083
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62740.1
China_AnhuiXCGQ_2018    
China_ASFV-SY18_2018    
Poland_Pol16_20186_o7_2016-2017    
Poland_Pol16_20538_o9_2016-2017    
Poland_Pol16_20540_o10_2016-2017    
Poland_Pol16_29413_o23_2016-2017    
Poland_Pol17_03029_C201_2016-2017    
Poland_Pol17_04461_C210_2016-2017    
Poland_Pol17_05838_C220_2016-2017    
Poland_ASFV_POL_Podlaskie_2015    
Uganda_R8_2015    
Uganda_R7_2015    
Uganda_R25_2015    
Uganda_N10_2015    
Uganda_R35_2015    
Estonia_2014    
Italy_26544_OG10_2010 Protein
AJZ77076.1
Italy_47_Ss_2008_2008 Protein
AOO54390.1
Portugal_OURT_88.3_1988 Protein
CAN10406.1
Spain_E75_1975 Protein
CBH29159.1
Russia_Georgia_2007    
Kenya_Tk1_2005    
Kenya_Bus_2006    
Russia_Odintsovo_2014    
Portugal_L60_1960    
Portugal_NHV_1968 Protein
AIY22408.1
Russia_Kashino_2013    
Benin_1997 Protein
Protein
CAN10158.1
CAN10158.1
South_Africa_KNP_Pretorisuskop_1996    
South_Africa_MGR_Mkuzi_1979 Protein
AIY22249.1
Malawi_Lil_1983    
Kenya_1950    
Namibia_Warthog_1980 Protein
QGM12720.1
South_Africa_Warmbaths_1987    
Malawi_Tengani_1962    
China_HLJ_2018    
China_LN_2018    
China_wbBS01_2018    
Ukraine_Kyiv_2014    
Belgium_Etalle_wb_2018    
Lithuania_LT14_2014    
South_Africa_1985    
South_Africa_2_2008    
Zambia_LIV_1983    
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