Strain

South_Africa_MGR_Mkuzi_1979 (Region: South Africa, Mkuzi Game Reserve; Strain: Mkuzi 1979; Date: 1979)

Gene

MGF 360-9L CDS

Description

With frameshift mutation but translatable, SPS73439.1

Location

AY261362.1(-):25887-26939

GenBank Accession

SPS73439.1

Full name

Protein MGF 360-19R

CDS

ATGGTCCTCTCTCTGCAGACTCTCACCAAAAAGGTGCTGGCCAGCCAGTATCCGGCCAAATGCCATCCTCATTTTTTGAAGTGCTGCGGTCTATGGTGGCATAATGGCCCTATCATGTATCATCAAAAGAAAATATGGACGCCGTATTTTAAGAACGGCACAAATCTTAACGCGGCCTTGGTGAAAGCTGTGGAGGAAAACAATCACGATCTAATAGAATTGTTCACCGAGTGGGGCGCAAACATCAACTACGGTTTGCTTTCTGTCAACACGGAGCACACCCGAGACCTGTGTAGGCAGCTAGGTGCCAAAGAACAGTTAAATGACCAGGAAATTTTACGATTTTTTTACACATTGAAACGTGATCTAACTAGCAGTAACATCATTTTCTGCCATGAGGTATTTTCTAATAATCCCATTTTAGATACTATAAATCGTTTTGAAGTAAAGGGAATGATTTATGAACAACTGGAGGGATTAATGGTAGAAACCGATATATTAAGCGAGATGTTTACTAAATATTGGTACGCGATGGCAATAGAATTTAACCTTAAGGAGGCGATTTGCTATTTTTATCAGAGATATGCTCATCTACATCGGTGGCGGCTTATGTGCGCCCTTTTTTACAATAATGTGTTCGACCTTCACGAGCTGTACGCAAAGGAGAAGGTTCGTATGGACATGGATGAAATGCTAAGGTGGGCCTGTCGCAAGAACTATAACTATTTAACGATTTATTACTGTTGCGTCGTCTTAGGGGCTGATATCAATCAGGCCATGTTTCATTCTATTCAGTTCTATAATATCGGAAACATATTCTTTTGTATAGACTTAGGCGCCAATGCCTTTGAGGAGGGAAAGACTCTAGCGCATCAAAAAGACAACTCGTTCATTGCCAGCATGTTATCATTAAATTGTTATAGCATGAATGATTCTTTATCTTTAAAAGAAACTGATCCCGAAGTTATAAAACGTATGTTAAAAGATTATCATTCAAAAAACTTGTTCATAGCACATAAACACTATATTAATGATGGGTTTAATGATATATAA

Protein

MVLSLQTLTKKVLASQYPAKCHPHFLKCCGLWWHNGPIMYHQKKIWTPYFKNGTNLNAALVKAVEENNHDLIELFTEWGANINYGLLSVNTEHTRDLCRQLGAKEQLNDQEILRFFYTLKRDLTSSNIIFCHEVFSNNPILDTINRFEVKGMIYEQLEGLMVETDILSEMFTKYWYAMAIEFNLKEAICYFYQRYAHLHRWRLMCALFYNNVFDLHELYAKEKVRMDMDEMLRWACRKNYNYLTIYYCCVVLGADINQAMFHSIQFYNIGNIFFCIDLGANAFEEGKTLAHQKDNSFIASMLSLNCYSMNDSLSLKETDPEVIKRMLKDYHSKNLFIAHKHYINDGFNDI

Function

Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.

Similarity

Belongs to the asfivirus MGF 360 family.

