Strain

South_Africa_MGR_Mkuzi_1979 (Region: South Africa, Mkuzi Game Reserve; Strain: Mkuzi 1979; Date: 1979)

Gene

MGF_360-2L

Description

With frameshift mutation but translatable, MGF_360-2L

Location

AY261362.1(-):3438-4526

GenBank Accession

AXZ95947.1

Full name

Protein MGF 360-1L       + More
Protein MGF 360-19R
Protein MGF 360-18R
Protein MGF 360-22R

CDS

ATGTCTACTCCACTTTCTCTGCAGGCTCTTGCTAAAAAAATACTGGCCACACAGCACATATCTAAAGAACACTACTTTATTTTGAAATATTGTGGTTTGTGGTGGCATGGAGCTCCAATCATGCTTTCTACTAATGAGAATAATCAATTGATGATAAAATCAGCAATTTTTAAAGATGGTTTAGATTTAAATCTCGCATTAATGAAAGCTGTGCAGGAAAACAACTATGATCTAATAGAGTTGTTTACCGAATGGGGTGCAGACATCAACTCTAGCTTAGTCACCGTCAATACGGAGCATACTTGGAATTTCTGCCGGGAGTTAGGCGCAAAAATTTTGAATGAAATGGATATTGTACAAATATTTTATAAAATACATCGTATTAAAACTAGTAGTAATATTATTCTATGCCATAAATTGTTATCTAATAATCCCCTTTTCCAGAATATAGAGGAATTAAAAATAATAATCTGTTGTTTTCTAGAGAAGATATCGATCAACTTTATATTGAATGAAATAACATTGAACGAAATGCTAGCTAGATTATGGTATAGTATAGCGGTACGATATCACCTAACGGAAGCTATCCAATATTTTTATCAACGTTATAGACATTTTAAAGATTGGCGGCTAATATGTGGGCTTTCTTTTAATAACGTGTCTGATCTTCATGAAATATATCATATAAAAAAGGTTGATATGAATATTGATGAAATGATGTATCTGGCATGTATGAGAGATAGCAATTTTTTAACCATTTTCTATTGTTTTGCATTAGGGGCTGACATCAATCGGGCAATGGTTACTTCGGTAAAAAACTTTTATACTAATAACATGTTCTTTTGTATAGATTTAGGAGCTAATGCTTTCGAAGAGAGCTTAGAATTAGCAAAACAAAAGAATCATGATAAATTAGTAGAAATATTATCATTTAAAGATTTTTATAGTTCAAACATCTCTCTTTTATCATTAAAAACGACAGATCCAGAAAAAATTAATGCCTTGTTAACAAACTATAGATCTAAAAATATAATGAGGTATAAAAAGTTGTGTCCACAAATAATACGGTGGGCGAGATTTATTATGTAA

Protein

MSTPLSLQALAKKILATQHISKEHYFILKYCGLWWHGAPIMLSTNENNQLMIKSAIFKDGLDLNLALMKAVQENNYDLIELFTEWGADINSSLVTVNTEHTWNFCRELGAKILNEMDIVQIFYKIHRIKTSSNIILCHKLLSNNPLFQNIEELKIIICCFLEKISINFILNEITLNEMLARLWYSIAVRYHLTEAIQYFYQRYRHFKDWRLICGLSFNNVSDLHEIYHIKKVDMNIDEMMYLACMRDSNFLTIFYCFALGADINRAMVTSVKNFYTNNMFFCIDLGANAFEESLELAKQKNHDKLVEILSFKDFYSSNISLLSLKTTDPEKINALLTNYRSKNIMRYKKLCPQIIRWARFIM

Function

Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.

Similarity

Belongs to the asfivirus MGF 360 family.

Keywords

Complete proteome ANK repeat Reference proteome

Feature

chain Protein MGF 360-1L

Uniprot

A0A385KN43 P0C9L9 A0A0C5AZ90 P0C9S0 D4I5I2 P0C9R8 + More
P0C9R5 A0A0A1E0V6 A0A2X0RU57 A9JM99 A0A0A1DYF6 A9JLG8 A0A0N7CVN2 P23164 Q65269 A0A0C5BCX7 A0A2Z5DG36 A0A2X0RV94

Pubmed

25645905 25406173 18198370 26618713 2325203 11831707 + More
8409937 8021596

EMBL

MG939585 MG939589 AXZ95947.1 AXZ96221.1 AY261360 KM111294 + More
AJL34005.1 AY261363 FN557520 CBH29258.1 AY261366 KM262844 AIY22348.1 LS478113 SPS73420.1 SPS73582.1 AM712240 CAN10507.1 KM262845 AIY22507.1 AM712239 CAN10256.1 KM102979 KP055815 KX354450 AJZ77082.1 AKO62838.1 AOO54535.1 M57545 U18466 X71982 AY261361 KM111295 AJL34333.1 MH025916 MH025917 MH025918 MH025919 MH025920 AXB49385.1 AXB49559.1 AXB49731.1 AXB49902.1 AXB50075.1 MG939583 MG939587 MG939588 AXZ95795.1 AXZ95983.1 AXZ96078.1 SPS73439.1

