ASFVdb The African Swine Fever Virus Database
Strain
Namibia_Warthog_1980 (Region: Namibia;  Strain: Warthog;  Date: 1980)
Gene
pEP402R
Description
With frameshift mutation but translatable,  pEP402R
GenBank Accession
Full name
CD2 homolog      
Alternative Name
5HL
CD2v
PEP402R
T-lymphocyte CD2 receptor-like protein
 

Sequence

CDS
ATGATAATTTTTATTGTATCTGGAATAACAATAAGTATTTTTATATCAATCATAACTTTTTTATCTTTACGAAAAAGAAAAAAACATGTTGAAGAAATAGAGAGTCCACCACCTGAATCTAATGAAGAAGAACAATGTCAGCATGATGACACCACTTCTATACATGAACCATCTCCCAGAGAACCATTACTTCCTAAACCTTACAGTCGTTATCAGTATAATACACCTATTTACTACATGCGTCCCTCAACACAACCACTCAACCCATTTCCCCTACCTAAACCATGCCCGCCACCTAAACCGTGTCCTCCACCCAAACCATGCCCGCCACCCAAACCATGCCCGCCACCTAAACCATGTCCTCCACCCAAACCATGCCCGCCACCTAAACCATGTCCTCCACCTGAATCATATTCTCCACCCAAACCACTACCTAGTATCCCGCTGCTACCCAATATCCCGCCATTATCTACACAAAATATTTCGCTTATT
Protein
MIIFIVSGITISIFISIITFLSLRKRKKHVEEIESPPPESNEEEQCQHDDTTSIHEPSPREPLLPKPYSRYQYNTPIYYMRPSTQPLNPFPLPKPCPPPKPCPPPKPCPPPKPCPPPKPCPPPKPCPPPKPCPPPESYSPPKPLPSIPLLPNIPPLSTQNISLI

Summary

Function
May play an immunosuppressive role by inhibiting lymphocyte proliferation and subsequently facilitating viral replication and generalization of infection (By similarity). Responsible for viral hemadsorption, which may help viral spread. Increases virus replication in the tick vector at the step of virus uptake or replication in the tick gut. May play a role in the host Golgi reorganization to yield viral factories (By similarity).
Subunit
Both glycosylated and nonglycosylated forms interact (via C-terminus) with the host AP-1 complex.
Similarity
Belongs to the asfivirus CD2 homolog protein family.
Keywords
Complete proteome   Disulfide bond   Glycoprotein   Host membrane   Late protein   Membrane   Receptor   Signal   Transmembrane   Transmembrane helix  
Feature
chain  CD2 homolog
Interpro
IPR013783   Ig-like_fold
IPR036179   Ig-like_dom_sf
SUPFAM
SSF48726   SSF48726
Gene 3D
PDB
1HNG     E-value=0.000874314,     Score=101

Ontologies

Subcellular Location

From MSLVP
Single-Pass Membrane
From Uniprot
Host membrane   Localizes around the cytoplasmic viral factories which are probably derived from the host Golgi membrane (By similarity). Both proteolytic fragments localize to membrane compartments (By similarity).   With evidence from 2 publications.

Topology

Length:
164
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
19.97983
Exp number, first 60 AAs:
19.97983
Total prob of N-in:
0.46731
POSSIBLE N-term signal
sequence
outside
1  -  3
TMhelix
4  -  23
inside
24  -  164
 
 

Population Genetic Test Statistics

Pi
0.0692669
Theta
0.082675
Tajima's D
-0.8400265
CLR
0.04151
Interpretation
No evidence of Selection

Multiple alignment of Orthologues

 
 

Gene Tree

 
 

Orthologous in Strains

Strain Availability Status Gene
Spain_BA71_1971 Protein
AKO62740.1
China_AnhuiXCGQ_2018    
China_ASFV-SY18_2018    
Poland_Pol16_20186_o7_2016-2017    
Poland_Pol16_20538_o9_2016-2017    
Poland_Pol16_20540_o10_2016-2017    
Poland_Pol16_29413_o23_2016-2017    
Poland_Pol17_03029_C201_2016-2017    
Poland_Pol17_04461_C210_2016-2017    
Poland_Pol17_05838_C220_2016-2017    
Poland_ASFV_POL_Podlaskie_2015    
Uganda_R8_2015    
Uganda_R7_2015    
Uganda_R25_2015    
Uganda_N10_2015    
Uganda_R35_2015    
Estonia_2014    
Italy_26544_OG10_2010 Protein
AJZ77076.1
Italy_47_Ss_2008_2008 Protein
AOO54390.1
Portugal_OURT_88.3_1988 Protein
CAN10406.1
Spain_E75_1975 Protein
CBH29159.1
Russia_Georgia_2007    
Kenya_Tk1_2005    
Kenya_Bus_2006    
Russia_Odintsovo_2014    
Portugal_L60_1960    
Portugal_NHV_1968 Protein
AIY22408.1
Russia_Kashino_2013    
Benin_1997 Protein
Protein
CAN10158.1
CAN10158.1
South_Africa_KNP_Pretorisuskop_1996    
South_Africa_MGR_Mkuzi_1979 Protein
AIY22249.1
Malawi_Lil_1983    
Kenya_1950    
Namibia_Warthog_1980 Protein
QGM12720.1
South_Africa_Warmbaths_1987    
Malawi_Tengani_1962    
China_HLJ_2018    
China_LN_2018    
China_wbBS01_2018    
Ukraine_Kyiv_2014    
Belgium_Etalle_wb_2018    
Lithuania_LT14_2014    
South_Africa_1985    
South_Africa_2_2008    
Zambia_LIV_1983    
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