Keywords

ANK repeat Complete proteome Reference proteome

Feature

chain Protein MGF 360-19R

Uniprot

A0A2X0RV94 A0A385KN43 A0A2X0RU57 A0A0A1E0V6 D4I5I2 A9JLG8 + More
A0A0N7CVN2 P23164 A9JM99 A0A0A1DYF6 A0A385KMG1

Pubmed

25406173 18198370 26618713 2325203 11831707

EMBL

MG939583 MG939587 MG939588 LS478113 AXZ95795.1 AXZ95983.1 + More
AXZ96078.1 SPS73439.1 MG939585 MG939589 AXZ95947.1 AXZ96221.1 SPS73420.1 SPS73582.1 KM262844 AIY22348.1 FN557520 CBH29258.1 AM712239 CAN10256.1 KM102979 KP055815 KX354450 AJZ77082.1 AKO62838.1 AOO54535.1 M57545 U18466 AM712240 CAN10507.1 KM262845 AIY22507.1 AXZ95796.1 AXZ95984.1 AXZ96079.1

Proteomes

UP000142390 UP000101090 UP000130745 UP000117635 UP000241813 UP000266411 + More
UP000000624 UP000108903 UP000110401

PRIDE

P23164

Pfam

PF01671 ASFV_360

Interpro

IPR002595   ASFV_MGF360
IPR036770   Ankyrin_rpt-contain_sf
IPR020683   Ankyrin_rpt-contain_dom
IPR002110   Ankyrin_rpt

SUPFAM

SSF48403 SSF48403

ProteinModelPortal

A0A2X0RV94 A0A385KN43 A0A2X0RU57 A0A0A1E0V6 D4I5I2 A9JLG8 + More
A0A0N7CVN2 P23164 A9JM99 A0A0A1DYF6 A0A385KMG1

PDB

1XR7 E-value=1.4143, Score=73

Ontologies

KEGG

vg:22220382

GO

GO:0042330 P:taxis

Subcellular Location

From MSLVP

Multi-Pass Membrane

Topology

Length:

350

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.31848

Exp number, first 60 AAs:

0.00205

Total prob of N-in:

0.15909

outside

1 - 350

Population Genetic Test Statistics

Pi

0.0836696

Theta

0.0660588

Tajima's D

0.5025249

CLR

0.32119

Interpretation

Possibly Balancing Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62700.1
China_AnhuiXCGQ_2018	Protein	AYW33988.1
China_ASFV-SY18_2018	Protein	AKO62700.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95795.1
Poland_Pol16_20538_o9_2016-2017	Protein	SPS73439.1
Poland_Pol16_20540_o10_2016-2017	Protein	SPS73439.1
Poland_Pol16_29413_o23_2016-2017	Protein	SPS73439.1
Poland_Pol17_03029_C201_2016-2017	Protein	AXZ95983.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96078.1
Poland_Pol17_05838_C220_2016-2017	Protein	SPS73439.1
Poland_ASFV_POL_Podlaskie_2015	Protein	SPS73439.1
Uganda_R8_2015	Protein	AXB49248.1
Uganda_R7_2015	Protein	AXB49422.1
Uganda_R25_2015	Protein	AXB49594.1
Uganda_N10_2015	Protein	AXB49767.1
Uganda_R35_2015	Protein	AXB49938.1
Estonia_2014	Protein Protein	SPS73439.1 SPS73439.1
Italy_26544_OG10_2010	Protein	AJZ77090.1
Italy_47_Ss_2008_2008	Protein	AOO54335.1
Portugal_OURT_88.3_1988	Protein	CAN10373.1
Spain_E75_1975	Protein	CBH29119.1
Russia_Georgia_2007	Protein	CBW46682.1
Kenya_Tk1_2005	Protein	AJL34034.1
Kenya_Bus_2006	Protein	AJL34198.1
Russia_Odintsovo_2014	Protein	SPS73439.1
Portugal_L60_1960	Protein	AIY22209.1
Portugal_NHV_1968	Protein	AIY22375.1
Russia_Kashino_2013	Protein	SPS73439.1
Benin_1997	Protein	CAN10117.1
South_Africa_KNP_Pretorisuskop_1996
South_Africa_MGR_Mkuzi_1979	Protein	SPS73439.1
Malawi_Lil_1983
Kenya_1950
Namibia_Warthog_1980
South_Africa_Warmbaths_1987
Malawi_Tengani_1962	Protein	SPS73439.1
China_HLJ_2018	Protein	QBH90504.1
China_LN_2018	Protein	QBH90689.1
China_wbBS01_2018	Protein	QDL88047.1
Ukraine_Kyiv_2014	Protein	QED21572.1
Belgium_Etalle_wb_2018	Protein	QED90459.1
Lithuania_LT14_2014	Protein	QEY87822.1
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983

Sequence