Proteomes

UP000000861 UP000105860 UP000000859 UP000101090 UP000000858 UP000142390 + More
UP000108903 UP000110401 UP000130745 UP000117635 UP000241813 UP000266411 UP000000624 UP000000860 UP000101566

PRIDE

P23164 Q65269

Pfam

PF01671 ASFV_360

Interpro

IPR002595 ASFV_MGF360
IPR036770 Ankyrin_rpt-contain_sf

SUPFAM

SSF48403 SSF48403

ProteinModelPortal

A0A385KN43 P0C9L9 A0A0C5AZ90 P0C9S0 D4I5I2 P0C9R8 + More
P0C9R5 A0A0A1E0V6 A0A2X0RU57 A9JM99 A0A0A1DYF6 A9JLG8 A0A0N7CVN2 P23164 Q65269 A0A0C5BCX7 A0A2Z5DG36 A0A2X0RV94

PDB

3LHX E-value=3.93914, Score=69

Ontologies

KEGG

vg:22220382

GO

GO:0042330 P:taxis

Subcellular Location

From MSLVP

Single-Pass Membrane

Topology

Length:

362

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.07511

Exp number, first 60 AAs:

0.04202

Total prob of N-in:

0.01115

outside

1 - 362

Population Genetic Test Statistics

Pi

0.1218858

Theta

0.2337517

Tajima's D

-1.8325515

CLR

1.44563

Interpretation

No evidence of Selection

Multiple alignment of Orthologues

Gene Tree

Orthologous in Strains

Strain	Status	Gene
Spain_BA71_1971	Protein	AKO62685.1
China_AnhuiXCGQ_2018	Protein	AYW33954.1
China_ASFV-SY18_2018	Protein Protein	AKO62685.1 AKO62839.1
Poland_Pol16_20186_o7_2016-2017	Protein	AXZ95934.1
Poland_Pol16_20538_o9_2016-2017	Protein	AXZ95945.1
Poland_Pol16_20540_o10_2016-2017	Protein Protein	AXZ95947.1 AXZ95947.1
Poland_Pol16_29413_o23_2016-2017	Protein	AXZ95965.1
Poland_Pol17_03029_C201_2016-2017	Protein	AXZ96059.1
Poland_Pol17_04461_C210_2016-2017	Protein	AXZ96217.1
Poland_Pol17_05838_C220_2016-2017	Protein	AXZ96221.1
Poland_ASFV_POL_Podlaskie_2015	Protein	AXZ95947.1
Uganda_R8_2015
Uganda_R7_2015
Uganda_R25_2015
Uganda_N10_2015
Uganda_R35_2015
Estonia_2014
Italy_26544_OG10_2010	Protein	AJZ77102.1
Italy_47_Ss_2008_2008	Protein	AOO54310.1
Portugal_OURT_88.3_1988	Protein	CAN10351.1
Spain_E75_1975
Russia_Georgia_2007	Protein	CBW46644.1
Kenya_Tk1_2005	Protein	AJL34007.1
Kenya_Bus_2006
Russia_Odintsovo_2014	Protein	AXZ95947.1
Portugal_L60_1960	Protein	AIY22190.1
Portugal_NHV_1968	Protein	AIY22353.1
Russia_Kashino_2013	Protein	AXZ95947.1
Benin_1997	Protein	CAN10099.1
South_Africa_KNP_Pretorisuskop_1996	Protein	AXZ95947.1
South_Africa_MGR_Mkuzi_1979	Protein Protein	AXZ95947.1 QGM12881.1
Malawi_Lil_1983
Kenya_1950
Namibia_Warthog_1980
South_Africa_Warmbaths_1987	Protein Protein	AXZ95947.1 QGM12881.1
Malawi_Tengani_1962	Protein	AXZ95947.1
China_HLJ_2018	Protein	QBH90467.1
China_LN_2018	Protein	QBH90652.1
China_wbBS01_2018	Protein	QDL88011.1
Ukraine_Kyiv_2014	Protein	QED21541.1
Belgium_Etalle_wb_2018	Protein	QED90425.1
Lithuania_LT14_2014	Protein	QEY87784.1
South_Africa_1985
South_Africa_2_2008
Zambia_LIV_1983

Sequence